PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32307979-3 2020 We found that in normal cells, the levels of wnt3a, beta-catenin, glycogen synthase kinase-3beta phosphorylated at serine 9 (p-GSK-3beta(Ser9)), cyclinD1, proto-oncogene c-myc and vascular endothelial growth factor (VEGF) in arsenic intervention group were higher than those in control group, and the level of glycogen synthase kinase-3beta (GSK-3beta) was lower than that in control group (P<0.05, respectively). Serine 115-121 cyclin D1 Homo sapiens 145-175 8058338-5 1994 Phosphoamino acid analysis and two-dimensional phosphopeptide mapping of wild-type and truncated cyclin D1 proteins showed that PKA phosphorylates three distinct serine residues in cyclin D1 at positions 90, 197 and 234. Serine 162-168 cyclin D1 Homo sapiens 97-106 8058338-5 1994 Phosphoamino acid analysis and two-dimensional phosphopeptide mapping of wild-type and truncated cyclin D1 proteins showed that PKA phosphorylates three distinct serine residues in cyclin D1 at positions 90, 197 and 234. Serine 162-168 cyclin D1 Homo sapiens 181-190 8058338-6 1994 Serine-90 is located within the cyclin box, raising the possibility that phosphorylation of cyclin D1 might play a role in regulating the interaction with other proteins. Serine 0-6 cyclin D1 Homo sapiens 92-101 31191746-8 2019 Western blot detection showed that CCND1 and phosphorylated Rb transcriptional corepressor 1 at ser-807/811 (pRb1-ser807/811) expression levels were downregulated when NFE2L3 was inhibited in those two cell lines. Serine 96-99 cyclin D1 Homo sapiens 35-40 31219365-5 2019 Expert opinion: The cyclin D1 gene encodes the regulatory subunit of a proline-directed serine-threonine kinase that phosphorylates several substrates. Serine 88-94 cyclin D1 Homo sapiens 20-29 26203195-3 2015 In addition, our results suggest that activation of the cyclin D1-CDK4 complex by NGP-1 via maintaining the stoichiometry between cyclin D1-CDK4 complex and p21 resulted in hyperphosphorylation of retinoblastoma protein at serine 780 (p-RB(Ser-780)) followed by the up-regulation of E2F1 target genes required to promote G1 to S phase transition. Serine 223-229 cyclin D1 Homo sapiens 56-65 30535469-8 2019 Inhibition of glycogen synthase kinase 3beta activity by phosphorylation of its N-terminal serine increases accumulation of cyclin D1, which promotes the cell cycle and improves cell proliferation through the PI3K/Akt signaling pathway. Serine 91-97 cyclin D1 Homo sapiens 124-133 30305722-4 2019 Serine-dephosphorylated form of Leo1 binds directly to beta-catenin, promoting the nuclear accumulation of beta-catenin and transactivation of TCF/LEF downstream target genes such as cyclin D1 and c-myc. Serine 0-6 cyclin D1 Homo sapiens 183-192 26203195-3 2015 In addition, our results suggest that activation of the cyclin D1-CDK4 complex by NGP-1 via maintaining the stoichiometry between cyclin D1-CDK4 complex and p21 resulted in hyperphosphorylation of retinoblastoma protein at serine 780 (p-RB(Ser-780)) followed by the up-regulation of E2F1 target genes required to promote G1 to S phase transition. Serine 240-243 cyclin D1 Homo sapiens 56-65 24726840-9 2014 In vitro assays prove that Ser-727 phosphorylation of Stat3 affects the transcriptional activity of its downstream targets like SOCS3, bcl-xl and Cyclin D1. Serine 27-30 cyclin D1 Homo sapiens 146-155 26135564-6 2015 We found glucagon, which is substantially raised in patients with T2D, rapidly phosphorylates beta-catenin on serine 552 that is associated with increased expression of genes cyclin D1 (CCND1) and c-Myc (MYC), which are known to be involved in liver cancer. Serine 110-116 cyclin D1 Homo sapiens 175-184 26135564-6 2015 We found glucagon, which is substantially raised in patients with T2D, rapidly phosphorylates beta-catenin on serine 552 that is associated with increased expression of genes cyclin D1 (CCND1) and c-Myc (MYC), which are known to be involved in liver cancer. Serine 110-116 cyclin D1 Homo sapiens 186-191 21356307-4 