PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11700329-3 2002 Whereas the inhibition of nuclear factor-kappaB by aspirin and sodium salicylate can be partly accounted for by their binding to IkappaB kinase-beta, the broad range of transcriptional targets of NSAID suggests that the products of COX activity might affect one or more among the early steps in the TCR-signaling cascade. Sodium Salicylate 63-80 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 129-148 10553070-10 1999 Sodium salicylate, an inhibitor of IKK beta, but not IKK alpha, activity, inhibited IL-2 promoter activation as well as IL-2 secretion and interfered in activation of both the heterodimeric as well as the homodimeric IKK complexes in primary CD4+ T cells. Sodium Salicylate 0-17 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 35-43 9817203-5 1998 Here we demonstrate that the anti-inflammatory agents aspirin and sodium salicylate specifically inhibit IKK-beta activity in vitro and in vivo. Sodium Salicylate 66-83 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 105-113 9817203-6 1998 The mechanism of aspirin and sodium salicylate inhibition is due to binding of these agents to IKK-beta to reduce ATP binding. Sodium Salicylate 29-46 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 95-103 10480951-4 1999 Recently, we demonstrated that both aspirin and sodium salicylate, but not indomethacin, inhibited the activity of an IkappaB kinase beta (IKKbeta) that is required to activate the nuclear factor-kappaB (NF-kappaB) pathway. Sodium Salicylate 48-65 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 118-137 10480951-4 1999 Recently, we demonstrated that both aspirin and sodium salicylate, but not indomethacin, inhibited the activity of an IkappaB kinase beta (IKKbeta) that is required to activate the nuclear factor-kappaB (NF-kappaB) pathway. Sodium Salicylate 48-65 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 139-146