PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2365684-3	1990	Using the pH probe 2",7"-bis-(carboxyethyl)-5(6)-carboxyfluorescein we report here the kinetics of simultaneous cytoplasmic pH and Ca2+ changes in thrombin-stimulated platelets, measured in single cells by flow cytometry.	2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein	19-67	coagulation factor II, thrombin	Homo sapiens	147-155	
9657246-6	1998	In addition, intracellular pH and thrombin-induced pH variations were measured with the fluorescent probe BCECF.	2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein	106-111	coagulation factor II, thrombin	Homo sapiens	34-42	
1527727-4	1992	Thrombin, but not U46619, increased intracellular pH from 7.44 +/- 0.03 to 7.55 +/- 0.06 (n = 4, P = .012) in 2",7"-bis(carboxyethyl)-5(6)-carboxyfluorescein-loaded cells.	2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein	110-157	coagulation factor II, thrombin	Homo sapiens	0-8	
2546796-2	1989	Adrenaline markedly enhanced the thrombin-induced increase in cytoplasmic pH (pHi) in BCECF-loaded platelets.	2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein	86-91	coagulation factor II, thrombin	Homo sapiens	33-41	
2539730-5	1989	Studies with the intracellular pH indicator dye 2,7-bis(carboxyethyl)-5(6)-carboxyfluorescein demonstrated thrombin activation of Na+ -H+ antiport, an effect blocked by either HMA or EIPA.	2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein	48-93	coagulation factor II, thrombin	Homo sapiens	107-115	
2539810-4	1989	(1) Pulse stimulation of platelets by successive addition of hirudin (4 unit/ml) and thrombin (0.2 unit/ml) induced a shape change of 43 +/- 8% and a fall in BCECF fluorescence, which both remained unchanged when Na+/H+ exchange was inhibited by ethylisopropylamiloride (EIPA, 100 microM).	2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein	158-163	coagulation factor II, thrombin	Homo sapiens	85-93	
2539810-7	1989	(4) A second addition of thrombin to platelets that had already undergone shape change induced an immediate increase in BCECF fluorescence without a prior decrease.	2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein	120-125	coagulation factor II, thrombin	Homo sapiens	25-33	
2831980-1	1988	Isolated human blood platelets, loaded with the pH-sensitive fluorescence dye 2",7"-bis(carboxyethyl)-5,6-carboxyfluorescein show cytoplasmic alkalinization upon stimulation with thrombin but acidification with ADP stimulation.	2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein	78-124	coagulation factor II, thrombin	Homo sapiens	179-187	
3434788-3	1987	We report here a modification of the previously published 6-CF technique and confirm the thrombin-induced cytoplasmic pH change in the human platelet using a second fluorescein derivative, BCECF.	2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein	189-194	coagulation factor II, thrombin	Homo sapiens	89-97