PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6526271-4 1984 Most of the mutations in MT-II processed gene are silent except that the amino acid glycine (GGT) at position 10 is changed to serine (AGT) due to a transition. Serine 127-133 angiotensinogen Homo sapiens 135-138 6696878-7 1984 The amino-terminal sequence contained the covalent structure of angiotensin I and was Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-X-Glu-Ser-Thr-Cys-Gl u-. Serine 144-147 angiotensinogen Homo sapiens 64-77 6385771-0 1984 Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D. Serine 139-142 angiotensinogen Homo sapiens 68-83 33091310-2 2021 CREB is activated by phosphorylation on a key serine residue, Ser 311, in response to a wide variety of extracellular stimuli including angiotensin II (Ang II). Serine 46-52 angiotensinogen Homo sapiens 136-150 33524188-9 2021 Moreover, SF2809E, an inhibitor of serine protease chymase (an enzyme generating most tissue angiotensin II) may also block TMPRRS2, a host serine protease that primes SARS-CoV-2 spike glycoprotein before adhesion to ACE2. Serine 35-41 angiotensinogen Homo sapiens 93-107 33091310-2 2021 CREB is activated by phosphorylation on a key serine residue, Ser 311, in response to a wide variety of extracellular stimuli including angiotensin II (Ang II). Serine 46-52 angiotensinogen Homo sapiens 152-158 33091310-2 2021 CREB is activated by phosphorylation on a key serine residue, Ser 311, in response to a wide variety of extracellular stimuli including angiotensin II (Ang II). Serine 62-65 angiotensinogen Homo sapiens 136-150 33091310-2 2021 CREB is activated by phosphorylation on a key serine residue, Ser 311, in response to a wide variety of extracellular stimuli including angiotensin II (Ang II). Serine 62-65 angiotensinogen Homo sapiens 152-158 27727489-2 2017 This interaction is disrupted by some disease-causing mutations in either WNK4 or KLHL3, or by angiotensin II- and insulin-induced phosphorylation of KLHL3 at serine 433, which is also a site frequently mutated in patients. Serine 159-165 angiotensinogen Homo sapiens 95-109 31239152-6 2019 Therefore, we hypothesized that Ang II might attenuate I2PP2A expression to activate PP2A, which downregulates eNOS Ser 1177 phosphorylation, leading to eNOS dysfunction. Serine 116-119 angiotensinogen Homo sapiens 32-38 33278189-7 2020 They are inhibited by protease nexin 1 or serine E2 (PN1) that is upregulated by angiotensin II but downregulated by aldosterone. Serine 42-48 angiotensinogen Homo sapiens 81-95 32212693-5 2020 In addition, PIZ inhibits angiotensin II (Ang II)-induced vascular factor secretion and expression by blocking inflammation and apoptosis through nuclear factor kappaB (NF-kappaB), nuclear erythroid 2-related factor 2 (Nrf2), mitogen-activated protein kinases (MAPKs), and the serine/threonine kinase (Akt) signal pathways. Serine 277-283 angiotensinogen Homo sapiens 26-40 32212693-5 2020 In addition, PIZ inhibits angiotensin II (Ang II)-induced vascular factor secretion and expression by blocking inflammation and apoptosis through nuclear factor kappaB (NF-kappaB), nuclear erythroid 2-related factor 2 (Nrf2), mitogen-activated protein kinases (MAPKs), and the serine/threonine kinase (Akt) signal pathways. Serine 277-283 angiotensinogen Homo sapiens 42-48 27241643-8 2016 A G>A substitution at nucleotide 1243 in exon 8 that changes glycine (GGT) to serine (AGT) was observed in most of our patients. Serine 81-87 angiotensinogen Homo sapiens 89-92 24736929-9 2014 DNA sequence analysis revealed a c.1636 G/A transition in exon 25 of the COL2A1 gene, which converted the codon GGT for glycine at position 546 to AGT, a codon for serine. Serine 164-170 angiotensinogen Homo sapiens 147-150 25219839-9 2014 In cultured atrial myocytes and fibroblasts, Ang-II induced tyrosine and serine phosphorylation of STAT3 showing interaction with MMP1 and MMP2 and DNA promoter sequences in atrial fibroblasts. Serine 73-79 angiotensinogen Homo sapiens 45-51 22028412-7 2012 Moreover, point mutations of IRS-1 at Ser(636/639) to