PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16528022-9 2006 A 10-fold increase in Bad phosphorylation at Ser-112 was detected following infection, which was suppressed after inhibition of ERK. Serine 45-48 mitogen-activated protein kinase 1 Homo sapiens 128-131 15972258-6 2006 Importantly, phosphorylation of Bad at Ser-112 was found to be regulated by p38 MAPK and PP2A. Serine 39-42 mitogen-activated protein kinase 1 Homo sapiens 76-79 16407301-4 2006 MEKK3-dependent activation of an NF-kappaB reporter gene as well as ERK, JNK, and p38 MAP kinases correlated with a requirement for serine at position 526. Serine 132-138 mitogen-activated protein kinase 1 Homo sapiens 68-71 16389635-6 2006 At an early intracellular level, angiotensin II, acting through JAK-2/IRS-1/PI3-kinase, JNK and ERK, may induce the serine phosphorylation and inhibition of key elements of the insulin-signaling pathway. Serine 116-122 mitogen-activated protein kinase 1 Homo sapiens 96-99 16406008-10 2006 Thus, Ser-447 on Ca(v)2.2 and Ser-161 and Ser-348 of Ca(v)beta1b appear to be both necessary and sufficient for ERK-dependent modulation of these channels. Serine 6-9 mitogen-activated protein kinase 1 Homo sapiens 112-115 16406008-10 2006 Thus, Ser-447 on Ca(v)2.2 and Ser-161 and Ser-348 of Ca(v)beta1b appear to be both necessary and sufficient for ERK-dependent modulation of these channels. Serine 30-33 mitogen-activated protein kinase 1 Homo sapiens 112-115 16406008-10 2006 Thus, Ser-447 on Ca(v)2.2 and Ser-161 and Ser-348 of Ca(v)beta1b appear to be both necessary and sufficient for ERK-dependent modulation of these channels. Serine 30-33 mitogen-activated protein kinase 1 Homo sapiens 112-115 16286470-6 2006 Intriguingly, active ERK-promoted phospho-Ser(296) MKP-1 bound to SCF(Skp2) ubiquitin ligase in vivo and in vitro. Serine 42-45 mitogen-activated protein kinase 1 Homo sapiens 21-24 15916534-9 2005 In the present study, we report that phosphorylation at Ser-104 blocks ERK binding to PEA-15 in vitro and in vivo, whereas phosphorylation at Ser-116 promotes its binding to FADD. Serine 56-59 mitogen-activated protein kinase 1 Homo sapiens 71-74 16286470-3 2006 Active ERK2 docking to the DEF motif (FXFP, residues 339-342) of N-terminally truncated MKP-1 in vitro initiated phosphorylation at the Ser(296)/Ser(323) domain, which was not affected by substituting Ala for Ser at Ser(359)/Ser(364). Serine 136-139 mitogen-activated protein kinase 1 Homo sapiens 7-11 16286470-3 2006 Active ERK2 docking to the DEF motif (FXFP, residues 339-342) of N-terminally truncated MKP-1 in vitro initiated phosphorylation at the Ser(296)/Ser(323) domain, which was not affected by substituting Ala for Ser at Ser(359)/Ser(364). Serine 145-148 mitogen-activated protein kinase 1 Homo sapiens 7-11 16286470-3 2006 Active ERK2 docking to the DEF motif (FXFP, residues 339-342) of N-terminally truncated MKP-1 in vitro initiated phosphorylation at the Ser(296)/Ser(323) domain, which was not affected by substituting Ala for Ser at Ser(359)/Ser(364). Serine 145-148 mitogen-activated protein kinase 1 Homo sapiens 7-11 16286470-4 2006 The DEF and Ser(296)/Ser(323) sites were essential for ubiquitin-mediated MKP-1 proteolysis stimulated by MKK1-ERK signaling in H293 cells, whereas the N-terminal domain and Ser(359)/Ser(364) sites were dispensable. Serine 12-15 mitogen-activated protein kinase 1 Homo sapiens 111-114 16286470-4 2006 The DEF and Ser(296)/Ser(323) sites were essential for ubiquitin-mediated MKP-1 proteolysis stimulated by MKK1-ERK signaling in H293 cells, whereas the N-terminal domain and Ser(359)/Ser(364) sites were dispensable. Serine 21-24 mitogen-activated protein kinase 1 Homo sapiens 111-114 16286470-4 2006 The DEF and Ser(296)/Ser(323) sites were essential for ubiquitin-mediated MKP-1 proteolysis stimulated by MKK1-ERK signaling in H293 cells, whereas the N-terminal domain and Ser(359)/Ser(364) sites were dispensable. Serine 21-24 mitogen-activated protein kinase 1 Homo sapiens 111-114 16286470-4 2006 The DEF and Ser(296)/Ser(323) sites were essential for ubiquitin-mediated MKP-1 proteolysis stimulated by MKK1-ERK signaling in H293 cells, whereas the N-terminal domain and Ser(359)/Ser(364) sites were dispensable. Serine 21-24 mitogen-activated protein kinase 1 Homo sapiens 111-114 16286470-5 2006 ERK activation by serum increased the endogenous level of ubiquitinated phospho-Ser(296) MKP-1 and the degradation of MKP-1. Serine 80-83 mitogen-activated protein kinase 1 Homo sapiens 0-3 16324217-3 2005 Moreover, acute ethanol induced Stat1 serine phosphorylation, which was partially mediated by the p38 MAPK pathway. Serine 38-44 mitogen-activated protein kinase 1 Homo sapiens 98-101 16156666-2 2005 We have mapped the ERK phosphorylation sites to Ser 207, Ser 203, and Thr 178 in Smad3. Serine 48-51 mitogen-activated protein kinase 1 Homo sapiens 19-22 16156666-2 2005 We have mapped the ERK phosphorylation sites to Ser 207, Ser 203, and Thr 178 in Smad3. Serine 57-60 mitogen-activated protein kinase 1 Homo sapiens 19-22 16156666-4 2005 Ser 207 is the best ERK site in Smad3. Serine 0-3 mitogen-activated protein kinase 1 Homo sapiens 20-23 15833272-10 2005 Pretreating the cells with SB202190, a specific inhibitor of p38, resulted in an increase in basal phosphorylation of ERK1/2 and a subsequent increase in basal serine phosphorylation of STAT-3. Serine 160-166 mitogen-activated protein kinase 1 Homo sapiens 61-64 15817653-0 2005 p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211. Serine 231-237 mitogen-activated protein kinase 1 Homo sapiens 38-42 15972681-5 2005 By chromatin immunoprecipitation assay, we demonstrate that activation of ERK leads to the phosphorylation of serine 10 on histone H3 at the il-10 gene, making the promoter more accessible to transcription factors generated in response to p38 activation. Serine 110-116 mitogen-activated protein kinase 1 Homo sapiens 74-77 15826939-5 2005 The addition of Integrilin (alpha(IIb)beta(3)-fibrinogen blocker) or okadaic acid (serine/threonine phosphatase inhibitor) dramatically enhanced ERK2 and MLC phosphorylation in the Pro(33)-negative platelets when compared with Pro(33)-positive platelets, suggesting that integrin engagement during platelet aggregation activates serine/threonine phosphatases. Serine 83-89 mitogen-activated protein kinase 1 Homo sapiens 145-149 15826939-5 2005 The addition of Integrilin (alpha(IIb)beta(3)-fibrinogen blocker) or okadaic acid (serine/threonine phosphatase inhibitor) dramatically enhanced ERK2 and MLC phosphorylation in the Pro(33)-negative platelets when compared with Pro(33)-positive platelets, suggesting that integrin engagement during platelet aggregation activates serine/threonine phosphatases. Serine 329-335 mitogen-activated protein kinase 1 Homo sapiens 145-149 15899852-0 2005 Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor. Serine 6-12 mitogen-activated protein kinase 1 Homo sapiens 86-123 15817653-0 2005 p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211. Serine 231-237 mitogen-activated protein kinase 1 Homo sapiens 141-145 15865443-2 2005 Previous studies have shown that p42(mapk/erk2) phosphorylates Ser and Thr residues (T236, S240, S244, and S270) in the membrane proximal region of TNF-R1 and that mutation of these residues to Glu and Asp residues (TNF-R1.4D/E) mimics the effect of phosphorylation on receptor signaling and localization. Serine 63-66 mitogen-activated protein kinase 1 Homo sapiens 42-46 15865443-6 2005 Incubation of Sepharose bead-bound GST-TNF-R1(207)(-)(425).4D/E fusion protein with lysates containing activated p42(mapk/erk2) led to the phosphorylation of Ser and Thr residues in addition to the previously defined sites at T236, S240, S244, and S270. Serine 158-161 mitogen-activated protein kinase 1 Homo sapiens 122-126 15568999-2 2005 In the present study, we show that, in addition to being phosphorylated on Thr-581 and Ser-360 by ERK1/2 or p38, MSK1 can autophosphorylate on at least six sites: Ser-212, Ser-376, Ser-381, Ser-750, Ser-752 and Ser-758. Serine 87-90 mitogen-activated protein kinase 1 Homo sapiens 108-111 15689616-4 2005 The CTS contains several motifs such as a nuclear localization signal, a nuclear export signal, PEST sequences, and a serine residue (Ser-446) that can be phosphorylated by activated ERK, suggesting an important regulatory role(s). Serine 118-124 mitogen-activated protein kinase 1 Homo sapiens 183-186 15689616-4 2005 The CTS contains several motifs such as a nuclear localization signal, a nuclear export signal, PEST sequences, and a serine residue (Ser-446) that can be phosphorylated by activated ERK, suggesting an important regulatory role(s). Serine 134-137 mitogen-activated protein kinase 1 Homo sapiens 183-186 15494312-3 2004 In the present study we demonstrate that activated ERK phosphorylates paxillin on serine 83 and that mutation of this site eliminates HGF-stimulated increased association of paxillin and FAK in subconfluent cells. Serine 82-88 mitogen-activated protein kinase 1 Homo sapiens 51-54 15728359-2 2005 We have identified three sites phosphorylated by ERK2 (Ser-15 and Ser-205) and cyclin-dependent PK 5 (Cdk5) (Ser-17), within the actin-binding domain of spinophilin. Serine 55-58 mitogen-activated protein kinase 1 Homo sapiens 49-53 15728359-2 2005 We have identified three sites phosphorylated by ERK2 (Ser-15 and Ser-205) and cyclin-dependent PK 5 (Cdk5) (Ser-17), within the actin-binding domain of spinophilin. Serine 66-69 mitogen-activated protein kinase 1 Homo sapiens 49-53 15728359-2 2005 We have identified three sites phosphorylated by ERK2 (Ser-15 and Ser-205) and cyclin-dependent PK 5 (Cdk5) (Ser-17), within the actin-binding domain of spinophilin. Serine 66-69 mitogen-activated protein kinase 1 Homo sapiens 49-53 15657420-10 2005 Ser(676) is also targeted by the ERK MAP kinase, which interacts with NFAT at a distinct region than RSK. Serine 0-3 mitogen-activated protein kinase 1 Homo sapiens 33-36 15616583-4 2005 Phosphorylation of DAPK at Ser 735 by ERK increases the catalytic activity of DAPK both in vitro and in vivo. Serine 27-30 mitogen-activated protein kinase 1 Homo sapiens 38-41 15988067-2 2005 Phosphorylation of PDE4s by ERK2 is dependent on two docking domains on either side of the target serine that allow specificity and high-fidelity binding of the kinase. Serine 98-104 mitogen-activated protein kinase 1 Homo sapiens 28-32 15632084-4 2005 In vitro phosphorylation assays using glutathione S-transferase (GST)-MKP-3 fusion proteins indicated that ERK2 could phosphorylate MKP-3 on serines 159 and 197. Serine 141-148 mitogen-activated protein kinase 1 Homo sapiens 107-111 15325847-8 2004 We also found that WKYMVm stimulated