PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19738618-0	2009	Induction of thrombospondin-1 partially mediates the anti-angiogenic activity of dexrazoxane.	Dexrazoxane	81-92	thrombospondin 1	Homo sapiens	13-29	
19738618-9	2009	Treatment of microvascular endothelial cells in vitro with subtoxic doses of dexrazoxane stimulated thrombospondin-1 (THBS-1) secretion.	Dexrazoxane	77-88	thrombospondin 1	Homo sapiens	100-116	
19738618-9	2009	Treatment of microvascular endothelial cells in vitro with subtoxic doses of dexrazoxane stimulated thrombospondin-1 (THBS-1) secretion.	Dexrazoxane	77-88	thrombospondin 1	Homo sapiens	118-124	
19738618-10	2009	Knockdown of THBS-1 with siRNA removed the angiogenesis inhibition effect of dexrazoxane, which is consistent with the anti-angiogenic and vascular normalising properties of the drug being principally mediated by THBS-1.	Dexrazoxane	77-88	thrombospondin 1	Homo sapiens	13-19	
19738618-11	2009	CONCLUSION: We show that dexrazoxane administered in small repeated doses is strongly anti-angiogenic and that this activity is mediated by induction of the anti-angiogenic THBS-1 in endothelial cells.	Dexrazoxane	25-36	thrombospondin 1	Homo sapiens	173-179