PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15559367-1 2004 C-reactive protein (CRP) is a blood component comprised of five identical subunits with a combined molecular mass of 110 kDa; in the presence of Ca++ it binds phosphocholine (PC) with high affinity. Phosphorylcholine 159-173 C-reactive protein Homo sapiens 0-18 15559367-1 2004 C-reactive protein (CRP) is a blood component comprised of five identical subunits with a combined molecular mass of 110 kDa; in the presence of Ca++ it binds phosphocholine (PC) with high affinity. Phosphorylcholine 159-173 C-reactive protein Homo sapiens 20-23 15559367-1 2004 C-reactive protein (CRP) is a blood component comprised of five identical subunits with a combined molecular mass of 110 kDa; in the presence of Ca++ it binds phosphocholine (PC) with high affinity. Phosphorylcholine 175-177 C-reactive protein Homo sapiens 0-18 15559367-1 2004 C-reactive protein (CRP) is a blood component comprised of five identical subunits with a combined molecular mass of 110 kDa; in the presence of Ca++ it binds phosphocholine (PC) with high affinity. Phosphorylcholine 175-177 C-reactive protein Homo sapiens 20-23 12634320-0 2003 Carbohydrate-binding properties of human neo-CRP and its relationship to phosphorylcholine-binding site. Phosphorylcholine 73-90 C-reactive protein Homo sapiens 45-48 12749911-1 2003 C-reactive protein (CRP) is an acute phase protein in humans and rabbits that has the ability to bind a number of biologically important ligands including phosphocholine (PCh), histones, and polycations. Phosphorylcholine 155-169 C-reactive protein Homo sapiens 0-18 12749911-1 2003 C-reactive protein (CRP) is an acute phase protein in humans and rabbits that has the ability to bind a number of biologically important ligands including phosphocholine (PCh), histones, and polycations. Phosphorylcholine 155-169 C-reactive protein Homo sapiens 20-23 12749911-1 2003 C-reactive protein (CRP) is an acute phase protein in humans and rabbits that has the ability to bind a number of biologically important ligands including phosphocholine (PCh), histones, and polycations. Phosphorylcholine 171-174 C-reactive protein Homo sapiens 0-18 12749911-1 2003 C-reactive protein (CRP) is an acute phase protein in humans and rabbits that has the ability to bind a number of biologically important ligands including phosphocholine (PCh), histones, and polycations. Phosphorylcholine 171-174 C-reactive protein Homo sapiens 20-23 12531203-0 2003 Quantitative detection of C-reactive protein using phosphocholine-labelled enzyme or microspheres. Phosphorylcholine 51-65 C-reactive protein Homo sapiens 26-44 12531203-4 2003 Thus, generic systems for CRP detection, based solely on the interaction between CRP and phosphocholine (PC), have been developed. Phosphorylcholine 89-103 C-reactive protein Homo sapiens 26-29 12531203-4 2003 Thus, generic systems for CRP detection, based solely on the interaction between CRP and phosphocholine (PC), have been developed. Phosphorylcholine 105-107 C-reactive protein Homo sapiens 26-29 12244213-0 2002 C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids. Phosphorylcholine 106-123 C-reactive protein Homo sapiens 0-18 12218140-2 2002 CRP also binds, in a PCh-inhibitable manner, to ligands that do not contain PCh, such as fibronectin (Fn). Phosphorylcholine 76-79 C-reactive protein Homo sapiens 0-3 12218140-3 2002 Crystallographic data on CRP-PCh complexes indicate that Phe(66) and Glu(81) contribute to the formation of the PCh binding site of CRP. Phosphorylcholine 29-32 C-reactive protein Homo sapiens 25-28 12218140-3 2002 Crystallographic data on CRP-PCh complexes indicate that Phe(66) and Glu(81) contribute to the formation of the PCh binding site of CRP. Phosphorylcholine 29-32 C-reactive protein Homo sapiens 132-135 12218140-3 2002 Crystallographic data on CRP-PCh complexes indicate that Phe(66) and Glu(81) contribute to the formation of the PCh binding site of CRP. Phosphorylcholine 112-115 C-reactive protein Homo sapiens 25-28 12218140-3 2002 Crystallographic data on CRP-PCh complexes indicate that Phe(66) and Glu(81) contribute to the formation of the PCh binding site of CRP. Phosphorylcholine 112-115 C-reactive protein Homo sapiens 132-135 12218140-4 2002 We used site-directed mutagenesis to analyze the contribution of Phe(66) and Glu(81) to the binding of CRP to PCh, and to generate a CRP mutant that does not bind to PCh-containing ligands. Phosphorylcholine 110-113 C-reactive protein Homo sapiens 103-106 12218140-10 2002 We conclude that Phe(66) is the major determinant of CRP-PCh interaction and is critical for binding of CRP to PnC. Phosphorylcholine 57-60 C-reactive protein Homo sapiens 53-56 12218140-11 2002 The data also suggest that the binding sites for PCh and Fn on CRP are distinct. Phosphorylcholine 49-52 C-reactive protein Homo sapiens 63-66 12218140-12 2002 A CRP mutant incapable of binding to PCh provides a tool to assess PCh-inhibitable interactions of CRP with its other biologically significant ligands, and to further investigate the functions of CRP in host defense and inflammation. Phosphorylcholine 37-40 C-reactive protein Homo sapiens 2-5 12218140-12 2002 A CRP mutant incapable of binding to PCh provides a tool to assess PCh-inhibitable interactions of CRP with its other biologically significant ligands, and to further investigate the functions of CRP in host defense and inflammation. Phosphorylcholine 67-70 C-reactive protein Homo sapiens 2-5 12218140-12 2002 A CRP mutant incapable of binding to PCh provides a tool to assess PCh-inhibitable interactions of CRP with its other biologically significant ligands, and to further investigate the functions of CRP in host defense and inflammation. Phosphorylcholine 67-70 C-reactive protein Homo sapiens 99-102 12218140-12 2002 A CRP mutant incapable of binding to PCh provides a tool to assess PCh-inhibitable interactions of CRP with its other biologically significant ligands, and to further investigate the functions of CRP in host defense and inflammation. Phosphorylcholine 67-70 C-reactive protein Homo sapiens 99-102 14650743-5 2003 CRP can bind phosphocholine largely present in bacterial membranes, cell membrane and lipoproteins, in addition CRP can recognize nuclear constituent in damaged cells. Phosphorylcholine 13-27 C-reactive protein Homo sapiens 0-3 14650743-5 2003 CRP can bind phosphocholine largely present in bacterial membranes, cell membrane and lipoproteins, in addition CRP can recognize nuclear constituent in damaged cells. Phosphorylcholine 13-27 C-reactive protein Homo sapiens 112-115 12218140-1 2002 C-reactive protein (CRP), the major human acute-phase plasma protein, binds to phosphocholine (PCh) residues present in pneumococcal C-polysaccharide (PnC) of Streptococcus pneumoniae and to PCh exposed on damaged and apoptotic cells. Phosphorylcholine 79-93 C-reactive protein Homo sapiens 0-18 12218140-1 2002 C-reactive protein (CRP), the major human acute-phase plasma protein, binds to phosphocholine (PCh) residues present in pneumococcal C-polysaccharide (PnC) of Streptococcus pneumoniae and to PCh exposed on damaged and apoptotic cells. Phosphorylcholine 79-93 C-reactive protein Homo sapiens 20-23 12218140-1 2002 C-reactive protein (CRP), the major human acute-phase plasma protein, binds to phosphocholine (PCh) residues present in pneumococcal C-polysaccharide (PnC) of Streptococcus pneumoniae and to PCh exposed on damaged and apoptotic cells. Phosphorylcholine 95-98 C-reactive protein Homo sapiens 0-18 12218140-1 2002 C-reactive protein (CRP), the major human acute-phase plasma protein, binds to phosphocholine (PCh) residues present in pneumococcal C-polysaccharide (PnC) of Streptococcus pneumoniae and to PCh exposed on damaged and apoptotic cells. Phosphorylcholine 95-98 C-reactive protein Homo sapiens 20-23 12218140-1 2002 C-reactive protein (CRP), the major human acute-phase plasma protein, binds to phosphocholine (PCh) residues present in pneumococcal C-polysaccharide (PnC) of Streptococcus pneumoniae and to PCh exposed on damaged and apoptotic cells. Phosphorylcholine 191-194 C-reactive protein Homo sapiens 0-18 12218140-1 2002 C-reactive protein (CRP), the major human acute-phase plasma protein, binds to phosphocholine (PCh) residues present in pneumococcal C-polysaccharide (PnC) of Streptococcus pneumoniae and to PCh exposed on damaged and apoptotic cells. Phosphorylcholine 191-194 C-reactive protein Homo sapiens 20-23 12218140-2 2002 CRP also binds, in a PCh-inhibitable manner, to ligands that do not contain PCh, such as fibronectin (Fn). Phosphorylcholine 21-24 C-reactive protein Homo sapiens 0-3 12244213-1 2002 C-reactive protein (CRP) is an acute-phase protein that binds specifically to phosphorylcholine (PC) as a component of microbial capsular polysaccharide and participates in the innate immune response against microorganisms. Phosphorylcholine 97-99 C-reactive protein Homo sapiens 0-18 12244213-1 2002 C-reactive protein (CRP) is an acute-phase protein that binds specifically to phosphorylcholine (PC) as a component of microbial capsular polysaccharide and participates in the innate immune response against microorganisms. Phosphorylcholine 97-99 C-reactive protein Homo sapiens 20-23 12244213-6 2002 We now report that CRP binds to oxidized LDL (OxLDL) and oxidized PtC (OxPtC), but does not bind to native, nonoxidized LDL nor to nonoxidized PtC, and its binding is mediated through the recognition of a PC moiety. Phosphorylcholine 205-207 C-reactive protein Homo sapiens 19-22 12244213-9 2002 These data suggest that CRP binds OxLDL and apoptotic cells by recognition of a PC moiety that becomes accessible as a result of oxidation of PtC molecule. Phosphorylcholine 80-82 C-reactive protein Homo sapiens 24-27 12037301-3 2002 The role of hCRP in host defence and the calcium-dependent ligand-binding specificity of hCRP for phosphocholine moieties have long been recognized. Phosphorylcholine 98-112 C-reactive protein Homo sapiens 89-93 12654086-6 2002 Whereas CRP increased macrophage responses to phosphorylcholine coated erythrocytes, no significant alteration in tumour necrosis factor-alpha, interleukin (IL)-10 or IL-12 production from PBMs was observed between CRP opsonized or unopsonized L. donovani promastigotes. Phosphorylcholine 46-63 C-reactive protein Homo sapiens 8-11 12083784-0 2002 Secretory production of recombinant human C-reactive protein in Escherichia coli, capable of binding with phosphorylcholine, and its characterization. Phosphorylcholine 106-123 C-reactive protein Homo sapiens 42-60 11594754-2 2001 Here we show that the human C-reactive protein is two-dimensionally crystallized upon specific adsorption on the phosphorylcholine ligand containing membranes by monolayer approach. Phosphorylcholine 113-130 C-reactive protein Homo sapiens 28-46 11684681-0 2002 Mapping the binding areas of human C-reactive protein for phosphorylcholine and polycationic compounds. Phosphorylcholine 58-75 C-reactive protein Homo sapiens 35-53 11684681-3 2002 Using this method, we compared the phosphorylcholine (PC)- and polycation-based binding activities of human CRP. Phosphorylcholine 35-52 C-reactive protein Homo sapiens 108-111 11684681-3 2002 Using this method, we compared the phosphorylcholine (PC)- and polycation-based binding activities of human CRP. Phosphorylcholine 54-56 C-reactive protein Homo sapiens 108-111 11684681-5 2002 The published crystallographic structures of CRP and the CRP.PC complex show it to be a ring-shaped pentamer with a single PC-binding site per subunit facing the same direction. Phosphorylcholine 61-63 C-reactive protein Homo sapiens 57-60 10521363-8 1999 Binding was Ca(2+)-dependent and inhibitable by phosphorylcholine, and the complement-activating property of E-LDL was destroyed by treatment with phospholipase C. These results indicated that CRP binds to phosphorylcholine groups that become exposed in enzymatically degraded LDL particles. Phosphorylcholine 48-65 C-reactive protein Homo sapiens 193-196 11179352-3 2001 CRP binds to phosphorylcholine (ChoP), a constituent of eukaryotic membranes that is also found on the cell surface of major bacterial pathogens of the human respiratory tract, including Streptococcus pneumoniae and Haemophilus influenzae. Phosphorylcholine 13-30 C-reactive protein Homo sapiens 0-3 11532280-1 2001 C-reactive protein (CRP) is an acute-phase protein featuring a homopentameric structure and Ca-binding specificity for phosphocholine (PCh). Phosphorylcholine 119-133 C-reactive protein Homo sapiens 0-18 11532280-1 2001 C-reactive protein (CRP) is an acute-phase protein featuring a homopentameric structure and Ca-binding specificity for phosphocholine (PCh). Phosphorylcholine 119-133 C-reactive protein Homo sapiens 20-23 11532280-1 2001 C-reactive protein (CRP) is an acute-phase protein featuring a homopentameric structure and Ca-binding specificity for phosphocholine (PCh). Phosphorylcholine 135-138 C-reactive protein Homo sapiens 0-18 11532280-1 2001 C-reactive protein (CRP) is an acute-phase