extracellular signal regulated kinase (ERK), and that ERK activity is required for STAT3 serine phosphorylation. Serine 126-132 mitogen-activated protein kinase 1 Homo sapiens 91-94 15379552-4 2004 To address this question in this report we examined extracellular signal-regulated kinases 1/2 (ERK) specific serine/threonine phosphorylation of the entire Gab1 engaged in insulin signaling in more detail in vitro. Serine 110-116 mitogen-activated protein kinase 1 Homo sapiens 52-94 15379552-4 2004 To address this question in this report we examined extracellular signal-regulated kinases 1/2 (ERK) specific serine/threonine phosphorylation of the entire Gab1 engaged in insulin signaling in more detail in vitro. Serine 110-116 mitogen-activated protein kinase 1 Homo sapiens 96-99 15184391-6 2004 Site-directed mutagenesis revealed that ERK2 mainly phosphorylated the serine 189 residue of vinexin beta. Serine 71-77 mitogen-activated protein kinase 1 Homo sapiens 40-44 15231836-3 2004 Transactivation assays performed in epithelial Madin-Darby canine kidney cells co-transfected with SER and a Ras-responsive reporter vector indicated that SER was able to trigger a Ras/ERK pathway in response to human epidermal growth factor (EGF). Serine 155-158 mitogen-activated protein kinase 1 Homo sapiens 185-188 15069084-9 2004 These studies show a rapid, novel, and selective phosphorylation of Rb Ser(795) by mitogens and demonstrate an unexpected rapid linkage between the actions of the Ras --> Raf --> MEK --> ERK pathway and the phosphorylation state of Rb. Serine 71-74 mitogen-activated protein kinase 1 Homo sapiens 196-199 14988395-0 2004 Insulin-activated Erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding Protein-2 at serine residues 432 and 455 in vivo. Serine 117-123 mitogen-activated protein kinase 1 Homo sapiens 18-21 15069084-0 2004 Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation. Serine 41-47 mitogen-activated protein kinase 1 Homo sapiens 128-131 15069084-6 2004 Rb Ser(795) phosphorylation could be blocked by PD98059, a MEK inhibitor, and greatly attenuated by apigenin, an inhibitor of the Ras --> Raf --> MEK --> ERK pathway. Serine 3-6 mitogen-activated protein kinase 1 Homo sapiens 163-166 15023352-3 2004 ERK2 catalyses the transfer of the gamma-phosphate of adenosine triphosphate to serine or threonine residues found in Ser-Pro or Thr-Pro motifs on proteins. Serine 80-86 mitogen-activated protein kinase 1 Homo sapiens 0-4 15081531-9 2004 The FcgammaRIIb-associated ERKs may phosphorylate the membrane proximal serine of the receptor. Serine 72-78 mitogen-activated protein kinase 1 Homo sapiens 27-31 15023352-3 2004 ERK2 catalyses the transfer of the gamma-phosphate of adenosine triphosphate to serine or threonine residues found in Ser-Pro or Thr-Pro motifs on proteins. Serine 118-121 mitogen-activated protein kinase 1 Homo sapiens 0-4 14701740-4 2004 This inhibition is mediated by extracellular signal-regulated kinases 1 and/or 2 (ERK1/2), which interact with C/EBPalpha through an FXFP docking site and phosphorylate serine 21. Serine 169-175 mitogen-activated protein kinase 1 Homo sapiens 31-80 14613483-3 2004 We previously reported that PKA (cAMP-dependent protein kinase) phosphorylates Ser-23 within the KIM of HePTP, resulting in dissociation of HePTP from ERK2. Serine 79-82 mitogen-activated protein kinase 1 Homo sapiens 151-155 12911635-2 2003 We report that the phosphorylation of Akt, ERK, JNK and p38 kinases, whose activities depend on serine, threonine and tyrosine phosphorylation, were all increased during OGD. Serine 96-102 mitogen-activated protein kinase 1 Homo sapiens 43-46 14678993-4 2003 The MAPK kinase (MEK)/extracellular signal-regulated kinase (ERK)/RSK MAPK signaling module is constitutively hyperactivated, and Bad is maintained in its inactive state by phosphorylation at Ser(75) in a MEK/ERK/RSK-dependent manner in melanoma cells. Serine 192-195 mitogen-activated protein kinase 1 Homo sapiens 4-8 14678993-4 2003 The MAPK kinase (MEK)/extracellular signal-regulated kinase (ERK)/RSK MAPK signaling module is constitutively hyperactivated, and Bad is maintained in its inactive state by phosphorylation at Ser(75) in a MEK/ERK/RSK-dependent manner in melanoma cells. Serine 192-195 mitogen-activated protein kinase 1 Homo sapiens 61-64 12551909-6 2003 Using SPOT DS, we confirmed as a proof of principle that Elk-1 Ser(383) phosphorylation by ERK-2 kinase is stimulated by the presence of the Elk-1-docking domain. Serine 63-66 mitogen-activated protein kinase 1 Homo sapiens 91-96 12763029-6 2003 AngII-induced-phosphorylation of Rb (Ser 795 and Ser 807/811), -cyclin D1 expression, and -DNA synthesis was also markedly enhanced by pharmacological inhibition of the p38 MAPK pathway. Serine 37-40 mitogen-activated protein kinase 1 Homo sapiens 169-172 12763029-6 2003 AngII-induced-phosphorylation of Rb (Ser 795 and Ser 807/811), -cyclin D1 expression, and -DNA synthesis was also markedly enhanced by pharmacological inhibition of the p38 MAPK pathway. Serine 49-52 mitogen-activated protein kinase 1 Homo sapiens 169-172 12899942-7 2003 Enhancement of ERK phosphorylation by antioxidants correlated with increased and sustained serine phosphorylation of the src-family kinase lck, a known ERK substrate. Serine 91-97 mitogen-activated protein kinase 1 Homo sapiens 15-18 12899942-7 2003 Enhancement of ERK phosphorylation by antioxidants correlated with increased and sustained serine phosphorylation of the src-family kinase lck, a known ERK substrate. Serine 91-97 mitogen-activated protein kinase 1 Homo sapiens 152-155 12824291-4 2003 Total serine phosphorylation of Smad2/3, but not phosphorylation of the C-terminal SS(P)XS(P) motif, was decreased by pretreatment with the MEK/ERK inhibitors, PD98059 (10 microM) or U0126 (25 microM). Serine 6-12 mitogen-activated protein kinase 1 Homo sapiens 144-147 12691603-2 2003 In the present study, we examined heregulin (HRG)-induced signal transduction of ErbB4 receptor and found that the phosphatidylinositol 3"-kinase (PI3K)-Akt pathway negatively regulated the extracellular signal-regulated kinase (ERK) cascade by phosphorylating Raf-1 on Ser(259). Serine 270-273 mitogen-activated protein kinase 1 Homo sapiens 190-227 12832467-5 2003 Complex dissociation requires phosphorylation of RSK1 serine 749, which is a mitogen-regulated phosphorylation site located near the ERK docking site. Serine 54-60 mitogen-activated protein kinase 1 Homo sapiens 133-136 12763138-0 2003 Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway. Serine 23-29 mitogen-activated protein kinase 1 Homo sapiens 101-104 12763138-9 2003 Further analysis showed that MSK1 is activated downstream of ERK, and retroviral transductions with kinase-inactive MSK1 revealed that MSK1 is necessary for STAT3 serine phosphorylation. Serine 163-169 mitogen-activated protein kinase 1 Homo sapiens 61-64 12763138-11 2003 CONCLUSIONS: The EPO-induced STAT3 serine 727 phosphorylation is mediated by a pathway involving MEK, ERK, and MSK1. Serine 35-41 mitogen-activated protein kinase 1 Homo sapiens 102-105 12620228-4 2003 Phosphopeptide mapping and mutational analysis reveals two serine residues (S633 and S649) that are phosphorylated by ERK and RSK kinases. Serine 59-65 mitogen-activated protein kinase 1 Homo sapiens 118-121 12447691-8 2002 In contrast, MAPK (Erk2) and MPF phosphorylate Ser-126 and Ser-128 within the CRS. Serine 47-50 mitogen-activated protein kinase 1 Homo sapiens 19-23 12427756-4 2003 Experiments using "add-back" mutants showed that three serine residues (Ser(257), Ser(275), and Ser(295)) in the TAD were phosphorylated in vitro by ERK. Serine 55-61 mitogen-activated protein kinase 1 Homo sapiens 149-152 12427756-4 2003 Experiments using "add-back" mutants showed that three serine residues (Ser(257), Ser(275), and Ser(295)) in the TAD were phosphorylated in vitro by ERK. Serine 72-75 mitogen-activated protein kinase 1 Homo sapiens 149-152 12427756-4 2003 Experiments using "add-back" mutants showed that three serine residues (Ser(257), Ser(275), and Ser(295)) in the TAD were phosphorylated in vitro by ERK. Serine 82-85 mitogen-activated protein kinase 1 Homo sapiens 149-152 12427756-4 2003 Experiments using "add-back" mutants showed that three serine residues (Ser(257), Ser(275), and Ser(295)) in the TAD were phosphorylated in vitro by ERK. Serine 82-85 mitogen-activated protein kinase 1 Homo sapiens 149-152 12447691-8 2002 In contrast, MAPK (Erk2) and MPF phosphorylate Ser-126 and Ser-128 within the CRS. Serine 59-62 mitogen-activated protein kinase 1 Homo sapiens 19-23 12050114-0 2002 Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation. Serine 36-43 mitogen-activated protein kinase 1 Homo sapiens 63-67 12130710-9 2002 Time-dependent increases in phospho-extracellular signal-regulated kinase (ERK) 1/2 were found to occur simultaneously with increases in serine 727 phospho-Stat3. Serine 137-143 mitogen-activated protein kinase 1 Homo sapiens 28-83 11940578-9 2002 Therefore, during PKC activation, the c-Raf/MEK/extracellular signal-regulated kinase-1/2 (ERK1/2) pathway mediates both the Thr-421/Ser-424 and the Thr-389 phosphorylation in an mTOR-independent and -dependent manner, respectively. Serine 133-136 mitogen-activated protein kinase 1 Homo sapiens 48-89 11971957-7 2002 cAMP increased Raf-1 serine 259 phosphorylation in a PKA-dependent manner with kinetics that correlated with ERK deactivation. Serine 21-27 mitogen-activated protein kinase 1 Homo sapiens 109-112 12018856-6 2002 Notably, the enhanced serine phosphorylation of STAT1 was observed upon Ras-transfection, which was specifically associated with the induction of MAPK, but not Akt activity in these cells. Serine 22-28 mitogen-activated protein kinase 1 Homo sapiens 146-150 12018856-7 2002 The data suggest that Ras/MAPK module components may positively regulate STAT1 activity by inducing the serine-phosphorylation of STAT1. Serine 104-110 mitogen-activated protein kinase 1 Homo sapiens 26-30 11799119-6 2002 Indeed, evidence is presented that mTOR may initially be required for the phosphorylation of Thr(45) in a priming step, which is necessary for the subsequent phosphorylation of Ser(64) and Thr(69) through an Erk-dependent pathway. Serine 177-180 mitogen-activated protein kinase 1 Homo sapiens 208-211 12213813-4 2002 Two in vivo RSK1 phosphorylation sites within ER81, Ser(191) and Ser(216), were identified, whose mutation to alanine reduces ER81 activity upon ERK-MAPK stimulation. Serine 52-55 mitogen-activated protein kinase 1 Homo sapiens 145-148 12213813-4 2002 Two in vivo RSK1 phosphorylation sites within ER81, Ser(191) and Ser(216), were identified, whose mutation to alanine reduces ER81 