PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27017111-0	2016	Design, synthesis and bioactivity of novel phthalimide derivatives as acetylcholinesterase inhibitors.	phthalimide	43-54	acetylcholinesterase (Cartwright blood group)	Homo sapiens	70-90	
24379961-5	2013	MATERIALS AND METHODS: In the current study, based on the potential inhibitory activity of phthalimide derivatives towards acetylcholinesterase enzyme, a new series of phthalimide-based compounds were synthesized (4a-4e) and anti-acetylcholinesterase effect was assessed using Ellman"s test.	phthalimide	91-102	acetylcholinesterase (Cartwright blood group)	Homo sapiens	123-143	
24379961-5	2013	MATERIALS AND METHODS: In the current study, based on the potential inhibitory activity of phthalimide derivatives towards acetylcholinesterase enzyme, a new series of phthalimide-based compounds were synthesized (4a-4e) and anti-acetylcholinesterase effect was assessed using Ellman"s test.	phthalimide	91-102	acetylcholinesterase (Cartwright blood group)	Homo sapiens	230-250	
24379961-5	2013	MATERIALS AND METHODS: In the current study, based on the potential inhibitory activity of phthalimide derivatives towards acetylcholinesterase enzyme, a new series of phthalimide-based compounds were synthesized (4a-4e) and anti-acetylcholinesterase effect was assessed using Ellman"s test.	phthalimide	168-179	acetylcholinesterase (Cartwright blood group)	Homo sapiens	123-143	
24379961-5	2013	MATERIALS AND METHODS: In the current study, based on the potential inhibitory activity of phthalimide derivatives towards acetylcholinesterase enzyme, a new series of phthalimide-based compounds were synthesized (4a-4e) and anti-acetylcholinesterase effect was assessed using Ellman"s test.	phthalimide	168-179	acetylcholinesterase (Cartwright blood group)	Homo sapiens	230-250	
24379961-8	2013	CONCLUSION: The new synthesized phthalimide based analogs could function as potential acetylcholinesterase inhibitors.	phthalimide	32-43	acetylcholinesterase (Cartwright blood group)	Homo sapiens	86-106	
29938351-2	2018	Various reports have shown that phthalimide derivatives are potent inhibitors of AChE, a key enzyme involved in the deterioration of the cholinergic system during the development of Alzheimer"s disease.	phthalimide	32-43	acetylcholinesterase (Cartwright blood group)	Homo sapiens	81-85	
27721153-3	2017	In vitro studies showed that the majority of saccharin derivatives with piperazine moiety and one phthalimide derivative with 3-aminopiperidine fragment exhibited inhibitory potency toward acetylcholinesterase (AChE) with EeAChE IC50 values ranging from 0.83 muM to 19.18 muM.	phthalimide	98-109	acetylcholinesterase (Cartwright blood group)	Homo sapiens	189-209	
27721153-3	2017	In vitro studies showed that the majority of saccharin derivatives with piperazine moiety and one phthalimide derivative with 3-aminopiperidine fragment exhibited inhibitory potency toward acetylcholinesterase (AChE) with EeAChE IC50 values ranging from 0.83 muM to 19.18 muM.	phthalimide	98-109	acetylcholinesterase (Cartwright blood group)	Homo sapiens	211-215	
26898241-1	2016	In order to develop potent dual-binding cholinesterase inhibitors as potential drugs for the treatment of Alzheimer"s disease, we designed and synthesized phthalimide-based acetylcholinesterase (AChE) inhibitors (7) containing a substituted N-benzylpyridinium residue.	phthalimide	155-166	acetylcholinesterase (Cartwright blood group)	Homo sapiens	40-54	
26898241-1	2016	In order to develop potent dual-binding cholinesterase inhibitors as potential drugs for the treatment of Alzheimer"s disease, we designed and synthesized phthalimide-based acetylcholinesterase (AChE) inhibitors (7) containing a substituted N-benzylpyridinium residue.	phthalimide	155-166	acetylcholinesterase (Cartwright blood group)	Homo sapiens	173-193	
26898241-1	2016	In order to develop potent dual-binding cholinesterase inhibitors as potential drugs for the treatment of Alzheimer"s disease, we designed and synthesized phthalimide-based acetylcholinesterase (AChE) inhibitors (7) containing a substituted N-benzylpyridinium residue.	phthalimide	155-166	acetylcholinesterase (Cartwright blood group)	Homo sapiens	195-199