PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27365393-0 2016 Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity. Serine 46-52 leukotriene C4 synthase Homo sapiens 19-42 27365393-8 2016 Comparative molecular dynamics indicated that Ser(36) upon phosphorylation will pull the first luminal loop of LTC4S toward the neighboring subunit of the functional homotrimer, thereby forming hydrogen bonds with Arg(104) in the adjacent subunit. Serine 46-49 leukotriene C4 synthase Homo sapiens 111-116 27365393-11 2016 Thus, our mutational and kinetic data, together with molecular simulations, suggest that phosphorylation of Ser(36) inhibits the catalytic function of LTC4S by interference with the catalytic machinery. Serine 108-111 leukotriene C4 synthase Homo sapiens 151-156