Ala prevented the ANG II-mediated inhibition of insulin signaling. Serine 38-41 angiotensinogen Homo sapiens 72-78 23524303-10 2013 The inhibitory effects of angiotensin II on insulin signalling are, at least in part, mediated by an increased serine phosphorylation of IRS1. Serine 111-117 angiotensinogen Homo sapiens 26-40 23524303-11 2013 Angiotensin (1-7) inhibits the serine phosphorylation of IRS1 induced by angiotensin II. Serine 31-37 angiotensinogen Homo sapiens 73-87 23569086-8 2013 Western blotting demonstrated that incubation of isolated TAL with AngII increased phosphorylation of p47(phox) at Ser(304), suggesting that AngII stimulates the basolateral Cl channels by increasing NADPH oxidase-dependent superoxide generation. Serine 115-118 angiotensinogen Homo sapiens 67-72 23569086-8 2013 Western blotting demonstrated that incubation of isolated TAL with AngII increased phosphorylation of p47(phox) at Ser(304), suggesting that AngII stimulates the basolateral Cl channels by increasing NADPH oxidase-dependent superoxide generation. Serine 115-118 angiotensinogen Homo sapiens 141-146 22531885-6 2012 This report explores the potential impact of such a dinucleotide variation, which promotes the change of alanine (A) to serine (S) at the AGT protein structure (A237S). Serine 120-126 angiotensinogen Homo sapiens 138-141 22028412-5 2012 ANG II increased phosphorylation of insulin receptor substrate-1 (IRS-1) at Ser(636/639) and inhibited the insulin-stimulated phosphorylation of endothelial nitric oxide synthase (eNOS). Serine 76-79 angiotensinogen Homo sapiens 0-6 22028412-6 2012 An inhibitor of mTOR, rapamycin, attenuated the ANG II-stimulated phosphorylation of p70S6K and phosphorylation of IRS-1 (Ser(636/639)) and blocked the ability of ANG II to impair insulin-stimulated phosphorylation of eNOS, nitric oxide production, and mesenteric-arteriole vasodilation. Serine 122-125 angiotensinogen Homo sapiens 48-54 24098385-3 2013 Angiotensin II caused attenuation of phosphorylated Akt (p-Akt), at serine 473; the p-Akt/Akt ratio decreased to 0.5+-0.2-fold the control value without angiotensin II (p<0.001). Serine 68-74 angiotensinogen Homo sapiens 0-14 22028412-8 2012 From these results, we conclude that activation of mTOR/p70S6K by ANG II in vascular endothelium may contribute to impairment of insulin-stimulated vasodilation through phosphorylation of IRS-1 at Ser(636/639). Serine 197-200 angiotensinogen Homo sapiens 66-72 21304260-3 2011 The activity of serine : pyruvate/alanine : glyoxylate aminotransferase (SPT/AGT) or glyoxylate reductase/hydroxypyruvate reductase (GRHPR), the key enzyme of primary hyperoxlauria type 1 and 2, respectively, and their subcellular distribution highly affects the oxalate production. Serine 16-22 angiotensinogen Homo sapiens 77-80 21148411-8 2011 AII-induced ERK activation was reduced by >65% by synthetic peptides containing an RGD (arginine-glycine-aspartic acid) sequence that inhibit alpha(5)beta(1)-integrin, and by ~60% by the KTS (lysine-threonine-serine)-containing peptides specific for integrin-alpha(1)beta(1). Serine 212-218 angiotensinogen Homo sapiens 0-3 21115923-6 2010 RT-PCR analysis confirmed the presence of EWS-CHOP chimeric transcript type 1, in which exon 7 of EWS was in-frame fused to exon 2 of CHOP with a serine (AGT) to methionine (ATG) transition at the junction. Serine 146-152 angiotensinogen Homo sapiens 154-157 21797710-1 2011 We describe a high oxygen affinity hemoglobin (Hb) variant (Hb Vanderbilt) as a result of a heterozygous novel base change from T to A at codon 89 (AGT>AGA) leading to an amino acid change from serine to arginine. Serine 197-203 angiotensinogen Homo sapiens 148-151 20086103-2 2010 In human mesangial cells (HMC) both processes are induced by angiotensin II (AngII) via protein kinase Cdelta (PKCdelta)-triggered serine phosphorylation of HuR. Serine 131-137 angiotensinogen Homo sapiens 61-75 20299462-4 2010 We hypothesized that Ang II stimulates TAL NO production via AT(2)-mediated Akt1 activation, which phosphorylates NOS3 at