2011 Here, we show that mutation of the ERalpha monoUbq sites prevents the E2-induced ERalpha phosphorylation in the serine residue 118 (S118), reduces ERalpha transcriptional activity, and precludes the ERalpha-mediated extranuclear activation of signaling pathways (i.e., AKT activation) thus impeding the E2-induced cyclin D1 promoter activation and consequently cell proliferation. Serine 112-118 cyclin D1 Homo sapiens 314-323 22406084-7 2012 A marked reduction of cyclin D1 and of CDK4 expression was evident in the cells transfected with Cav-1 siRNA and consequently of phospho-Rb on ser(795) and ser(780). Serine 143-146 cyclin D1 Homo sapiens 22-31 22406084-7 2012 A marked reduction of cyclin D1 and of CDK4 expression was evident in the cells transfected with Cav-1 siRNA and consequently of phospho-Rb on ser(795) and ser(780). Serine 156-159 cyclin D1 Homo sapiens 22-31 22369110-7 2012 A phosphorylation of retinoblastoma protein (RB) at serine 780, a target site of cyclin D1-dependent kinase 4, was rapidly decreased in GGA-treated HuH-7 cells. Serine 52-58 cyclin D1 Homo sapiens 81-90 21084836-6 2010 Interestingly, the STAT1 serine 727 phosphorylation site and not the STAT1 tyrosine 701 site is required for cyclin D1-dependent proteosomal degradation. Serine 25-31 cyclin D1 Homo sapiens 109-118 21084836-7 2010 Furthermore, IFN-gamma-STAT1 cyclin D1 reduction correlated with decreased amount of p-Rb Ser-795, cyclin E and increased amounts of the cell cycle inhibitors p27(Kip1) and p21(Cip1). Serine 90-93 cyclin D1 Homo sapiens 29-38 19592491-4 2009 Here we show that SRPK2, a protein kinase specific for the serine/arginine (SR) family of splicing factors, triggers cell cycle progression in neurons and induces apoptosis through regulation of nuclear cyclin D1. Serine 59-65 cyclin D1 Homo sapiens 203-212 20628053-10 2010 Importantly, Erk-mediated serine phosphorylation of paxillin is also required for DHT-induced prostate-specific antigen mRNA expression in LnCAP cells as well as EGF-induced cyclin D1 mRNA expression in PC3 cells, suggesting that paxillin may regulate prostate cancer proliferation by serving as a liaison between extra-nuclear kinase signaling and intra-nuclear transcriptional signals. Serine 26-32 cyclin D1 Homo sapiens 174-183 19940156-5 2010 Cyclin D1, a major target of ERalpha, is transcriptionally up-regulated by IKKepsilon in a phospho-ERalpha-Ser-167-dependent manner. Serine 107-110 cyclin D1 Homo sapiens 0-9 18938028-4 2009 The association between phospho-pRb (Ser-807/811) levels and exposure to tobacco smoke was different according to the statuses of cyclin D1 expression and p16 methylation, suggesting that their statuses might play a role as an effect modifier in the relationship between phospho-pRb (Ser-807/811) levels and exposure to tobacco smoke. Serine 37-40 cyclin D1 Homo sapiens 130-139 19182994-7 2009 Ha-ras-induced Stat3 phosphorylation at serine-727 plays a pivotal role in transcriptional activation of cyclin D1 and suppression of cell apoptosis. Serine 40-46 cyclin D1 Homo sapiens 105-114 17334399-5 2007 In particular, we have identified Ser 632 of BRCA1 as a cyclin D1/cdk4 phosphorylation site in vitro. Serine 34-37 cyclin D1 Homo sapiens 56-65 17909257-5 2007 METHODS: We designed a CCND1-specific peptide nucleic acid (PNA) hybridization sequence (CTGGTGTTCCAT), separated by a C-terminal spacer to a cyclized IGF1 peptide analog (d-Cys-Ser-Lys-Cys), for IGF1R-mediated endocytosis. Serine 178-181 cyclin D1 Homo sapiens 23-28 17638069-5 2008 The decrease in cyclin D1 protein expression accompanies a dramatic decline in nuclear but not membranous beta-catenin expression and activation of glycogen synthase kinase-3-beta (GSK3beta) caused by inhibition of its serine-9 phosphorylation. Serine 219-225 cyclin D1 Homo sapiens 16-25 17976956-3 2008 OSM treatment significantly reduced levels of cyclin D1 protein and phosphorylation of retinoblastoma protein (Rb) at Ser-795, a CDK4-specific phosphorylation site. Serine 118-121 cyclin D1 Homo