activity upon ERK-MAPK stimulation. Serine 52-55 mitogen-activated protein kinase 1 Homo sapiens 149-153 12213813-4 2002 Two in vivo RSK1 phosphorylation sites within ER81, Ser(191) and Ser(216), were identified, whose mutation to alanine reduces ER81 activity upon ERK-MAPK stimulation. Serine 65-68 mitogen-activated protein kinase 1 Homo sapiens 145-148 12213813-4 2002 Two in vivo RSK1 phosphorylation sites within ER81, Ser(191) and Ser(216), were identified, whose mutation to alanine reduces ER81 activity upon ERK-MAPK stimulation. Serine 65-68 mitogen-activated protein kinase 1 Homo sapiens 149-153 12225966-9 2002 Inhibition of isoproterenol-stimulated ERK activity by PTX treatment was associated with an increase in Akt activation and phosphorylation of Raf-1 on the inhibitory residue Ser(259). Serine 174-177 mitogen-activated protein kinase 1 Homo sapiens 39-42 12045255-4 2002 The binding of renin induced a fourfold increase of the catalytic efficiency of angiotensinogen conversion to angiotensin I and induced an intracellular signal with phosphorylation of serine and tyrosine residues associated to an activation of MAP kinases ERK1 and ERK2. Serine 184-190 mitogen-activated protein kinase 1 Homo sapiens 265-269 12006497-5 2002 Here, we describe that the Mad1-like SID domain of the Sp1-like repressor TIEG2 is inhibited by the epidermal growth factor (EGF)-Ras-MEK1-ERK2 signaling pathway, via phosphorylation of four serine/threonine sites adjacent to the SID. Serine 191-197 mitogen-activated protein kinase 1 Homo sapiens 139-143 12083364-3 2002 In addition, MKP-1 stability increases upon ERK-dependent phosphorylation of two serine residues in its C-terminus. Serine 81-87 mitogen-activated protein kinase 1 Homo sapiens 44-47 11818515-7 2002 The phospho-Ser/Thr-Pro content (characteristic of ERK1/2 substrates) of Triton-insoluble proteins (75 and 80 kDa) increased during capacitation and also appeared to be regulated by O(2)(-)* and the ERK pathway. Serine 12-15 mitogen-activated protein kinase 1 Homo sapiens 51-54 12050114-2 2002 Tob is rapidly phosphorylated at Ser 152, Ser 154, and Ser 164 by Erk1 and Erk2 upon growth-factor stimulation. Serine 33-36 mitogen-activated protein kinase 1 Homo sapiens 75-79 11922392-10 2002 We propose that the FGF-1-induced signaling pathway that leads to promatrilysin expression is ERK-dependent and leads to phosphorylation of Ser-727 on STAT3, phosphorylated STAT3, then binds and transactivates the matrilysin promoter. Serine 140-143 mitogen-activated protein kinase 1 Homo sapiens 94-97 11500364-6 2001 PDK1 is required for activation of members of the AGC kinase family; we show that two such kinases, p70 S6 kinase (regulated via mTOR) and p90(RSK1) (activated by Erk), phosphorylate eEF2k at a conserved serine and inhibit its activity. Serine 204-210 mitogen-activated protein kinase 1 Homo sapiens 163-166 11553624-5 2001 Phosphorylation of STAT3 (Ser(727)) is also markedly prevented by a dominant negative mutant of ERK2, c-Jun N-terminal kinase 1 (JNK1), or p38 kinase and in knockout Jnk1(-/-) or Jnk2(-/-) cells. Serine 26-29 mitogen-activated protein kinase 1 Homo sapiens 96-100 11553624-6 2001 Furthermore, STAT3 (Ser(727)) phosphorylation is suppressed by C- or N-terminal "kinase-dead" mutants of mitogen- and stress-activated protein kinase 1 (MSK1), a downstream kinase of ERKs and p38 kinase, and H89, a potential MSK1 inhibitor. Serine 20-23 mitogen-activated protein kinase 1 Homo sapiens 183-187 11585926-0 2001 The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes. Serine 122-128 mitogen-activated protein kinase 1 Homo sapiens 47-93 11585926-4 2001 Infection of cultured cardiomyocytes with an activated MEK1-expressing adenovirus induced robust phosphorylation of serine 105 in GATA4, while a dominant-negative MEK1-expressing adenovirus blocked agonist-induced phosphorylation of serine 105, implicating extracellular signal-regulated kinase (ERK) as a GATA4 kinase. Serine 116-122 mitogen-activated protein kinase 1 Homo sapiens 257-294 11585926-4 2001 Infection of cultured cardiomyocytes with an activated MEK1-expressing adenovirus induced robust phosphorylation of serine 105 in GATA4, while a dominant-negative MEK1-expressing adenovirus blocked agonist-induced phosphorylation of serine 105, implicating extracellular signal-regulated kinase (ERK) as a GATA4 kinase. Serine 116-122 mitogen-activated protein kinase 1 Homo sapiens 296-299 11585926-5 2001 Indeed, bacterially purified ERK2 protein directly phosphorylated purified GATA4 at serine 105 in vitro. Serine 84-90 mitogen-activated protein kinase 1 Homo sapiens 29-33 11546790-8 2001 Co-transfections with MAP-2c and the extracellular signal-regulated kinase 2 (ERK2) demonstrated that MAP-2c is threonine/serine-phosphorylated on its RTPPKSP motif and that threonine phosphorylation abolished the MAP-2c/Fyn binding. Serine 122-128 mitogen-activated protein kinase 1 Homo sapiens 37-76 11546790-8 2001 Co-transfections with MAP-2c and the extracellular signal-regulated kinase 2 (ERK2) demonstrated that MAP-2c is threonine/serine-phosphorylated on its RTPPKSP motif and that threonine phosphorylation abolished the MAP-2c/Fyn binding. Serine 122-128 mitogen-activated protein kinase 1 Homo sapiens 78-82 11606045-5 2001 These findings suggest that human death receptors segregate into two groups along lines of phylogeny with respect to Ser/Thr phosphorylation by p42(mapk/erk2). Serine 117-120 mitogen-activated protein kinase 1 Homo sapiens 153-157 11278279-12 2001 These data indicate clearly that p90(RSK) Ser(381) may be phosphorylated by activation of JNKs or ERKs, but not p38 kinase. Serine 42-45 mitogen-activated protein kinase 1 Homo sapiens 98-102 11279232-5 2001 The p70(S6K) phosphorylation at Ser(411) and Thr(421)/Ser(424) was inhibited by rapamycin, PD98059, or DNM-ERK2 but not by wortmannin, SB202190, DNM-Deltap85, or DNM-p38. Serine 32-35 mitogen-activated protein kinase 1 Homo sapiens 103-111 11279232-5 2001 The p70(S6K) phosphorylation at Ser(411) and Thr(421)/Ser(424) was inhibited by rapamycin, PD98059, or DNM-ERK2 but not by wortmannin, SB202190, DNM-Deltap85, or DNM-p38. Serine 54-57 mitogen-activated protein kinase 1 Homo sapiens 103-111 11309409-5 2001 Furthermore, when we activated ERK in nonadherent cells by expression of active components of the ERK cascade, subsequent phosphorylation of Elk-1 at serine 383 and Elk-1-mediated transactivation were still impaired compared with adherent cells. Serine 150-156 mitogen-activated protein kinase 1 Homo sapiens 31-34 11309409-5 2001 Furthermore, when we activated ERK in nonadherent cells by expression of active components of the ERK cascade, subsequent phosphorylation of Elk-1 at serine 383 and Elk-1-mediated transactivation were still impaired compared with adherent cells. Serine 150-156 mitogen-activated protein kinase 1 Homo sapiens 98-101 11245472-5 2001 Stable expression of a dominant negative mutant of ERK2 or p38 kinase or their respective inhibitor, PD98059 or SB202190, repressed the phosphorylation of p53 at serine 15. Serine 162-168 mitogen-activated protein kinase 1 Homo sapiens 51-55 11245472-10 2001 These data strongly suggest that both ERKs and p38 kinase mediate resveratrol-induced activation of p53 and apoptosis through phosphorylation of p53 at serine 15. Serine 152-158 mitogen-activated protein kinase 1 Homo sapiens 38-42 11342545-3 2001 ET-1-induced serine phosphorylation of p66(Shc) requires activation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling module and is efficiently inhibited by both a MAPK/ERK kinase (MEK)-selective inhibitor and adenovirus-mediated transfer of a dominant interfering MEK1 mutant. Serine 13-19 mitogen-activated protein kinase 1 Homo sapiens 154-157 11342545-3 2001 ET-1-induced serine phosphorylation of p66(Shc) requires activation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling module and is efficiently inhibited by both a MAPK/ERK kinase (MEK)-selective inhibitor and adenovirus-mediated transfer of a dominant interfering MEK1 mutant. Serine 13-19 mitogen-activated protein kinase 1 Homo sapiens 220-223 11301320-4 2001 ERKs phosphorylate GRIP1 at a specific site, Ser-736, the integrity of which is required for full growth factor induction of GRIP1 transcriptional activation and coactivator function. Serine 45-48 mitogen-activated protein kinase 1 Homo sapiens 0-4 11279232-7 2001 In vitro assays indicated that Ser(411) on immunoprecipitated p70(S6K) proteins is phosphorylated by active JNKs and ERKs, but not p38 kinase, and Thr(421)/Ser(424) is phosphorylated by ERK1, but not ERK2, JNKs, or p38 kinase. Serine 31-34 mitogen-activated protein kinase 1 Homo sapiens 200-204 11278279-3 2001 In this study, results show that UVA-induced phosphorylation of p90(RSK) at Ser(381) through ERKs and JNKs, but not p38 kinase pathways. Serine 76-79 mitogen-activated protein kinase 1 Homo sapiens 93-97 11278279-5 2001 Both PD98059 and a dominant negative mutant of ERK2 blocked ERKs and p90(RSK) Ser(381) phosphorylation, as well as p90(RSK) activity. Serine 78-81 mitogen-activated protein kinase 1 Homo sapiens 47-51 11231586-4 2001 Mitogen-activated protein kinase/extracellular-signal-regulated kinase (MAPK/ERK) efficiently phosphorylates hnRNP-K both in vitro and in vivo at serines 284 and 353. Serine 146-153 mitogen-activated protein kinase 1 Homo sapiens 72-76 11231586-4 2001 Mitogen-activated protein kinase/extracellular-signal-regulated kinase (MAPK/ERK) efficiently phosphorylates hnRNP-K both in vitro and in vivo at serines 284 and 353. Serine 146-153 mitogen-activated protein kinase 1 Homo sapiens 77-80 11007796-5 2000 Also, deletion of Glut1 residues 469-492 was without effect, but mutations involving serine 465 or arginine 468 yielded dominant-negative forms that inhibited glucose-dependent ERK activation. Serine 85-91 mitogen-activated protein kinase 1 Homo sapiens 177-180 10922466-3 2000 The proline-directed p42 mitogen-activated protein kinase (ERK2) was used to phosphorylate the serine side chain in Pro-Arg-Ser-Pro-Phe-4-nitroanilide under conditions where different amounts of cis prolyl isomer of the substrate were present. Serine 95-101 mitogen-activated protein kinase 1 Homo sapiens 59-63 10993892-6 2000 This stimulation and the phosphorylation of GAIP by Erk2 were abrogated when serine at position 151 in the RGS domain was substituted by an alanine residue using site-directed mutagenesis. Serine 77-83 mitogen-activated protein kinase 1 Homo sapiens 52-56 11027949-0 2000 cAMP-dependent protein kinase (PKA) inhibits T cell activation by phosphorylating ser-43 of raf-1 in the MAPK/ERK pathway. Serine 82-85 mitogen-activated protein kinase 1 Homo sapiens 105-109 11027949-0 2000 