PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28184015-7 2017 The significant treatment responses were confirmed in mice with Apc and Pik3ca-mutant colon cancers as measured using endoscopy with a reduction in median lumen occlusion of 53% with BEZ235 and a 24% reduction with LY3023414 compared with an increase of 53% in controls (P < 0.001 and P = 0.03, respectively). LY3023414 215-224 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Mus musculus 72-78