protein featuring a homopentameric structure and Ca-binding specificity for phosphocholine (PCh). Phosphorylcholine 135-138 C-reactive protein Homo sapiens 20-23 11532280-4 2001 The wide distribution of PCh in polysaccharides of pathogens and in cellular membranes allows CRP to recognize a range of pathogenic targets as well as membranes of damaged and necrotic host cells. Phosphorylcholine 25-28 C-reactive protein Homo sapiens 94-97 11238646-4 2001 The three-dimensional structure of CRP shows the presence of a deep, extended cleft in each protomer on the face of the pentamer opposite that containing the phosphocholine-binding sites. Phosphorylcholine 158-172 C-reactive protein Homo sapiens 35-38 11260477-1 2001 Streptococcus pneumoniae is a major human pathogen and many interactions of this bacterium with its host appear to be mediated, directly or indirectly, by components of the bacterial cell wall, specifically by the phosphorylcholine residues which serve as anchors for surface-located choline-binding proteins and are also recognized by components of the host response, such as the human C-reactive protein, a class of myeloma proteins and PAF receptors. Phosphorylcholine 214-231 C-reactive protein Homo sapiens 387-405 10959695-8 2000 Incubation of plasma with heparin and protamine in vitro generated complement-CRP complexes, which was blocked by phosphorylcholine and stimulated by exogenous CRP. Phosphorylcholine 114-131 C-reactive protein Homo sapiens 78-81 10521363-8 1999 Binding was Ca(2+)-dependent and inhibitable by phosphorylcholine, and the complement-activating property of E-LDL was destroyed by treatment with phospholipase C. These results indicated that CRP binds to phosphorylcholine groups that become exposed in enzymatically degraded LDL particles. Phosphorylcholine 206-223 C-reactive protein Homo sapiens 193-196 8977209-0 1997 Site-directed mutagenesis of the phosphocholine-binding site of human C-reactive protein: role of Thr76 and Trp67. Phosphorylcholine 33-47 C-reactive protein Homo sapiens 70-88 10368284-0 1999 The physiological structure of human C-reactive protein and its complex with phosphocholine. Phosphorylcholine 77-91 C-reactive protein Homo sapiens 37-55 10368284-3 1999 However, CRP is likely to have important host defence, scavenging and metabolic functions through its capacity for calcium-dependent binding to exogenous and autologous molecules containing phosphocholine (PC) and then activating the classical complement pathway. Phosphorylcholine 190-204 C-reactive protein Homo sapiens 9-12 10368284-3 1999 However, CRP is likely to have important host defence, scavenging and metabolic functions through its capacity for calcium-dependent binding to exogenous and autologous molecules containing phosphocholine (PC) and then activating the classical complement pathway. Phosphorylcholine 206-208 C-reactive protein Homo sapiens 9-12 10368284-8 1999 CONCLUSIONS: The structure shows how large ligands containing PC may be bound by CRP via a phosphate oxygen that projects away from the surface of the protein. Phosphorylcholine 62-64 C-reactive protein Homo sapiens 81-84 10368284-11 1999 The hydrophobic pocket adjacent to bound PC invites the design of inhibitors of CRP binding that may have therapeutic relevance to the possible role of CRP in atherothrombotic events. Phosphorylcholine 41-43 C-reactive protein Homo sapiens 80-83 10368284-11 1999 The hydrophobic pocket adjacent to bound PC invites the design of inhibitors of CRP binding that may have therapeutic relevance to the possible role of CRP in atherothrombotic events. Phosphorylcholine 41-43 C-reactive protein Homo sapiens 152-155 9614930-1 1998 C-reactive protein (CRP) is an acute phase serum protein that binds to phosphocholine (PC) and to components of damaged tissue. Phosphorylcholine 71-85 C-reactive protein Homo sapiens 0-18 9614930-1 1998 C-reactive protein (CRP) is an acute phase serum protein that binds to phosphocholine (PC) and to components of damaged tissue. Phosphorylcholine 71-85 C-reactive protein Homo sapiens 20-23 9614930-1 1998 C-reactive protein (CRP) is an acute phase serum protein that binds to phosphocholine (PC) and to components of damaged tissue. Phosphorylcholine 87-89 C-reactive protein Homo sapiens 0-18 9614930-1 1998 C-reactive protein (CRP) is an acute phase serum protein that binds to phosphocholine (PC) and to components of damaged tissue. Phosphorylcholine 87-89 C-reactive protein Homo sapiens 20-23 8977209-1 1997 We have reported previously that residues Lys57, Arg58, and Trp67 of human C-reactive protein (CRP) contribute to the structure of the phosphocholine (PCh)-binding site. Phosphorylcholine 135-149 C-reactive protein Homo sapiens 75-93 8977209-1 1997 We have reported previously that residues Lys57, Arg58, and Trp67 of human C-reactive protein (CRP) contribute to the structure of the phosphocholine (PCh)-binding site. Phosphorylcholine 135-149 C-reactive protein Homo sapiens 95-98 8977209-1 1997 We have reported previously that residues Lys57, Arg58, and Trp67 of human C-reactive protein (CRP) contribute to the structure of the phosphocholine (PCh)-binding site. Phosphorylcholine 151-154 C-reactive protein Homo sapiens 75-93 8977209-1 1997 We have reported previously that residues Lys57, Arg58, and Trp67 of human C-reactive protein (CRP) contribute to the structure of the phosphocholine (PCh)-binding site. Phosphorylcholine 151-154 C-reactive protein Homo sapiens 95-98 8977209-2 1997 In this study, based on the three-dimensional structures of human CRP and serum amyloid P, we constructed an additional mutant, T76Y, to probe the structural determinants of the PCh-binding site of CRP. Phosphorylcholine 178-181 C-reactive protein Homo sapiens 198-201 8599761-1 1996 The structure of the classical acute phase reactant human C-reactive protein provides evidence that phosphocholine binding is mediated through calcium and a hydrophobic pocket centred on Phe 66. Phosphorylcholine 100-114 C-reactive protein Homo sapiens 58-76 8906746-1 1996 C-reactive protein (CRP) is an acute phase serum protein that binds to phosphocholine (PC) on phospholipids and polysaccharides and to protein components of chromatin and small nuclear ribonucleoproteins. Phosphorylcholine 71-85 C-reactive protein Homo sapiens 0-18 8906746-1 1996 C-reactive protein (CRP) is an acute phase serum protein that binds to phosphocholine (PC) on phospholipids and polysaccharides and to protein components of chromatin and small nuclear ribonucleoproteins. Phosphorylcholine 71-85 C-reactive protein Homo sapiens 20-23 8906746-1 1996 C-reactive protein (CRP) is an acute phase serum protein that binds to phosphocholine (PC) on phospholipids and polysaccharides and to protein components of chromatin and small nuclear ribonucleoproteins. Phosphorylcholine 87-89 C-reactive protein Homo sapiens 0-18 8906746-1 1996 C-reactive protein (CRP) is an acute phase serum protein that binds to phosphocholine (PC) on phospholipids and polysaccharides and to protein components of chromatin and small nuclear ribonucleoproteins. Phosphorylcholine 87-89 C-reactive protein Homo sapiens 20-23 7485521-0 1995 Phosphocholine reverses inhibition of pulmonary surfactant adsorption caused by C-reactive protein. Phosphorylcholine 0-14 C-reactive protein Homo sapiens 80-98 8573206-2 1995 Special attention is paid to the specific interaction of C-reactive protein with Ca(2+)-dependent and Ca(2+)-independent ligands: phosphorylcholine-containing compounds, lipoproteins, chromatin, galactans, polycations, etc. Phosphorylcholine 130-147 C-reactive protein Homo sapiens 57-75 18475716-6 1996 Phosphorylcholine abolished the inhibitory activity of CRP but not of SAP or lactoferrin. Phosphorylcholine 0-17 C-reactive protein Homo sapiens 55-58 7485521-6 1995 These data suggest that the potent inhibition of surfactant adsorption by CRP is primarily a result of a specific interaction between CRP and the phosphocholine headgroup of surfactant lipids in the subphase and that it can be reversed by the water-soluble CRP ligand, phosphocholine. Phosphorylcholine 269-283 C-reactive protein Homo sapiens 134-137 7485521-4 1995 The effect of CRP required the presence of calcium and was reversed by the addition of phosphocholine in a concentration-dependent manner. Phosphorylcholine 87-101 C-reactive protein Homo sapiens 14-17 7485521-6 1995 These data suggest that the potent inhibition of surfactant adsorption by CRP is primarily a result of a specific interaction between CRP and the phosphocholine headgroup of surfactant lipids in the subphase and that it can be reversed by the water-soluble CRP ligand, phosphocholine. Phosphorylcholine 269-283 C-reactive protein Homo sapiens 134-137 7485521-5 1995 The inhibition of surfactant adsorption by CRP was effectively eliminated by the addition of phosphocholine at a molar ratio of 300:1 (phosphocholine:CRP), but it was not diminished by the addition of identical molar ratios of o-phosphoethanolamine or DL-alpha-glycerophosphate at the same molar ratios. Phosphorylcholine 93-107 C-reactive protein Homo sapiens 43-46 7485521-5 1995 The inhibition of surfactant adsorption by CRP was effectively eliminated by the addition of phosphocholine at a molar ratio of 300:1 (phosphocholine:CRP), but it was not diminished by the addition of identical molar ratios of o-phosphoethanolamine or DL-alpha-glycerophosphate at the same molar ratios. Phosphorylcholine 93-107 C-reactive protein Homo sapiens 150-153 7485521-5 1995 The inhibition of surfactant adsorption by CRP was effectively eliminated by the addition of phosphocholine at a molar ratio of 300:1 (phosphocholine:CRP), but it was not diminished by the addition of identical molar ratios of o-phosphoethanolamine or DL-alpha-glycerophosphate at the same molar ratios. Phosphorylcholine 135-149 C-reactive protein Homo sapiens 43-46 7485521-6 1995 These data suggest that the potent inhibition of surfactant adsorption by CRP is primarily a result of a specific interaction between CRP and the phosphocholine headgroup of surfactant lipids in the subphase and that it can be reversed by the water-soluble CRP ligand, phosphocholine. Phosphorylcholine 146-160 C-reactive protein Homo sapiens 74-77 7485521-6 1995 These data suggest that the potent inhibition of surfactant adsorption by CRP is primarily a result of a specific interaction between CRP and the phosphocholine headgroup of surfactant lipids in the subphase and that it can be reversed by the water-soluble CRP ligand, phosphocholine. Phosphorylcholine 146-160 C-reactive protein Homo sapiens 134-137 7485521-6 1995 These data suggest that the potent inhibition of surfactant adsorption by CRP is primarily a result of a specific interaction between CRP and the phosphocholine headgroup of surfactant lipids in the subphase and that it can be reversed by the water-soluble CRP ligand, phosphocholine. Phosphorylcholine 146-160 C-reactive protein Homo sapiens 134-137 7485521-6 1995 These data suggest that the potent inhibition of surfactant adsorption by CRP is primarily a result of a specific interaction between CRP and the phosphocholine headgroup of surfactant lipids in the subphase and that it can be reversed by the water-soluble CRP ligand, phosphocholine. Phosphorylcholine 269-283 C-reactive protein Homo sapiens 74-77 7620766-1 1995 The developed enzyme immunoassay of C-reactive protein is based on the use of a plane modified by a phosphorylcholine derivative lisolecithin. Phosphorylcholine 100-117 C-reactive protein Homo sapiens 36-54 8144569-3 1994 Externally labeled SAP rapidly binds to two distinct forms of immobilized CRP (direct and phosphorylcholine captured) with a relatively high affinity (KD = 5 nM) at a molar ratio of specifically bound SAP/CRP = 0.3. Phosphorylcholine 90-107 C-reactive protein Homo sapiens 74-77 8189060-3 1994 Wild-type (wt) and all mutant rCRPs bound to phosphocholine-substituted BSA and also to pneumococcal C-polysaccharide with apparent avidities similar to native CRP, except for the R116L mutant which bound slightly less avidly. Phosphorylcholine 45-59 C-reactive protein Homo sapiens 31-34 8119992-0 1994 Effects of calcium, magnesium, and phosphorylcholine on secondary structures of human C-reactive protein and serum amyloid P component observed by infrared spectroscopy. Phosphorylcholine 35-52 C-reactive protein Homo sapiens 86-104 8119992-6 1994 Phosphorylcholine in the presence of calcium also affected the spectrum of CRP but not the spectrum of SAP. Phosphorylcholine 0-17 C-reactive protein Homo sapiens 75-78 7780685-8 1995 Preincubation of CRP with phosphorylcholine led to a concentration-dependent loss of CRP-induced inhibition of substrate hydrolysis. Phosphorylcholine 26-43 C-reactive protein Homo sapiens 17-20 7780685-8 1995 Preincubation of CRP with phosphorylcholine led to a concentration-dependent loss of CRP-induced inhibition of substrate hydrolysis. Phosphorylcholine 26-43 C-reactive protein Homo sapiens 85-88 7979374-6 1994 Both SAP and CRP displayed a similar binding preference for PC vs