cAMP-dependent protein kinase (PKA) inhibits T cell activation by phosphorylating ser-43 of raf-1 in the MAPK/ERK pathway. Serine 82-85 mitogen-activated protein kinase 1 Homo sapiens 110-113 11027949-6 2000 Phosphopeptide mapping identified Ser-43 of Raf-1 as the only site phosphorylated by PKA in the Ras/MAPK pathway. Serine 34-37 mitogen-activated protein kinase 1 Homo sapiens 100-104 11018017-4 2000 Phosphorylation of Ser 62 is required for Ras-induced stabilization of Myc, likely mediated through the action of ERK. Serine 19-22 mitogen-activated protein kinase 1 Homo sapiens 114-117 10806218-8 2000 More importantly, incubation of active ERK2 or p38 kinase with H3 protein resulted in phosphorylation of H3 at serine 10 in vitro. Serine 111-117 mitogen-activated protein kinase 1 Homo sapiens 39-43 10806218-8 2000 More importantly, incubation of active ERK2 or p38 kinase with H3 protein resulted in phosphorylation of H3 at serine 10 in vitro. Serine 111-117 mitogen-activated protein kinase 1 Homo sapiens 47-50 10806218-0 2000 ERKs and p38 kinases mediate ultraviolet B-induced phosphorylation of histone H3 at serine 10. Serine 84-90 mitogen-activated protein kinase 1 Homo sapiens 0-4 10806218-9 2000 These results suggest that ERK and p38 kinase are at least two important mediators of phosphorylation of H3 at serine 10. Serine 111-117 mitogen-activated protein kinase 1 Homo sapiens 27-30 10806218-0 2000 ERKs and p38 kinases mediate ultraviolet B-induced phosphorylation of histone H3 at serine 10. Serine 84-90 mitogen-activated protein kinase 1 Homo sapiens 9-12 10806218-9 2000 These results suggest that ERK and p38 kinase are at least two important mediators of phosphorylation of H3 at serine 10. Serine 111-117 mitogen-activated protein kinase 1 Homo sapiens 35-38 10807665-2 2000 Activated Erk phosphorylates specific serine residues within cytosolic phospholipase A(2) (PLA(2)), promoting enzyme translocation to membranes and facilitating liberation of arachidonic acid (AA). Serine 38-44 mitogen-activated protein kinase 1 Homo sapiens 10-13 10806218-4 2000 In the present study, we show that both ERKs and p38 kinase may mediate ultraviolet B-induced phosphorylation of H3 at serine 10. Serine 119-125 mitogen-activated protein kinase 1 Homo sapiens 40-44 10806218-4 2000 In the present study, we show that both ERKs and p38 kinase may mediate ultraviolet B-induced phosphorylation of H3 at serine 10. Serine 119-125 mitogen-activated protein kinase 1 Homo sapiens 49-52 10828059-3 2000 These straddle the target residue, Ser(579), for ERK2 phosphorylation of PDE4D3. Serine 35-38 mitogen-activated protein kinase 1 Homo sapiens 49-53 10760518-2 2000 Enzyme activity is regulated both by translocation to the membrane in a Ca(2+)-dependent manner and serine phosphorylation by members of the mitogen-activated protein kinase (MAPK) family. Serine 100-106 mitogen-activated protein kinase 1 Homo sapiens 175-179 10702794-8 2000 Tyrosine phosphorylated ERK2, but not ERK1, p38, or JNK1, efficiently bound to catalytically inactive HePTP mutants in which the active site cysteine (HePTP-C/S) or the conserved aspartic acid residue (HePTP-D/A) had been exchanged for serine and alanine, respectively. Serine 236-242 mitogen-activated protein kinase 1 Homo sapiens 24-28 10733581-5 2000 Indeed, ERK directly phosphorylates TTF-1 at three serine residues, and concomitant mutation of these serines to alanines completely abolishes ERK-mediated phosphorylation both in vitro and in vivo. Serine 51-57 mitogen-activated protein kinase 1 Homo sapiens 8-11 10733581-5 2000 Indeed, ERK directly phosphorylates TTF-1 at three serine residues, and concomitant mutation of these serines to alanines completely abolishes ERK-mediated phosphorylation both in vitro and in vivo. Serine 51-57 mitogen-activated protein kinase 1 Homo sapiens 143-146 10733581-5 2000 Indeed, ERK directly phosphorylates TTF-1 at three serine residues, and concomitant mutation of these serines to alanines completely abolishes ERK-mediated phosphorylation both in vitro and in vivo. Serine 102-109 mitogen-activated protein kinase 1 Homo sapiens 8-11 10733581-5 2000 Indeed, ERK directly phosphorylates TTF-1 at three serine residues, and concomitant mutation of these serines to alanines completely abolishes ERK-mediated phosphorylation both in vitro and in vivo. Serine 102-109 mitogen-activated protein kinase 1 Homo sapiens 143-146 10652349-4 2000 We show that JNK, ERK, and p38 physically associate with the NFATc N-terminal regulatory domain and can directly phosphorylate functionally important residues involved in regulating NFATc subcellular localization, namely Ser(172) and the conserved NFATc Ser-Pro repeats. Serine 221-224 mitogen-activated protein kinase 1 Homo sapiens 18-21 10677502-7 2000 p44MAPK/extracellular signal-regulated kinase 1 (ERK1) and p42 MAPK/ERK2 are activated by IL-3, colocalize with mitochondrial Bcl2, and can directly phosphorylate Bcl2 on Ser-70 in a stauro-resistant manner both in vitro and in vivo. Serine 171-174 mitogen-activated protein kinase 1 Homo sapiens 59-67 10828601-2 2000 In this pathway, the MAP kinases ERK1/ERK2 are phosphorylated and activated by the dual-specificity kinases MEK1 and MEK2, which in turn are activated by serine phosphorylation by a number of MAP kinase kinase kinases. Serine 154-160 mitogen-activated protein kinase 1 Homo sapiens 38-42 10648599-10 2000 In addition, TFII-I can be phosphorylated in vitro by ERK and mutation of consensus MAP kinase substrate sites at serines 627 and 633 impairs the phosphorylation of TFII-I by ERK and its activity on the c-fos promoter. Serine 114-121 mitogen-activated protein kinase 1 Homo sapiens 54-57 10648599-10 2000 In addition, TFII-I can be phosphorylated in vitro by ERK and mutation of consensus MAP kinase substrate sites at serines 627 and 633 impairs the phosphorylation of TFII-I by ERK and its activity on the c-fos promoter. Serine 114-121 mitogen-activated protein kinase 1 Homo sapiens 175-178 10645003-6 2000 IFN-gamma also rapidly and transiently activates extracellular signal-regulated kinase 1,2 (ERK1,2) and blocking ERK1,2 pathway (Raf/MEK1,2/ERK1,2) by specific MEK1,2 inhibitor PD98059 partially (by 50%) prevents Ser-727 phosphorylation of STAT1 and suppression of MMP-13 expression by IFN-gamma. Serine 213-216 mitogen-activated protein kinase 1 Homo sapiens 49-90 10523304-0 1999 p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons. Serine 37-43 mitogen-activated protein kinase 1 Homo sapiens 0-3 10601235-4 1999 By using vascular smooth muscle cells in which we have demonstrated Ras/extracellular signal-regulated kinase (ERK) activation through Ca(2+)-dependent, epidermal growth factor (EGF) receptor transactivation by G(q)-coupled angiotensin II (Ang II) receptor, we present a unique cross-talk required for Ser(411) phosphorylation of p70(S6K) by Ang II. Serine 302-305 mitogen-activated protein kinase 1 Homo sapiens 111-114 10574913-7 1999 Ser(670) is located in a peptide sequence that conforms to an ERK consensus phosphorylation sequence, and in vitro, in the presence of heparin, ERK1 phosphorylates GRK2. Serine 0-3 mitogen-activated protein kinase 1 Homo sapiens 62-65 10514499-2 1999 Extracellular signal-regulated kinases (ERKs) phosphorylate the high molecular mass isoform of the actin-binding protein caldesmon (h-CaD) at two sites (Ser(759) and Ser(789)) during smooth muscle stimulation. Serine 153-156 mitogen-activated protein kinase 1 Homo sapiens 40-44 10514499-2 1999 Extracellular signal-regulated kinases (ERKs) phosphorylate the high molecular mass isoform of the actin-binding protein caldesmon (h-CaD) at two sites (Ser(759) and Ser(789)) during smooth muscle stimulation. Serine 166-169 mitogen-activated protein kinase 1 Homo sapiens 40-44 10514499-9 1999 These data 1) identify Ser(789) of h-CaD as the major site of ERK-dependent phosphorylation in carotid arteries; 2) show that the level of phosphorylation at Ser(789) is relatively constant following carotid arterial muscle stimulation, despite an increase in total protein phosphate content; and 3) suggest a functional role for ERK-dependent l-CaD phosphorylation in cell division. Serine 23-26 mitogen-activated protein kinase 1 Homo sapiens 62-65 10514499-9 1999 These data 1) identify Ser(789) of h-CaD as the major site of ERK-dependent phosphorylation in carotid arteries; 2) show that the level of phosphorylation at Ser(789) is relatively constant following carotid arterial muscle stimulation, despite an increase in total protein phosphate content; and 3) suggest a functional role for ERK-dependent l-CaD phosphorylation in cell division. Serine 158-161 mitogen-activated protein kinase 1 Homo sapiens 62-65 10523304-9 1999 Therefore, p38 plays a key role in the serine phosphorylation of STAT1 and transcriptional changes induced by both IFNs. Serine 39-45 mitogen-activated protein kinase 1 Homo sapiens 11-14 10523304-7 1999 In an inducible 3T3-L1 clone, expression of dominant-negative p38 led to defective STAT1 serine phosphorylation and diminished IFN-gamma-mediated protection against viral killing. Serine 89-95 mitogen-activated protein kinase 1 Homo sapiens 62-65 10473609-0 1999 SH2-B, a membrane-associated adapter, is phosphorylated on multiple serines/threonines in response to nerve growth factor by kinases within the MEK/ERK cascade. Serine 68-75 mitogen-activated protein kinase 1 Homo sapiens 148-151 10417333-0 1999 Extracellular signal-regulated protein kinase (ERK)-dependent and ERK-independent pathways target STAT3 on serine-727 in human neutrophils stimulated by chemotactic factors and cytokines. Serine 107-113 mitogen-activated protein kinase 1 Homo sapiens 47-50 10417333-0 1999 Extracellular signal-regulated protein kinase (ERK)-dependent and ERK-independent pathways target STAT3 on serine-727 in human neutrophils stimulated by chemotactic factors and cytokines. Serine 107-113 mitogen-activated protein kinase 1 Homo sapiens 66-69 10417333-4 1999 (2-Amino-3"-methoxyphenyl)oxanaphthalen-4-one (PD 98059), an inhibitor of extracellular signal-regulated protein kinase (ERK) activation, blocked the serine phosphorylation of STAT3 induced by chemotactic factors or PMA. Serine 150-156 mitogen-activated protein kinase 1 Homo sapiens 74-119 10417333-4 1999 (2-Amino-3"-methoxyphenyl)oxanaphthalen-4-one (PD 98059), an inhibitor of extracellular signal-regulated protein kinase (ERK) activation, blocked the serine phosphorylation of STAT3 induced by chemotactic factors or PMA. Serine 150-156 mitogen-activated protein kinase 1 Homo sapiens 121-124 10417333-7 1999 We propose that neutrophils use both ERK-dependent and ERK-independent pathways to phosphorylate Ser-727 on STAT3. Serine 97-100 mitogen-activated