serine 1177. Serine 122-128 angiotensinogen Homo sapiens 21-27 20299462-15 2010 Ang II increased phospho-NOS3 at serine 1177 by 130% (p < 0.01) and 150% after 5 and 10 min (p < 0.02). Serine 33-39 angiotensinogen Homo sapiens 0-6 20299462-16 2010 Ang II increased phosphoNOS3 at serine 633 by 50% after 5 min (p < 0.01). Serine 32-38 angiotensinogen Homo sapiens 0-6 20299462-18 2010 We concluded that Ang II enhances TAL NO production via activation of AT(2) and Akt1-dependent phosphorylation of NOS3 at serines 1177 and 633. Serine 122-129 angiotensinogen Homo sapiens 18-24 20659889-3 2010 Using primary cultured aortic vascular smooth muscle cells, we show that activation of the IKK complex and NF-kappaB transcription factors by Ang II is regulated by phosphorylation of the catalytic subunit IKKbeta on serine residues 177 and 181 in the activation T-loop. Serine 217-223 angiotensinogen Homo sapiens 142-148 20601126-4 2010 We found that Ang II significantly inhibited insulin-induced phosphorylation of tyrosine 608 of IRS-1 and serine 473 of Akt, a downstream member of anti-mitogenic pathway of insulin. Serine 106-112 angiotensinogen Homo sapiens 14-20 20601126-5 2010 In contrast, Ang II increased the serine phosphorylation of IRS-1 which was not affected by the presence of insulin. Serine 34-40 angiotensinogen Homo sapiens 13-19 20086103-2 2010 In human mesangial cells (HMC) both processes are induced by angiotensin II (AngII) via protein kinase Cdelta (PKCdelta)-triggered serine phosphorylation of HuR. Serine 131-137 angiotensinogen Homo sapiens 77-82 20086103-3 2010 By testing different point-mutated Flag-tagged HuR proteins, we found that Ser 318 within RNA recognition motif 3 (RRM3) is essential for AngII-induced binding to ARE-bearing mRNA but irrelevant for nucleocytoplasmic HuR shuttling. Serine 75-78 angiotensinogen Homo sapiens 138-143 20086103-4 2010 Conversely, mutation at Ser 221 within the HuR hinge region prevents AngII-triggered HuR export without affecting mRNA binding of HuR. Serine 24-27 angiotensinogen Homo sapiens 69-74 20086103-5 2010 Using phosphorylation state-specific antibodies, we found a transient increase in HuR phosphorylation at both serines by AngII. Serine 110-117 angiotensinogen Homo sapiens 121-126 19348241-1 2009 Angiotensin II suppresses the insulin sensitivity via enhancement of serine phosphorylation of insulin receptor and suppression of tyrosine phosphorylation of IRS-1. Serine 69-75 angiotensinogen Homo sapiens 0-14 19940161-5 2010 We show that Ang II stimulates Akt-dependent PGC-1 alpha serine 570 phosphorylation, which is required for the binding of the histone acetyltransferase GCN5 (general control nonderepressible 5) to PGC-1 alpha and for its lysine acetylation. Serine 57-63 angiotensinogen Homo sapiens 13-19 19303015-0 2009 Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis. Serine 68-71 angiotensinogen Homo sapiens 0-14 19303015-7 2009 Autocrine angiotensin II stimulated IKK-mediated phosphorylation of RelA at Ser(536), which was required for nuclear transport and transcriptional activity of NF-kappaB. Serine 76-79 angiotensinogen Homo sapiens 10-24 19303015-8 2009 Inhibition of angiotensin II, the angiotensin II receptor type 1 (AT1), or IKK blocked Ser(536) phosphorylation and stimulated myofibroblast apoptosis. Serine 87-90 angiotensinogen Homo sapiens 14-28 18855718-4 2008 At early intracellular level angiotensin II acts on JAK-2/IRS1-IRS2/PI3-kinase, JNK and ERK to phosphorylate serine residues of key elements of insulin signaling pathway therefore inhibiting signaling by the insulin receptor. Serine 109-115 angiotensinogen Homo sapiens 29-43 16513650-6 2006 The use of pharmacological inhibitors that inhibit the activation of MEK by Ang II revealed that phosphorylation of p65 on serine 536 did not require the MEK-ERK-RSK signaling pathway. Serine 123-129 angiotensinogen Homo sapiens 76-82 18258854-0 2008 Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1. Serine 90-93 angiotensinogen Homo sapiens 0-14 18285462-7 2008 Mapping of phosphorylation sites