phosphoethanolamine (PE). Phosphorylcholine 60-62 C-reactive protein Homo sapiens 13-16 8228279-0 1993 A capillary electrophoresis-based assay for the binding of Ca2+ and phosphorylcholine to human C-reactive protein. Phosphorylcholine 68-85 C-reactive protein Homo sapiens 95-113 8144898-8 1994 Treatment of Raji cells with human serum led to calcium-dependent phosphocholine-inhibitable CRP binding. Phosphorylcholine 66-80 C-reactive protein Homo sapiens 93-96 7508422-4 1993 As previously reported, FP shares the capacity of C-reactive protein (CRP) in other species to bind phosphocholine and we show here that it also resembles human CRP in binding only weakly to agarose, to human AA amyloid fibrils in vitro, and to mouse AA amyloid deposits in vivo. Phosphorylcholine 100-114 C-reactive protein Homo sapiens 50-68 7508422-4 1993 As previously reported, FP shares the capacity of C-reactive protein (CRP) in other species to bind phosphocholine and we show here that it also resembles human CRP in binding only weakly to agarose, to human AA amyloid fibrils in vitro, and to mouse AA amyloid deposits in vivo. Phosphorylcholine 100-114 C-reactive protein Homo sapiens 70-73 8228279-1 1993 Affinity capillary electrophoresis was performed to quantitate the binding of Ca2+ and phosphorylcholine to human C-reactive protein (CRP). Phosphorylcholine 87-104 C-reactive protein Homo sapiens 114-132 8228279-1 1993 Affinity capillary electrophoresis was performed to quantitate the binding of Ca2+ and phosphorylcholine to human C-reactive protein (CRP). Phosphorylcholine 87-104 C-reactive protein Homo sapiens 134-137 1991964-3 1991 CRP binding to several substrates, including phosphocholine, individual denatured histones, and chromatin, has been demonstrated. Phosphorylcholine 45-59 C-reactive protein Homo sapiens 0-3 1375509-3 1992 CRP proteins are identified by their calcium-dependent interaction with phosphorylcholine. Phosphorylcholine 72-89 C-reactive protein Homo sapiens 0-3 1375509-5 1992 Thus, human CRP and SAP show high specificity that is complementary for the related compounds, phosphorylcholine and phosphorylethanolamine, respectively. Phosphorylcholine 95-112 C-reactive protein Homo sapiens 12-23 1989977-1 1991 C-reactive protein (CRP) is an acute phase inflammatory protein in man which binds to phosphocholine, chromatin, histones, and the 70-kDa protein of the U1 small nuclear ribonucleoprotein particle in a calcium-dependent, phosphocholine-inhibitable manner. Phosphorylcholine 86-100 C-reactive protein Homo sapiens 0-18 1989977-1 1991 C-reactive protein (CRP) is an acute phase inflammatory protein in man which binds to phosphocholine, chromatin, histones, and the 70-kDa protein of the U1 small nuclear ribonucleoprotein particle in a calcium-dependent, phosphocholine-inhibitable manner. Phosphorylcholine 86-100 C-reactive protein Homo sapiens 20-23 1989977-1 1991 C-reactive protein (CRP) is an acute phase inflammatory protein in man which binds to phosphocholine, chromatin, histones, and the 70-kDa protein of the U1 small nuclear ribonucleoprotein particle in a calcium-dependent, phosphocholine-inhibitable manner. Phosphorylcholine 221-235 C-reactive protein Homo sapiens 0-18 1989977-1 1991 C-reactive protein (CRP) is an acute phase inflammatory protein in man which binds to phosphocholine, chromatin, histones, and the 70-kDa protein of the U1 small nuclear ribonucleoprotein particle in a calcium-dependent, phosphocholine-inhibitable manner. Phosphorylcholine 221-235 C-reactive protein Homo sapiens 20-23 1989977-10 1991 The N-terminal (15 amino acid) fragment of H2A blocked CRP-induced precipitation of phosphocholine-coupled bovine serum albumin and histone H2A, whereas the C-terminal fragment showed no inhibition. Phosphorylcholine 84-98 C-reactive protein Homo sapiens 55-58 1460031-0 1992 Probing the phosphocholine-binding site of human C-reactive protein by site-directed mutagenesis. Phosphorylcholine 12-26 C-reactive protein Homo sapiens 49-67 1460031-2 1992 Most known CRP ligands bind to the phosphocholine (PCh)-binding site of the protein. Phosphorylcholine 35-49 C-reactive protein Homo sapiens 11-14 1460031-2 1992 Most known CRP ligands bind to the phosphocholine (PCh)-binding site of the protein. Phosphorylcholine 51-54 C-reactive protein Homo sapiens 11-14 1460031-3 1992 In the present study, we used oligonucleotide-directed site-specific mutagenesis to investigate structural determinants of the PCh-binding site of CRP. Phosphorylcholine 127-130 C-reactive protein Homo sapiens 147-150 1460031-10 1992 We conclude that the residues Lys-57, Arg-58, and Trp-67 contribute to the structure of the PCh-binding site of human CRP. Phosphorylcholine 92-95 C-reactive protein Homo sapiens 118-121 1717553-4 1991 Three of the 5 mAb inhibited the Ca(2+)-dependent phosphorylcholine-(PC) binding activity of CRP, but did not bind to the PC-binding region itself. Phosphorylcholine 50-67 C-reactive protein Homo sapiens 93-96 1704398-0 1991 A synthetic peptide corresponding to the phosphorylcholine (PC)-binding region of human C-reactive protein possesses the TEPC-15 myeloma PC-idiotype. Phosphorylcholine 41-58 C-reactive protein Homo sapiens 88-106 1704398-0 1991 A synthetic peptide corresponding to the phosphorylcholine (PC)-binding region of human C-reactive protein possesses the TEPC-15 myeloma PC-idiotype. Phosphorylcholine 60-62 C-reactive protein Homo sapiens 88-106 1704398-2 1991 CRP molecules from all species display Ca2(+)-dependent binding to phosphorylcholine (PC). Phosphorylcholine 67-84 C-reactive protein Homo sapiens 0-3 1704398-2 1991 CRP molecules from all species display Ca2(+)-dependent binding to phosphorylcholine (PC). Phosphorylcholine 86-88 C-reactive protein Homo sapiens 0-3 1704398-3 1991 The conserved PC-binding region of CRP corresponds to amino acids 51-66 within the human CRP sequence. Phosphorylcholine 14-16 C-reactive protein Homo sapiens 35-38 1704398-3 1991 The conserved PC-binding region of CRP corresponds to amino acids 51-66 within the human CRP sequence. Phosphorylcholine 14-16 C-reactive protein Homo sapiens 89-92 1991964-6 1991 CRP binding to the H2A-H2B dimer and (H3-H4)2 tetramer was demonstrated and these reactions were inhibited by phosphocholine. Phosphorylcholine 110-124 C-reactive protein Homo sapiens 0-3 2022721-3 1991 Serum levels of CRP showed an inverse correlation (rs = -0.37; P less than 0.05) with phosphocholine (PC)-containing filarial antigen that was present in the circulation of patients with bancroftian filariasis. Phosphorylcholine 86-100 C-reactive protein Homo sapiens 16-19 2022721-3 1991 Serum levels of CRP showed an inverse correlation (rs = -0.37; P less than 0.05) with phosphocholine (PC)-containing filarial antigen that was present in the circulation of patients with bancroftian filariasis. Phosphorylcholine 102-104 C-reactive protein Homo sapiens 16-19 2227796-0 1990 Binding of low density lipoprotein (LDL) to C-reactive protein (CRP): a possible binding through apolipoprotein B in LDL at phosphorylcholine-binding site of CRP. Phosphorylcholine 124-141 C-reactive protein Homo sapiens 44-62 2227796-0 1990 Binding of low density lipoprotein (LDL) to C-reactive protein (CRP): a possible binding through apolipoprotein B in LDL at phosphorylcholine-binding site of CRP. Phosphorylcholine 124-141 C-reactive protein Homo sapiens 64-67 2227796-0 1990 Binding of low density lipoprotein (LDL) to C-reactive protein (CRP): a possible binding through apolipoprotein B in LDL at phosphorylcholine-binding site of CRP. Phosphorylcholine 124-141 C-reactive protein Homo sapiens 158-161 2395439-0 1990 Binding and immunological properties of a synthetic peptide corresponding to the phosphorylcholine-binding region of C-reactive protein. Phosphorylcholine 81-98 C-reactive protein Homo sapiens 117-135 2365997-1 1990 Human C-reactive protein (CRP) is known to activate the C system upon reaction with phosphocholine-containing or polycation-containing ligands. Phosphorylcholine 84-98 C-reactive protein Homo sapiens 6-24 2365997-1 1990 Human C-reactive protein (CRP) is known to activate the C system upon reaction with phosphocholine-containing or polycation-containing ligands. Phosphorylcholine 84-98 C-reactive protein Homo sapiens 26-29 2395439-1 1990 A synthetic peptide corresponding to amino acid residues 47-63 of human C-reactive protein (CRP) was synthesized and evaluated for its ability to bind phosphorylcholine (PC) and to react with mAb specific for the PC-binding region of CRP. Phosphorylcholine 151-168 C-reactive protein Homo sapiens 72-90 2395439-1 1990 A synthetic peptide corresponding to amino acid residues 47-63 of human C-reactive protein (CRP) was synthesized and evaluated for its ability to bind phosphorylcholine (PC) and to react with mAb specific for the PC-binding region of CRP. Phosphorylcholine 151-168 C-reactive protein Homo sapiens 92-95 2395439-1 1990 A synthetic peptide corresponding to amino acid residues 47-63 of human C-reactive protein (CRP) was synthesized and evaluated for its ability to bind phosphorylcholine (PC) and to react with mAb specific for the PC-binding region of CRP. Phosphorylcholine 170-172 C-reactive protein Homo sapiens 72-90 2395439-1 1990 A synthetic peptide corresponding to amino acid residues 47-63 of human C-reactive protein (CRP) was synthesized and evaluated for its ability to bind phosphorylcholine (PC) and to react with mAb specific for the PC-binding region of CRP. Phosphorylcholine 170-172 C-reactive protein Homo sapiens 92-95 34975846-4 2021 Cryo-electron microscopy was used to solve structures of CRP at pH 7.5 or pH 5 and in the presence or absence of the ligand phosphocholine (PCh), which yielded 7 new high-resolution structures of CRP, including pentameric and decameric complexes. Phosphorylcholine 124-138 C-reactive protein Homo sapiens 196-199 2210970-2 1990 CRP has been known to bind with phosphorylcholine in a calcium-dependent manner. Phosphorylcholine 32-49 C-reactive protein Homo sapiens 0-3 34975846-4 2021 Cryo-electron microscopy was used to solve structures of CRP at pH 7.5 or pH 5 and in the presence or absence of the ligand phosphocholine (PCh), which yielded 7 new high-resolution structures of CRP, including pentameric and decameric complexes. Phosphorylcholine 140-143 C-reactive protein Homo sapiens 196-199 34416432-4 2021 In particular, the hydrogel contains phosphocholine moieties to specifically recognize C-Reactive protein (CRP). Phosphorylcholine 37-51 C-reactive protein Homo sapiens 87-105 34416432-4 2021 In particular, the hydrogel contains phosphocholine moieties to specifically recognize C-Reactive protein (CRP). Phosphorylcholine 37-51 C-reactive protein Homo sapiens 107-110 2745572-1 1989 Human CRP binds to the basement membrane protein laminin in vitro in a Ca2+-dependent manner via the phosphorylcholine (PC) binding site of C-reactive protein (CRP). Phosphorylcholine 101-118 C-reactive protein Homo sapiens 6-9 2593200-2 1989 CRP binds to phosphorylcholine (PC) in a calcium-ion dependent manner. Phosphorylcholine 13-30 C-reactive protein Homo sapiens 0-3 2593200-2 1989 CRP binds to phosphorylcholine (PC) in a calcium-ion dependent manner. Phosphorylcholine 32-34 C-reactive protein Homo sapiens 0-3 2593200-3 1989 The structural homology between PC and the major phospholipid component of surfactant, dipalmitoyl phosphatidylcholine (DPPC), led to the present study in which we examined if CRP levels might be increased in patients with adult respiratory distress syndrome (ARDS), and subsequently interfere with surfactant function. Phosphorylcholine 32-34 C-reactive protein Homo sapiens 176-179 2692716-8 1989 Protease-cleaved CRP loses the ability to bind to the Ca2+-dependent ligand phosphorylcholine but remains the ability to bind to the Ca2+-independent ligand arginine-rich histone. Phosphorylcholine 76-93 C-reactive protein Homo sapiens 17-20 2745572-1 1989 Human CRP binds to the basement membrane protein laminin in vitro in a Ca2+-dependent manner via the phosphorylcholine (PC) binding site of C-reactive protein (CRP). Phosphorylcholine 101-118 C-reactive protein Homo sapiens 140-158 2745572-1 1989 Human CRP binds to the basement membrane protein laminin in vitro in a Ca2+-dependent manner via the phosphorylcholine (PC) binding site of C-reactive protein (CRP). Phosphorylcholine 101-118 C-reactive protein Homo sapiens 160-163 2745572-1 1989 Human CRP binds to the basement membrane protein laminin in vitro in a Ca2+-dependent manner via the phosphorylcholine (PC) binding site of C-reactive protein (CRP). Phosphorylcholine 120-122 C-reactive protein Homo sapiens 6-9 2745572-1 1989 Human CRP binds to the basement membrane protein laminin in vitro in a Ca2+-dependent manner via the phosphorylcholine (PC) binding site of C-reactive protein (CRP). Phosphorylcholine 120-122 C-reactive protein Homo sapiens 140-158 2745572-1 1989 Human CRP binds to the basement membrane protein laminin in vitro in a Ca2+-dependent manner via the phosphorylcholine (PC) binding site of C-reactive protein (CRP). Phosphorylcholine 120-122 C-reactive protein Homo sapiens 160-163 2745572-5 1989 The binding of Ca2+ to CRP causes a conformational change in the molecule, which is required for binding to PC and to laminin. Phosphorylcholine 108-110 C-reactive protein Homo sapiens 23-26 2443837-4 1987 Native-CRP bound by capture ELISA to phosphorylcholine-containing ligand or anti-native-CRP did not express neo-CRP antigenicity, suggesting that PC ligand- or antibody binding is not sufficient to induce expression of the neoantigen. Phosphorylcholine 37-54 C-reactive protein Homo sapiens 7-10 2521604-3 1989 The inhibition of cell attachment was dependent on the concentration of the CRP and involved the phosphorylcholine (PC) binding site of CRP since inhibition was prevented by allowing the CRP to react with either PC (or closely related monophosphate compounds) or a mAb specific for the PC-binding site of CRP. Phosphorylcholine 97-114 C-reactive protein Homo sapiens 76-79 2521604-3 1989 The inhibition of cell attachment was dependent on the concentration of the CRP and involved the phosphorylcholine (PC) binding site of CRP since inhibition was prevented by allowing the CRP to react with either PC (or closely related monophosphate compounds) or a mAb specific for the PC-binding site of CRP. Phosphorylcholine 97-114 C-reactive protein Homo sapiens 136-139 2521604-3 1989 The inhibition of cell attachment was dependent on the concentration of the CRP and involved the phosphorylcholine (PC) binding site of CRP since inhibition was prevented by allowing the CRP to react with either PC (or closely related monophosphate compounds) or a mAb specific for the PC-binding site of CRP. Phosphorylcholine 97-114 C-reactive protein Homo sapiens 136-139 2521604-3 1989 The inhibition of cell attachment was dependent on the concentration of the CRP and involved the phosphorylcholine (PC) binding site of CRP since inhibition was prevented by allowing the CRP to react with either PC (or closely related monophosphate compounds) or a mAb specific for the PC-binding site of CRP. Phosphorylcholine 97-114 C-reactive protein Homo sapiens 136-139 2521604-3 1989 The inhibition of cell attachment was dependent on the concentration of the CRP and involved the phosphorylcholine (PC) binding site of CRP since inhibition was prevented by allowing the CRP to react with either PC (or closely related monophosphate compounds) or a mAb specific for the PC-binding site of CRP. Phosphorylcholine 116-118 C-reactive protein Homo sapiens 76-79 2521604-3 1989 The inhibition of cell attachment was dependent on the concentration of the CRP and involved the phosphorylcholine (PC) binding site of CRP since inhibition was prevented by allowing the CRP to react with either PC (or closely related monophosphate compounds) or a mAb specific for the PC-binding site of CRP. Phosphorylcholine 116-118 C-reactive protein Homo sapiens 136-139 2521604-3 1989 The inhibition of cell attachment was dependent on the concentration of the CRP and involved the phosphorylcholine (PC) binding site of CRP since inhibition was prevented by allowing the CRP to react with either PC (or closely related monophosphate compounds) or a mAb specific for the PC-binding site of CRP. Phosphorylcholine 116-118 C-reactive protein Homo sapiens 136-139 2521604-3 1989 The inhibition of cell attachment was dependent on the concentration of the CRP and involved the phosphorylcholine (PC) binding site of CRP since inhibition was prevented by allowing the CRP to react with either PC (or closely related monophosphate compounds) or a mAb specific for the PC-binding site of CRP. Phosphorylcholine 116-118 C-reactive protein Homo sapiens 136-139 2521604-3 1989 The inhibition of cell attachment was dependent on the concentration of the CRP and involved the phosphorylcholine (PC) binding site of CRP since inhibition was prevented by allowing the CRP to react with either PC (or closely related monophosphate compounds) or a mAb specific for the PC-binding site of CRP. Phosphorylcholine 212-214 C-reactive protein Homo sapiens 76-79 2521604-3 1989 The inhibition of cell attachment was dependent on the concentration of the CRP and involved the phosphorylcholine (PC) binding site of CRP since inhibition was prevented by allowing the CRP to react with either PC (or closely related monophosphate compounds) or a mAb specific for the PC-binding site of CRP. Phosphorylcholine 212-214 C-reactive protein Homo sapiens 136-139 2521604-3 1989 The inhibition of cell attachment was dependent on the concentration of the CRP and involved the phosphorylcholine (PC) binding site of CRP since inhibition was prevented by allowing the CRP to react with either PC (or closely related monophosphate compounds) or a mAb specific for the PC-binding site of CRP. Phosphorylcholine 212-214 C-reactive protein Homo sapiens 136-139 2521604-3 1989 The inhibition of cell attachment was dependent on the concentration of the CRP and involved the phosphorylcholine (PC) binding site of CRP since inhibition was prevented by allowing the CRP to react with either PC (or closely related monophosphate compounds) or a mAb specific for the PC-binding site of CRP. Phosphorylcholine 212-214 C-reactive protein Homo sapiens 136-139 2521604-3 1989 The inhibition of cell attachment was dependent on the concentration of the CRP and involved the phosphorylcholine (PC) binding site of CRP since inhibition was prevented by allowing the CRP to react with either PC (or closely related monophosphate compounds) or a mAb specific for the PC-binding site of CRP. Phosphorylcholine 212-214 C-reactive protein Homo sapiens 76-79 2521604-3 1989 The inhibition of cell attachment was dependent on the concentration of the CRP and involved the phosphorylcholine (PC) binding site of CRP since inhibition was prevented by allowing the CRP to react with either PC (or closely related monophosphate compounds) or a mAb specific for the PC-binding site of CRP. Phosphorylcholine 212-214 C-reactive protein Homo sapiens 136-139 2521604-3 1989 The inhibition of cell attachment was dependent on the concentration of the CRP and involved the phosphorylcholine (PC) binding site of CRP since inhibition was prevented by allowing the CRP to react with either PC (or closely related monophosphate compounds) or a mAb specific for the PC-binding site of CRP. Phosphorylcholine 212-214 C-reactive protein Homo sapiens 136-139 2521604-3 1989 The inhibition of cell attachment was dependent on the concentration of the CRP and involved the phosphorylcholine (PC) binding site of CRP since inhibition was prevented by allowing the CRP to react with either PC (or closely related monophosphate compounds) or a mAb specific for the PC-binding site of CRP. Phosphorylcholine 212-214 C-reactive protein Homo sapiens 136-139 2460754-5 1988 The binding involves the phosphorylcholine (PC)-binding site of CRP since the addition of PC inhibits binding to Fn and those mAbs to CRP that bind at or near the PC-binding site selectively inhibit the CRP to Fn binding. Phosphorylcholine 25-42 C-reactive protein Homo sapiens 64-67 2460754-5 1988 The binding involves the phosphorylcholine (PC)-binding site of CRP since the addition of PC inhibits binding to Fn and those mAbs to CRP that bind at or near the PC-binding site selectively inhibit the CRP to Fn binding. Phosphorylcholine 25-42 C-reactive protein Homo sapiens 134-137 2460754-5 1988 The binding involves the phosphorylcholine (PC)-binding site of CRP since the addition of PC inhibits binding to Fn and those mAbs to CRP that bind at or near the PC-binding site selectively inhibit the CRP to Fn binding. Phosphorylcholine 25-42 C-reactive protein Homo sapiens 134-137 2460754-5 1988 The binding involves the phosphorylcholine (PC)-binding site of CRP since the addition of PC inhibits binding to Fn and those mAbs to CRP that bind at or near the PC-binding site selectively inhibit the CRP to Fn binding. Phosphorylcholine 44-46 C-reactive protein Homo sapiens 64-67 2460754-5 1988 The binding involves the phosphorylcholine (PC)-binding site of CRP since the addition of PC inhibits binding to Fn and those mAbs to CRP that bind at or near the PC-binding site selectively inhibit the CRP to Fn binding. Phosphorylcholine 44-46 C-reactive protein Homo sapiens 134-137 2460754-5 1988 The binding involves the phosphorylcholine (PC)-binding site of CRP since the addition of PC inhibits binding to Fn and those mAbs to CRP that bind at or near the PC-binding site selectively inhibit the CRP to Fn binding. Phosphorylcholine 44-46 C-reactive protein Homo sapiens 134-137 2460754-5 1988 The binding involves the phosphorylcholine (PC)-binding site of CRP since the addition of PC inhibits binding to Fn and those mAbs to CRP that bind at or near the PC-binding site selectively inhibit the CRP to Fn binding. Phosphorylcholine 90-92 C-reactive protein Homo sapiens 64-67 2460754-5 1988 The binding involves the phosphorylcholine (PC)-binding site of CRP since the addition of PC inhibits binding to Fn and those mAbs to CRP that bind at or near the PC-binding site selectively inhibit the CRP to Fn binding. Phosphorylcholine 90-92 C-reactive protein Homo sapiens 134-137 2460754-5 1988 The binding involves the phosphorylcholine (PC)-binding site of CRP since the addition of PC inhibits binding to Fn and those mAbs to CRP that bind at or near the PC-binding site selectively inhibit the CRP to Fn binding. Phosphorylcholine 90-92 C-reactive protein Homo sapiens 134-137 2460754-5 1988 The binding involves the phosphorylcholine (PC)-binding site of CRP since the addition of PC inhibits binding to Fn and those mAbs to CRP that bind at or near the PC-binding site selectively inhibit the CRP to Fn binding. Phosphorylcholine 90-92 C-reactive protein Homo sapiens 64-67 2460754-5 1988 The binding involves the phosphorylcholine (PC)-binding site of CRP since the addition of PC inhibits binding to Fn and those mAbs to CRP that bind at or near the PC-binding site selectively inhibit the CRP to Fn binding. Phosphorylcholine 90-92 C-reactive protein Homo sapiens 134-137 2460754-5 1988 The binding involves the phosphorylcholine (PC)-binding site of CRP since the addition of PC inhibits binding to Fn and those mAbs to CRP that bind at or near the PC-binding site selectively inhibit the CRP to Fn binding. Phosphorylcholine 90-92 C-reactive protein Homo sapiens 134-137 3038302-6 1987 Unlike CTX induced by lipopolysaccharide, CRP-induced CTX was completely inhibited by preincubation of CRP with phosphorylcholine, a CRP ligand, at a concentration of 5.5 molecules phosphorylcholine per molecule CRP. Phosphorylcholine 112-129 C-reactive protein Homo sapiens 42-45 3038302-6 1987 Unlike CTX induced by lipopolysaccharide, CRP-induced CTX was completely inhibited by preincubation of CRP with phosphorylcholine, a CRP ligand, at a concentration of 5.5 molecules phosphorylcholine per molecule CRP. Phosphorylcholine 112-129 C-reactive protein Homo sapiens 103-106 3038302-6 1987 Unlike CTX induced by lipopolysaccharide, CRP-induced CTX was completely inhibited by preincubation of CRP with phosphorylcholine, a CRP ligand, at a concentration of 5.5 molecules phosphorylcholine per molecule CRP. Phosphorylcholine 112-129 C-reactive protein Homo sapiens 103-106 3038302-6 1987 Unlike CTX induced by lipopolysaccharide, CRP-induced CTX was completely inhibited by preincubation of CRP with phosphorylcholine, a CRP ligand, at a concentration of 5.5 molecules phosphorylcholine per molecule CRP. Phosphorylcholine 112-129 C-reactive protein Homo sapiens 103-106 3038302-6 1987 Unlike CTX induced by lipopolysaccharide, CRP-induced CTX was completely inhibited by preincubation of CRP with phosphorylcholine, a CRP ligand, at a concentration of 5.5 molecules phosphorylcholine per molecule CRP. Phosphorylcholine 181-198 C-reactive protein Homo sapiens 42-45 3038302-6 1987 Unlike CTX induced by lipopolysaccharide, CRP-induced CTX was completely inhibited by preincubation of CRP with phosphorylcholine, a CRP ligand, at a concentration of 5.5 molecules phosphorylcholine per molecule CRP. Phosphorylcholine 181-198 C-reactive protein Homo sapiens 103-106 3038302-6 1987 Unlike CTX induced by lipopolysaccharide, CRP-induced CTX was completely inhibited by preincubation of CRP with phosphorylcholine, a CRP ligand, at a concentration of 5.5 molecules phosphorylcholine per molecule CRP. Phosphorylcholine 181-198 C-reactive protein Homo sapiens 103-106 3038302-6 1987 Unlike CTX induced by lipopolysaccharide, CRP-induced CTX was completely inhibited by preincubation of CRP with phosphorylcholine, a CRP ligand, at a concentration of 5.5 molecules phosphorylcholine per molecule CRP. Phosphorylcholine 181-198 C-reactive protein Homo sapiens 103-106 3038302-9 1987 CRP-induced Mo CTX was observed, however, when Mo were exposed to CRP in medium preincubated with phosphorylcholine-treated immobilized CRP, suggesting that an active serum component which complexed with CRP was not removed. Phosphorylcholine 98-115 C-reactive protein Homo sapiens 0-3 3038302-9 1987 