PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20086103-2	2010	In human mesangial cells (HMC) both processes are induced by angiotensin II (AngII) via protein kinase Cdelta (PKCdelta)-triggered serine phosphorylation of HuR.	Serine	131-137	angiotensinogen	Homo sapiens	61-75	
20086103-2	2010	In human mesangial cells (HMC) both processes are induced by angiotensin II (AngII) via protein kinase Cdelta (PKCdelta)-triggered serine phosphorylation of HuR.	Serine	131-137	angiotensinogen	Homo sapiens	77-82	
20086103-3	2010	By testing different point-mutated Flag-tagged HuR proteins, we found that Ser 318 within RNA recognition motif 3 (RRM3) is essential for AngII-induced binding to ARE-bearing mRNA but irrelevant for nucleocytoplasmic HuR shuttling.	Serine	75-78	angiotensinogen	Homo sapiens	138-143	
20086103-4	2010	Conversely, mutation at Ser 221 within the HuR hinge region prevents AngII-triggered HuR export without affecting mRNA binding of HuR.	Serine	24-27	angiotensinogen	Homo sapiens	69-74	
20086103-5	2010	Using phosphorylation state-specific antibodies, we found a transient increase in HuR phosphorylation at both serines by AngII.	Serine	110-117	angiotensinogen	Homo sapiens	121-126	
19348241-1	2009	Angiotensin II suppresses the insulin sensitivity via enhancement of serine phosphorylation of insulin receptor and suppression of tyrosine phosphorylation of IRS-1.	Serine	69-75	angiotensinogen	Homo sapiens	0-14	
19303015-8	2009	Inhibition of angiotensin II, the angiotensin II receptor type 1 (AT1), or IKK blocked Ser(536) phosphorylation and stimulated myofibroblast apoptosis.	Serine	87-90	angiotensinogen	Homo sapiens	14-28	
19940161-5	2010	We show that Ang II stimulates Akt-dependent PGC-1 alpha serine 570 phosphorylation, which is required for the binding of the histone acetyltransferase GCN5 (general control nonderepressible 5) to PGC-1 alpha and for its lysine acetylation.	Serine	57-63	angiotensinogen	Homo sapiens	13-19	
19303015-0	2009	Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis.	Serine	68-71	angiotensinogen	Homo sapiens	0-14	
19303015-7	2009	Autocrine angiotensin II stimulated IKK-mediated phosphorylation of RelA at Ser(536), which was required for nuclear transport and transcriptional activity of NF-kappaB.	Serine	76-79	angiotensinogen	Homo sapiens	10-24	
18855718-4	2008	At early intracellular level angiotensin II acts on JAK-2/IRS1-IRS2/PI3-kinase, JNK and ERK to phosphorylate serine residues of key elements of insulin signaling pathway therefore inhibiting signaling by the insulin receptor.	Serine	109-115	angiotensinogen	Homo sapiens	29-43	
18285462-7	2008	Mapping of phosphorylation sites identified serines 221 and 318 as critical target sites for PKCdelta-triggered HuR phosphorylation and AngII-induced HuR export to the cytoplasm.	Serine	44-51	angiotensinogen	Homo sapiens	136-141	
16513650-6	2006	The use of pharmacological inhibitors that inhibit the activation of MEK by Ang II revealed that phosphorylation of p65 on serine 536 did not require the MEK-ERK-RSK signaling pathway.	Serine	123-129	angiotensinogen	Homo sapiens	76-82	
18258854-0	2008	Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1.	Serine	90-93	angiotensinogen	Homo sapiens	0-14	
17595324-5	2007	Instead, Ang II rapidly induced RelA phosphorylation at Ser residue 536, and complex formation with the Ser(536) kinase known as the NF-kappaB-inducing kinase (NIK)/MEKK14.	Serine	56-59	angiotensinogen	Homo sapiens	9-15	
17595324-5	2007	Instead, Ang II rapidly induced RelA phosphorylation at Ser residue 536, and complex formation with the Ser(536) kinase known as the NF-kappaB-inducing kinase (NIK)/MEKK14.	Serine	104-107	angiotensinogen	Homo sapiens	9-15	
17595324-10	2007	NIK down-regulation prevents Ang II-induced phospho-Ser(536) RelA formation, indicating that it is essential for RelA activation.	Serine	52-55	angiotensinogen	Homo sapiens	29-35	
17595324-11	2007	The Ang II pathway further involves the RhoA small GTP-binding protein because RhoA inhibition blocks Ang II-induced transcriptional activity and formation of phospho-Ser(536) RelA formation.	Serine	167-170	angiotensinogen	Homo sapiens	4-10	
