PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29257269-0 2018 Protective effects of psoralidin on IL-1beta-induced chondrocyte apoptosis. psoralidin 22-32 interleukin 1 beta Rattus norvegicus 36-44 29257269-2 2018 The present study aimed to investigate the protective effects of psoralidin on interleukin (IL)-1beta-induced chondrocyte apoptosis and explore the underlying mechanisms. psoralidin 65-75 interleukin 1 beta Rattus norvegicus 79-101 29257269-8 2018 The results of the present study demonstrated that psoralidin may reduce IL-1beta-induced chondrocyte apoptosis. psoralidin 51-61 interleukin 1 beta Rattus norvegicus 73-81 29257269-9 2018 Psoralidin pretreatment also reversed the inhibitory effects of IL-1beta on B-cell lymphoma 2 (Bcl-2) expression, and decreased the IL-1beta-induced expression of Bcl-2-associated X protein, matrix metalloproteinase (MMP)-1 and MMP-13. psoralidin 0-10 interleukin 1 beta Rattus norvegicus 64-72 29257269-9 2018 Psoralidin pretreatment also reversed the inhibitory effects of IL-1beta on B-cell lymphoma 2 (Bcl-2) expression, and decreased the IL-1beta-induced expression of Bcl-2-associated X protein, matrix metalloproteinase (MMP)-1 and MMP-13. psoralidin 0-10 interleukin 1 beta Rattus norvegicus 132-140 29257269-10 2018 Furthermore, psoralidin decreased IL-1beta-induced caspase-3 and -9 activity, NO release, ROS production and nuclear factor (NF)-kappaB nuclear translocation. psoralidin 13-23 interleukin 1 beta Rattus norvegicus 34-42 29257269-11 2018 In addition, the NF-kappaB inhibitor pyrriolidine-dithiocarbamate exerted similar effects to psoralidin, thus suggesting that IL-1beta induced proapoptotic effects in rat chondrocytes via an NF-kappaB-dependent pathway. psoralidin 93-103 interleukin 1 beta Rattus norvegicus 126-134 29257269-12 2018 Since psoralidin could protect chondrocytes from IL-1beta-induced apoptosis and MMP expression, the present results suggested that psoralidin may be considered a drug candidate for the treatment of osteoarthritis. psoralidin 6-16 interleukin 1 beta Rattus norvegicus 49-57 29257269-12 2018 Since psoralidin could protect chondrocytes from IL-1beta-induced apoptosis and MMP expression, the present results suggested that psoralidin may be considered a drug candidate for the treatment of osteoarthritis. psoralidin 131-141 interleukin 1 beta Rattus norvegicus 49-57