CRP-induced Mo CTX was observed, however, when Mo were exposed to CRP in medium preincubated with phosphorylcholine-treated immobilized CRP, suggesting that an active serum component which complexed with CRP was not removed. Phosphorylcholine 98-115 C-reactive protein Homo sapiens 66-69 3038302-9 1987 CRP-induced Mo CTX was observed, however, when Mo were exposed to CRP in medium preincubated with phosphorylcholine-treated immobilized CRP, suggesting that an active serum component which complexed with CRP was not removed. Phosphorylcholine 98-115 C-reactive protein Homo sapiens 66-69 3038302-9 1987 CRP-induced Mo CTX was observed, however, when Mo were exposed to CRP in medium preincubated with phosphorylcholine-treated immobilized CRP, suggesting that an active serum component which complexed with CRP was not removed. Phosphorylcholine 98-115 C-reactive protein Homo sapiens 66-69 3198919-1 1988 C-reactive protein (CRP) is an acute phase serum protein in man which binds to phosphocholine (PC) in a calcium-dependent manner. Phosphorylcholine 79-93 C-reactive protein Homo sapiens 0-18 3198919-1 1988 C-reactive protein (CRP) is an acute phase serum protein in man which binds to phosphocholine (PC) in a calcium-dependent manner. Phosphorylcholine 79-93 C-reactive protein Homo sapiens 20-23 3198919-1 1988 C-reactive protein (CRP) is an acute phase serum protein in man which binds to phosphocholine (PC) in a calcium-dependent manner. Phosphorylcholine 95-97 C-reactive protein Homo sapiens 0-18 3198919-1 1988 C-reactive protein (CRP) is an acute phase serum protein in man which binds to phosphocholine (PC) in a calcium-dependent manner. Phosphorylcholine 95-97 C-reactive protein Homo sapiens 20-23 3198919-16 1988 By blotting and by ELISA all CRP reactions were blocked by PC and EDTA indicating binding through the calcium-dependent PC-binding site on CRP. Phosphorylcholine 59-61 C-reactive protein Homo sapiens 29-32 3198919-16 1988 By blotting and by ELISA all CRP reactions were blocked by PC and EDTA indicating binding through the calcium-dependent PC-binding site on CRP. Phosphorylcholine 59-61 C-reactive protein Homo sapiens 139-142 3198919-16 1988 By blotting and by ELISA all CRP reactions were blocked by PC and EDTA indicating binding through the calcium-dependent PC-binding site on CRP. Phosphorylcholine 120-122 C-reactive protein Homo sapiens 29-32 3198919-16 1988 By blotting and by ELISA all CRP reactions were blocked by PC and EDTA indicating binding through the calcium-dependent PC-binding site on CRP. Phosphorylcholine 120-122 C-reactive protein Homo sapiens 139-142 2453452-5 1988 Group I MAbs recognized the Ca++-dependent phosphorylcholine (PC)-binding site of CRP since their reactivity was inhibited by PC. Phosphorylcholine 43-60 C-reactive protein Homo sapiens 82-85 2453452-5 1988 Group I MAbs recognized the Ca++-dependent phosphorylcholine (PC)-binding site of CRP since their reactivity was inhibited by PC. Phosphorylcholine 62-64 C-reactive protein Homo sapiens 82-85 2453452-5 1988 Group I MAbs recognized the Ca++-dependent phosphorylcholine (PC)-binding site of CRP since their reactivity was inhibited by PC. Phosphorylcholine 126-128 C-reactive protein Homo sapiens 82-85 6656768-15 1983 In the absence of calcium, exposure to urea led to increased electrophoretic mobility and exposure of a new antigenic reactivity, and to alterations in the phosphocholine- but not the polycation-binding sites of the native CRP molecule; this new antigenic reactivity may be of value in further studies on the CRP molecule. Phosphorylcholine 156-170 C-reactive protein Homo sapiens 223-226 3015932-17 1986 The coding regions of the Limulus and human CRP genes share approximately 25% identity and two stretches of highly conserved regions, one of which falls in the region proposed as the phosphorylcholine binding site, while the other site is very similar to the consensus sequence required for calcium binding in calmodulin and related proteins. Phosphorylcholine 183-200 C-reactive protein Homo sapiens 44-47 4084018-2 1985 CRP was purified using 4-step procedure including absorption on Sepharose 4B, phosphocholine-Sepharose, DE-52 ion exchange chromatography and gel filtration on Sephacryl S-200. Phosphorylcholine 78-92 C-reactive protein Homo sapiens 0-3 6363539-1 1984 C-reactive protein (CRP) is an acute phase serum protein in man that binds to the cell wall C-polysaccharide (PnC) of Streptococcus pneumoniae via phosphocholine (PC) determinants. Phosphorylcholine 147-161 C-reactive protein Homo sapiens 0-18 6363539-1 1984 C-reactive protein (CRP) is an acute phase serum protein in man that binds to the cell wall C-polysaccharide (PnC) of Streptococcus pneumoniae via phosphocholine (PC) determinants. Phosphorylcholine 147-161 C-reactive protein Homo sapiens 20-23 6363539-1 1984 C-reactive protein (CRP) is an acute phase serum protein in man that binds to the cell wall C-polysaccharide (PnC) of Streptococcus pneumoniae via phosphocholine (PC) determinants. Phosphorylcholine 163-165 C-reactive protein Homo sapiens 0-18 6363539-1 1984 C-reactive protein (CRP) is an acute phase serum protein in man that binds to the cell wall C-polysaccharide (PnC) of Streptococcus pneumoniae via phosphocholine (PC) determinants. Phosphorylcholine 163-165 C-reactive protein Homo sapiens 20-23 6195262-0 1983 Localization of the phosphocholine-binding sites on C-reactive protein by immunoelectron microscopy. Phosphorylcholine 20-34 C-reactive protein Homo sapiens 52-70 6195262-1 1983 C-reactive protein (CRP) was reacted with monoclonal IgG antibody or Fab antibody fragments directed against the phosphocholine- (PC) binding site or a second unrelated site. Phosphorylcholine 113-127 C-reactive protein Homo sapiens 0-18 6195262-1 1983 C-reactive protein (CRP) was reacted with monoclonal IgG antibody or Fab antibody fragments directed against the phosphocholine- (PC) binding site or a second unrelated site. Phosphorylcholine 113-127 C-reactive protein Homo sapiens 20-23 6195262-1 1983 C-reactive protein (CRP) was reacted with monoclonal IgG antibody or Fab antibody fragments directed against the phosphocholine- (PC) binding site or a second unrelated site. Phosphorylcholine 130-132 C-reactive protein Homo sapiens 0-18 6195262-1 1983 C-reactive protein (CRP) was reacted with monoclonal IgG antibody or Fab antibody fragments directed against the phosphocholine- (PC) binding site or a second unrelated site. Phosphorylcholine 130-132 C-reactive protein Homo sapiens 20-23 6195262-6 1983 Thus, the PC-binding site and the non-PC-binding site are oriented nearly perpendicular but on opposite sides with respect to the plane of the CRP molecule. Phosphorylcholine 10-12 C-reactive protein Homo sapiens 143-146 6195262-6 1983 Thus, the PC-binding site and the non-PC-binding site are oriented nearly perpendicular but on opposite sides with respect to the plane of the CRP molecule. Phosphorylcholine 38-40 C-reactive protein Homo sapiens 143-146 3028793-4 1987 CRP was also found to enhance neutrophil phagocytosis of particles not containing phosphorylcholine, the native CRP ligand. Phosphorylcholine 82-99 C-reactive protein Homo sapiens 0-3 3086219-4 1986 Thus, the anti-galactan reactivity of CRP can be attributed to the protein"s classical anti-phosphate/anti-phosphorylcholine specificity. Phosphorylcholine 107-124 C-reactive protein Homo sapiens 38-41 3919022-2 1985 CRP of all species binds to phosphorylcholine residues. Phosphorylcholine 28-45 C-reactive protein Homo sapiens 0-3 6747291-2 1984 CRP reacts with the phosphocholine moiety of pneumococcal cell wall C-polysaccharide, and this reaction can lead to complement activation in vitro and protection against pneumococcal infection in vivo. Phosphorylcholine 20-34 C-reactive protein Homo sapiens 0-3 6877243-2 1983 CRP binds with phosphocholine and phosphate esters; initiates reactions of agglutination, opsonization and complement consumption; and precipitates with protamine and synthetic polymers of lysine and arginine, and these reactivities are modulated by calcium and phosphocholine. Phosphorylcholine 15-29 C-reactive protein Homo sapiens 0-3 6877243-2 1983 CRP binds with phosphocholine and phosphate esters; initiates reactions of agglutination, opsonization and complement consumption; and precipitates with protamine and synthetic polymers of lysine and arginine, and these reactivities are modulated by calcium and phosphocholine. Phosphorylcholine 262-276 C-reactive protein Homo sapiens 0-3 6885107-3 1983 C-reactive protein (CRP) is known to bind to molecules containing phosphocholine-substituents following reaction with Ca2+ ions. Phosphorylcholine 66-80 C-reactive protein Homo sapiens 0-18 6885107-3 1983 C-reactive protein (CRP) is known to bind to molecules containing phosphocholine-substituents following reaction with Ca2+ ions. Phosphorylcholine 66-80 C-reactive protein Homo sapiens 20-23 7046573-4 1982 Phosphorylcholine is bound by CRP with much higher affinity than other phosphate monoesters speaking for a second binding site with specificity for the positively charged trimethylammonium group. Phosphorylcholine 0-17 C-reactive protein Homo sapiens 30-33 6300060-10 1983 The dogfish C-reactive protein, which exists as a Mr = 50,000 dimer, bound 2 mol of the phosphorylcholine spin label per mol of protein, and this binding exhibited negative cooperativity as indicated by a Hill coefficient of 0.75. Phosphorylcholine 88-105 C-reactive protein Homo sapiens 12-30 7086355-1 1982 C-reactive protein (CRP), the classical acute-phase protein, can bind phospholipids by virtue of its specific, calcium-dependent reactivity with phosphorylcholine residues. Phosphorylcholine 145-162 C-reactive protein Homo sapiens 0-18 7086355-1 1982 C-reactive protein (CRP), the classical acute-phase protein, can bind phospholipids by virtue of its specific, calcium-dependent reactivity with phosphorylcholine residues. Phosphorylcholine 145-162 C-reactive protein Homo sapiens 20-23 7046573-6 1982 Protein that has been coupled with phosphorylcholine or phosphorylethanolamine is able to precipitate with CRP. Phosphorylcholine 35-52 C-reactive protein Homo sapiens 107-110 7046573-7 1982 Several natural substances including pneumococcal-C polysaccharide which react with CRP have been found to contain phosphorylcholine. Phosphorylcholine 115-132 C-reactive protein Homo sapiens 84-87 7276568-5 1981 However, in the presence of phosphocholine, CRP rapidly precipitated and formed stable complexes with the polycationic polymers in the otherwise inhibitory calcium concentrations. Phosphorylcholine 28-42 C-reactive protein Homo sapiens 44-47 7041546-4 1982 Studies of its binding specificities have indicated that CRP has reactivity with (a) phosphocholine and phosphate esters, and hence with lipids widely distributed in mammalian and microbial cells; and (b) with multiple widely distributed polycations, including those derived from leukocyte granules. Phosphorylcholine 85-99 C-reactive protein Homo sapiens 57-60 7028874-9 1981 Reactivity of CRP with a multimeric form of phosphocholine (PC) (KLH-PC44) led to binding comparable to that observed with CPS, whereas monomeric PC inhibited the binding. Phosphorylcholine 44-58 C-reactive protein Homo sapiens 14-17 7028874-9 1981 Reactivity of CRP with a multimeric form of phosphocholine (PC) (KLH-PC44) led to binding comparable to that observed with CPS, whereas monomeric PC inhibited the binding. Phosphorylcholine 60-62 C-reactive protein Homo sapiens 14-17 7276568-7 1981 These results extend the characterization of the binding reactivity of CRP for polycations and suggest a relationship between this binding site and the sites for calcium and phosphocholine. Phosphorylcholine 174-188 C-reactive protein Homo sapiens 71-74 7276568-8 1981 We propose that CRP-polycation interactions in the presence of phosphocholine may have physiologic significance during the acute inflammatory process. Phosphorylcholine 63-77 C-reactive protein Homo sapiens 16-19 6166719-1 1981 Binding of human 125I-C-reactive protein (CRP) to sheep erythrocytes sensitized with pneumococcal C polysaccharide (E-PnC) was found to be Ca++ dependent and inhibitable by phosphocholine, CRP, and HOPC 8. Phosphorylcholine 173-187 C-reactive protein Homo sapiens 17-40 7217669-4 1981 A weak interaction between CRP and agarose was observed, which was also CA++-dependent and could be inhibited by phosphocholine and galactose. Phosphorylcholine 113-127 C-reactive protein Homo sapiens 27-30 6166719-1 1981 Binding of human 125I-C-reactive protein (CRP) to sheep erythrocytes sensitized with pneumococcal C polysaccharide (E-PnC) was found to be Ca++ dependent and inhibitable by phosphocholine, CRP, and HOPC 8. Phosphorylcholine 173-187 C-reactive protein Homo sapiens 42-45 885587-7 1977 Inhibition studies demonstrated that PC is a potent inhibitor of the serum CRP-PPS and myeloma protein-PPS precipitation reactions. Phosphorylcholine 37-39 C-reactive protein Homo sapiens 75-78 7462634-6 1981 We have found that this binding is more