PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27863043-1	2016	The GPR17 receptor is a G protein-coupled receptor (GPCR) that seems to respond to two unrelated families of endogenous ligands: nucleotide sugars (UDP, UDP-galactose, and UDP-glucose) and cysteinyl leukotrienes (LTD4 , LTC4 , and LTE4 ), with significant affinity at micromolar and nanomolar concentrations, respectively.	Uridine Diphosphate Glucose	172-183	G protein-coupled receptor 17	Homo sapiens	4-9	
23640798-0	2013	UDP-glucose enhances outward K(+) currents necessary for cell differentiation and stimulates cell migration by activating the GPR17 receptor in oligodendrocyte precursors.	Uridine Diphosphate Glucose	0-11	G protein-coupled receptor 17	Homo sapiens	126-131	
23640798-8	2013	The effect of UDP-glucose on K(+) currents is concentration-dependent, blocked by the GPR17 antagonists MRS2179 and cangrelor, and sensitive to the K(+) channel blocker tetraethyl-ammonium, which also inhibits oligodendrocyte maturation.	Uridine Diphosphate Glucose	14-25	G protein-coupled receptor 17	Homo sapiens	86-91	
23288840-6	2013	Both UDP-glucose and LTD(4) increased GPR17 internalization, although with different efficiency.	Uridine Diphosphate Glucose	5-16	G protein-coupled receptor 17	Homo sapiens	38-43	
19625605-6	2009	[35S]GTPgammaS binding in long-GPR17-expressing 1321N1 cells revealed concentration-dependent responses to uracil nucleotides (UDP-galactose = UDP > UDP-glucose) and cysteinyl leukotrienes (LTC4 > LTD4), which were counteracted by a purinergic (cangrelor) and a cysteinyl leukotriene antagonist (montelukast), respectively.	Uridine Diphosphate Glucose	152-163	G protein-coupled receptor 17	Homo sapiens	31-36	
18974869-3	2008	Here we show that, in brain telencephalon, GPR17, a recently deorphanized receptor for both uracil nucleotides and cysLTs (e.g., UDP-glucose and LTD(4)), is normally present on neurons and on a subset of parenchymal quiescent oligodendrocyte precursor cells.	Uridine Diphosphate Glucose	129-140	G protein-coupled receptor 17	Homo sapiens	43-48	
18974869-9	2008	To confirm a specific role for GPR17 in oligodendrocyte differentiation, the in vitro exposure of cortical pre-oligodendrocytes to the GPR17 endogenous ligands UDP-glucose and LTD(4) promoted the expression of myelin basic protein, confirming progression toward mature oligodendrocytes.	Uridine Diphosphate Glucose	160-171	G protein-coupled receptor 17	Homo sapiens	135-140	
21531793-1	2011	G protein-coupled receptor (GPR) 17 is a P2Y-like receptor that responds to both uracil nucleotides (as UDP-glucose) and cysteinyl-leukotrienes (cysLTs, as LTD(4)).	Uridine Diphosphate Glucose	104-115	G protein-coupled receptor 17	Homo sapiens	41-58	
21531793-6	2011	Both UDP-glucose and LTD(4) induced a time- and concentration-dependent GPR17 loss of response (homologous desensitization) with similar kinetics.	Uridine Diphosphate Glucose	5-16	G protein-coupled receptor 17	Homo sapiens	72-77	
21531793-9	2011	Finally, activation of GPR17 by UDP-glucose (but not vice versa) induced a partial heterologous desensitization of LTD(4)-mediated responses, suggesting that nucleotides have a hierarchy in producing desensitizing signals.	Uridine Diphosphate Glucose	32-43	G protein-coupled receptor 17	Homo sapiens	23-28	
19528093-2	2009	Here we show that, in non-injured spinal cord parenchyma, GPR17, a P2Y-like receptor responding to both uracil nucleotides (e.g. UDP-glucose) and cysteinyl-leukotrienes (e.g. LTD4 and LTC4), is present on a subset of neurons and of oligodendrocytes at different stages of maturation, whereas it is not expressed by astrocytes.	Uridine Diphosphate Glucose	129-140	G protein-coupled receptor 17	Homo sapiens	58-63	
19528093-2	2009	Here we show that, in non-injured spinal cord parenchyma, GPR17, a P2Y-like receptor responding to both uracil nucleotides (e.g. UDP-glucose) and cysteinyl-leukotrienes (e.g. LTD4 and LTC4), is present on a subset of neurons and of oligodendrocytes at different stages of maturation, whereas it is not expressed by astrocytes.	Uridine Diphosphate Glucose	129-140	G protein-coupled receptor 17	Homo sapiens	67-84