17595324-11	2007	The Ang II pathway further involves the RhoA small GTP-binding protein because RhoA inhibition blocks Ang II-induced transcriptional activity and formation of phospho-Ser(536) RelA formation.	Serine	167-170	angiotensinogen	Homo sapiens	102-108	
17595324-12	2007	Finally, we demonstrate that Ang II infusion in vivo rapidly induces phospho-Ser(536) RelA formation and activation of the NF-kappaB-dependent IL-6 gene.	Serine	77-80	angiotensinogen	Homo sapiens	29-35	
17595324-13	2007	These data indicate that Ang II induces NF-kappaB-dependent transcription through an alternative pathway, being largely independent of IkappaB proteolysis, but mediated by the small GTPases Rac/RhoA, required for NIK.RelA complex formation and inducible Ser(536) RelA phosphorylation.	Serine	254-257	angiotensinogen	Homo sapiens	25-31	
17240116-0	2007	Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells.	Serine	36-39	angiotensinogen	Homo sapiens	76-90	
17240116-0	2007	Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells.	Serine	45-48	angiotensinogen	Homo sapiens	76-90	
17505626-6	2007	At an early intracellular level, AII, acting through JAK-2/IRS-1/PI3-kinase, JNK and ERK, may induce the serine phosphorylation and inhibition of key elements of the Ins-signaling pathway.	Serine	105-111	angiotensinogen	Homo sapiens	33-36	
16513650-9	2006	Collectively, our data demonstrate that the proinflammatory activity of Ang II is independent of the classical pathway leading to IkappaBalpha phosphorylation and degradation but clearly depends on the recruitment of an IKK complex signaling cascade leading to phosphorylation of p65 on serine 536.	Serine	287-293	angiotensinogen	Homo sapiens	72-78	
16158823-10	2005	We found overexpression of the p53 protein in lymphoid cells and a point missense mutation in codon 280 at exon 8 that changed AGA (Arg) to AGT (Ser).	Serine	145-148	angiotensinogen	Homo sapiens	140-143	
16389635-6	2006	At an early intracellular level, angiotensin II, acting through JAK-2/IRS-1/PI3-kinase, JNK and ERK, may induce the serine phosphorylation and inhibition of key elements of the insulin-signaling pathway.	Serine	116-122	angiotensinogen	Homo sapiens	33-47	
16338965-3	2006	It was shown previously that phorbol esters and angiotensin II and serotonin induce the phosphorylation of both Ser-11 and Ser-18 of the Na,K-ATPase alpha-subunit.	Serine	112-115	angiotensinogen	Homo sapiens	48-62	
16338965-3	2006	It was shown previously that phorbol esters and angiotensin II and serotonin induce the phosphorylation of both Ser-11 and Ser-18 of the Na,K-ATPase alpha-subunit.	Serine	123-126	angiotensinogen	Homo sapiens	48-62	
12763029-6	2003	AngII-induced-phosphorylation of Rb (Ser 795 and Ser 807/811), -cyclin D1 expression, and -DNA synthesis was also markedly enhanced by pharmacological inhibition of the p38 MAPK pathway.	Serine	37-40	angiotensinogen	Homo sapiens	0-5	
15095302-2	2004	A selective mutation in TP53 (AGG-->AGT at codon 249, Arg-->Ser) has been identified as a hotspot in HCCs from such areas, reflecting DNA damage caused by aflatoxin metabolites.	Serine	66-69	angiotensinogen	Homo sapiens	39-42	
15069084-2	2004	Brief treatment of the cells with 100 nm angiotensin II or 1 microm serotonin resulted in serine phosphorylation of Rb that was equal in magnitude to that induced by treating cells for 20 h with 10% fetal bovine serum ( approximately 3 x basal).	Serine	90-96	angiotensinogen	Homo sapiens	41-60	
12860993-5	2003	Ang II-induced Ser-65 phosphorylation was ROS-dependent as assessed by pretreatment with ebselen (3.6 +/- 0.2 versus 1.1 +/- 0.2), diphenylene iodonium (3.6 +/- 0.2 versus 1.0 +/- 0.1), and N-acetyl cysteine (3.6 +/- 0.2 versus 1.2 +/- 0.1), but Ang II-stimulated phosphorylation of Thr-70 was ROS-insensitive.	Serine	15-18	angiotensinogen	Homo sapiens	0-6	
12860993-5	2003	Ang II-induced Ser-65 phosphorylation was ROS-dependent as assessed by pretreatment with ebselen (3.6 +/- 0.2 versus 1.1 +/- 0.2), diphenylene iodonium (3.6 +/- 0.2 versus 1.0 +/- 0.1), and N-acetyl cysteine (3.6 +/- 0.2 versus 1.2 +/- 0.1), but Ang II-stimulated phosphorylation of Thr-70 was ROS-insensitive.	Serine	15-18	angiotensinogen	Homo sapiens	246-252	
