PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8615885-10	1996	Incubation of loratadine with cDNA-expressed CYP3A4 and CYP2D6 microsomes catalysed the formation of DCL with formation rates of 135 and 633 pmol/min/nmol P450, respectively.	desloratadine	101-104	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	45-51	
8615885-1	1996	Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6.	desloratadine	13-37	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	41-47	
8615885-11	1996	The results indicated that loratadine was metabolized to DCL primarily by the CYP3A4 and CYP2D6 enzymes in human liver microsomes.	desloratadine	57-60	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	78-84	
8615885-7	1996	With the addition of ketoconazole (CYP3A4 inhibitor) to the incubation mixtures, the residual rate of formation of DCL correlated (r2 = 0.81) with that for dextromethorphan O-demethylation, a CYP2D6 reaction.	desloratadine	115-118	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	35-41	
8615885-12	1996	In the presence of a CYP3A4 inhibitor, loratadine was metabolized to DCL by the CYP2D6 enzyme.	desloratadine	69-72	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	21-27	
8615885-8	1996	Rabbit polyclonal antibodies raised against the rat CYP3A1 enzyme (5 mg IgG/nmol P450) and troleandomycin (0.5 microM), a specific inhibitor of CYP3A4, decreased the formation of DCL by 53 and 75%, respectively, when added to 1.42 microM loratadine microsomal incubations.	desloratadine	179-182	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	144-150	
26135009-4	2015	Desloratadine (10 microM) caused no inhibition (<15%) of CYP1A2, CYP2C8, CYP2C9, or CYP2C19 and weak inhibition (32-48%) of CYP2B6, CYP2D6, and CYP3A4/5.	desloratadine	0-13	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	147-153