PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20144642-5	2010	Moreover, the PI3K inhibitor wortmannin blocked activation of STAT3 and Akt without affecting the JAK2 activation, whereas JAK2 inhibitor AG490 suppressed the levels of phospho-STAT3, phospho-Akt, and PI3K, suggesting that PI3K activation occurs after JAK2 phosphorylation, and both PI3K and JAK2 kinases cooperate to mediate STAT3 and Akt phosphorylation.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	138-143	AKT serine/threonine kinase 1	Homo sapiens	192-195	
31217064-8	2019	The inhibition of Akt expression with LY294002 or STAT3 expression with AG490 abolished the TCDD-induced cyclin D1 upregulation and cell proliferation.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	72-77	AKT serine/threonine kinase 1	Homo sapiens	18-21	
24731555-6	2014	In the presence of AG490, the phosphorylation of PLCgamma2, protein kinase C (PKC), Akt or JNK in collagen-activated aggregation of human platelets was also inhibited.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	19-24	AKT serine/threonine kinase 1	Homo sapiens	84-87	
24244375-8	2013	Pre-treatment with SC514 (NF-kappaB inhibitor), LY294002 (PI3K inhibitor), AG490 (JAK2 inhibitor) and Janex-1 (JAK3 inhibitor) showed partial reduction of the Tat-mediated induction of CCL5 suggesting involvement of JAK, PI3K/Akt and NF-kappaB in CCL5 expression.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	75-80	AKT serine/threonine kinase 1	Homo sapiens	226-229	
22931649-1	2012	This study was aimed to investigate the effect of AG490, a JAK2 inhibitor, on expression of PHLPP and p-Akt in K562.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	50-55	AKT serine/threonine kinase 1	Homo sapiens	104-107	
23300886-7	2012	Pharmacological inhibition of JAK/STAT3, PI3K/Akt or MEK/ERK signaling by AG490, Wortmannin or U0126, respectively, reduced leptin-induced cyclin D1 expression and NP cell proliferation.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	74-79	AKT serine/threonine kinase 1	Homo sapiens	46-49	
29934528-7	2018	Interestingly, AG490 dose-dependently increased p-Akt levels, and our epistasis analysis suggested that the effect of JAK/STAT inhibition on p-Akt is via the regulation of GRAMD1B expression.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	15-20	AKT serine/threonine kinase 1	Homo sapiens	50-53	
29934528-7	2018	Interestingly, AG490 dose-dependently increased p-Akt levels, and our epistasis analysis suggested that the effect of JAK/STAT inhibition on p-Akt is via the regulation of GRAMD1B expression.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	15-20	AKT serine/threonine kinase 1	Homo sapiens	143-146	
20144642-5	2010	Moreover, the PI3K inhibitor wortmannin blocked activation of STAT3 and Akt without affecting the JAK2 activation, whereas JAK2 inhibitor AG490 suppressed the levels of phospho-STAT3, phospho-Akt, and PI3K, suggesting that PI3K activation occurs after JAK2 phosphorylation, and both PI3K and JAK2 kinases cooperate to mediate STAT3 and Akt phosphorylation.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	138-143	AKT serine/threonine kinase 1	Homo sapiens	192-195	
18695355-0	2008	AG490, a Jak2-specific inhibitor, induces osteoclast survival by activating the Akt and ERK signaling pathways.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	0-5	AKT serine/threonine kinase 1	Homo sapiens	80-83	
18695355-6	2008	AG490 stimulated the phosphorylation of Akt and ERK.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	0-5	AKT serine/threonine kinase 1	Homo sapiens	40-43	
17919239-6	2007	AG490, a JAK inhibitor, blocked JAK1 phosphorylation accompanied by inhibition of PI3K and Akt activation as well as alpha1(I) collagen mRNA expression, indicating a JAK1-dependent mechanism.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	0-5	AKT serine/threonine kinase 1	Homo sapiens	91-94	
12445202-9	2002	Interestingly, Janus tyrosine kinase inhibitor, AG490, treatment strongly blocked the phosphotidyl inositol 3-kinase pathway activation, as evidenced by the decrease in phospho-Akt level.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	48-53	AKT serine/threonine kinase 1	Homo sapiens	177-180	
16442704-6	2006	The JAK2 inhibitor AG490 abolished the anti-apoptotic effect of G-Gly and inhibited phosphorylation of Akt but not of JNK.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	19-24	AKT serine/threonine kinase 1	Homo sapiens	103-106