12759348-4	2003	Ang II stimulation led to phosphorylation of the alpha subunit Ser-11 and Ser-18 residues, and substitution of these amino acids with alanine residues completely abolished the Ang II-induced stimulation of Na+,K+-ATPase-mediated Rb+ transport.	Serine	63-66	angiotensinogen	Homo sapiens	0-6	
12759348-4	2003	Ang II stimulation led to phosphorylation of the alpha subunit Ser-11 and Ser-18 residues, and substitution of these amino acids with alanine residues completely abolished the Ang II-induced stimulation of Na+,K+-ATPase-mediated Rb+ transport.	Serine	63-66	angiotensinogen	Homo sapiens	176-182	
12759348-4	2003	Ang II stimulation led to phosphorylation of the alpha subunit Ser-11 and Ser-18 residues, and substitution of these amino acids with alanine residues completely abolished the Ang II-induced stimulation of Na+,K+-ATPase-mediated Rb+ transport.	Serine	74-77	angiotensinogen	Homo sapiens	0-6	
12759348-4	2003	Ang II stimulation led to phosphorylation of the alpha subunit Ser-11 and Ser-18 residues, and substitution of these amino acids with alanine residues completely abolished the Ang II-induced stimulation of Na+,K+-ATPase-mediated Rb+ transport.	Serine	74-77	angiotensinogen	Homo sapiens	176-182	
12759348-5	2003	Thus, for Ang II-dependent stimulation of Na+,K+-ATPase activity, phosphorylation of these serine residues is essential and may constitute a triggering signal for recruitment of Na+,K+-ATPase molecules to the plasma membrane.	Serine	91-97	angiotensinogen	Homo sapiens	10-16	
12823591-8	2003	In one patient, two base substitutions at rt204 (ATG --> AGT; T to G and G to T) lead to a methionine to serine change (YMDD --> YSDD).	Serine	108-114	angiotensinogen	Homo sapiens	60-63	
15044323-2	2004	There is evidence that angiotensin II (AII) may impair insulin signaling to the IRS-1/phosphatydilinositol 3-kinase (PI 3-kinase) pathway by enhancing Ser phosphorylation.	Serine	151-154	angiotensinogen	Homo sapiens	23-37	
15044323-2	2004	There is evidence that angiotensin II (AII) may impair insulin signaling to the IRS-1/phosphatydilinositol 3-kinase (PI 3-kinase) pathway by enhancing Ser phosphorylation.	Serine	151-154	angiotensinogen	Homo sapiens	39-42	
12763029-6	2003	AngII-induced-phosphorylation of Rb (Ser 795 and Ser 807/811), -cyclin D1 expression, and -DNA synthesis was also markedly enhanced by pharmacological inhibition of the p38 MAPK pathway.	Serine	49-52	angiotensinogen	Homo sapiens	0-5	
12560337-10	2003	Angiotensin II induced rapid serine phosphorylation of p47(phox) (within 1 min, peaking at approximately 15 min), a 1.9 +/- 0.1-fold increase in p47(phox)-p22(phox) complex formation and a 1.6 +/- 0.2-fold increase in NADPH-dependent O(2)-* production (p < 0.05).	Serine	29-35	angiotensinogen	Homo sapiens	0-14	
12560337-12	2003	These data indicate that angiotensin II-stimulated endothelial NADPH oxidase activity is regulated through serine phosphorylation of p47(phox) and its enhanced binding to p22(phox).	Serine	107-113	angiotensinogen	Homo sapiens	25-39	
12660328-1	2003	Serine:pyruvate/alanine:glyoxylate aminotransferase (SPT/AGT) is largely located in mitochondria in carnivores, whereas it is entirely found within peroxisomes in herbivores and humans.	Serine	0-6	angiotensinogen	Homo sapiens	57-60	
11522624-6	2001	Fifty percent (7/14) of the nontumorous samples from lung cancer cases showed a high frequency of codon 249 AGG(arg) to AGT(ser) mutations (P < 0.02).	Serine	124-127	angiotensinogen	Homo sapiens	120-123	
11574421-3	2001	Angiotensin II synthesis increased at 45 min and 1 h, resulting in p38 mitogen-activated protein (MAP) kinase-driven p53 phosphorylation at Ser 390.	Serine	140-143	angiotensinogen	Homo sapiens	0-14	
12165803-6	2002	In BMP2 gene, AGA right curved arrow AGT transversion in exon 3, converting arginine to serine was detected.	Serine	88-94	angiotensinogen	Homo sapiens	37-40	