protein kinase 1 Homo sapiens 37-40 10417333-7 1999 We propose that neutrophils use both ERK-dependent and ERK-independent pathways to phosphorylate Ser-727 on STAT3. Serine 97-100 mitogen-activated protein kinase 1 Homo sapiens 55-58 9811754-2 1998 By using biochemical and mass spectrometric analyses of phosphopeptides obtained from metabolically radiolabeled L protein, a single phosphorylation site was identified at serine 118 as part of a PX(S/T)P motif, which is strongly preferred by ERK-type mitogen-activated protein kinases (MAP kinases). Serine 172-178 mitogen-activated protein kinase 1 Homo sapiens 243-246 10347142-1 1999 The functions of beta-arrestin1 to facilitate clathrin-mediated endocytosis of the beta2-adrenergic receptor and to promote agonist-induced activation of extracellular signal-regulated kinases (ERK) are regulated by its phosphorylation/dephosphorylation at Ser-412. Serine 257-260 mitogen-activated protein kinase 1 Homo sapiens 154-192 10347142-1 1999 The functions of beta-arrestin1 to facilitate clathrin-mediated endocytosis of the beta2-adrenergic receptor and to promote agonist-induced activation of extracellular signal-regulated kinases (ERK) are regulated by its phosphorylation/dephosphorylation at Ser-412. Serine 257-260 mitogen-activated protein kinase 1 Homo sapiens 194-197 10347142-5 1999 ERK1 and ERK2 phosphorylate beta-arrestin1 at Ser-412 in vitro. Serine 46-49 mitogen-activated protein kinase 1 Homo sapiens 9-13 10212189-5 1999 UVC-induced phosphorylation of p53 at serine 389 was markedly impaired by either pretreatment of cells with p38 kinase inhibitor, SB202190, or stable expression of a dominant negative mutant of p38 kinase. Serine 38-44 mitogen-activated protein kinase 1 Homo sapiens 194-197 10212189-8 1999 Incubation of active p38 kinase with p53 protein caused the phosphorylation of p53 protein at serine 389 in vitro, while no phosphorylation of p53 at serine 389 was observed when p53 was incubated with activated JNK2 or ERK2. Serine 94-100 mitogen-activated protein kinase 1 Homo sapiens 21-24 10212189-10 1999 These results strongly suggest that the p38 kinase is at least one of the most important mediators of p53 phosphorylation at serine 389 induced by UVC radiation. Serine 125-131 mitogen-activated protein kinase 1 Homo sapiens 40-43 9872331-2 1998 Recent studies have indicated that STATs are also phosphorylated by MAPK, or extracellular signal-regulated kinase (ERK) on serine. Serine 124-130 mitogen-activated protein kinase 1 Homo sapiens 77-114 9872331-2 1998 Recent studies have indicated that STATs are also phosphorylated by MAPK, or extracellular signal-regulated kinase (ERK) on serine. Serine 124-130 mitogen-activated protein kinase 1 Homo sapiens 116-119 9872331-6 1998 ERK2 phosphorylates Stat3 on three serine-containing peptides and decreases its tyrosine phosphorylation induced by EGF treatment. Serine 35-41 mitogen-activated protein kinase 1 Homo sapiens 0-4 10417333-0 1999 Extracellular signal-regulated protein kinase (ERK)-dependent and ERK-independent pathways target STAT3 on serine-727 in human neutrophils stimulated by chemotactic factors and cytokines. Serine 107-113 mitogen-activated protein kinase 1 Homo sapiens 0-45 10212189-0 1999 p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389. Serine 65-71 mitogen-activated protein kinase 1 Homo sapiens 0-3 10212189-4 1999 Here, we report that the UV-induced phosphorylation of p53 at serine 389 is mediated by p38 kinase. Serine 62-68 mitogen-activated protein kinase 1 Homo sapiens 88-91 10212189-5 1999 UVC-induced phosphorylation of p53 at serine 389 was markedly impaired by either pretreatment of cells with p38 kinase inhibitor, SB202190, or stable expression of a dominant negative mutant of p38 kinase. Serine 38-44 mitogen-activated protein kinase 1 Homo sapiens 108-111 9811754-3 1998 ERK2 specifically phosphorylated L at serine 118 in vitro, and L phosphorylation was inhibited by a coexpressed MAP kinase-specific phosphatase. Serine 38-44 mitogen-activated protein kinase 1 Homo sapiens 0-4 9528766-0 1998 Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation. Serine 136-142 mitogen-activated protein kinase 1 Homo sapiens 30-67 9811332-2 1998 The extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway is a likely target, linking receptor tyrosine kinase activation to downstream serine/threonine phosphorylation events regulating proliferation and differentiation. Serine 174-180 mitogen-activated protein kinase 1 Homo sapiens 4-41 9811332-2 1998 The extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway is a likely target, linking receptor tyrosine kinase activation to downstream serine/threonine phosphorylation events regulating proliferation and differentiation. Serine 174-180 mitogen-activated protein kinase 1 Homo sapiens 43-46 9736697-8 1998 MEKs and ERKs inhibited IL-6 activation of Stat3 harboring a mutation at serine-727, the major site for serine phosphorylation, similar to inhibition of wild-type Stat3, and inhibited Janus kinases Jak1 and Jak2 upstream of Stat3 in the Jak-STAT-signaling pathway. Serine 73-79 mitogen-activated protein kinase 1 Homo sapiens 9-13 9736697-8 1998 MEKs and ERKs inhibited IL-6 activation of Stat3 harboring a mutation at serine-727, the major site for serine phosphorylation, similar to inhibition of wild-type Stat3, and inhibited Janus kinases Jak1 and Jak2 upstream of Stat3 in the Jak-STAT-signaling pathway. Serine 104-110 mitogen-activated protein kinase 1 Homo sapiens 9-13 9528766-0 1998 Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation. Serine 136-142 mitogen-activated protein kinase 1 Homo sapiens 72-75 9528766-3 1998 NGF activates the extracellular signal-regulated kinase (ERK) mitogen-activated protein kinases (MAPKs), which in turn activate the pp90 ribosomal S6 kinase (RSK) family of Ser/Thr kinases, all three members of which were found to catalyze CREB Ser-133 phosphorylation in vitro and in vivo. Serine 173-176 mitogen-activated protein kinase 1 Homo sapiens 18-55 9528766-3 1998 NGF activates the extracellular signal-regulated kinase (ERK) mitogen-activated protein kinases (MAPKs), which in turn activate the pp90 ribosomal S6 kinase (RSK) family of Ser/Thr kinases, all three members of which were found to catalyze CREB Ser-133 phosphorylation in vitro and in vivo. Serine 173-176 mitogen-activated protein kinase 1 Homo sapiens 57-60 9528766-4 1998 In addition to the ERK/RSK pathway, we found that NGF activated the p38 MAPK and its downstream effector, MAPK-activated protein kinase 2 (MAPKAP kinase 2), resulting in phosphorylation of CREB at Ser-133. Serine 197-200 mitogen-activated protein kinase 1 Homo sapiens 68-71 9528766-4 1998 In addition to the ERK/RSK pathway, we found that NGF activated the p38 MAPK and its downstream effector, MAPK-activated protein kinase 2 (MAPKAP kinase 2), resulting in phosphorylation of CREB at Ser-133. Serine 197-200 mitogen-activated protein kinase 1 Homo sapiens 72-76 9528766-6 1998 However, inhibition of both the ERK/RSK and the p38/MAPKAP kinase 2 pathways completely abolished NGF-induced CREB Ser-133 phosphorylation. Serine 115-118 mitogen-activated protein kinase 1 Homo sapiens 32-35 9528766-6 1998 However, inhibition of both the ERK/RSK and the p38/MAPKAP kinase 2 pathways completely abolished NGF-induced CREB Ser-133 phosphorylation. Serine 115-118 mitogen-activated protein kinase 1 Homo sapiens 48-51 9335504-4 1997 Phosphorylation occurs at specific serines within the region linking the inhibitory and effector domains of Smad1, and is catalysed by the Erk family of mitogen-activated protein kinases. Serine 35-42 mitogen-activated protein kinase 1 Homo sapiens 139-142 9343414-0 1997 STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Serine 6-12 mitogen-activated protein kinase 1 Homo sapiens 32-35 9343414-4 1997 We provide in vitro and in vivo evidence that the ERK family of mitogen-activated protein (MAP) kinases, but not JNK or p38, specifically phosphorylate STAT3 at serine 727 in response to growth factors. Serine 161-167 mitogen-activated protein kinase 1 Homo sapiens 50-53 9482836-2 1998 We demonstrate that JNK and ERK but not p38 phosphorylate GR in vitro primarily at Ser-246. Serine 83-86 mitogen-activated protein kinase 1 Homo sapiens 28-31 9482836-3 1998 Selective activation of either ERK or JNK in vivo inhibits GR-mediated transcriptional activation, which depends on receptor phosphorylation at Ser-246 by JNK but not ERK. Serine 144-147 mitogen-activated protein kinase 1 Homo sapiens 31-34 9335504-5 1997 In contrast to the BMP-stimulated phosphorylation of Smad1, which affects carboxy-terminal serines and induces nuclear accumulation of Smad1, Erk-mediated phosphorylation specifically inhibits the nuclear accumulation of Smad1. Serine 91-98 mitogen-activated protein kinase 1 Homo sapiens 142-145 9322921-6 1997 In contrast, activation of the ERK MAP kinase pathway with both insulin and osmotic shock resulted in the serine phosphorylation of STAT3. Serine 106-112 mitogen-activated protein kinase 1 Homo sapiens 31-34 9010227-5 1997 We provide evidence that this residue, serine 608 of pRB, is an authentic phosphorylation site that can be phosphorylated in vitro by cyclin A-CDK2 and cyclin D1-CDK4 kinases but not by cyclin E-CDK2 kinase or the mitogen activated kinase ERK2. Serine 39-45 mitogen-activated protein kinase 1 Homo sapiens 239-243 9020176-7 1997 Although PK40(erk2) prefers some phosphorylation sites, most notably Ser235, followed by Ser199 or Ser202 and Thr205, the phosphorylation of multiple Ser/Thr-Pro sites is not highly sequential. Serine 69-72 mitogen-activated protein kinase 1 Homo sapiens 14-18 8668214-4 1996 The results showed that AML1 is phosphorylated in vivo on two serine residues within the proline-, serine-, and threonine-rich region, with dependence on the activation of extracellular signal-regulated kinase (ERK) and with interleukin-3 stimulation in a hematopoietic cell line. Serine 99-105 mitogen-activated protein kinase 1 Homo sapiens 211-214 34314419-4 2021 Migration requires ERG serine 96 phosphorylation via endogenous Ras/ERK signaling. Serine 23-29 mitogen-activated protein kinase 1 Homo sapiens 68-71 8537333-2 1995 STAT activation, which has been described as being Ras-independent, requires tyrosine phosphorylation, but STAT transactivating activity is enhanced by phosphorylation on serine as well, probably by extracellular signal-regulated kinase/mitogen-activated protein kinase(s) (ERK/MAPK). Serine 171-177 mitogen-activated protein kinase 1 Homo sapiens 274-277 8525474-10 1995 Activation of MAPK has been shown to cause activation of AP-1 and other transcription factors via serine and/or threonine