PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11337504-2 2001 Glucosylceramide synthase (GCS) transfers glucose from UDP-Glc to ceramide, catalyzing the first glycosylation step in the formation of higher order glycosphingolipids. Uridine Diphosphate Glucose 55-62 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 0-25 11337504-2 2001 Glucosylceramide synthase (GCS) transfers glucose from UDP-Glc to ceramide, catalyzing the first glycosylation step in the formation of higher order glycosphingolipids. Uridine Diphosphate Glucose 55-62 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 27-30 11337504-4 2001 We previously identified His-193 of rat GCS as an important residue in UDP-Glc and GCS inhibitor binding; however, little else is known about the GCS active site. Uridine Diphosphate Glucose 71-78 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 40-43 8567691-1 1996 We present a method for solubilizing and purifying UDP-Glc:ceramide glucosyltransferase (EC 2.4.1.80; glucosylceramide synthase (GCS) from a rat liver and present data on its substrate specificity. Uridine Diphosphate Glucose 51-58 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 102-127 10393098-0 1999 Histidine-193 of rat glucosylceramide synthase resides in a UDP-glucose- and inhibitor (D-threo-1-phenyl-2-decanoylamino-3-morpholinopropan-1-ol)-binding region: a biochemical and mutational study. Uridine Diphosphate Glucose 60-71 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 21-46 10393098-1 1999 Glucosylceramide synthase (GCS) catalyses the transfer of glucose from UDP-glucose (UDP-Glc) to ceramide to form glucosylceramide, the common precursor of most higher-order glycosphingolipids. Uridine Diphosphate Glucose 71-82 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 0-25 10393098-1 1999 Glucosylceramide synthase (GCS) catalyses the transfer of glucose from UDP-glucose (UDP-Glc) to ceramide to form glucosylceramide, the common precursor of most higher-order glycosphingolipids. Uridine Diphosphate Glucose 71-82 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 27-30 10393098-1 1999 Glucosylceramide synthase (GCS) catalyses the transfer of glucose from UDP-glucose (UDP-Glc) to ceramide to form glucosylceramide, the common precursor of most higher-order glycosphingolipids. Uridine Diphosphate Glucose 84-91 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 0-25 10393098-1 1999 Glucosylceramide synthase (GCS) catalyses the transfer of glucose from UDP-glucose (UDP-Glc) to ceramide to form glucosylceramide, the common precursor of most higher-order glycosphingolipids. Uridine Diphosphate Glucose 84-91 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 27-30 10393098-5 1999 The histidine-modifying agent diethyl pyrocarbonate (DEPC) inhibited recombinant rat GCS expressed in bacteria; this inhibition was rapidly reversible by hydroxylamine and could be diminished by preincubation of GCS with UDP-Glc. Uridine Diphosphate Glucose 221-228 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 212-215 10393098-6 1999 These data suggest that DEPC acts on histidine residues within or near the UDP-Glc-binding site of GCS. Uridine Diphosphate Glucose 75-82 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 99-102 10393098-9 1999 These results indicate that His193 is the primary target of DEPC and is at, or near, the UDP-Glc-binding site of GCS. Uridine Diphosphate Glucose 89-96 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 113-116 9867864-1 1999 Glucosylceramide synthase (GCS) catalyzes the transfer of glucose from UDP-glucose to ceramide to form glucosylceramide, the precursor of most higher order glycosphingolipids. Uridine Diphosphate Glucose 71-82 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 0-25 9867864-1 1999 Glucosylceramide synthase (GCS) catalyzes the transfer of glucose from UDP-glucose to ceramide to form glucosylceramide, the precursor of most higher order glycosphingolipids. Uridine Diphosphate Glucose 71-82 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 27-30 8567691-1 1996 We present a method for solubilizing and purifying UDP-Glc:ceramide glucosyltransferase (EC 2.4.1.80; glucosylceramide synthase (GCS) from a rat liver and present data on its substrate specificity. Uridine Diphosphate Glucose 51-58 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 129-132 8567691-3 1996 GCS activity was monitored throughout purification using UDP-Glc and a fluorescent ceramide analog as substrates. Uridine Diphosphate Glucose 57-64 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 0-3 8567691-4 1996 Purification of GCS was achieved via a two-step dye-agarose chromatography procedure using UDP-Glc to elute the enzyme. Uridine Diphosphate Glucose 91-98 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 16-19 2524552-0 1989 Regulation of UDP-galactose:ceramide galactosyltransferase and UDP-glucose:ceramide glucosyltransferase after crush and transection nerve injury. Uridine Diphosphate Glucose 63-74 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 75-103 6228260-6 1983 This is shown by the different effect obtained with two UDP-Glc utilizing membrane-bound enzymes : UDP-Glc : phospho-dolichyl glucosyltransferase and UDP-Glc : ceramide glucosyltransferase : the first one not being affected but the second one being markedly inhibited under the same condition, although both are inhibited when the membrane environment is disturbed by detergent. Uridine Diphosphate Glucose 56-63 UDP-glucose ceramide glucosyltransferase Rattus norvegicus 160-188