identified serines 221 and 318 as critical target sites for PKCdelta-triggered HuR phosphorylation and AngII-induced HuR export to the cytoplasm. Serine 44-51 angiotensinogen Homo sapiens 136-141 17595324-5 2007 Instead, Ang II rapidly induced RelA phosphorylation at Ser residue 536, and complex formation with the Ser(536) kinase known as the NF-kappaB-inducing kinase (NIK)/MEKK14. Serine 56-59 angiotensinogen Homo sapiens 9-15 17595324-5 2007 Instead, Ang II rapidly induced RelA phosphorylation at Ser residue 536, and complex formation with the Ser(536) kinase known as the NF-kappaB-inducing kinase (NIK)/MEKK14. Serine 104-107 angiotensinogen Homo sapiens 9-15 17595324-10 2007 NIK down-regulation prevents Ang II-induced phospho-Ser(536) RelA formation, indicating that it is essential for RelA activation. Serine 52-55 angiotensinogen Homo sapiens 29-35 17595324-11 2007 The Ang II pathway further involves the RhoA small GTP-binding protein because RhoA inhibition blocks Ang II-induced transcriptional activity and formation of phospho-Ser(536) RelA formation. Serine 167-170 angiotensinogen Homo sapiens 4-10 17595324-11 2007 The Ang II pathway further involves the RhoA small GTP-binding protein because RhoA inhibition blocks Ang II-induced transcriptional activity and formation of phospho-Ser(536) RelA formation. Serine 167-170 angiotensinogen Homo sapiens 102-108 17595324-12 2007 Finally, we demonstrate that Ang II infusion in vivo rapidly induces phospho-Ser(536) RelA formation and activation of the NF-kappaB-dependent IL-6 gene. Serine 77-80 angiotensinogen Homo sapiens 29-35 17595324-13 2007 These data indicate that Ang II induces NF-kappaB-dependent transcription through an alternative pathway, being largely independent of IkappaB proteolysis, but mediated by the small GTPases Rac/RhoA, required for NIK.RelA complex formation and inducible Ser(536) RelA phosphorylation. Serine 254-257 angiotensinogen Homo sapiens 25-31 17240116-0 2007 Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells. Serine 36-39 angiotensinogen Homo sapiens 76-90 17240116-0 2007 Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells. Serine 45-48 angiotensinogen Homo sapiens 76-90 17505626-6 2007 At an early intracellular level, AII, acting through JAK-2/IRS-1/PI3-kinase, JNK and ERK, may induce the serine phosphorylation and inhibition of key elements of the Ins-signaling pathway. Serine 105-111 angiotensinogen Homo sapiens 33-36 16513650-9 2006 Collectively, our data demonstrate that the proinflammatory activity of Ang II is independent of the classical pathway leading to IkappaBalpha phosphorylation and degradation but clearly depends on the recruitment of an IKK complex signaling cascade leading to phosphorylation of p65 on serine 536. Serine 287-293 angiotensinogen Homo sapiens 72-78 16338965-3 2006 It was shown previously that phorbol esters and angiotensin II and serotonin induce the phosphorylation of both Ser-11 and Ser-18 of the Na,K-ATPase alpha-subunit. Serine 112-115 angiotensinogen Homo sapiens 48-62 16389635-6 2006 At an early intracellular level, angiotensin II, acting through JAK-2/IRS-1/PI3-kinase, JNK and ERK, may induce the serine phosphorylation and inhibition of key elements of the insulin-signaling pathway. Serine 116-122 angiotensinogen Homo sapiens 33-47 16338965-3 2006 It was shown previously that phorbol esters and angiotensin II and serotonin induce the phosphorylation of both Ser-11 and Ser-18 of the Na,K-ATPase alpha-subunit. Serine 123-126 angiotensinogen Homo sapiens 48-62 15069084-2 2004 Brief treatment of the cells with 100 nm angiotensin II or 1 microm serotonin resulted in serine phosphorylation of Rb that was equal in magnitude to that induced by treating cells for 20 h with 10% fetal bovine serum ( approximately 3 x basal). Serine 90-96 angiotensinogen Homo sapiens 41-60 15095302-2 2004 A selective mutation in TP53 (AGG-->AGT at codon 249, Arg-->Ser) has been identified as a hotspot in HCCs from such areas, reflecting DNA damage caused by aflatoxin metabolites. Serine 66-69 angiotensinogen