sapiens 46-55 17951252-6 2007 Inhibitory Ser-9 phosphorylation of glycogen synthase kinase 3beta (GSK3beta) by Akt prevented proteasome-mediated cyclin D1 degradation and induced cell cycle progress in LeTx-intoxicated THP-1 cells. Serine 11-14 cyclin D1 Homo sapiens 115-124 16964287-8 2007 Although phosphorylation of c-Jun at Ser-63 is required for activator protein 1 (AP-1)-dependent expression of cyclin D1, it decreased in LMB-treated cells compared to untreated cells. Serine 37-40 cyclin D1 Homo sapiens 111-120 16964287-10 2007 We propose that inhibition of cyclin D1 expression by LMB is mediated by the LMB-induced nuclear accumulation of PP2A, leading to sustained dephosphorylation of c-Jun at Ser-63, which leads to inactivation of the transcription of the AP-1-responsive cyclin D1 gene. Serine 170-173 cyclin D1 Homo sapiens 30-39 17047061-11 2006 Cyclin D1 regulated p27(KIP1) abundance at the posttranslational level, inhibiting the Skp2 promoter, Skp2 abundance, and induced p27(KIP1) phosphorylation at Ser(10). Serine 159-162 cyclin D1 Homo sapiens 0-9 17200689-6 2006 IGF-1 increases the cyclic AMP-responsive element (CRE) binding transcription factor CREB phosphorylation at Ser 133 and CRE-binding activity in mesangial cells, which parallels cyclin D1 and fibronectin expressions. Serine 109-112 cyclin D1 Homo sapiens 178-187 15172998-2 2004 Here, we establish that KLF6 mediates growth inhibition through an interaction with cyclin D1, leading to reduced phosphorylation of the retinoblastoma protein (Rb) at Ser(795). Serine 168-171 cyclin D1 Homo sapiens 84-93 16613857-5 2006 Mutagenesis of Runx2 serine-472, a consensus Cdk site, to alanine increases the half-life of Runx2 and causes loss of sensitivity to cyclin D1-induced Runx2 degradation. Serine 21-27 cyclin D1 Homo sapiens 133-142 16153458-9 2005 Our results suggest that serine 795 but not serine 780 is the preferred phosphorylation site induced by cyclin D1. Serine 25-31 cyclin D1 Homo sapiens 104-113 15178330-0 2004 Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin D1 in breast cancer cells. Serine 32-38 cyclin D1 Homo sapiens 71-80 14646596-9 2003 Also, analysis of phosphorylated serine/threonine sites on RB catalyzed by CDK4/cyclin D1 and CDK2/cyclin A showed significant differences in their preference of phosphorylation sites in RB C-terminal domain. Serine 33-39 cyclin D1 Homo sapiens 80-89 10022898-4 1999 Accordingly, cyclin D1-associated phosphorylation of pRb at Ser-780 is lacking even in newly senescent fibroblasts that have a low amount of p16. Serine 60-63 cyclin D1 Homo sapiens 13-22 12540838-3 2003 We found that CREB activity, including its DNA binding ability and phosphorylation on residue Ser-133, was strongly inhibited by Cpd 5, followed by suppression of CRE-mediated transcription of cyclin D1 and Bcl-2 genes. Serine 94-97 cyclin D1 Homo sapiens 193-202 11773438-6 2002 The expression of cyclin D1, a critical regulator of the G1/S transition, was significantly increased by PRL and was associated with hyperphosphorylation of retinoblastoma protein at Ser(780). Serine 183-186 cyclin D1 Homo sapiens 18-27 11114297-4 2001 One site displays homology to a preferential D-type cyclin-dependent kinase site (serine 780) on the retinoblastoma susceptibility gene product (pRB) and, consistent with this homology, is more efficiently phosphorylated by cyclin D1-CDK4 than by the other cyclin-dependent kinases (CDK) that were tested. Serine 82-88 cyclin D1 Homo sapiens 224-233 9342364-11 1997 Notably, this RA-signaled cyclin D1 proteolysis depended on the C-terminal PEST sequence, a region rich in proline (P), glutamate (E), serine (S), and threonine (T). Serine 135-141 cyclin D1 Homo sapiens 26-35 9010227-5 1997 We provide evidence that this residue, serine 608 of pRB, is an authentic phosphorylation site that can be phosphorylated in vitro by cyclin A-CDK2 and cyclin D1-CDK4 kinases but not by cyclin E-CDK2 kinase or the mitogen activated kinase ERK2. Serine 39-45 cyclin D1 Homo sapiens 152-161