12065324-11	2002	Acute Ang II stimulation (10 to 15 minutes) increased p47phox serine phosphorylation and induced p47phox and p67phox translocation.	Serine	62-68	angiotensinogen	Homo sapiens	6-12	
11994255-6	2002	Nuclear factor-kappaB activation was accompanied by phosphorylation of IkappaBalpha on serine 32 as well as degradation of IkappaBalpha, suggesting that the effects of Ang II were mediated through an IkappaBalpha-dependent pathway.	Serine	87-93	angiotensinogen	Homo sapiens	168-174	
11739292-12	2001	We conclude that following Ang II stimulation of cells, PKCepsilon phosphorylates serine 67 of the AE3 cytoplasmic domain, inducing the Ang II-induced increase in anion transport observed in the hypertrophic myocardium.	Serine	82-88	angiotensinogen	Homo sapiens	27-33	
11739292-12	2001	We conclude that following Ang II stimulation of cells, PKCepsilon phosphorylates serine 67 of the AE3 cytoplasmic domain, inducing the Ang II-induced increase in anion transport observed in the hypertrophic myocardium.	Serine	82-88	angiotensinogen	Homo sapiens	136-142	
11522624-7	2001	Four of these seven samples with AGT(ser) mutations also showed a high frequency of codon 249 AGG(arg) to ATG(met) mutations, whereas only one sample showed a codon 250 CCC to ACC transversion.	Serine	37-40	angiotensinogen	Homo sapiens	33-36	
10675660-6	2000	Single-strand conformation polymorphism (SSCP) and direct sequence analysis confirmed the presence of a one-base substitution situated at the codon 50 from AGT (Ser) to ATT (Ile) in both patients, that corresponded to the increased molecular weight of 26.0.	Serine	161-164	angiotensinogen	Homo sapiens	156-159	
11410419-0	2001	Alpha128 Arg-->Ser (CGT-->AGT) spectrin mutation associated with severe neonatal elliptopoikilocytosis in Spain.	Serine	18-21	angiotensinogen	Homo sapiens	32-35	
11758231-4	2001	RESULT: A single nucleotide substitution T 58G in exon 1, which caused a missense mutation Ser(AGT) 11 Arg(AGG) in signal peptide, was identified by DNA sequencing.	Serine	91-94	angiotensinogen	Homo sapiens	95-98	
11526495-4	2001	One spinal paraganglioma and similar cerebellar tumours that developed 22 years later in the same patient contained a missense mutation at codon 12 (GGT-->AGT, Gly-->Ser) and a silent mutation at codon 68 (AGC-->AGT, Ser-->Ser).	Serine	172-175	angiotensinogen	Homo sapiens	158-161	
11526495-4	2001	One spinal paraganglioma and similar cerebellar tumours that developed 22 years later in the same patient contained a missense mutation at codon 12 (GGT-->AGT, Gly-->Ser) and a silent mutation at codon 68 (AGC-->AGT, Ser-->Ser).	Serine	172-175	angiotensinogen	Homo sapiens	221-224	
11227941-12	2001	One variant with a single nucleotide change at position 647 (amino acid 29, AAT-->AGT, asparagine to serine) was found in 38 percent (8/21) of the samples.	Serine	104-110	angiotensinogen	Homo sapiens	85-88	
11330044-1	2000	Glyoxylate is an immediate precursor of oxalate, but in its metabolism the conversion into glycine catalyzed by serine:pyruvate/alanine:glyoxylate aminotransferase (SPT/AGT) appears to be the main route.	Serine	112-118	angiotensinogen	Homo sapiens	169-172	
10601235-5	1999	Both p70(S6K) Ser(411) and Akt Ser(473) phosphorylation by Ang II appear to involve EGF receptor transactivation and were inhibited by dominant-negative Ras, whereas the phosphorylation of p70(S6K) and ERK but not Akt was sensitive to the MEK inhibitor.	Serine	31-34	angiotensinogen	Homo sapiens	59-65	
11156700-1	2000	Primary hyperoxaluria Type 1 (PH1) is caused by a functional deficiency of a liver enzyme, serine:pyruvate/alanine:glyoxylate aminotransferase (SPT/AGT), which catalyzes transamination between L-serine or l-alanine as an amino acid substrate and glyoxylate or pyruvate as an alpha-keto acid substrate.	Serine	193-201	angiotensinogen	Homo sapiens	148-151	
11156700-13	2000	It is therefore possible that both mitochondrial and peroxisomal SPT/AGT contribute to the metabolism of glyoxylate and serine, but the subcellular site for glyoxylate metabolism is different in herbivores and carnivores.	Serine	120-126	angiotensinogen	Homo sapiens	69-72	