Homo sapiens 39-42 16158823-10 2005 We found overexpression of the p53 protein in lymphoid cells and a point missense mutation in codon 280 at exon 8 that changed AGA (Arg) to AGT (Ser). Serine 145-148 angiotensinogen Homo sapiens 140-143 12759348-4 2003 Ang II stimulation led to phosphorylation of the alpha subunit Ser-11 and Ser-18 residues, and substitution of these amino acids with alanine residues completely abolished the Ang II-induced stimulation of Na+,K+-ATPase-mediated Rb+ transport. Serine 63-66 angiotensinogen Homo sapiens 0-6 15044323-2 2004 There is evidence that angiotensin II (AII) may impair insulin signaling to the IRS-1/phosphatydilinositol 3-kinase (PI 3-kinase) pathway by enhancing Ser phosphorylation. Serine 151-154 angiotensinogen Homo sapiens 23-37 15044323-2 2004 There is evidence that angiotensin II (AII) may impair insulin signaling to the IRS-1/phosphatydilinositol 3-kinase (PI 3-kinase) pathway by enhancing Ser phosphorylation. Serine 151-154 angiotensinogen Homo sapiens 39-42 12860993-5 2003 Ang II-induced Ser-65 phosphorylation was ROS-dependent as assessed by pretreatment with ebselen (3.6 +/- 0.2 versus 1.1 +/- 0.2), diphenylene iodonium (3.6 +/- 0.2 versus 1.0 +/- 0.1), and N-acetyl cysteine (3.6 +/- 0.2 versus 1.2 +/- 0.1), but Ang II-stimulated phosphorylation of Thr-70 was ROS-insensitive. Serine 15-18 angiotensinogen Homo sapiens 0-6 12860993-5 2003 Ang II-induced Ser-65 phosphorylation was ROS-dependent as assessed by pretreatment with ebselen (3.6 +/- 0.2 versus 1.1 +/- 0.2), diphenylene iodonium (3.6 +/- 0.2 versus 1.0 +/- 0.1), and N-acetyl cysteine (3.6 +/- 0.2 versus 1.2 +/- 0.1), but Ang II-stimulated phosphorylation of Thr-70 was ROS-insensitive. Serine 15-18 angiotensinogen Homo sapiens 246-252 12759348-4 2003 Ang II stimulation led to phosphorylation of the alpha subunit Ser-11 and Ser-18 residues, and substitution of these amino acids with alanine residues completely abolished the Ang II-induced stimulation of Na+,K+-ATPase-mediated Rb+ transport. Serine 63-66 angiotensinogen Homo sapiens 176-182 12759348-4 2003 Ang II stimulation led to phosphorylation of the alpha subunit Ser-11 and Ser-18 residues, and substitution of these amino acids with alanine residues completely abolished the Ang II-induced stimulation of Na+,K+-ATPase-mediated Rb+ transport. Serine 74-77 angiotensinogen Homo sapiens 0-6 12759348-4 2003 Ang II stimulation led to phosphorylation of the alpha subunit Ser-11 and Ser-18 residues, and substitution of these amino acids with alanine residues completely abolished the Ang II-induced stimulation of Na+,K+-ATPase-mediated Rb+ transport. Serine 74-77 angiotensinogen Homo sapiens 176-182 12759348-5 2003 Thus, for Ang II-dependent stimulation of Na+,K+-ATPase activity, phosphorylation of these serine residues is essential and may constitute a triggering signal for recruitment of Na+,K+-ATPase molecules to the plasma membrane. Serine 91-97 angiotensinogen Homo sapiens 10-16 12560337-10 2003 Angiotensin II induced rapid serine phosphorylation of p47(phox) (within 1 min, peaking at approximately 15 min), a 1.9 +/- 0.1-fold increase in p47(phox)-p22(phox) complex formation and a 1.6 +/- 0.2-fold increase in NADPH-dependent O(2)-* production (p < 0.05). Serine 29-35 angiotensinogen Homo sapiens 0-14 12823591-8 2003 In one patient, two base substitutions at rt204 (ATG --> AGT; T to G and G to T) lead to a methionine to serine change (YMDD --> YSDD). Serine 108-114 angiotensinogen Homo sapiens 60-63 12560337-12 2003 These data indicate that angiotensin II-stimulated endothelial NADPH oxidase activity is regulated through serine phosphorylation of p47(phox) and its enhanced binding to p22(phox). Serine 107-113 angiotensinogen Homo sapiens 25-39 12763029-6 2003 AngII-induced-phosphorylation of Rb (Ser 795 and Ser 807/811), -cyclin D1 expression, and -DNA synthesis was also markedly enhanced by pharmacological inhibition of the p38 MAPK pathway. Serine 37-40 angiotensinogen Homo sapiens 0-5 12763029-6 2003 AngII-induced-phosphorylation of Rb (Ser 795 and Ser 