PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28560386-0	2017	Fangchinoline suppresses growth and metastasis of melanoma cells by inhibiting the phosphorylation of FAK.	fangchinoline	0-13	protein tyrosine kinase 2	Homo sapiens	102-105	
28560386-7	2017	We also found that fangchinoline could significantly reduce the phosphorylation of Focal adhesion kinase (FAK).	fangchinoline	19-32	protein tyrosine kinase 2	Homo sapiens	83-104	
28560386-7	2017	We also found that fangchinoline could significantly reduce the phosphorylation of Focal adhesion kinase (FAK).	fangchinoline	19-32	protein tyrosine kinase 2	Homo sapiens	106-109	
28560386-8	2017	In summary, we demonstrated that fangchinoline inhibits the proliferation and metastasis of melanoma cells by suppressing FAK and its downstream signaling pathway.	fangchinoline	33-46	protein tyrosine kinase 2	Homo sapiens	122-125	
25539072-0	2015	Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549.	fangchinoline	0-13	protein tyrosine kinase 2	Homo sapiens	44-47	
25539072-0	2015	Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549.	fangchinoline	0-13	protein tyrosine kinase 2	Homo sapiens	63-66	
25539072-5	2015	RESULTS: Fangchinoline effectively suppressed proliferation and invasion of A549 cell line but not NCI-H292, NCI-H446, and NCI-H460 cell lines by inhibiting the phosphorylation of FAK (Tyr397) and its downstream pathways, due to the significant differences of Fak expression between A549 and the other three cell lines.	fangchinoline	9-22	protein tyrosine kinase 2	Homo sapiens	180-183	
25539072-5	2015	RESULTS: Fangchinoline effectively suppressed proliferation and invasion of A549 cell line but not NCI-H292, NCI-H446, and NCI-H460 cell lines by inhibiting the phosphorylation of FAK (Tyr397) and its downstream pathways, due to the significant differences of Fak expression between A549 and the other three cell lines.	fangchinoline	9-22	protein tyrosine kinase 2	Homo sapiens	260-263	
25539072-6	2015	And all FAK-paxillin/MMP2/MMP9 pathway, FAK-Akt pathway, and FAK-MEK-ERK1/2 pathway could be inhibited by fangchinoline.	fangchinoline	106-119	protein tyrosine kinase 2	Homo sapiens	8-11	
25539072-6	2015	And all FAK-paxillin/MMP2/MMP9 pathway, FAK-Akt pathway, and FAK-MEK-ERK1/2 pathway could be inhibited by fangchinoline.	fangchinoline	106-119	protein tyrosine kinase 2	Homo sapiens	40-43	
25539072-6	2015	And all FAK-paxillin/MMP2/MMP9 pathway, FAK-Akt pathway, and FAK-MEK-ERK1/2 pathway could be inhibited by fangchinoline.	fangchinoline	106-119	protein tyrosine kinase 2	Homo sapiens	40-43	
25539072-7	2015	DISCUSSION: Fangchinoline effectively suppressed proliferation and invasion of A549 cell line by inhibiting the phosphorylation of FAK (Tyr397) and its downstream pathways.	fangchinoline	12-25	protein tyrosine kinase 2	Homo sapiens	131-134	
25539072-8	2015	CONCLUSION: Fangchinoline could inhibit the phosphorylation of FAK(p-Tyr397), at least partially.	fangchinoline	12-25	protein tyrosine kinase 2	Homo sapiens	63-66	
25539072-9	2015	Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway and inhibits the growth and the invasion in tumor cells which highly expressed FAK such as A549 cell line.	fangchinoline	0-13	protein tyrosine kinase 2	Homo sapiens	44-47	
25539072-9	2015	Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway and inhibits the growth and the invasion in tumor cells which highly expressed FAK such as A549 cell line.	fangchinoline	0-13	protein tyrosine kinase 2	Homo sapiens	63-66	
25539072-9	2015	Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway and inhibits the growth and the invasion in tumor cells which highly expressed FAK such as A549 cell line.	fangchinoline	0-13	protein tyrosine kinase 2	Homo sapiens	63-66