phosphorylation. Serine 98-104 mitogen-activated protein kinase 1 Homo sapiens 14-18 7536808-7 1995 In this case two Ser/Thr phosphates are removed at different rates during inactivation: One phosphate is very quickly removed to result in the formation of a high-mobility 39-kDa ERK2 species without consequence for activity; the other, slowly removed Ser/Thr phosphate controls the activity but has no effect on the gel mobility of ERK2. Serine 17-20 mitogen-activated protein kinase 1 Homo sapiens 179-183 7536808-7 1995 In this case two Ser/Thr phosphates are removed at different rates during inactivation: One phosphate is very quickly removed to result in the formation of a high-mobility 39-kDa ERK2 species without consequence for activity; the other, slowly removed Ser/Thr phosphate controls the activity but has no effect on the gel mobility of ERK2. Serine 17-20 mitogen-activated protein kinase 1 Homo sapiens 333-337 7536808-7 1995 In this case two Ser/Thr phosphates are removed at different rates during inactivation: One phosphate is very quickly removed to result in the formation of a high-mobility 39-kDa ERK2 species without consequence for activity; the other, slowly removed Ser/Thr phosphate controls the activity but has no effect on the gel mobility of ERK2. Serine 252-255 mitogen-activated protein kinase 1 Homo sapiens 179-183 8264614-5 1994 The data demonstrate that p42mapk but not p44mapk becomes phosphorylated on serine, threonine, and tyrosine during platelet activation. Serine 76-82 mitogen-activated protein kinase 1 Homo sapiens 26-33 2032290-1 1991 We recently described the purification and cloning of extracellular signal-regulated kinase 1 (ERK1), which appears to play a pivotal role in converting tyrosine phosphorylation into the serine/threonine phosphorylations that regulate downstream events. Serine 187-193 mitogen-activated protein kinase 1 Homo sapiens 54-93 2032290-1 1991 We recently described the purification and cloning of extracellular signal-regulated kinase 1 (ERK1), which appears to play a pivotal role in converting tyrosine phosphorylation into the serine/threonine phosphorylations that regulate downstream events. Serine 187-193 mitogen-activated protein kinase 1 Homo sapiens 95-99 34779126-2 2021 The Moloney sarcoma oncogene (MOS) encodes a serine/threonine kinase that activates the ERK signaling cascade during oocyte maturation in vertebrates. Serine 45-51 mitogen-activated protein kinase 1 Homo sapiens 88-91 34859235-6 2021 The RAS-RAF-MEK-ERK pathway is activated in the majority of cutaneous melanomas, most commonly by point mutations in the Braf serine-threonine kinase. Serine 126-132 mitogen-activated protein kinase 1 Homo sapiens 16-19 34837907-2 2021 Proto-oncogene serine/threonine-protein kinase (RAF-1) functions as a part of the MAPK/ERK signal transduction pathway. Serine 15-21 mitogen-activated protein kinase 1 Homo sapiens 82-86 34837907-2 2021 Proto-oncogene serine/threonine-protein kinase (RAF-1) functions as a part of the MAPK/ERK signal transduction pathway. Serine 15-21 mitogen-activated protein kinase 1 Homo sapiens 87-90 34403210-4 2021 Hypoxia significantly activated extracellular signal-regulated kinase (ERK), increased phosphorylation of dynamin-related protein 1 (Drp1) at serine 616 and decreased phosphorylation of Drp1 at serine 637. Serine 194-200 mitogen-activated protein kinase 1 Homo sapiens 32-69 33971490-1 2021 Mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs) are located at the meeting-point of ERK and p38 MAPK signaling pathways, which can phosphorylate eukaryotic translation initiation factor 4E (eIF4E) at the conserved serine 209 exclusively. Serine 233-239 mitogen-activated protein kinase 1 Homo sapiens 103-106 34699606-4 2021 The mechanism investigation showed that zinc induced activation of extracellular regulated protein kinases (ERK) and Janus kinase 2 (JAK2), which phosphorylated signal transduction and transcription activator 3 (Stat3) at serine 727 (S727-Stat3) and tyrosine 705 (Y705-Stat3) respectively, resulting in activation of Stat3. Serine 222-228 mitogen-activated protein kinase 1 Homo sapiens 67-106 34699606-4 2021 The mechanism investigation showed that zinc induced activation of extracellular regulated protein kinases (ERK) and Janus kinase 2 (JAK2), which phosphorylated signal transduction and transcription activator 3 (Stat3) at serine 727 (S727-Stat3) and tyrosine 705 (Y705-Stat3) respectively, resulting in activation of Stat3. Serine 222-228 mitogen-activated protein kinase 1 Homo sapiens 108-111 34844526-1 2021 B-Raf is one among the most frequently mutating proto-oncogene which is associated with the serine/threonine Raf kinase family involved in the RAS-RAF-MEK-ERK pathway, which is the most deregulated pathway in human cancers. Serine 92-98 mitogen-activated protein kinase 1 Homo sapiens 155-158 34564169-8 2021 RSK is a vertebrate family of cytosolic serine-threonine kinases that act downstream of the ras-ERK1/2 (extracellular-signal-regulated kinase 1/2) pathway, which phosphorylates substrates shown to regulate several cellular processes, including growth, survival, and proliferation. Serine 40-46 mitogen-activated protein kinase 1 Homo sapiens 104-145 34202904-1 2021 Ribosomal S6 Kinases (RSKs) are a group of serine/threonine kinases that function downstream of the Ras/Raf/MEK/ERK signaling pathway. Serine 43-49 mitogen-activated protein kinase 1 Homo sapiens 112-115 35196191-10 2022 Together, we demonstrated that defective autophagy played an important role in EEC-EMT in IUA via the DIO2-MAPK/ERK-MTOR pathway, which provided a potential target for therapeutic implications.Abbreviations: ACTA2/alpha-SMA: actin alpha 2, smooth muscle; AMPK: adenosine 5"-monophosphate-activated protein kinase; AKT/protein kinase B: AKT serine/threonine kinase; ATG: autophagy related; CDH1/E-cadherin: cadherin 1; CDH2/N-cadherin: cadherin 2; CQ: chloroquine; CTSD: cathepsin D; DIO2: iodothyronine deiodinase 2; DEGs: differentially expressed genes; EECs: endometrial epithelial cells; EMT: epithelial-mesenchymal transition; FN1: fibronectin 1; IUA: intrauterine adhesions; LAMP1: lysosomal associated membrane protein 1; LPS: lipopolysaccharide; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAPK: mitogen-activated protein kinase; MTOR: mechanistic target of rapamycin kinase; Rapa: rapamycin; SQSTM1/p62: sequestosome 1; T3: triiodothyronine; T4: tetraiodothyronine; TFEB: transcription factor EB; PBS: phosphate-buffered saline; TEM: transmission electron microscopy; TGFB/TGFbeta: transforming growth factor beta. Serine 340-346 mitogen-activated protein kinase 1 Homo sapiens 112-115 35546143-0 2022 TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC. Serine 38-44 mitogen-activated protein kinase 1 Homo sapiens 30-34 34992144-6 2022 The NSC59984-sustained ERK2 activation is required for MDM2 phosphorylation at serine-166. Serine 79-85 mitogen-activated protein kinase 1 Homo sapiens 23-27 34997083-2 2022 In this molecular dynamics study, we examined how phosphorylation of the PEA-15 C-terminal tail residues, Ser-104 and Ser-116, allosterically mediates conformational changes of the DED and alters the binding specificity from extracellular-regulated kinase (ERK) to Fas-associated death domain (FADD) protein. Serine 106-109 mitogen-activated protein kinase 1 Homo sapiens 225-255 35174144-14 2022 CEFFE protected MLO-Y4 from apoptosis by activating the serine/threonine-selective protein kinase (ERK) signaling pathways. Serine 56-62 mitogen-activated protein kinase 1 Homo sapiens 99-102 35110502-4 2022 Tamoxifen at slightly higher concentrations induced the rapid phosphorylation of EphA2 at Ser-897 via the MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK)-ERK-ribosomal S6 kinases (RSK) pathway in HeLa cells. Serine 90-93 mitogen-activated protein kinase 1 Homo sapiens 168-171 34997083-4 2022 While the unphosphorylated serine residues do not directly interact with ERK2, the phosphorylated Ser-116 engages in strong electrostatic interactions with arginine residues on FADD DED. Serine 98-101 mitogen-activated protein kinase 1 Homo sapiens 73-77 31215069-5 2020 Knockdown of Nqo1 enhanced activity of the serine/threonine phosphatase, protein phosphatase 2A, which operates at the intersection of the PI3K/Akt and MAPK/ERK pathways and dephosphorylates and inactivates pyruvate dehydrogenase kinase 1, Akt, Raf, mitogen-activated protein kinase kinase, and ERK1/2. Serine 43-49 mitogen-activated protein kinase 1 Homo sapiens 157-160 33152171-6 2021 Our data further revealed that DRP1 activation through serine 616 phosphorylation is regulated by ERK/AKT and CDK2 in lung adenocarcinoma cell lines. Serine 55-61 mitogen-activated protein kinase 1 Homo sapiens 98-101 33133138-8 2020 Kinomic analysis using tyrosine (PTK) and serine/threonine (STK) arrays reveals that combination treatment results in the most potent inhibition of kinases involved in the CDK and ERK pathways compared to either agent alone. Serine 42-48 mitogen-activated protein kinase 1 Homo sapiens 180-183 33073187-9 2020 In line with these findings, a C-tail serine/threonine mutant that has decreased beta-arrestin recruitment also showed enhanced ERK activation. Serine 38-44 mitogen-activated protein kinase 1 Homo sapiens 128-131 31053301-4 2019 We also identified Ser-1026 as an ErbB4-specific ERK target site in the CYT-1 region. Serine 19-22 mitogen-activated protein kinase 1 Homo sapiens 49-52 31184227-0 2019 Ras-ERK signalling represses H1.4 phosphorylation at serine 36 to promote non-small-cell lung carcinoma cells growth and migration. Serine 53-59 mitogen-activated protein kinase 1 Homo sapiens 4-7 31387295-4 2019 CDDO-Me increased dynamin-related proteins 1 (DRP1)-serine 616 phosphorylation via activating extracellular-signal-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase (JNK), but not protein kinase A (PKA) or protein phosphatases (PPs). Serine 52-58 mitogen-activated protein kinase 1 Homo sapiens 94-135 30962349-3 2019 We show here that HIF-2alpha is phosphorylated under hypoxia (1% O2) by extracellular signal-regulated protein kinases 1 and 2 (ERK1/2; also known as MAPK3 and MAPK1, respectively) at serine residue 672, as identified by in vitro phosphorylation assays. Serine 184-190 mitogen-activated protein kinase 1 Homo sapiens 160-165 31013829-2 2019 Upon activation, Erk1 and Erk2 directly phosphorylate FGF receptor 1 (FGFR1) at a specific serine residue in the C-terminal part of the receptor, substantially reducing the tyrosine phosphorylation in the receptor kinase domain and its signaling. Serine 91-97 mitogen-activated protein kinase 1 Homo sapiens 26-30 30835471-2 2019 This pathway is under tight regulation, which is in part mediated