characteristic of CRP interactions with polycations than CRP interactions with phosphocholine- (PC) containing molecules. Phosphorylcholine 119-133 C-reactive protein Homo sapiens 97-100 7462634-6 1981 We have found that this binding is more characteristic of CRP interactions with polycations than CRP interactions with phosphocholine- (PC) containing molecules. Phosphorylcholine 136-138 C-reactive protein Homo sapiens 97-100 471064-3 1979 CRP has a Ca2+-dependent binding specificity for phosphorylcholine, the polar head group of two widely distributed lipids, lecithin (phosphatidylcholine, PC) and sphingomyelin (SM). Phosphorylcholine 49-66 C-reactive protein Homo sapiens 0-3 7190145-2 1980 CRP caused as much agglutination of suspensions composed of egg yolk phosphatidylcholine, cholesterol, and Span 60 as of those composed of cholesterol and Span 60, suggesting that phosphocholine residues of phosphatidylcholine are not important as binding sites for CRP. Phosphorylcholine 180-194 C-reactive protein Homo sapiens 0-3 7190145-4 1980 Although phosphatidylcholine is not an essential component for agglutination of suspensions, it may modify the mode of interaction of CRP with its binding site on lipid suspensions, since the sensitivity of the agglutination to phosphocholine and the Ca2+ requirement were influenced by the presence of phosphatidylcholine in the suspensions. Phosphorylcholine 228-242 C-reactive protein Homo sapiens 134-137 32903624-4 2020 Phosphocholine-complexed human CRP activates the complement system in both human and murine sera. Phosphorylcholine 0-14 C-reactive protein Homo sapiens 31-34 14211-6 1977 Since C-reactive protein binds specifically to the phosphorylcholine residue of pneumococcal C-polysaccharide, it is unlikely that pneumococcal cell walls must combine with C-reactive protein in order to activate the alternative pathway. Phosphorylcholine 51-68 C-reactive protein Homo sapiens 6-24 809531-8 1975 The relative inhibitory capacity of phosphorylcholine and polycations in CPS- and polycations-CRP systems was consistent with the concept that phosphate esters and polycations react at the same or an overlapping combining site. Phosphorylcholine 36-53 C-reactive protein Homo sapiens 94-97 4395924-0 1971 Specificity of C-reactive protein for choline phosphate residues of pneumococcal C-polysaccharide. Phosphorylcholine 38-55 C-reactive protein Homo sapiens 15-33 33224343-3 2020 Methods: In order to test the possibility of direct interaction, we performed an in silico study by testing the orientation of the respective ligands (statins) and phosphorylcholine (the standard ligand of CRP) in the CRP active site using Molecular Operating Environment (MOE) software. Phosphorylcholine 164-181 C-reactive protein Homo sapiens 206-209 33224343-3 2020 Methods: In order to test the possibility of direct interaction, we performed an in silico study by testing the orientation of the respective ligands (statins) and phosphorylcholine (the standard ligand of CRP) in the CRP active site using Molecular Operating Environment (MOE) software. Phosphorylcholine 164-181 C-reactive protein Homo sapiens 218-221 33224343-6 2020 According to the above-mentioned results, rosuvastatin, fluvastatin, pitavastatin and atorvastatin were found to have stronger binding to CRP compared with the standard ligand phosphocholine (pKi = 14.55). Phosphorylcholine 176-190 C-reactive protein Homo sapiens 138-141 32269097-9 2020 Interaction of phosphocholine groups on VLDL with CRP is the major driver for complex formation and phosphocholine can disrupt the complexes to reverse their inhibitory effects on phagocytosis and bacterial clearance. Phosphorylcholine 15-29 C-reactive protein Homo sapiens 50-53 32269097-9 2020 Interaction of phosphocholine groups on VLDL with CRP is the major driver for complex formation and phosphocholine can disrupt the complexes to reverse their inhibitory effects on phagocytosis and bacterial clearance. Phosphorylcholine 100-114 C-reactive protein Homo sapiens 50-53 31840602-6 2020 At sites of local inflammation and tissue injury it may bind to phosphocholine-rich membranes of activated and apoptotic cells and their microparticles, undergoing irreversible dissociation to five monomeric subunits, termed monomeric CRP (mCRP). Phosphorylcholine 64-78 C-reactive protein Homo sapiens 235-238 32374279-5 2021 CRP was assayed using a functional turbidimetric assay based on the interaction of CRP with phosphocholine containing particles (Intralipid ). Phosphorylcholine 92-106 C-reactive protein Homo sapiens 0-3 32374279-5 2021 CRP was assayed using a functional turbidimetric assay based on the interaction of CRP with phosphocholine containing particles (Intralipid ). Phosphorylcholine 92-106 C-reactive protein Homo sapiens 83-86 32117266-1 2020 A monomeric form of C-reactive protein (CRP) which precipitates with cell wall pneumococcal C polysaccharide (CWPS) and retains the ability to reversibly bind to its ligand phosphocholine has been produced through urea-induced dissociation at an optimized concentration of 3 M urea over a 10 weeks period. Phosphorylcholine 173-187 C-reactive protein Homo sapiens 20-38 32117266-1 2020 A monomeric form of C-reactive protein (CRP) which precipitates with cell wall pneumococcal C polysaccharide (CWPS) and retains the ability to reversibly bind to its ligand phosphocholine has been produced through urea-induced dissociation at an optimized concentration of 3 M urea over a 10 weeks period. Phosphorylcholine 173-187 C-reactive protein Homo sapiens 40-43 32117266-6 2020 Both the in vitro monomeric C-reactive protein and the human serum monomeric protein displayed a molecular weight of approximately 23 kDa, both were recognized by the same anti-CRP monoclonal antibody and both reversibly bound to phosphocholine in a calcium-dependent manner. Phosphorylcholine 230-244 C-reactive protein Homo sapiens 28-46 32117266-6 2020 Both the in vitro monomeric C-reactive protein and the human serum monomeric protein displayed a molecular weight of approximately 23 kDa, both were recognized by the same anti-CRP monoclonal antibody and both reversibly bound to phosphocholine in a calcium-dependent manner. Phosphorylcholine 230-244 C-reactive protein Homo sapiens 177-180 31092031-2 2019 METHODS: The relationship between serum PC-specific IgM level and C-reactive protein level or white blood cell counts was examined in patients with severe upper respiratory tract infections (ie, acute epiglottitis and peritonsillar abscess). Phosphorylcholine 40-42 C-reactive protein Homo sapiens 66-84 31118224-3 2019 This study shows that complexed CRP (phosphocholine [PC]:CRP) (formed by binding of CRP to PC moieties), but not soluble CRP, synergized with specific TLRs to posttranscriptionally amplify TNF, IL-1beta, and IL-23 production by human inflammatory macrophages. Phosphorylcholine 37-51 C-reactive protein Homo sapiens 32-35 31118224-3 2019 This study shows that complexed CRP (phosphocholine [PC]:CRP) (formed by binding of CRP to PC moieties), but not soluble CRP, synergized with specific TLRs to posttranscriptionally amplify TNF, IL-1beta, and IL-23 production by human inflammatory macrophages. Phosphorylcholine 37-51 C-reactive protein Homo sapiens 57-60 31118224-3 2019 This study shows that complexed CRP (phosphocholine [PC]:CRP) (formed by binding of CRP to PC moieties), but not soluble CRP, synergized with specific TLRs to posttranscriptionally amplify TNF, IL-1beta, and IL-23 production by human inflammatory macrophages. Phosphorylcholine 37-51 C-reactive protein Homo sapiens 57-60 31118224-3 2019 This study shows that complexed CRP (phosphocholine [PC]:CRP) (formed by binding of CRP to PC moieties), but not soluble CRP, synergized with specific TLRs to posttranscriptionally amplify TNF, IL-1beta, and IL-23 production by human inflammatory macrophages. Phosphorylcholine 37-51 C-reactive protein Homo sapiens 57-60 29728047-0 2019 Label-Free Specific Detection and Collection of C-Reactive Protein Using Zwitterionic Phosphorylcholine-Polymer-Protected Magnetic Nanoparticles. Phosphorylcholine 86-103 C-reactive protein Homo sapiens 48-66 30268669-3 2019 The results demonstrated in a step-wise manner that the phosphocholine-modified screen-printed carbon electrodes were highly responsive to the clinically required range of C-reactive protein (CRP) (0.005 - 500 mg L-1; r2 = 0.993) levels with a detection limit (3sigma/slope) of 0.001 mg L-1. Phosphorylcholine 56-70 C-reactive protein Homo sapiens 172-190 30268669-3 2019 The results demonstrated in a step-wise manner that the phosphocholine-modified screen-printed carbon electrodes were highly responsive to the clinically required range of C-reactive protein (CRP) (0.005 - 500 mg L-1; r2 = 0.993) levels with a detection limit (3sigma/slope) of 0.001 mg L-1. Phosphorylcholine 56-70 C-reactive protein Homo sapiens 192-195 30268669-4 2019 The optimal binding frequency of CRP-phosphocholine interaction was determined to be 100 Hz. Phosphorylcholine 37-51 C-reactive protein Homo sapiens 33-36 31114584-3 2019 Human CRP is a pentamer made up of five identical subunits which binds to phosphocholine (PCh) in a Ca2+-dependent manner. Phosphorylcholine 74-88 C-reactive protein Homo sapiens 6-9 31114584-3 2019 Human CRP is a pentamer made up of five identical subunits which binds to phosphocholine (PCh) in a Ca2+-dependent manner. Phosphorylcholine 90-93 C-reactive protein Homo sapiens 6-9 31114584-10 2019 Literature indicates that the binding ability of CRP to PCh is less relevant than its binding to other ligands. Phosphorylcholine 56-59 C-reactive protein Homo sapiens 49-52 29728047-5 2019 After coming into contact with CRP, the nanoparticles aggregated as CRP comprises five subunits, and each subunit can bind to a phosphorylcholine group with two free Ca2+ ions. Phosphorylcholine 128-145 C-reactive protein Homo sapiens 31-34 29728047-5 2019 After coming into contact with CRP, the nanoparticles aggregated as CRP comprises five subunits, and each subunit can bind to a phosphorylcholine group with two free Ca2+ ions. Phosphorylcholine 128-145 C-reactive protein Homo sapiens 68-71 28513744-0 2017 High-affinity recognition of the human C-reactive protein independent of phosphocholine. Phosphorylcholine 73-87 C-reactive protein Homo sapiens 39-57 29120646-1 2018 C-reactive protein (CRP), a biomarker for cardiovascular disease, has been reported to have a strong affinity to zwitterionic phosphorylcholine (PC) groups in the presence of calcium ions. Phosphorylcholine 145-147 C-reactive protein Homo sapiens 0-18 29120646-1 2018 C-reactive protein (CRP), a biomarker for cardiovascular disease, has been reported to have a strong affinity to zwitterionic phosphorylcholine (PC) groups in the presence of calcium ions. Phosphorylcholine 145-147 C-reactive protein Homo sapiens 20-23 29120646-3 2018 By appropriately using the features of PC-immobilized surfaces, including specific recognition to CRP and nonfouling surface, it is reasonable to create an antibody-free biosensor for the specific capture of CRP. Phosphorylcholine 39-41 C-reactive protein Homo sapiens 98-101 29120646-3 2018 By appropriately using the features of PC-immobilized surfaces, including specific recognition to CRP and nonfouling surface, it is reasonable to create an antibody-free biosensor for the specific capture of CRP. Phosphorylcholine 39-41 C-reactive protein Homo sapiens 208-211 29120646-7 2018 The specific interaction of CRP with PC groups was monitored by using a quartz crystal microbalance with dissipation (QCM-D). Phosphorylcholine 37-39 C-reactive protein Homo sapiens 28-31 29120646-10 2018 Notably, the dissipation energy also dropped during the binding process between CRP and PC, indicating the release of water molecules from the PC groups during CRP adsorption. Phosphorylcholine 88-90 C-reactive protein Homo sapiens 80-83 29120646-10 2018 Notably, the dissipation energy also dropped during the binding process between CRP and PC, indicating the release of water molecules from the PC groups during CRP adsorption. Phosphorylcholine 88-90 C-reactive protein Homo sapiens 160-163 30030926-3 2018 As C-reactive protein (CRP) can act as an innate receptor with ability to bind the phosphocholine moiety of PC in lipoproteins, we investigated whether EgAgB and CRP could interact during cystic echinococcosis infection (CE), and how CRP binding could affect the modulation activities exerted by EgAgB on macrophages. Phosphorylcholine 83-97 C-reactive protein Homo sapiens 3-21 30030926-3 2018 As C-reactive protein (CRP) can act as an innate receptor with ability to bind the phosphocholine moiety of PC in lipoproteins, we investigated whether EgAgB and CRP could interact during cystic echinococcosis infection (CE), and how CRP binding could affect the modulation activities exerted by EgAgB on macrophages. Phosphorylcholine 83-97 C-reactive protein Homo sapiens 23-26 30030926-6 2018 Furthermore, human CRP was capable of binding specifically to EgAgB with high affinity (0.6 +- 0.1 nM); this