807/811), -cyclin D1 expression, and -DNA synthesis was also markedly enhanced by pharmacological inhibition of the p38 MAPK pathway. Serine 49-52 angiotensinogen Homo sapiens 0-5 12165803-6 2002 In BMP2 gene, AGA right curved arrow AGT transversion in exon 3, converting arginine to serine was detected. Serine 88-94 angiotensinogen Homo sapiens 37-40 12660328-1 2003 Serine:pyruvate/alanine:glyoxylate aminotransferase (SPT/AGT) is largely located in mitochondria in carnivores, whereas it is entirely found within peroxisomes in herbivores and humans. Serine 0-6 angiotensinogen Homo sapiens 57-60 11522624-6 2001 Fifty percent (7/14) of the nontumorous samples from lung cancer cases showed a high frequency of codon 249 AGG(arg) to AGT(ser) mutations (P < 0.02). Serine 124-127 angiotensinogen Homo sapiens 120-123 11994255-6 2002 Nuclear factor-kappaB activation was accompanied by phosphorylation of IkappaBalpha on serine 32 as well as degradation of IkappaBalpha, suggesting that the effects of Ang II were mediated through an IkappaBalpha-dependent pathway. Serine 87-93 angiotensinogen Homo sapiens 168-174 11739292-12 2001 We conclude that following Ang II stimulation of cells, PKCepsilon phosphorylates serine 67 of the AE3 cytoplasmic domain, inducing the Ang II-induced increase in anion transport observed in the hypertrophic myocardium. Serine 82-88 angiotensinogen Homo sapiens 27-33 11739292-12 2001 We conclude that following Ang II stimulation of cells, PKCepsilon phosphorylates serine 67 of the AE3 cytoplasmic domain, inducing the Ang II-induced increase in anion transport observed in the hypertrophic myocardium. Serine 82-88 angiotensinogen Homo sapiens 136-142 11574421-3 2001 Angiotensin II synthesis increased at 45 min and 1 h, resulting in p38 mitogen-activated protein (MAP) kinase-driven p53 phosphorylation at Ser 390. Serine 140-143 angiotensinogen Homo sapiens 0-14 12065324-11 2002 Acute Ang II stimulation (10 to 15 minutes) increased p47phox serine phosphorylation and induced p47phox and p67phox translocation. Serine 62-68 angiotensinogen Homo sapiens 6-12 11522624-7 2001 Four of these seven samples with AGT(ser) mutations also showed a high frequency of codon 249 AGG(arg) to ATG(met) mutations, whereas only one sample showed a codon 250 CCC to ACC transversion. Serine 37-40 angiotensinogen Homo sapiens 33-36 11227941-12 2001 One variant with a single nucleotide change at position 647 (amino acid 29, AAT-->AGT, asparagine to serine) was found in 38 percent (8/21) of the samples. Serine 104-110 angiotensinogen Homo sapiens 85-88 11758231-4 2001 RESULT: A single nucleotide substitution T 58G in exon 1, which caused a missense mutation Ser(AGT) 11 Arg(AGG) in signal peptide, was identified by DNA sequencing. Serine 91-94 angiotensinogen Homo sapiens 95-98 11526495-4 2001 One spinal paraganglioma and similar cerebellar tumours that developed 22 years later in the same patient contained a missense mutation at codon 12 (GGT-->AGT, Gly-->Ser) and a silent mutation at codon 68 (AGC-->AGT, Ser-->Ser). Serine 172-175 angiotensinogen Homo sapiens 158-161 11526495-4 2001 One spinal paraganglioma and similar cerebellar tumours that developed 22 years later in the same patient contained a missense mutation at codon 12 (GGT-->AGT, Gly-->Ser) and a silent mutation at codon 68 (AGC-->AGT, Ser-->Ser). Serine 172-175 angiotensinogen Homo sapiens 221-224 11410419-0 2001 Alpha128 Arg-->Ser (CGT-->AGT) spectrin mutation associated with severe neonatal elliptopoikilocytosis in Spain. Serine 18-21 angiotensinogen Homo sapiens 32-35 11156700-1 2000 Primary hyperoxaluria Type 1 (PH1) is caused by a functional deficiency of a liver enzyme, serine:pyruvate/alanine:glyoxylate aminotransferase (SPT/AGT), which catalyzes transamination between L-serine or l-alanine as an amino acid substrate and glyoxylate or pyruvate as an alpha-keto acid substrate. Serine 193-201 angiotensinogen Homo sapiens 148-151 10675660-6 2000 Single-strand conformation polymorphism (SSCP) and direct sequence analysis confirmed the presence of a one-base