PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19851870-6 2010 Our results suggest that psoralidin inhibits constitutive and TNF-induced expression of TNF-alpha and its downstream prosurvival signaling molecules such as NF-kappaB and Bcl-2 in AIPC cells. psoralidin 25-35 BCL2 apoptosis regulator Homo sapiens 171-176 19223576-6 2009 While dissecting the molecular events, both upstream and downstream of Akt, we found that psoralidin inhibits phosphatidylinositol 3-kinase activation and transcriptionally represses the activation of nuclear factor-kappaB and its target genes (Bcl-2, Survivin, and Bcl-xL, etc. psoralidin 90-100 BCL2 apoptosis regulator Homo sapiens 245-250 27025925-5 2019 Psoralidin also increases the expression of pro-apoptosis genes Bax, Bid and p53 while decreases the expression of pro-survival genes Bcl-2 and Bcl-xL, both in a concentration dependent manner between 4 and 64 mumol/L (P<0.05 at 16 and 64 mumol/L). psoralidin 0-10 BCL2 apoptosis regulator Homo sapiens 134-139 31786860-13 2019 DAPI staining revealed that Psoralidin triggered apoptotic cell death of HepG2 cells which was accompanied with activation of caspases 3 and 9, upregulation of Bax and downregulation of Bcl-2. psoralidin 28-38 BCL2 apoptosis regulator Homo sapiens 186-191 26870201-0 2016 Differential effect of psoralidin in enhancing apoptosis of colon cancer cells via nuclear factor-kappaB and B-cell lymphoma-2/B-cell lymphoma-2-associated X protein signaling pathways. psoralidin 23-33 BCL2 apoptosis regulator Homo sapiens 109-126 26870201-0 2016 Differential effect of psoralidin in enhancing apoptosis of colon cancer cells via nuclear factor-kappaB and B-cell lymphoma-2/B-cell lymphoma-2-associated X protein signaling pathways. psoralidin 23-33 BCL2 apoptosis regulator Homo sapiens 127-144 26870201-12 2016 Furthermore, psoralidin was able to reduce Bcl-2 protein expression and increase Bax protein expression in SW480 cells. psoralidin 13-23 BCL2 apoptosis regulator Homo sapiens 43-48 26870201-13 2016 Notably, Bcl-2 inhibitor was observed to enhance the effects of psoralidin on SW480 cells. psoralidin 64-74 BCL2 apoptosis regulator Homo sapiens 9-14 26870201-14 2016 The results of the present study suggest that psoralidin may be a candidate drug for the treatment of colon cancer by inhibition of the NF-kappaB and Bcl-2/Bax signaling pathways. psoralidin 46-56 BCL2 apoptosis regulator Homo sapiens 150-155