PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31121972-2 2019 The xanthone 5 was used as a starting point for the construction of a library of 3,4-dioxygenated xanthones bearing chemical moieties of described MDM2-p53 inhibitors. Xanthones 98-107 MDM2 proto-oncogene Homo sapiens 147-151 31121972-3 2019 Eleven aminated xanthones were successfully synthesized and initially screened for their ability to disrupt the MDM2-p53 interaction using a yeast cell-based assay. Xanthones 16-25 MDM2 proto-oncogene Homo sapiens 112-116