substitution situated at the codon 50 from AGT (Ser) to ATT (Ile) in both patients, that corresponded to the increased molecular weight of 26.0. Serine 161-164 angiotensinogen Homo sapiens 156-159 11330044-1 2000 Glyoxylate is an immediate precursor of oxalate, but in its metabolism the conversion into glycine catalyzed by serine:pyruvate/alanine:glyoxylate aminotransferase (SPT/AGT) appears to be the main route. Serine 112-118 angiotensinogen Homo sapiens 169-172 11156700-13 2000 It is therefore possible that both mitochondrial and peroxisomal SPT/AGT contribute to the metabolism of glyoxylate and serine, but the subcellular site for glyoxylate metabolism is different in herbivores and carnivores. Serine 120-126 angiotensinogen Homo sapiens 69-72 10502786-4 1999 Genomic DNA was extracted and denaturinggradient gel electrophoresis of exon 7 of the androgen receptor gene followed by sequence analysis revealed a new mutation, a C A transversion, altering codon 840 from arginine (CGT) to serine (AGT). Serine 226-232 angiotensinogen Homo sapiens 234-237 10601235-5 1999 Both p70(S6K) Ser(411) and Akt Ser(473) phosphorylation by Ang II appear to involve EGF receptor transactivation and were inhibited by dominant-negative Ras, whereas the phosphorylation of p70(S6K) and ERK but not Akt was sensitive to the MEK inhibitor. Serine 31-34 angiotensinogen Homo sapiens 59-65 10601235-0 1999 Intracellular signaling of angiotensin II-induced p70 S6 kinase phosphorylation at Ser(411) in vascular smooth muscle cells. Serine 83-86 angiotensinogen Homo sapiens 27-41 10601235-4 1999 By using vascular smooth muscle cells in which we have demonstrated Ras/extracellular signal-regulated kinase (ERK) activation through Ca(2+)-dependent, epidermal growth factor (EGF) receptor transactivation by G(q)-coupled angiotensin II (Ang II) receptor, we present a unique cross-talk required for Ser(411) phosphorylation of p70(S6K) by Ang II. Serine 302-305 angiotensinogen Homo sapiens 224-238 10601235-5 1999 Both p70(S6K) Ser(411) and Akt Ser(473) phosphorylation by Ang II appear to involve EGF receptor transactivation and were inhibited by dominant-negative Ras, whereas the phosphorylation of p70(S6K) and ERK but not Akt was sensitive to the MEK inhibitor. Serine 14-17 angiotensinogen Homo sapiens 59-65 10362672-2 1999 Stimulation of the cells with ANG II led to a marked increase in the kinase activity of Akt/PKB, which coincided with Ser-473 phosphorylation. Serine 118-121 angiotensinogen Homo sapiens 30-36 10391929-6 1999 In addition, we show that Ang II-induced serine phosphorylation of STAT3 in VSMCs is mediated by mitogen-activated protein kinase and that dephosphorylation is mediated by protein phosphatase 2A (PP2A). Serine 41-47 angiotensinogen Homo sapiens 26-32 10479726-8 1999 Also, a haplotype analysis using a breast cancer patient database showed that the chromosome bearing serine 694-AGT carried IVS8+2T-->C. A second more common variant, IVS8-58delT, was characterized as a polymorphism. Serine 101-107 angiotensinogen Homo sapiens 112-115 9000456-6 1997 A missense mutation (AAT to AGT) was identified in the codon corresponding to codon 361 of the deduced human TrkC sequence, converting an encoded Asn to Ser. Serine 153-156 angiotensinogen Homo sapiens 28-31 9861481-12 1998 In codon 273, CGT for arginine was mutated to AGT for serine by a C to A transversion of the first letter. Serine 54-60 angiotensinogen Homo sapiens 46-49 8125929-4 1994 The stimulation of phosphorylation was apparent at 20 min and persisted for at least 12 h. Phosphoamino acid analysis revealed that serine is the major residue of eIF-4E phosphorylated by angiotensin II. Serine 132-138 angiotensinogen Homo sapiens 188-202 7860081-2 1994 Here we describe a novel polymorphism of human C7, namely a nucleotide sequence polymorphism changing codon 367 from AGT (encoding Ser) to ACT (encoding Thr). Serine 131-134 angiotensinogen Homo sapiens 117-120 8196175-3 1994 The known point mutations that cause euthyroid hyperthyroxinemia are Ala109 (ACC) to Thr (GCC) and Gly6 (GGT) to