by dual-specific phosphatases (DUSPs), which dephosphorylate serine, threonine, and tyrosine residues of the ERK family of proteins. Serine 127-133 mitogen-activated protein kinase 1 Homo sapiens 175-178 30972179-6 2019 By site-directed mutagenesis and pharmacological inhibition of MEK, we found that the ubiquitylation of KLF8 by NEDD4 depends upon the phosphorylation of KLF8 at serine 48 by ERK. Serine 162-168 mitogen-activated protein kinase 1 Homo sapiens 175-178 29540527-5 2018 We identify truncated domains of Lin28a and of TRBP that are sufficient to support coassociation and mutual elevation of protein levels, and a requirement for MAPK-dependent phosphorylation of TRBP at putative Erk-target serine 152, as well as Lin28a serine 200 phosphorylation, in mediating the increase of Lin28a protein by TRBP. Serine 221-227 mitogen-activated protein kinase 1 Homo sapiens 159-163 30535970-4 2019 We have previously reported that activation HIF-1alpha by ERK involves modification of two serine residues and masking of a nuclear export signal (NES), all inside a 43-amino acid domain termed ERK Targeted Domain (ETD). Serine 91-97 mitogen-activated protein kinase 1 Homo sapiens 58-61 30009260-5 2018 Using a chemical genetic approach, we identified a key serine residue in TRM9L that undergoes hyperphosphorylation downstream of the oxidative stress-activated MEK (mitogen-activated protein kinase kinase)-ERK (extracellular signal-regulated kinase)-RSK (ribosomal protein S6 kinase) signaling cascade. Serine 55-61 mitogen-activated protein kinase 1 Homo sapiens 206-209 31385665-6 2019 RESULTS: Here we show that the phosphorylation of both Ser residues is mediated mainly by casein kinase 2 (CK2) and that active ERK may assist in the phosphorylation of the N-terminal Ser. Serine 55-58 mitogen-activated protein kinase 1 Homo sapiens 128-131 31385665-6 2019 RESULTS: Here we show that the phosphorylation of both Ser residues is mediated mainly by casein kinase 2 (CK2) and that active ERK may assist in the phosphorylation of the N-terminal Ser. Serine 184-187 mitogen-activated protein kinase 1 Homo sapiens 128-131 30380514-6 2018 Our results showed that cyclonerodiol blocked serine phosphorylation of Stat6 by affecting its association with p38 and Erk1/2. Serine 46-52 mitogen-activated protein kinase 1 Homo sapiens 112-115 29540527-5 2018 We identify truncated domains of Lin28a and of TRBP that are sufficient to support coassociation and mutual elevation of protein levels, and a requirement for MAPK-dependent phosphorylation of TRBP at putative Erk-target serine 152, as well as Lin28a serine 200 phosphorylation, in mediating the increase of Lin28a protein by TRBP. Serine 221-227 mitogen-activated protein kinase 1 Homo sapiens 210-213 29540527-5 2018 We identify truncated domains of Lin28a and of TRBP that are sufficient to support coassociation and mutual elevation of protein levels, and a requirement for MAPK-dependent phosphorylation of TRBP at putative Erk-target serine 152, as well as Lin28a serine 200 phosphorylation, in mediating the increase of Lin28a protein by TRBP. Serine 251-257 mitogen-activated protein kinase 1 Homo sapiens 210-213 29445193-4 2018 Here, we show that in metabolically stressed cancer cells, FoxO3A is recruited to the mitochondria through activation of MEK/ERK and AMPK, which phosphorylate serine 12 and 30, respectively, on FoxO3A N-terminal domain. Serine 159-165 mitogen-activated protein kinase 1 Homo sapiens 125-128 29545175-4 2018 Here, we identified a novel C-RAF-binding protein, RUVBL1, which activates the RAF/MEK/ERK pathway by inhibiting phosphorylation of the C-RAF protein at serine 259. Serine 153-159 mitogen-activated protein kinase 1 Homo sapiens 87-90 29545175-8 2018 In conclusion, we have shown that RUVBL1 could activate the RAF/MEK/ERK pathway by inhibiting phosphorylation of the C-RAF protein at serine 259, to promote lung cancer progression. Serine 134-140 mitogen-activated protein kinase 1 Homo sapiens 68-71 29380370-10 2018 LPS-mediated ERK phosphorylation resulted in FOXC2-ERK protein ligation, ERK-dependent FOXC2 serine and threonine phosphorylation, and subsequent activation of DLL4 gene expression. Serine 93-99 mitogen-activated protein kinase 1 Homo sapiens 13-16 29197575-1 2018 Our previous study showed that the phosphorylation of a highly conserved serine residue, Ser16 in the human immunodeficiency virus type 1 (HIV-1) capsid (CA) protein is promoted by virion-incorporated extracellular signal-regulated kinase 2 (ERK2) and required for proper peptidyl-prolyl isomerase (Pin1)-mediated uncoating. Serine 73-79 mitogen-activated protein kinase 1 Homo sapiens 242-246 28383811-5 2018 ERK activation subsequently phosphorylates HSF1 at serine 307, leading to a secondary phosphorylation by glycogen synthase kinase III (GSK3) at serine 303. Serine 51-57 mitogen-activated protein kinase 1 Homo sapiens 0-3 28383811-5 2018 ERK activation subsequently phosphorylates HSF1 at serine 307, leading to a secondary phosphorylation by glycogen synthase kinase III (GSK3) at serine 303. Serine 144-150 mitogen-activated protein kinase 1 Homo sapiens 0-3 30381640-6 2018 Interestingly, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, an AMP-activated protein kinase activator, suppresses TNF-alpha-induced IRS-1 serine phosphorylation at 636/639 and the phosphorylation of ERK by enhancing interactions between ERK and dual-specificity phosphatase-9. Serine 149-155 mitogen-activated protein kinase 1 Homo sapiens 210-213 30381640-6 2018 Interestingly, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, an AMP-activated protein kinase activator, suppresses TNF-alpha-induced IRS-1 serine phosphorylation at 636/639 and the phosphorylation of ERK by enhancing interactions between ERK and dual-specificity phosphatase-9. Serine 149-155 mitogen-activated protein kinase 1 Homo sapiens 248-251 28887309-6 2017 Here, we report a mechanism whereby ERK-mediated phosphorylation of ERG at one serine residue causes a conformational change that allows ERK phosphorylation at a second serine residue, Ser-96. Serine 79-85 mitogen-activated protein kinase 1 Homo sapiens 36-39 28887309-6 2017 Here, we report a mechanism whereby ERK-mediated phosphorylation of ERG at one serine residue causes a conformational change that allows ERK phosphorylation at a second serine residue, Ser-96. Serine 79-85 mitogen-activated protein kinase 1 Homo sapiens 137-140 28887309-6 2017 Here, we report a mechanism whereby ERK-mediated phosphorylation of ERG at one serine residue causes a conformational change that allows ERK phosphorylation at a second serine residue, Ser-96. Serine 169-175 mitogen-activated protein kinase 1 Homo sapiens 36-39 28887309-6 2017 Here, we report a mechanism whereby ERK-mediated phosphorylation of ERG at one serine residue causes a conformational change that allows ERK phosphorylation at a second serine residue, Ser-96. Serine 169-175 mitogen-activated protein kinase 1 Homo sapiens 137-140 28887309-6 2017 Here, we report a mechanism whereby ERK-mediated phosphorylation of ERG at one serine residue causes a conformational change that allows ERK phosphorylation at a second serine residue, Ser-96. Serine 185-188 mitogen-activated protein kinase 1 Homo sapiens 36-39 28887309-6 2017 Here, we report a mechanism whereby ERK-mediated phosphorylation of ERG at one serine residue causes a conformational change that allows ERK phosphorylation at a second serine residue, Ser-96. Serine 185-188 mitogen-activated protein kinase 1 Homo sapiens 137-140 27689466-6 2017 Immunoblot analysis revealed that cisplatin induced the phosphorylation of ERalpha at serine 118 via ERK cascade. Serine 86-92 mitogen-activated protein kinase 1 Homo sapiens 101-104 26303380-4 2016 The extracellular signal-regulated kinases (ERK) inhibitor U0126 suppressed cerulein-induced phosphorylation of serine 431 and reorganization of K8. Serine 112-118 mitogen-activated protein kinase 1 Homo sapiens 4-42 28393288-1 2017 p38 mitogen-activated protein kinase (MAPK) belongs to the MAPK superfamily, phosphorylating serine and/or threonine residues of the target proteins. Serine 93-99 mitogen-activated protein kinase 1 Homo sapiens 0-3 27924567-5 2017 This detachment exposes ERK1/2 to additional phosphorylation on two serine residues (SPS motif) within the nuclear translocation signal (NTS) of the kinases. Serine 68-74 mitogen-activated protein kinase 1 Homo sapiens 24-30 27986870-0 2016 MEK-ERK-mediated phosphorylation of Mdm2 at Ser-166 in hepatocytes. Serine 44-47 mitogen-activated protein kinase 1 Homo sapiens 4-7 28076932-11 2016 These results suggest that the Ser at the 4166 site in PC1 is crucial in the PC1 mediated MEK/ERK/myc signaling pathway, which might be the key pathophysiological cause of AD. Serine 31-34 mitogen-activated protein kinase 1 Homo sapiens 94-97 26303380-4 2016 The extracellular signal-regulated kinases (ERK) inhibitor U0126 suppressed cerulein-induced phosphorylation of serine 431 and reorganization of K8. Serine 112-118 mitogen-activated protein kinase 1 Homo sapiens 44-47 27793200-1 2016 BACKGROUND: MEK1 (MAP2K1) and MEK2 (MAP2K2) are closely related dual-specificity protein kinases which function by phosphorylating both serine/threonine and tyrosine residues of their substrates ERK1 and ERK2, controlling fundamental cellular processes that include cell growth and proliferation. Serine 136-142 mitogen-activated protein kinase 1 Homo sapiens 204-208 27339895-5 2016 Upon stimulating MOLT-4 with ionophore A23187/phorbol myristate acetate, endogenous IkappaBalpha and ERK undergo rapid phosphorylation in <5 min, and subsequently WWOX is Tyr-33 and Tyr-287 de-phosphorylated and Ser-14 phosphorylated. Serine 215-218 mitogen-activated protein kinase 1 Homo sapiens 101-104 27009860-0 2016 ERK2 phosphorylation of EBNA1 serine 383 residue is important for EBNA1-dependent transactivation. Serine 30-36 mitogen-activated protein kinase 1 Homo sapiens 0-4 27080258-8 2016 Thus, phosphorylation of YB-1 on Ser(102) is PKA-, ERK-, and RSK-2-dependent. Serine 33-36 mitogen-activated protein kinase 1 Homo sapiens 51-54 27080258-12 2016 Collectively, our results reveal that phosphorylation of YB-1 on Ser(102) via the ERK/RSK-2 signaling pathway is necessary for FSH-mediated expression of target genes required for maturation of follicles to a preovulatory phenotype. Serine 65-68 mitogen-activated protein kinase 1 Homo sapiens 82-85 27055868-0 2016 MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation. Serine 32-38 mitogen-activated protein kinase 1 Homo sapiens 5-9 27009860-3 2016 In accordance, ERK2 was found to phosphorylate EBNA1 serine 383 in a reaction suppressed by H20 (a structural congener of the ERK