binding was Ca2+ -dependent and involved the phosphocholine moiety of PC, but not EgAgB8/1, EgAgB8/2 or EgAgB8/3 apolipoproteins. Phosphorylcholine 154-168 C-reactive protein Homo sapiens 19-22 30105015-2 2018 CRP is a phosphocholine (PC)-binding pentraxin, mainly produced in the liver in response to elevated levels of interleukin-1beta (IL-1beta) and of the IL-1beta-dependent cytokine IL-6. Phosphorylcholine 9-23 C-reactive protein Homo sapiens 0-3 30105015-2 2018 CRP is a phosphocholine (PC)-binding pentraxin, mainly produced in the liver in response to elevated levels of interleukin-1beta (IL-1beta) and of the IL-1beta-dependent cytokine IL-6. Phosphorylcholine 25-27 C-reactive protein Homo sapiens 0-3 30105015-5 2018 Here, we demonstrate that CRP, in association with PC, efficiently reduces ATP-induced inflammasome activation and IL-1beta release from human peripheral blood mononuclear leukocytes and monocytic U937 cells. Phosphorylcholine 51-53 C-reactive protein Homo sapiens 26-29 29946323-7 2018 The dissociation of pCRP into its pro-inflammatory structural isoforms and thus activation of the CRP system occur on necrotic, apoptotic, and ischemic cells, regular beta-sheet structures such as beta-amyloid, the membranes of activated cells (e.g., platelets, monocytes, and endothelial cells), and/or the surface of microparticles, the latter by binding to phosphocholine. Phosphorylcholine 360-374 C-reactive protein Homo sapiens 21-24 28513744-3 2017 With the exception of antibodies, most molecular constructs take advantage of the known affinity for CRP of phosphocholine that depends on Ca2+ for its ability to bind. Phosphorylcholine 108-122 C-reactive protein Homo sapiens 101-104 28171699-2 2017 CRP, an acute-phase reactant binds to the phosphocholine expressed on the surface of dead or dying cells and some bacteria, thereby activating complement and promoting phagocytosis by macrophages. Phosphorylcholine 42-56 C-reactive protein Homo sapiens 0-3 28167277-6 2017 For example, CRP mutants incapable of binding to phosphocholine are generated to investigate the importance of the phosphocholine-binding property of CRP in mediating host defense. Phosphorylcholine 49-63 C-reactive protein Homo sapiens 13-16 28167277-6 2017 For example, CRP mutants incapable of binding to phosphocholine are generated to investigate the importance of the phosphocholine-binding property of CRP in mediating host defense. Phosphorylcholine 115-129 C-reactive protein Homo sapiens 13-16 28167277-6 2017 For example, CRP mutants incapable of binding to phosphocholine are generated to investigate the importance of the phosphocholine-binding property of CRP in mediating host defense. Phosphorylcholine 115-129 C-reactive protein Homo sapiens 150-153 28096464-2 2017 CRP, in its native pentameric structural conformation, binds to cells and molecules that have exposed phosphocholine (PCh) groups. Phosphorylcholine 102-116 C-reactive protein Homo sapiens 0-3 28096464-2 2017 CRP, in its native pentameric structural conformation, binds to cells and molecules that have exposed phosphocholine (PCh) groups. Phosphorylcholine 118-121 C-reactive protein Homo sapiens 0-3 28096464-3 2017 CRP, in its non-native pentameric structural conformation, binds to a variety of deposited, denatured, and aggregated proteins, in addition to binding to PCh-containing substances. Phosphorylcholine 154-157 C-reactive protein Homo sapiens 0-3 28096464-7 2017 Using oxidized LDL as a representative protein ligand for H2O2-treated CRP, we found that the binding occurred in a Ca2+-independent manner and did not involve the PCh-binding site of CRP. Phosphorylcholine 164-167 C-reactive protein Homo sapiens 71-74 26873368-0 2016 Engineered zwitterionic phosphorylcholine monolayers for elucidating multivalent binding kinetics of C-reactive protein. Phosphorylcholine 24-41 C-reactive protein Homo sapiens 101-119 26873368-2 2016 Previously, the use of a zwitterionic phosphorylcholine group, a biomimetic ligand for CRP in the presence of calcium ions, for binding experiments has revealed that the adsorption dynamics changed by ionic microenvironments. Phosphorylcholine 38-55 C-reactive protein Homo sapiens 87-90 26873368-10 2016 STATEMENT OF SIGNIFICANCE: C-reactive protein (CRP), a major acute-phase pentraxin, binds to plasma membranes through the multivalent contacts with zwitterionic phosphorylcholine groups. Phosphorylcholine 161-178 C-reactive protein Homo sapiens 27-45 26873368-10 2016 STATEMENT OF SIGNIFICANCE: C-reactive protein (CRP), a major acute-phase pentraxin, binds to plasma membranes through the multivalent contacts with zwitterionic phosphorylcholine groups. Phosphorylcholine 161-178 C-reactive protein Homo sapiens 47-50 27621811-0 2016 Phosphocholine-containing ligands direct CRP induction of M2 macrophage polarization independent of T cell polarization: Implication for chronic inflammatory states. Phosphorylcholine 0-14 C-reactive protein Homo sapiens 41-44 25548320-4 2015 Without antiplatelet antibodies, CRP was found to be inert toward platelets, but it bound to phosphorylcholine exposed after oxidation triggered by antiplatelet antibodies, thereby enhancing platelet phagocytosis. Phosphorylcholine 93-110 C-reactive protein Homo sapiens 33-36 26588324-0 2015 Poly(3,4-ethylenedioxythiophene) Bearing Phosphorylcholine Groups for Metal-Free, Antibody-Free, and Low-Impedance Biosensors Specific for C-Reactive Protein. Phosphorylcholine 41-58 C-reactive protein Homo sapiens 139-157 26588324-6 2015 The specific interaction of CRP with phosphorylcholine in a calcium-containing buffer solution was determined by differential pulse voltammetry, which measures the altered redox reaction between the indicators ferricyanide/ferrocyanide as a result of the binding event. Phosphorylcholine 37-54 C-reactive protein Homo sapiens 28-31 23432014-0 2013 Protein-directed immobilization of phosphocholine ligands on a gold surface for multivalent C-reactive protein binding. Phosphorylcholine 35-49 C-reactive protein Homo sapiens 92-110 24399680-0 2014 A new high-sensitive nephelometric method for assaying serum C-reactive protein based on phosphocholine interaction. Phosphorylcholine 89-103 C-reactive protein Homo sapiens 61-79 24399680-2 2014 Since CRP is able to bind phospholipids (mainly phosphocholine) in the presence of calcium ions, we explored the possibilities of developing a high-sensitive affordable nephelometric CRP assay based on diluted soy oil emulsions. Phosphorylcholine 48-62 C-reactive protein Homo sapiens 6-9 24552299-2 2014 To enable the parallel detection of the differently abundant analytes, the low binding affinity between CRP and phosphocholine is exploited in a "low-sensitive" sandwich assay for CRP. Phosphorylcholine 112-126 C-reactive protein Homo sapiens 104-107 24552299-2 2014 To enable the parallel detection of the differently abundant analytes, the low binding affinity between CRP and phosphocholine is exploited in a "low-sensitive" sandwich assay for CRP. Phosphorylcholine 112-126 C-reactive protein Homo sapiens 180-183 24948846-2 2014 First, in its native pentameric conformation, CRP recognizes molecules and cells with exposed phosphocholine (PCh) groups, such as microbial pathogens and damaged cells. Phosphorylcholine 94-108 C-reactive protein Homo sapiens 46-49 24948846-2 2014 First, in its native pentameric conformation, CRP recognizes molecules and cells with exposed phosphocholine (PCh) groups, such as microbial pathogens and damaged cells. Phosphorylcholine 110-113 C-reactive protein Homo sapiens 46-49 24948846-3 2014 PCh-containing ligand-bound CRP activates the complement system to destroy the ligand. Phosphorylcholine 0-3 C-reactive protein Homo sapiens 28-31 24948846-4 2014 Thus, the PCh-binding function of CRP is defensive if it occurs on foreign pathogens because it results in the killing of the pathogen via complement activation. Phosphorylcholine 10-13 C-reactive protein Homo sapiens 34-37 24948846-5 2014 On the other hand, the PCh-binding function of CRP is detrimental if it occurs on injured host cells because it causes more damage to the tissue via complement activation; this is how CRP worsens acute myocardial infarction and ischemia/reperfusion injury. Phosphorylcholine 23-26 C-reactive protein Homo sapiens 47-50 24948846-5 2014 On the other hand, the PCh-binding function of CRP is detrimental if it occurs on injured host cells because it causes more damage to the tissue via complement activation; this is how CRP worsens acute myocardial infarction and ischemia/reperfusion injury. Phosphorylcholine 23-26 C-reactive protein Homo sapiens 184-187 24948846-8 2014 In conclusion, temporarily inhibiting the PCh-binding function of CRP along with facilitating localized presence of nonnative pentameric CRP could be a promising approach to treat atherosclerosis and myocardial infarction. Phosphorylcholine 42-45 C-reactive protein Homo sapiens 66-69 24948846-8 2014 In conclusion, temporarily inhibiting the PCh-binding function of CRP along with facilitating localized presence of nonnative pentameric CRP could be a promising approach to treat atherosclerosis and myocardial infarction. Phosphorylcholine 42-45 C-reactive protein Homo sapiens 137-140 23432014-2 2013 CRP consisting of five identical, noncovalently linked subunits and having five phosphocholine-binding sites on the same face was complexed with 12-mercaptododecylphosphocholine. Phosphorylcholine 80-94 C-reactive protein Homo sapiens 0-3 19545552-7 2009 In contrast, PEt inhibited the binding of both CRP and mCRP to pneumococcal C-polysaccharide, another phosphocholine-containing ligand to which CRP and mCRP were found to bind. Phosphorylcholine 102-116 C-reactive protein Homo sapiens 47-50 21440634-1 2011 With its homo-pentameric structure and calcium-dependent specificity for phosphocholine (PCh), human c-reactive protein (CRP) is produced by the liver and secreted in elevated quantities in response to inflammation. Phosphorylcholine 73-87 C-reactive protein Homo sapiens 101-119 21440634-1 2011 With its homo-pentameric structure and calcium-dependent specificity for phosphocholine (PCh), human c-reactive protein (CRP) is produced by the liver and secreted in elevated quantities in response to inflammation. Phosphorylcholine 73-87 C-reactive protein Homo sapiens 121-124 21440634-1 2011 With its homo-pentameric structure and calcium-dependent specificity for phosphocholine (PCh), human c-reactive protein (CRP) is produced by the liver and secreted in elevated quantities in response to inflammation. Phosphorylcholine 89-92 C-reactive protein Homo sapiens 101-119 21440634-1 2011 With its homo-pentameric structure and calcium-dependent specificity for phosphocholine (PCh), human c-reactive protein (CRP) is produced by the liver and secreted in elevated quantities in response to inflammation. Phosphorylcholine 89-92 C-reactive protein Homo sapiens 121-124 21398452-1 2011 A turbidimetric method to determine serum C-reactive protein (CRP) concentration, based on soybean oil-phosphocholine interaction, was performed on horse serum samples to evaluate its potential diagnostic value in veterinary medicine. Phosphorylcholine 103-117 C-reactive protein Homo sapiens 62-65 21398452-3 2011 After 30 min of incubation at 37 C, the CRP-phosphocholine complexes were turbidimetrically, bichromatically (660 nm/700 nm) quantified on a commercial analyzer. Phosphorylcholine 45-59 C-reactive protein Homo sapiens 41-44 20415446-4 2010 Herein we describe how changing properties of substrate (phosphocholine, PC) self-assembly can affect both binding behavior and substrate affinity to a pentameric recognition protein (C-reactive protein, CRP). Phosphorylcholine 57-71 C-reactive protein Homo sapiens 184-202 20415446-4 2010 Herein we describe how changing properties of substrate (phosphocholine, PC) self-assembly can affect both binding behavior and substrate affinity to a pentameric recognition protein (C-reactive protein, CRP). Phosphorylcholine 57-71 C-reactive protein Homo sapiens 204-207 19435596-0 2009 Characterization of Ca2+ and phosphocholine interactions with C-reactive protein using a surface plasmon resonance biosensor. Phosphorylcholine 29-43 C-reactive protein Homo sapiens 62-80 22158621-1 2012 C-reactive protein (CRP) is a cyclic pentameric protein whose major binding specificity, at physiological pH, is for substances bearing exposed phosphocholine moieties. Phosphorylcholine 144-158 C-reactive protein Homo sapiens 0-18 22158621-1 2012 C-reactive protein (CRP) is a cyclic pentameric protein whose major binding specificity, at physiological pH, is for substances bearing exposed phosphocholine moieties. Phosphorylcholine 144-158 C-reactive protein Homo sapiens 20-23 21975508-0 2011 C-Reactive protein-directed immobilization of phosphocholine ligands on a solid surface. Phosphorylcholine 46-60 C-reactive protein Homo sapiens 0-18 21975508-1 2011 The complexes of C-reactive protein (CRP) with its polymerizable phosphocholine ligands adsorbed at the styrene-water interface were