10601235-0	1999	Intracellular signaling of angiotensin II-induced p70 S6 kinase phosphorylation at Ser(411) in vascular smooth muscle cells.	Serine	83-86	angiotensinogen	Homo sapiens	27-41	
10601235-4	1999	By using vascular smooth muscle cells in which we have demonstrated Ras/extracellular signal-regulated kinase (ERK) activation through Ca(2+)-dependent, epidermal growth factor (EGF) receptor transactivation by G(q)-coupled angiotensin II (Ang II) receptor, we present a unique cross-talk required for Ser(411) phosphorylation of p70(S6K) by Ang II.	Serine	302-305	angiotensinogen	Homo sapiens	224-238	
10601235-5	1999	Both p70(S6K) Ser(411) and Akt Ser(473) phosphorylation by Ang II appear to involve EGF receptor transactivation and were inhibited by dominant-negative Ras, whereas the phosphorylation of p70(S6K) and ERK but not Akt was sensitive to the MEK inhibitor.	Serine	14-17	angiotensinogen	Homo sapiens	59-65	
8196175-3	1994	The known point mutations that cause euthyroid hyperthyroxinemia are Ala109 (ACC) to Thr (GCC) and Gly6 (GGT) to Ser (AGT).	Serine	113-116	angiotensinogen	Homo sapiens	118-121	
10502786-4	1999	Genomic DNA was extracted and denaturinggradient gel electrophoresis of exon 7 of the androgen receptor gene followed by sequence analysis revealed a new mutation, a C A transversion, altering codon 840 from arginine (CGT) to serine (AGT).	Serine	226-232	angiotensinogen	Homo sapiens	234-237	
10479726-8	1999	Also, a haplotype analysis using a breast cancer patient database showed that the chromosome bearing serine 694-AGT carried IVS8+2T-->C. A second more common variant, IVS8-58delT, was characterized as a polymorphism.	Serine	101-107	angiotensinogen	Homo sapiens	112-115	
10391929-6	1999	In addition, we show that Ang II-induced serine phosphorylation of STAT3 in VSMCs is mediated by mitogen-activated protein kinase and that dephosphorylation is mediated by protein phosphatase 2A (PP2A).	Serine	41-47	angiotensinogen	Homo sapiens	26-32	
10362672-2	1999	Stimulation of the cells with ANG II led to a marked increase in the kinase activity of Akt/PKB, which coincided with Ser-473 phosphorylation.	Serine	118-121	angiotensinogen	Homo sapiens	30-36	
9000456-6	1997	A missense mutation (AAT to AGT) was identified in the codon corresponding to codon 361 of the deduced human TrkC sequence, converting an encoded Asn to Ser.	Serine	153-156	angiotensinogen	Homo sapiens	28-31	
7860081-2	1994	Here we describe a novel polymorphism of human C7, namely a nucleotide sequence polymorphism changing codon 367 from AGT (encoding Ser) to ACT (encoding Thr).	Serine	131-134	angiotensinogen	Homo sapiens	117-120	
9861481-12	1998	In codon 273, CGT for arginine was mutated to AGT for serine by a C to A transversion of the first letter.	Serine	54-60	angiotensinogen	Homo sapiens	46-49	
8943046-5	1996	We found a new hot spot created at the third base of Ser-31 when its wild-type AGT codon was substituted by AGC.	Serine	53-56	angiotensinogen	Homo sapiens	79-82	
8402653-5	1993	The proline at position 140 in mammalian AGTs is replaced by alanine in the Ada and yeast AGTs and by serine in the Ogt AGT.	Serine	102-108	angiotensinogen	Homo sapiens	41-44	
8245128-1	1993	Primary hyperoxaluria type 1 (PH 1), an inborn error of glyoxylate metabolism characterized by excessive synthesis of oxalate and glycolate, is caused by a defect in serine:pyruvate/alanine:glyoxylate aminotransferase (SPT/AGT).	Serine	166-172	angiotensinogen	Homo sapiens	223-226	
8240107-5	1993	It was a single base-pair transversion (AAT to AGT) leading to a serine-for-asparagine substitution.	Serine	65-71	angiotensinogen	Homo sapiens	47-50	
8125929-4	1994	The stimulation of phosphorylation was apparent at 20 min and persisted for at least 12 h. Phosphoamino acid analysis revealed that serine is the major residue of eIF-4E phosphorylated by angiotensin II.	Serine	132-138	angiotensinogen	Homo sapiens	188-202	
8019561-4	1994	Direct sequencing of the PCR products for exon 19 revealed a single base mutation that converted the codon of -GGT- for glycine at alpha 1-247 to -AGT-, a codon for serine.	Serine	165-171	angiotensinogen	Homo sapiens	147-150	
