PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10801823-2 2000 Ha-Ras loses 90% of its transforming activity if Cys(181) and Cys(184) are changed to serines, implying that palmitates make important contributions to oncogenicity. Serine 86-93 Harvey rat sarcoma virus oncogene Mus musculus 0-6 15172983-2 2004 We have previously reported that cell transformations induced by ornithine decarboxylase (ODC) and c-Ha-ras oncogene, commonly activated in various cancer cells, are associated with constitutively increased phosphorylation of c-Jun on Ser residues 63 and 73. Serine 235-238 Harvey rat sarcoma virus oncogene Mus musculus 99-107 1658621-6 1991 This induction could be suppressed by cotransfection of two inhibitory mutant ras genes, H-ras(Asn-17) or H-ras(Leu-61,Ser-186). Serine 119-122 Harvey rat sarcoma virus oncogene Mus musculus 106-111 3096340-1 1986 A decapeptide corresponding to residues 35-44(-Thr-Ile-Glu-Asp-Ser-Tyr-Arg-Lys-Gln-Val-) of p21ras was synthesized. Serine 63-66 Harvey rat sarcoma virus oncogene Mus musculus 92-98 19182994-3 2009 Further studies show that both serine-727 and tyrosine-705 of Stat3 were phosphorylated while Ha-ras was overexpressed. Serine 31-37 Harvey rat sarcoma virus oncogene Mus musculus 94-100 19182994-4 2009 Interleukin-6 (IL-6)-induced phosphorylation of tyrosine-705 and serine-727, as well as DNA-binding and transcriptional activity of Stat3 were further enhanced by Ha-ras overexpression. Serine 65-71 Harvey rat sarcoma virus oncogene Mus musculus 163-169 19182994-6 2009 We demonstrate that Ha-ras and Stat3 acting together synergistically induce Stat3 phosphorylation at serine-727 phosphorylation and cyclin D1 expression and further enhance transformation and tumorigenicity of the cell. Serine 101-107 Harvey rat sarcoma virus oncogene Mus musculus 20-26 19182994-7 2009 Ha-ras-induced Stat3 phosphorylation at serine-727 plays a pivotal role in transcriptional activation of cyclin D1 and suppression of cell apoptosis. Serine 40-46 Harvey rat sarcoma virus oncogene Mus musculus 0-6 19182994-8 2009 The effect of Ha-ras on Stat3 phosphorylation at serine-727 was also detected in human bladder (T24) and lung (H460) cancer cells. Serine 49-55 Harvey rat sarcoma virus oncogene Mus musculus 14-20