PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32380573-7	2020	Pretreatment with AG490 could block IL-6-induced tactile hypersensitivity and suppress the up-regulations of both TNF-alpha and IL-1beta.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	18-23	interleukin 6	Rattus norvegicus	36-40	
11110778-8	2000	Inhibition of JAK2 by its inhibitor AG490 (10 micromol/L) blocked not only JAK2 activation but also IL-6 synthesis.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	36-41	interleukin 6	Rattus norvegicus	100-104	
35465093-7	2022	Further studies demonstrated that intrarubral pretreatment with JAK2/STAT3 inhibitor AG490 suppressed the elevations of spinal TNF-alpha, IL-1beta, and IL-6 and promoted the expressions of TGF-beta and IL-10 in IL-6-evoked tactile allodynia rats.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	85-90	interleukin 6	Rattus norvegicus	211-215	
35465093-7	2022	Further studies demonstrated that intrarubral pretreatment with JAK2/STAT3 inhibitor AG490 suppressed the elevations of spinal TNF-alpha, IL-1beta, and IL-6 and promoted the expressions of TGF-beta and IL-10 in IL-6-evoked tactile allodynia rats.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	85-90	interleukin 6	Rattus norvegicus	152-156	
21470923-9	2011	Importantly, exogenous recombinant rat IL-6 can also induce phosphorylation of STAT3 concomitant with GFAP expression while JAK2 specific inhibitor AG490 could effectively block both cholera toxin- and IL-6-induced GFAP expression.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	148-153	interleukin 6	Rattus norvegicus	39-43	
29673861-10	2018	Consistently, AG490, a JAK2/STAT3 inhibitor, and PACAP 6-38, a PAC1 receptor antagonist, counteracted rIL-6-mediated protection.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	14-19	interleukin 6	Rattus norvegicus	102-107	
29392420-9	2018	All these beneficial effects of ghrelin, except its inhibitory action on IL-6 expression, were partially and significantly abolished by the co-administration of AG490.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	161-166	interleukin 6	Rattus norvegicus	73-77	
27450794-10	2016	The increased levels of IL-6 and TNF-alpha caused by high-dose linoleic acid were attenuated by JAK2 inhibitor AG490.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	111-116	interleukin 6	Rattus norvegicus	24-28	
25992975-6	2015	In contrast, AG490, an inhibitor of JAK, partially blocked these effects of IL-6.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	13-18	interleukin 6	Rattus norvegicus	76-80	
23499905-6	2013	Inhibition of JAK2 with AG490 or inhibition of cholinergic signaling with the M1 mAChR antagonist dicyclomine counteracted the attenuating effects of rIL-6 on phosphorylated extracellular signal-regulated kinase (ERK) expression, or on cognitive impairment in TMT-treated IL-6(-/-) mice.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	24-29	interleukin 6	Rattus norvegicus	150-155	
22431190-8	2012	Tyrosine kinase inhibitor AG490 decreased signal transducers and activators of transcription 3 (STAT3) phosphorylation and down-regulated prohibitin expression in cardiomyocytes pretreated with IL-6 and exposed to H(2)O(2), which further dampened the protective effects of IL-6 preconditioning.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	26-31	interleukin 6	Rattus norvegicus	194-198	
22431190-8	2012	Tyrosine kinase inhibitor AG490 decreased signal transducers and activators of transcription 3 (STAT3) phosphorylation and down-regulated prohibitin expression in cardiomyocytes pretreated with IL-6 and exposed to H(2)O(2), which further dampened the protective effects of IL-6 preconditioning.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	26-31	interleukin 6	Rattus norvegicus	273-277	
22069265-9	2011	Interleukin-6 increased the amount of early apoptotic cells; this increase was blocked by AG490 or N-monomethyl-L-arginine treatment.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	90-95	interleukin 6	Rattus norvegicus	0-13	
21369693-8	2011	Administration of RPM or AG490 decreased the activity of NF-kappaB and inhibited the release of TNF-alpha, IL-1beta, and IL-6.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	25-30	interleukin 6	Rattus norvegicus	121-125	
21470923-9	2011	Importantly, exogenous recombinant rat IL-6 can also induce phosphorylation of STAT3 concomitant with GFAP expression while JAK2 specific inhibitor AG490 could effectively block both cholera toxin- and IL-6-induced GFAP expression.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	148-153	interleukin 6	Rattus norvegicus	202-206	
21038693-7	2010	AG490 partially blocked the inhibitory effect of IL-6 on the NMDA-stimulated neuronal firing activity.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	0-5	interleukin 6	Rattus norvegicus	49-53	
11489535-5	2001	A Janus tyrosine kinase 2 inhibitor (tyrphostin AG490) suppressed the phosphorylation of signal transducers and activators of transcription (STAT)3 and only partially inhibited the anti-apoptotic activity of IL-6.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	48-53	interleukin 6	Rattus norvegicus	208-212