PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21222484-2 2011 In budding yeast, 5-FU promotes a large increase in the dUMP/dTMP ratio leading to massive polymerase-catalyzed incorporation of uracil (U) into genomic DNA, and to a lesser extent 5-FU, which are both excised by yeast uracil DNA glycosylase (UNG), leading to DNA fragmentation and cell death. 2'-deoxyuridylic acid 56-60 uracil DNA glycosylase Gallus gallus 243-246