1323434-8	1992	Phosphoamino acid analysis revealed that Ang II and PMA induced phosphorylation of both the kinases on serine/threonine as well as tyrosine residues.	Serine	103-109	angiotensinogen	Homo sapiens	41-47	
1326443-1	1992	In cultured vascular smooth muscle cells (VSMC) angiotensin II (ang II) induces tyrosine and serine/threonine phosphorylation and activation of two mitogen-activated protein (MAP) kinases.	Serine	93-99	angiotensinogen	Homo sapiens	48-70	
1323434-10	1992	These results indicate that in vascular smooth muscle cells Ang II activates two species of MBP/microtubule-associated protein 2 kinases mainly through the protein kinase C-signaling pathway and suggest that tyrosine and serine/threonine phosphorylation may be involved in this process.	Serine	221-227	angiotensinogen	Homo sapiens	60-66	
34460247-0	2021	Soybean-Derived Antihypertensive Peptide LSW (Leu-Ser-Trp) Antagonizes the Damage of Angiotensin II to Vascular Endothelial Cells through the Trans-vesicular Pathway.	Serine	50-53	angiotensinogen	Homo sapiens	85-99	
1797705-1	1991	The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin.	Serine	118-121	angiotensinogen	Homo sapiens	41-56	
1797705-1	1991	The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin.	Serine	232-235	angiotensinogen	Homo sapiens	41-56	
1903761-0	1991	A serine-to-arginine (AGT-to-CGT) mutation in codon 549 of the CFTR gene in an Italian patient with severe cystic fibrosis.	Serine	2-8	angiotensinogen	Homo sapiens	22-25	
1587525-5	1992	Whereas the mutation in exon 4 was not observed in case 2, a different single base substitution of A by C was detected at the Ser codon AGT in exon 3.	Serine	126-129	angiotensinogen	Homo sapiens	136-139	
1967219-4	1990	At onset, Gly (GGT) was changed to Ser (AGT) at codon 12, and at relapse, Gly (GGT) to Asp (GAT) was observed at the same codon.	Serine	35-38	angiotensinogen	Homo sapiens	40-43	
34233561-1	2021	Hb Tacoma (beta30(B12)Arg Ser) is a missense variant that is caused by either an AGG>AGT or AGG>AGC substitution at codon 30 of the HBB gene.	Serine	26-29	angiotensinogen	Homo sapiens	85-88	
2680365-8	1989	The results showed an AGG (Arg) to AGT (Ser) point mutation, resulting in the change of the interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-.	Serine	40-43	angiotensinogen	Homo sapiens	35-38	
2680365-8	1989	The results showed an AGG (Arg) to AGT (Ser) point mutation, resulting in the change of the interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-.	Serine	176-179	angiotensinogen	Homo sapiens	35-38	
32212693-5	2020	In addition, PIZ inhibits angiotensin II (Ang II)-induced vascular factor secretion and expression by blocking inflammation and apoptosis through nuclear factor kappaB (NF-kappaB), nuclear erythroid 2-related factor 2 (Nrf2), mitogen-activated protein kinases (MAPKs), and the serine/threonine kinase (Akt) signal pathways.	Serine	277-283	angiotensinogen	Homo sapiens	26-40	
3289535-5	1988	The results showed AGG (Arg) to AGT (Ser) point mutation, resulting in the change of interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-.	Serine	37-40	angiotensinogen	Homo sapiens	32-35	
3289535-5	1988	The results showed AGG (Arg) to AGT (Ser) point mutation, resulting in the change of interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-.	Serine	169-172	angiotensinogen	Homo sapiens	32-35	
6526271-4	1984	Most of the mutations in MT-II processed gene are silent except that the amino acid glycine (GGT) at position 10 is changed to serine (AGT) due to a transition.	Serine	127-133	angiotensinogen	Homo sapiens	135-138	
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Serine	139-142	angiotensinogen	Homo sapiens	68-83	
33524188-9	2021	Moreover, SF2809E, an inhibitor of serine protease chymase (an enzyme generating most tissue angiotensin II) may also block TMPRRS2, a host serine protease that primes SARS-CoV-2 spike glycoprotein before adhesion to ACE2.	Serine	35-41	angiotensinogen	Homo sapiens	93-107	
