PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33422760-5 2021 The results demonstrated that psoralidin activated the inflammasomes followed by secreting caspase-1 and interleukin 1beta (IL-1beta) in a dose-dependent manner. psoralidin 30-40 interleukin 1 alpha Mus musculus 124-132 33422760-7 2021 Moreover, psoralidin significantly induced IL-1beta maturation and caspase-1 activation in NLRP3-knockout bone marrow-derived macrophages (BMDMs), suggesting that psoralidin not only activates the NLRP3 inflammasome but also activates other types of inflammasomes. psoralidin 10-20 interleukin 1 alpha Mus musculus 43-51 33422760-7 2021 Moreover, psoralidin significantly induced IL-1beta maturation and caspase-1 activation in NLRP3-knockout bone marrow-derived macrophages (BMDMs), suggesting that psoralidin not only activates the NLRP3 inflammasome but also activates other types of inflammasomes. psoralidin 163-173 interleukin 1 alpha Mus musculus 43-51 33422760-9 2021 Importantly, in vivo data revealed that psoralidin induced hepatic inflammation, increased aminotransferase activity and increased the production of IL-1beta and tumor necrosis factor(TNF-alpha) in a susceptible mouse model of lipopolysaccharide (LPS)-mediated IDILI. psoralidin 40-50 interleukin 1 alpha Mus musculus 149-157 21669192-11 2011 Moreover, in vivo results from mouse lung indicate that psoralidin suppresses IR-induced expression of pro-inflammatory cytokines (TNF-alpha, TGF-beta, IL-6 and IL-1 alpha/beta) and ICAM-1. psoralidin 56-66 interleukin 1 alpha Mus musculus 161-171