PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32191437-0	2020	Laquinimod Mitigated IL-1beta-Induced Impairment of the Cartilage Extracellular Matrix in Human ATDC5 Chondrocytes.	laquinimod	0-10	interleukin 1 alpha	Homo sapiens	21-29	
32191437-5	2020	In our research, we found that laquinimod could ameliorate IL-1beta-induced generation of ROS and improve mitochondrial function by increasing mitochondrial membrane potential (DeltaPsim).	laquinimod	31-41	interleukin 1 alpha	Homo sapiens	59-67	
32191437-6	2020	Furthermore, treatment with laquinimod suppressed IL-1beta-induced production of TNF-alpha and IL-6.	laquinimod	28-38	interleukin 1 alpha	Homo sapiens	50-58	
32191437-9	2020	Mechanistically, laquinimod ameliorated IL-1beta-induced inflammation and degeneration of ECM by suppressing the activation of NF-kappaB.	laquinimod	17-27	interleukin 1 alpha	Homo sapiens	40-48	
32191437-10	2020	Taken together, our findings reveal that laquinimod possesses a beneficial effect against IL-1beta insults in human chondrocytes, implying an important role of laquinimod in OA.	laquinimod	41-51	interleukin 1 alpha	Homo sapiens	90-98	
33218208-3	2020	We show that human iAstrocytes expressed the receptor for the inflammatory mediator IL1 and responded to it via nuclear translocation of NFkappaB, an event that did not occur if cells were treated with Laquinimod, indicating a direct anti-inflammatory activity of the drug on the human astrocyte.	laquinimod	202-212	interleukin 1 alpha	Homo sapiens	84-87	
33203651-0	2021	Laquinimod dampens IL-1beta signaling and Th17-polarizing capacity of monocytes in patients with MS.	laquinimod	0-10	interleukin 1 alpha	Homo sapiens	19-27	
33203651-9	2021	LPS-stimulated monocytes of laquinimod-treated patients with MS secreted less IL-1beta following a downregulation of IL-1beta gene expression.	laquinimod	28-38	interleukin 1 alpha	Homo sapiens	78-86	
33203651-9	2021	LPS-stimulated monocytes of laquinimod-treated patients with MS secreted less IL-1beta following a downregulation of IL-1beta gene expression.	laquinimod	28-38	interleukin 1 alpha	Homo sapiens	117-125	
32249647-7	2020	Consistently, laquinimod prevented MPP+-induced secretions of interleukin 1beta (IL-1beta) and interleukin-18 (IL-18).	laquinimod	14-24	interleukin 1 alpha	Homo sapiens	81-89