33278189-7	2020	They are inhibited by protease nexin 1 or serine E2 (PN1) that is upregulated by angiotensin II but downregulated by aldosterone.	Serine	42-48	angiotensinogen	Homo sapiens	81-95	
6696878-7	1984	The amino-terminal sequence contained the covalent structure of angiotensin I and was Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-X-Glu-Ser-Thr-Cys-Gl u-.	Serine	144-147	angiotensinogen	Homo sapiens	64-77	
33091310-2	2021	CREB is activated by phosphorylation on a key serine residue, Ser 311, in response to a wide variety of extracellular stimuli including angiotensin II (Ang II).	Serine	46-52	angiotensinogen	Homo sapiens	136-150	
33091310-2	2021	CREB is activated by phosphorylation on a key serine residue, Ser 311, in response to a wide variety of extracellular stimuli including angiotensin II (Ang II).	Serine	46-52	angiotensinogen	Homo sapiens	152-158	
33091310-2	2021	CREB is activated by phosphorylation on a key serine residue, Ser 311, in response to a wide variety of extracellular stimuli including angiotensin II (Ang II).	Serine	62-65	angiotensinogen	Homo sapiens	136-150	
33091310-2	2021	CREB is activated by phosphorylation on a key serine residue, Ser 311, in response to a wide variety of extracellular stimuli including angiotensin II (Ang II).	Serine	62-65	angiotensinogen	Homo sapiens	152-158	
32212693-5	2020	In addition, PIZ inhibits angiotensin II (Ang II)-induced vascular factor secretion and expression by blocking inflammation and apoptosis through nuclear factor kappaB (NF-kappaB), nuclear erythroid 2-related factor 2 (Nrf2), mitogen-activated protein kinases (MAPKs), and the serine/threonine kinase (Akt) signal pathways.	Serine	277-283	angiotensinogen	Homo sapiens	42-48	
27241643-8	2016	A G>A substitution at nucleotide 1243 in exon 8 that changes glycine (GGT) to serine (AGT) was observed in most of our patients.	Serine	81-87	angiotensinogen	Homo sapiens	89-92	
31239152-6	2019	Therefore, we hypothesized that Ang II might attenuate I2PP2A expression to activate PP2A, which downregulates eNOS Ser 1177 phosphorylation, leading to eNOS dysfunction.	Serine	116-119	angiotensinogen	Homo sapiens	32-38	
27727489-2	2017	This interaction is disrupted by some disease-causing mutations in either WNK4 or KLHL3, or by angiotensin II- and insulin-induced phosphorylation of KLHL3 at serine 433, which is also a site frequently mutated in patients.	Serine	159-165	angiotensinogen	Homo sapiens	95-109	
25219839-9	2014	In cultured atrial myocytes and fibroblasts, Ang-II induced tyrosine and serine phosphorylation of STAT3 showing interaction with MMP1 and MMP2 and DNA promoter sequences in atrial fibroblasts.	Serine	73-79	angiotensinogen	Homo sapiens	45-51	
24736929-9	2014	DNA sequence analysis revealed a c.1636 G/A transition in exon 25 of the COL2A1 gene, which converted the codon GGT for glycine at position 546 to AGT, a codon for serine.	Serine	164-170	angiotensinogen	Homo sapiens	147-150	
24098385-3	2013	Angiotensin II caused attenuation of phosphorylated Akt (p-Akt), at serine 473; the p-Akt/Akt ratio decreased to 0.5+-0.2-fold the control value without angiotensin II (p<0.001).	Serine	68-74	angiotensinogen	Homo sapiens	0-14	
22531885-6	2012	This report explores the potential impact of such a dinucleotide variation, which promotes the change of alanine (A) to serine (S) at the AGT protein structure (A237S).	Serine	120-126	angiotensinogen	Homo sapiens	138-141	
23524303-10	2013	The inhibitory effects of angiotensin II on insulin signalling are, at least in part, mediated by an increased serine phosphorylation of IRS1.	Serine	111-117	angiotensinogen	Homo sapiens	26-40	
23524303-11	2013	Angiotensin (1-7) inhibits the serine phosphorylation of IRS1 induced by angiotensin II.	Serine	31-37	angiotensinogen	Homo sapiens	73-87	
23569086-8	2013	Western blotting demonstrated that incubation of isolated TAL with AngII increased phosphorylation of p47(phox) at Ser(304), suggesting that AngII stimulates the basolateral Cl channels by increasing NADPH oxidase-dependent superoxide generation.	Serine	115-118	angiotensinogen	Homo sapiens	67-72	