polymerized. Phosphorylcholine 65-79 C-reactive protein Homo sapiens 17-35 21975508-1 2011 The complexes of C-reactive protein (CRP) with its polymerizable phosphocholine ligands adsorbed at the styrene-water interface were polymerized. Phosphorylcholine 65-79 C-reactive protein Homo sapiens 37-40 20843812-2 2010 At physiological pH, native pentameric CRP exhibits calcium-dependent binding specificity for phosphocholine. Phosphorylcholine 94-108 C-reactive protein Homo sapiens 39-42 20843812-7 2010 Some modifications in CRP were reversible at pH 7.0, for example, the phosphocholine-binding activity of CRP, which was reduced at acidic pH, was restored after pH neutralization. Phosphorylcholine 70-84 C-reactive protein Homo sapiens 22-25 20843812-7 2010 Some modifications in CRP were reversible at pH 7.0, for example, the phosphocholine-binding activity of CRP, which was reduced at acidic pH, was restored after pH neutralization. Phosphorylcholine 70-84 C-reactive protein Homo sapiens 105-108 20842713-5 2010 Biochemical experiments confirmed the predicted binding site for UO(2) (2+) and it was demonstrated by surface plasmon resonance assays that UO(2) (2+) binding to CRP prevents the calcium-mediated binding of phosphorylcholine. Phosphorylcholine 208-225 C-reactive protein Homo sapiens 163-166 19545552-7 2009 In contrast, PEt inhibited the binding of both CRP and mCRP to pneumococcal C-polysaccharide, another phosphocholine-containing ligand to which CRP and mCRP were found to bind. Phosphorylcholine 102-116 C-reactive protein Homo sapiens 56-59 16962105-5 2006 Antioxidant activity of CRP was inhibited by phosphocholine (PC), indicating that the observed activity involves binding of CRP to oxPtC. Phosphorylcholine 45-59 C-reactive protein Homo sapiens 24-27 19778286-0 2009 A new turbidimetric method for assaying serum C-reactive protein based on phosphocholine interaction. Phosphorylcholine 74-88 C-reactive protein Homo sapiens 46-64 19778286-1 2009 BACKGROUND: C-reactive protein (CRP) is able to bind phospholipids (mainly phosphocholine) in the presence of calcium ions. Phosphorylcholine 75-89 C-reactive protein Homo sapiens 12-30 19778286-1 2009 BACKGROUND: C-reactive protein (CRP) is able to bind phospholipids (mainly phosphocholine) in the presence of calcium ions. Phosphorylcholine 75-89 C-reactive protein Homo sapiens 32-35 18322245-4 2008 As reported previously, phosphocholine (PCh) inhibited CRP-E-LDL interaction, indicating the involvement of the PCh-binding site of CRP in binding to E-LDL. Phosphorylcholine 24-38 C-reactive protein Homo sapiens 55-58 18322245-4 2008 As reported previously, phosphocholine (PCh) inhibited CRP-E-LDL interaction, indicating the involvement of the PCh-binding site of CRP in binding to E-LDL. Phosphorylcholine 24-38 C-reactive protein Homo sapiens 132-135 18322245-4 2008 As reported previously, phosphocholine (PCh) inhibited CRP-E-LDL interaction, indicating the involvement of the PCh-binding site of CRP in binding to E-LDL. Phosphorylcholine 40-43 C-reactive protein Homo sapiens 55-58 18322245-4 2008 As reported previously, phosphocholine (PCh) inhibited CRP-E-LDL interaction, indicating the involvement of the PCh-binding site of CRP in binding to E-LDL. Phosphorylcholine 40-43 C-reactive protein Homo sapiens 132-135 18322245-4 2008 As reported previously, phosphocholine (PCh) inhibited CRP-E-LDL interaction, indicating the involvement of the PCh-binding site of CRP in binding to E-LDL. Phosphorylcholine 112-115 C-reactive protein Homo sapiens 55-58 18322245-4 2008 As reported previously, phosphocholine (PCh) inhibited CRP-E-LDL interaction, indicating the involvement of the PCh-binding site of CRP in binding to E-LDL. Phosphorylcholine 112-115 C-reactive protein Homo sapiens 132-135 18322245-5 2008 However, the amino acids Phe66 and Glu81 in CRP that participate in CRP-PCh interaction were not required for CRP-E-LDL interaction. Phosphorylcholine 72-75 C-reactive protein Homo sapiens 44-47 18322245-5 2008 However, the amino acids Phe66 and Glu81 in CRP that participate in CRP-PCh interaction were not required for CRP-E-LDL interaction. Phosphorylcholine 72-75 C-reactive protein Homo sapiens 68-71 18322245-5 2008 However, the amino acids Phe66 and Glu81 in CRP that participate in CRP-PCh interaction were not required for CRP-E-LDL interaction. Phosphorylcholine 72-75 C-reactive protein Homo sapiens 68-71 18322245-6 2008 Surprisingly, blocking of the PCh-binding site with phosphoethanolamine (PEt) dramatically increased the binding of CRP to E-LDL. Phosphorylcholine 30-33 C-reactive protein Homo sapiens 116-119 18322245-7 2008 The PEt-mediated enhancement in the binding of CRP to E-LDL was selective for E-LDL because PEt inhibited the binding of CRP to another PCh-binding site-ligand pneumococcal C-polysaccharide. Phosphorylcholine 136-139 C-reactive protein Homo sapiens 47-50 18322245-7 2008 The PEt-mediated enhancement in the binding of CRP to E-LDL was selective for E-LDL because PEt inhibited the binding of CRP to another PCh-binding site-ligand pneumococcal C-polysaccharide. Phosphorylcholine 136-139 C-reactive protein Homo sapiens 121-124 17244159-5 2007 After binding to phosphocholine, native CRP bound C1q and significantly activated C1. Phosphorylcholine 17-31 C-reactive protein Homo sapiens 40-43 17244159-6 2007 Native CRP complexed to phosphocholine did not bind the complement regulatory proteins FH and C4BP. Phosphorylcholine 24-38 C-reactive protein Homo sapiens 7-10 19226172-2 2009 When phosphocholine is appended to the protein-binding face this supramolecular assembly binds multivalently to the pentameric human C-reactive protein, a biomolecule implicated in inflammation and heart disease. Phosphorylcholine 5-19 C-reactive protein Homo sapiens 133-151 19236874-2 2009 The present paper describes a robust and sensitive ELISA for CRP, based on the affinity of CRP for phosphocholine. Phosphorylcholine 99-113 C-reactive protein Homo sapiens 61-64 19236874-2 2009 The present paper describes a robust and sensitive ELISA for CRP, based on the affinity of CRP for phosphocholine. Phosphorylcholine 99-113 C-reactive protein Homo sapiens 91-94 19236874-4 2009 CRP present in a sample binds to the phosphocholine moiety presented at high density in the coating layer and is detectable by specific antibodies. Phosphorylcholine 37-51 C-reactive protein Homo sapiens 0-3 18486609-2 2008 An important binding specificity of CRP is for the modified forms of low-density lipoprotein (LDL) in which the phosphocholine-binding sites of CRP participate. Phosphorylcholine 112-126 C-reactive protein Homo sapiens 36-39 18486609-2 2008 An important binding specificity of CRP is for the modified forms of low-density lipoprotein (LDL) in which the phosphocholine-binding sites of CRP participate. Phosphorylcholine 112-126 C-reactive protein Homo sapiens 144-147 18486609-5 2008 RESULTS: We found that the blocking of the phosphocholine-binding sites of CRP with phosphoethanolamine (PEt) converted CRP into a potent molecule for binding to native LDL. Phosphorylcholine 43-57 C-reactive protein Homo sapiens 75-78 18486609-5 2008 RESULTS: We found that the blocking of the phosphocholine-binding sites of CRP with phosphoethanolamine (PEt) converted CRP into a potent molecule for binding to native LDL. Phosphorylcholine 43-57 C-reactive protein Homo sapiens 120-123 17207978-7 2007 Also, through antigen-antibody binding evaluation, the anti-C-reactive protein antibody immobilized on the PMBN surface worked well and it was confirmed that denaturation of the antibody on the PMBN layers was hardly occurred in spite of 60 days storage at 4 degrees C. The antibody conjugated phospholipid polymer layer with well-ordered phosphorylcholine group could be outstanding functional membrane for biomedical diagnostic devices without non-specific binding and reduction of immunologic activity of immobilized antibody. Phosphorylcholine 339-356 C-reactive protein Homo sapiens 60-78 16962105-5 2006 Antioxidant activity of CRP was inhibited by phosphocholine (PC), indicating that the observed activity involves binding of CRP to oxPtC. Phosphorylcholine 45-59 C-reactive protein Homo sapiens 124-127 16962105-5 2006 Antioxidant activity of CRP was inhibited by phosphocholine (PC), indicating that the observed activity involves binding of CRP to oxPtC. Phosphorylcholine 61-63 C-reactive protein Homo sapiens 24-27 16962105-5 2006 Antioxidant activity of CRP was inhibited by phosphocholine (PC), indicating that the observed activity involves binding of CRP to oxPtC. Phosphorylcholine 61-63 C-reactive protein Homo sapiens 124-127 15766555-7 2005 Finally, with the aid of anti-CRP monoclonal antibodies and by molecular modeling, we obtained evidence for involvement of the phosphorylcholine-binding site of CRP in cholesterol binding. Phosphorylcholine 127-144 C-reactive protein Homo sapiens 30-33 16337748-5 2006 CRP is known to bind to phosphocholine in dead eukaryote and some live bacterial cell walls suggesting that CRP facilitates the phagocytosis of fragmented or intact dead cells and/or enhances host bacterial defenses. Phosphorylcholine 24-38 C-reactive protein Homo sapiens 0-3 16337748-5 2006 CRP is known to bind to phosphocholine in dead eukaryote and some live bacterial cell walls suggesting that CRP facilitates the phagocytosis of fragmented or intact dead cells and/or enhances host bacterial defenses. Phosphorylcholine 24-38 C-reactive protein Homo sapiens 108-111 16751408-3 2006 C4BP bound to directly immobilized recombinant CRP as well as CRP attached to phosphorylcholine. Phosphorylcholine 78-95 C-reactive protein Homo sapiens 62-65 16643876-5 2006 Competition experiments with different phosphatemonoesters revealed that CRP and SAP as well as part of the IgM bound to the phospholipids head groups, SAP mainly to phosphorylethanolamine, CRP to phosphorylcholine and phosphorylethanolamine and to a lesser extent to phosphorylserine, and IgM to phosphorylcholine and phosphorylserine. Phosphorylcholine 197-214 C-reactive protein Homo sapiens 73-76 16643876-5 2006 Competition experiments with different phosphatemonoesters revealed that CRP and SAP as well as part of the IgM bound to the phospholipids head groups, SAP mainly to phosphorylethanolamine, CRP to phosphorylcholine and phosphorylethanolamine and to a lesser extent to phosphorylserine, and IgM to phosphorylcholine and phosphorylserine. Phosphorylcholine 197-214 C-reactive protein Homo sapiens 190-193 16643876-5 2006 Competition experiments with different phosphatemonoesters revealed that CRP and SAP as well as part of the IgM bound to the phospholipids head groups, SAP mainly to phosphorylethanolamine, CRP to phosphorylcholine and phosphorylethanolamine and to a lesser extent to phosphorylserine, and IgM to phosphorylcholine and phosphorylserine. Phosphorylcholine 297-314 C-reactive protein Homo sapiens 73-76 15766555-7 2005 Finally, with the aid of anti-CRP monoclonal antibodies and by molecular modeling, we obtained evidence for involvement of the phosphorylcholine-binding site of CRP in cholesterol binding. Phosphorylcholine 127-144 C-reactive protein Homo sapiens 161-164 15766555-8 2005 Thus, CRP can bind to cholesterol, and the interaction is mediated by the phosphorylcholine-binding site of CRP and the 3beta-hydroxyl group of cholesterol. Phosphorylcholine 74-91 C-reactive protein Homo sapiens 6-9 15766555-8 2005 Thus, CRP can bind to cholesterol, and the interaction is mediated by the phosphorylcholine-binding site of CRP and the 3beta-hydroxyl group of cholesterol. Phosphorylcholine 74-91 C-reactive protein Homo sapiens 108-111 15541272-1 2004 Natural IgM antibodies against phosphorylcholine (anti-Pc IgM) resemble C-reactive protein (CRP) regarding specificity and have gained increasing attention because of their supposed role in clearance of damaged cells and in cardiovascular disease. Phosphorylcholine 31-48 C-reactive protein Homo sapiens 72-90 15474020-1 2004 Phosphorylcholine (PC) is a classical ligand of C-reactive protein (CRP), a clinically important acute phase protein. Phosphorylcholine 0-17 C-reactive protein Homo sapiens 48-66 15474020-1 2004 Phosphorylcholine (PC) is a classical ligand of C-reactive protein (CRP), a clinically important acute phase protein. Phosphorylcholine 0-17 C-reactive protein Homo sapiens 68-71 15474020-1 2004 Phosphorylcholine (PC) is a classical ligand of C-reactive protein (CRP), a clinically important acute phase protein. Phosphorylcholine 19-21 C-reactive protein Homo sapiens 48-66 15474020-1 2004 Phosphorylcholine (PC) is a classical ligand of C-reactive protein (CRP), a clinically important acute phase protein. Phosphorylcholine 19-21 C-reactive protein Homo sapiens 68-71 15541272-1 2004 Natural IgM antibodies against phosphorylcholine (anti-Pc IgM) resemble C-reactive protein (CRP) regarding specificity and have gained increasing attention because of their supposed role in clearance of damaged cells and in cardiovascular disease. Phosphorylcholine 31-48 C-reactive protein Homo sapiens 92-95