PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11330837-1 2001 The carboxyterminal domain of the epidermal growth factor receptor (EGFR)--a putative binding site for the ubiquitin ligase Cbl--is the site of serine phosphorylation events which are essential for ligand-dependent EGFR desensitization and degradation. Serine 144-150 Cbl proto-oncogene Homo sapiens 124-127 15094368-1 2004 We found that engagement of beta2 integrins on human neutrophils triggered both tyrosine and serine phosphorylation of c-Cbl. Serine 93-99 Cbl proto-oncogene Homo sapiens 119-124 15094368-6 2004 Instead, c-Cbl that underwent PKC-induced serine phosphorylation associated with the scaffolding and anti-apoptotic 14-3-3 proteins. Serine 42-48 Cbl proto-oncogene Homo sapiens 9-14 11024037-6 2001 CD43 signals induced a Cbl serine phosphorylation-dependent interaction with the tau-isoform of 14-3-3. protein. Serine 27-33 Cbl proto-oncogene Homo sapiens 23-26 11024037-7 2001 Protein kinase C-mediated Cbl serine phosphorylation was required for this interaction, because the PKC inhibitor RO-31-8220 prevented it, as well as 14-3-3 dimerization. Serine 30-36 Cbl proto-oncogene Homo sapiens 26-29 11024037-10 2001 However, under normal conditions, PKC activation resulting from CD43 engagement was required to activate the MAPK pathway, suggesting that phosphorylation of Cbl on serine residues by PKC and its association with 14-3-3 molecules may play a role in preventing the Cbl inhibitory effect on the Ras-MAPK pathway. Serine 165-171 Cbl proto-oncogene Homo sapiens 158-161 11024037-11 2001 These data suggest that by inducing its phosphorylation on serine residues, CD43-mediated signals may regulate the molecular associations and functions of the Cbl adapter protein. Serine 59-65 Cbl proto-oncogene Homo sapiens 159-162 11024037-8 2001 Moreover, mutation of Cbl serine residues 619, 623, 639, and 642 abolished the interaction between Cbl and 14-3-3. Serine 26-32 Cbl proto-oncogene Homo sapiens 22-25 11024037-8 2001 Moreover, mutation of Cbl serine residues 619, 623, 639, and 642 abolished the interaction between Cbl and 14-3-3. Serine 26-32 Cbl proto-oncogene Homo sapiens 99-113 10092600-6 1999 Binding of 14-3-3tau to PKCmu is significantly enhanced upon phorbol ester stimulation of PKCmu kinase activity in Jurkat cells and occurs via a Cbl-like serine containing consensus motif. Serine 154-160 Cbl proto-oncogene Homo sapiens 145-148 10623852-5 2000 Tyrosine phosphorylation of Cbl in response to CD32 cross-linking was inhibited by calyculin, and this inhibition was linked with a slower electrophoretic mobility of Cbl as a consequence of its phosphorylation on serine/threonine residues. Serine 214-220 Cbl proto-oncogene Homo sapiens 28-31 10623852-5 2000 Tyrosine phosphorylation of Cbl in response to CD32 cross-linking was inhibited by calyculin, and this inhibition was linked with a slower electrophoretic mobility of Cbl as a consequence of its phosphorylation on serine/threonine residues. Serine 214-220 Cbl proto-oncogene Homo sapiens 167-170 10358153-6 1999 Furthermore, a serine-rich motif at the C terminus of Cbl, which is critical for PMA-induced 14-3-3 binding, is also phosphorylated by PKCalpha and PKCtheta in vitro. Serine 15-21 Cbl proto-oncogene Homo sapiens 54-57 10358153-7 1999 These results suggest that, by regulating tyrosine and serine phosphorylation of Cbl, PKC is able to control the association of Cbl with signaling intermediates, such as SH2 domain-containing proteins and 14-3-3 proteins, which may consequently result in the modulation of its function. Serine 55-61 Cbl