23569086-8	2013	Western blotting demonstrated that incubation of isolated TAL with AngII increased phosphorylation of p47(phox) at Ser(304), suggesting that AngII stimulates the basolateral Cl channels by increasing NADPH oxidase-dependent superoxide generation.	Serine	115-118	angiotensinogen	Homo sapiens	141-146	
22028412-5	2012	ANG II increased phosphorylation of insulin receptor substrate-1 (IRS-1) at Ser(636/639) and inhibited the insulin-stimulated phosphorylation of endothelial nitric oxide synthase (eNOS).	Serine	76-79	angiotensinogen	Homo sapiens	0-6	
22028412-7	2012	Moreover, point mutations of IRS-1 at Ser(636/639) to Ala prevented the ANG II-mediated inhibition of insulin signaling.	Serine	38-41	angiotensinogen	Homo sapiens	72-78	
22028412-8	2012	From these results, we conclude that activation of mTOR/p70S6K by ANG II in vascular endothelium may contribute to impairment of insulin-stimulated vasodilation through phosphorylation of IRS-1 at Ser(636/639).	Serine	197-200	angiotensinogen	Homo sapiens	66-72	
22028412-6	2012	An inhibitor of mTOR, rapamycin, attenuated the ANG II-stimulated phosphorylation of p70S6K and phosphorylation of IRS-1 (Ser(636/639)) and blocked the ability of ANG II to impair insulin-stimulated phosphorylation of eNOS, nitric oxide production, and mesenteric-arteriole vasodilation.	Serine	122-125	angiotensinogen	Homo sapiens	48-54	
21304260-3	2011	The activity of serine : pyruvate/alanine : glyoxylate aminotransferase (SPT/AGT) or glyoxylate reductase/hydroxypyruvate reductase (GRHPR), the key enzyme of primary hyperoxlauria type 1 and 2, respectively, and their subcellular distribution highly affects the oxalate production.	Serine	16-22	angiotensinogen	Homo sapiens	77-80	
21148411-8	2011	AII-induced ERK activation was reduced by >65% by synthetic peptides containing an RGD (arginine-glycine-aspartic acid) sequence that inhibit alpha(5)beta(1)-integrin, and by ~60% by the KTS (lysine-threonine-serine)-containing peptides specific for integrin-alpha(1)beta(1).	Serine	212-218	angiotensinogen	Homo sapiens	0-3	
21797710-1	2011	We describe a high oxygen affinity hemoglobin (Hb) variant (Hb Vanderbilt) as a result of a heterozygous novel base change from T to A at codon 89 (AGT>AGA) leading to an amino acid change from serine to arginine.	Serine	197-203	angiotensinogen	Homo sapiens	148-151	
20659889-3	2010	Using primary cultured aortic vascular smooth muscle cells, we show that activation of the IKK complex and NF-kappaB transcription factors by Ang II is regulated by phosphorylation of the catalytic subunit IKKbeta on serine residues 177 and 181 in the activation T-loop.	Serine	217-223	angiotensinogen	Homo sapiens	142-148	
21115923-6	2010	RT-PCR analysis confirmed the presence of EWS-CHOP chimeric transcript type 1, in which exon 7 of EWS was in-frame fused to exon 2 of CHOP with a serine (AGT) to methionine (ATG) transition at the junction.	Serine	146-152	angiotensinogen	Homo sapiens	154-157	
20299462-4	2010	We hypothesized that Ang II stimulates TAL NO production via AT(2)-mediated Akt1 activation, which phosphorylates NOS3 at serine 1177.	Serine	122-128	angiotensinogen	Homo sapiens	21-27	
20299462-15	2010	Ang II increased phospho-NOS3 at serine 1177 by 130% (p < 0.01) and 150% after 5 and 10 min (p < 0.02).	Serine	33-39	angiotensinogen	Homo sapiens	0-6	
20299462-16	2010	Ang II increased phosphoNOS3 at serine 633 by 50% after 5 min (p < 0.01).	Serine	32-38	angiotensinogen	Homo sapiens	0-6	
20299462-18	2010	We concluded that Ang II enhances TAL NO production via activation of AT(2) and Akt1-dependent phosphorylation of NOS3 at serines 1177 and 633.	Serine	122-129	angiotensinogen	Homo sapiens	18-24	
20601126-4	2010	We found that Ang II significantly inhibited insulin-induced phosphorylation of tyrosine 608 of IRS-1 and serine 473 of Akt, a downstream member of anti-mitogenic pathway of insulin.	Serine	106-112	angiotensinogen	Homo sapiens	14-20	
20601126-5	2010	In contrast, Ang II increased the serine phosphorylation of IRS-1 which was not affected by the presence of insulin.	Serine	34-40	angiotensinogen	Homo sapiens	13-19