Ser (AGT). Serine 113-116 angiotensinogen Homo sapiens 118-121 8943046-5 1996 We found a new hot spot created at the third base of Ser-31 when its wild-type AGT codon was substituted by AGC. Serine 53-56 angiotensinogen Homo sapiens 79-82 1323434-8 1992 Phosphoamino acid analysis revealed that Ang II and PMA induced phosphorylation of both the kinases on serine/threonine as well as tyrosine residues. Serine 103-109 angiotensinogen Homo sapiens 41-47 8019561-4 1994 Direct sequencing of the PCR products for exon 19 revealed a single base mutation that converted the codon of -GGT- for glycine at alpha 1-247 to -AGT-, a codon for serine. Serine 165-171 angiotensinogen Homo sapiens 147-150 8240107-5 1993 It was a single base-pair transversion (AAT to AGT) leading to a serine-for-asparagine substitution. Serine 65-71 angiotensinogen Homo sapiens 47-50 8245128-1 1993 Primary hyperoxaluria type 1 (PH 1), an inborn error of glyoxylate metabolism characterized by excessive synthesis of oxalate and glycolate, is caused by a defect in serine:pyruvate/alanine:glyoxylate aminotransferase (SPT/AGT). Serine 166-172 angiotensinogen Homo sapiens 223-226 8402653-5 1993 The proline at position 140 in mammalian AGTs is replaced by alanine in the Ada and yeast AGTs and by serine in the Ogt AGT. Serine 102-108 angiotensinogen Homo sapiens 41-44 1326443-1 1992 In cultured vascular smooth muscle cells (VSMC) angiotensin II (ang II) induces tyrosine and serine/threonine phosphorylation and activation of two mitogen-activated protein (MAP) kinases. Serine 93-99 angiotensinogen Homo sapiens 48-70 1323434-10 1992 These results indicate that in vascular smooth muscle cells Ang II activates two species of MBP/microtubule-associated protein 2 kinases mainly through the protein kinase C-signaling pathway and suggest that tyrosine and serine/threonine phosphorylation may be involved in this process. Serine 221-227 angiotensinogen Homo sapiens 60-66 1797705-1 1991 The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin. Serine 118-121 angiotensinogen Homo sapiens 41-56 1587525-5 1992 Whereas the mutation in exon 4 was not observed in case 2, a different single base substitution of A by C was detected at the Ser codon AGT in exon 3. Serine 126-129 angiotensinogen Homo sapiens 136-139 1797705-1 1991 The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin. Serine 232-235 angiotensinogen Homo sapiens 41-56 34460247-0 2021 Soybean-Derived Antihypertensive Peptide LSW (Leu-Ser-Trp) Antagonizes the Damage of Angiotensin II to Vascular Endothelial Cells through the Trans-vesicular Pathway. Serine 50-53 angiotensinogen Homo sapiens 85-99 1903761-0 1991 A serine-to-arginine (AGT-to-CGT) mutation in codon 549 of the CFTR gene in an Italian patient with severe cystic fibrosis. Serine 2-8 angiotensinogen Homo sapiens 22-25 1967219-4 1990 At onset, Gly (GGT) was changed to Ser (AGT) at codon 12, and at relapse, Gly (GGT) to Asp (GAT) was observed at the same codon. Serine 35-38 angiotensinogen Homo sapiens 40-43 34233561-1 2021 Hb Tacoma (beta30(B12)Arg Ser) is a missense variant that is caused by either an AGG>AGT or AGG>AGC substitution at codon 30 of the HBB gene. Serine 26-29 angiotensinogen Homo sapiens 85-88 2680365-8 1989 The results showed an AGG (Arg) to AGT (Ser) point mutation, resulting in the change of the interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-. Serine 40-43 angiotensinogen Homo sapiens 35-38 2680365-8 1989 The results showed an AGG (Arg) to AGT (Ser) point mutation, resulting in the change of the interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-. Serine 176-179 angiotensinogen Homo sapiens 35-38 3289535-5 1988 The results showed AGG (Arg) to AGT (Ser) point mutation, resulting in the change of interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-. Serine 37-40 angiotensinogen Homo sapiens 32-35 3289535-5 1988 The results showed AGG (Arg) to AGT (Ser) point mutation, resulting in the change of interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-. Serine 169-172 angiotensinogen Homo sapiens 32-35