proto-oncogene Homo sapiens 81-84 10358153-7 1999 These results suggest that, by regulating tyrosine and serine phosphorylation of Cbl, PKC is able to control the association of Cbl with signaling intermediates, such as SH2 domain-containing proteins and 14-3-3 proteins, which may consequently result in the modulation of its function. Serine 55-61 Cbl proto-oncogene Homo sapiens 128-131 9092538-0 1997 Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif. Serine 0-6 Cbl proto-oncogene Homo sapiens 26-29 9092538-6 1997 Phorbol 12-myristate 13-acetate stimulation induced serine phosphorylation of Cbl, and dephosphorylation of immunoprecipitated Cbl by a Ser/Thr phosphatase disrupted its interaction with 14-3-3. Serine 52-58 Cbl proto-oncogene Homo sapiens 78-81 9092538-7 1997 By using successive carboxyl-terminal deletion mutants of Cbl, the 14-3-3-binding domain was mapped to a serine-rich 30-amino acid region (residues 615-644) of Cbl. Serine 105-111 Cbl proto-oncogene Homo sapiens 58-61 9092538-0 1997 Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif. Serine 124-130 Cbl proto-oncogene Homo sapiens 26-29 9092538-7 1997 By using successive carboxyl-terminal deletion mutants of Cbl, the 14-3-3-binding domain was mapped to a serine-rich 30-amino acid region (residues 615-644) of Cbl. Serine 105-111 Cbl proto-oncogene Homo sapiens 160-163 9092538-9 1997 These results suggest that TCR stimulation induces both tyrosine and serine phosphorylation of Cbl. Serine 69-75 Cbl proto-oncogene Homo sapiens 95-98 20877636-8 2010 This obvious reduction in binding affinity, however, indicates that Cbl"s interactions with its TKB-centered binding partners may be more favorable in the absence of Ser/Thr phosphorylation, which is stimulation and context specific in vivo. Serine 166-169 Cbl proto-oncogene Homo sapiens 68-71 27261451-6 2016 We report that serine-to-tyrosine mutation leads to increased tyrosine phosphorylation of S1045Y-CFTR, followed by recruitment and binding of E3-ubiquitin ligase c-cbl, resulting in enhanced ubiquitination and passage of S1045Y-CFTR in the endosome/lysosome degradative compartments. Serine 15-21 Cbl proto-oncogene Homo sapiens 162-167 23897813-5 2013 Reduced ubiquitylation of EGFR is accompanied by PKC-dependent increase in serine phosphorylation of c-Cbl in cells expressing elevated levels of CD82. Serine 75-81 Cbl proto-oncogene Homo sapiens 101-106 16479008-8 2006 A mutant of hSpry2 that is deficient in serine phosphorylation displays enhanced tyrosine phosphorylation and c-Cbl binding, indicating that serine phosphorylation stabilizes hSpry2 by exerting an antagonistic effect on tyrosine phosphorylation. Serine 40-46 Cbl proto-oncogene Homo sapiens 110-115 20877636-0 2010 Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain. Serine 11-17 Cbl proto-oncogene Homo sapiens 133-138 18662810-5 2008 CBL showed maximum affinity for human tumor-associated Tn-antigens (GalNAcalpha1-Ser/Thr) at the molecular level and was 3.5 times higher than GalNAc. Serine 81-84 Cbl proto-oncogene Homo sapiens 0-3 17255109-10 2007 c-Cbl binding likely targets Spry2 for ubiquitin-linked destruction, whereas the phosphatase binding and activity are necessary to dephosphorylate specific Ser/Thr residues. Serine 156-159 Cbl proto-oncogene Homo sapiens 0-5 16479008-8 2006 A mutant of hSpry2 that is deficient in serine phosphorylation displays enhanced tyrosine phosphorylation and c-Cbl binding, indicating that serine phosphorylation stabilizes hSpry2 by exerting an antagonistic effect on tyrosine phosphorylation. Serine 141-147 Cbl proto-oncogene Homo sapiens 110-115