PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10329302-4 1999 The objective of this study was to evaluate the effect of diacerein, a new anti-OA agent and its active metabolite, rhein, on the production and function of IL-1beta, nitric oxide (NO) and receptor agonist (IL-1ra) in human OA cartilage and synovial tissue cultures. diacerein 58-67 interleukin 1 receptor antagonist Homo sapiens 207-213 10329302-11 1999 Diacerein and rhein decreased NO release in synovial tissue and cartilage media and increased IL-1ra levels in cartilage culture media. diacerein 0-9 interleukin 1 receptor antagonist Homo sapiens 94-100