inhibitor), U0126 (an inhibitor of MEK kinase), and mutations at substrate (S383A) or putative ERK docking sites. Serine 53-59 mitogen-activated protein kinase 1 Homo sapiens 15-19 27009860-3 2016 In accordance, ERK2 was found to phosphorylate EBNA1 serine 383 in a reaction suppressed by H20 (a structural congener of the ERK inhibitor), U0126 (an inhibitor of MEK kinase), and mutations at substrate (S383A) or putative ERK docking sites. Serine 53-59 mitogen-activated protein kinase 1 Homo sapiens 15-18 27009860-3 2016 In accordance, ERK2 was found to phosphorylate EBNA1 serine 383 in a reaction suppressed by H20 (a structural congener of the ERK inhibitor), U0126 (an inhibitor of MEK kinase), and mutations at substrate (S383A) or putative ERK docking sites. Serine 53-59 mitogen-activated protein kinase 1 Homo sapiens 126-129 27293988-0 2016 ERK2 phosphorylates Kruppel-like factor 8 protein at serine 48 to maintain its stability. Serine 53-59 mitogen-activated protein kinase 1 Homo sapiens 0-4 26846853-8 2016 beta-Arrestins also interact with non-phosphorylated ERK (extracellular signal-regulated protein kinase) through the arrestin-C domain to inhibit ERK phosphorylation, which affects Dorsal translocation into the nucleus and phosphorylation of Dorsal at Ser(276)that impairs Dorsal transcriptional activity. Serine 252-255 mitogen-activated protein kinase 1 Homo sapiens 53-56 26846853-8 2016 beta-Arrestins also interact with non-phosphorylated ERK (extracellular signal-regulated protein kinase) through the arrestin-C domain to inhibit ERK phosphorylation, which affects Dorsal translocation into the nucleus and phosphorylation of Dorsal at Ser(276)that impairs Dorsal transcriptional activity. Serine 252-255 mitogen-activated protein kinase 1 Homo sapiens 58-103 26846853-8 2016 beta-Arrestins also interact with non-phosphorylated ERK (extracellular signal-regulated protein kinase) through the arrestin-C domain to inhibit ERK phosphorylation, which affects Dorsal translocation into the nucleus and phosphorylation of Dorsal at Ser(276)that impairs Dorsal transcriptional activity. Serine 252-255 mitogen-activated protein kinase 1 Homo sapiens 146-149 25915848-5 2016 Mechanistically, PXN-mediated extracellular signal-regulated kinases (ERK) activation is responsible for TKI resistance via decreased Bcl2-interacting mediator of cell death (BIM) and increased Mcl-1 expression due to modulating their protein stabilities by phosphorylation of BIM at serine 69 and Mcl-1 at threonine 163. Serine 284-290 mitogen-activated protein kinase 1 Homo sapiens 30-68 25915848-5 2016 Mechanistically, PXN-mediated extracellular signal-regulated kinases (ERK) activation is responsible for TKI resistance via decreased Bcl2-interacting mediator of cell death (BIM) and increased Mcl-1 expression due to modulating their protein stabilities by phosphorylation of BIM at serine 69 and Mcl-1 at threonine 163. Serine 284-290 mitogen-activated protein kinase 1 Homo sapiens 70-73 26245900-4 2015 ERK silencing enhanced BIM up-regulation by GDC-0623 that was due to its loss of phosphorylation at Ser(69), confirmed by a BIM-EL phosphorylation-defective mutant (S69G) that increased protein stability and blocked BIM induction. Serine 100-103 mitogen-activated protein kinase 1 Homo sapiens 0-3 26346493-7 2016 S421 resides within a Ser-Pro phosphoacceptor motif that is typical for ERK1/2 and recombinant ERK2 phosphorylated DYRK1B at S421 in vitro. Serine 22-25 mitogen-activated protein kinase 1 Homo sapiens 95-99 28008418-6 2016 Association of ERK with mGluR1/5 enables the kinase to phosphorylate mGluR1/5 at a cluster of serine sites in the distal C terminus, including a serine residue within the Homer binding site. Serine 94-100 mitogen-activated protein kinase 1 Homo sapiens 15-18 28008418-6 2016 Association of ERK with mGluR1/5 enables the kinase to phosphorylate mGluR1/5 at a cluster of serine sites in the distal C terminus, including a serine residue within the Homer binding site. Serine 145-151 mitogen-activated protein kinase 1 Homo sapiens 15-18 25658205-4 2015 This fission is driven by Erk2-mediated phosphorylation of Drp1 on Serine 616, and both this phosphorylation and mitochondrial fragmentation are increased in human pancreatic cancer. Serine 67-73 mitogen-activated protein kinase 1 Homo sapiens 26-30 26171055-10 2015 In addition, EGF-induced tyrosine phosphorylation of the EGF receptor (EGFR) and tyrosine/serine phosphorylation of extracellular signal-regulated kinase (ERK) were also inhibited by infection with Ad-PKG II and treatment with the NO donor or precursor. Serine 90-96 mitogen-activated protein kinase 1 Homo sapiens 116-153 26171055-10 2015 In addition, EGF-induced tyrosine phosphorylation of the EGF receptor (EGFR) and tyrosine/serine phosphorylation of extracellular signal-regulated kinase (ERK) were also inhibited by infection with Ad-PKG II and treatment with the NO donor or precursor. Serine 90-96 mitogen-activated protein kinase 1 Homo sapiens 155-158 25908842-3 2015 RIP1 activates ERK, which negatively regulates TFEB though phosphorylation of serine 142. Serine 78-84 mitogen-activated protein kinase 1 Homo sapiens 15-18 25701783-2 2015 In contrast to the canonical EGFR activation in which tyrosine residues are engaged, we have demonstrated that the non-canonical pathway is triggered by phosphorylation of serine and threonine residues through p38 and ERK MAPKs, respectively. Serine 172-178 mitogen-activated protein kinase 1 Homo sapiens 218-221 26194464-3 2015 Smad2 linker phosphorylated by extracellular signal-regulated kinase (ERK) at the serine 255 residue interacts with STAT3 and p300 to transactivate, whereas carboxy-terminal unphosphorylated Smad3 interacts with STAT3 and protein inhibitor of activated STAT3 (PIAS3) to repress the Rorc and Il17a genes. Serine 82-88 mitogen-activated protein kinase 1 Homo sapiens 31-68 26194464-3 2015 Smad2 linker phosphorylated by extracellular signal-regulated kinase (ERK) at the serine 255 residue interacts with STAT3 and p300 to transactivate, whereas carboxy-terminal unphosphorylated Smad3 interacts with STAT3 and protein inhibitor of activated STAT3 (PIAS3) to repress the Rorc and Il17a genes. Serine 82-88 mitogen-activated protein kinase 1 Homo sapiens 70-73 26181363-4 2015 In the present study, we identified extracellular signal-regulated kinase (ERK)1/2 as the kinase responsible for phosphorylating the regulatory site, Ser(280), which leads to increased levels of mono-ubiquitination and an overall increase in MHC II activity. Serine 150-153 mitogen-activated protein kinase 1 Homo sapiens 36-82 26054059-1 2015 The F-recruitment site (FRS) of active ERK2 binds F-site (Phe-x-Phe-Pro) sequences found downstream of the Ser/Thr phospho-acceptor on cellular substrates. Serine 107-110 mitogen-activated protein kinase 1 Homo sapiens 39-43 25826088-0 2015 Paxillin promotes colorectal tumor invasion and poor patient outcomes via ERK-mediated stabilization of Bcl-2 protein by phosphorylation at Serine 87. Serine 140-146 mitogen-activated protein kinase 1 Homo sapiens 74-77 25826088-2 2015 Here, we present evidence from cell and animal models to demonstrate that stabilization of Bcl-2 protein by phosphorylation at Serine 87 (pBcl-2-S87) via PXN-mediated ERK activation is responsible for cancer cell invasiveness and occurs via upregulation of MMP2 expression. Serine 127-133 mitogen-activated protein kinase 1 Homo sapiens 167-170 24308965-7 2014 By overexpression of HSP27(15A) or HSP27(78/82A) phosphorylation mutant, we further showed that phosphorylation of HSP27 at serine 78/82 residues was essential to TRAIL-triggered Src-Akt/ERK signaling transduction. Serine 124-130 mitogen-activated protein kinase 1 Homo sapiens 187-190 25425646-7 2015 Using selective pharmacological inhibitors, we show that CCR7-induced phosphorylation of AMPK on Ser-485 is mediated by MEK and ERK. Serine 97-100 mitogen-activated protein kinase 1 Homo sapiens 128-131 25391654-7 2015 Similarly phosphorylation of Ser(910) by ERK in response to bombesin was increased by FAT opening. Serine 29-32 mitogen-activated protein kinase 1 Homo sapiens 41-44 25204653-5 2014 Studies of the epitope sequence recognized by the M-18 MKP-1 antibody revealed extensive phosphorylation of two serine residues in the C terminus of both MKP-1 and MKP-2 by the ERK pathway. Serine 112-118 mitogen-activated protein kinase 1 Homo sapiens 177-180 25478290-9 2014 Reduction of MUC18 serine phosphorylation by inhibiting ERK activity was associated with less production of IL-8 following polyI:C stimulation. Serine 19-25 mitogen-activated protein kinase 1 Homo sapiens 56-59 24509437-0 2014 Phosphorylation of human immunodeficiency virus type 1 capsid protein at serine 16, required for peptidyl-prolyl isomerase-dependent uncoating, is mediated by virion-incorporated extracellular signal-regulated kinase 2. Serine 73-79 mitogen-activated protein kinase 1 Homo sapiens 179-218 24509437-3 2014 Here, we showed that virion-associated extracellular signal-regulated kinase 2 (ERK2) phosphorylates Ser(16). Serine 101-104 mitogen-activated protein kinase 1 Homo sapiens 39-78 24509437-3 2014 Here, we showed that virion-associated extracellular signal-regulated kinase 2 (ERK2) phosphorylates Ser(16). Serine 101-104 mitogen-activated protein kinase 1 Homo sapiens 80-84 24509437-5 2014 Furthermore, a mass spectrometry-based in vitro kinase assay demonstrated that ERK2 specifically phosphorylated the Ser(16) residue in the Ser(16)-Pro(17) motif-containing substrate. Serine 116-119 mitogen-activated protein kinase 1 Homo sapiens 79-83 24509437-5 2014 Furthermore, a mass spectrometry-based in vitro kinase assay demonstrated that ERK2 specifically phosphorylated the Ser(16) residue in the Ser(16)-Pro(17) motif-containing substrate. Serine 139-142 mitogen-activated protein kinase 1 Homo sapiens 79-83 24509437-6 2014 The treatment of CEM/LAV-1 cells with the ERK2 inhibitor sc-222229 decreased the Ser(16) phosphorylation level inside virions, and virus partially defective in Ser(16) phosphorylation showed impaired reverse transcription and attenuated replication owing to attenuated Pin1-dependent uncoating. Serine 81-84 mitogen-activated protein kinase 1 Homo sapiens 42-46 24509437-6 2014 The treatment of CEM/LAV-1 cells with the ERK2 inhibitor sc-222229 decreased the Ser(16) phosphorylation level inside virions, and virus partially defective in Ser(16) phosphorylation showed impaired reverse transcription and attenuated replication owing to attenuated Pin1-dependent uncoating. Serine 160-163 mitogen-activated protein kinase 1 Homo sapiens 42-46 24509437-7 2014 Furthermore, the suppression of ERK2 expression by RNA interference in CEM/LAV-1 cells resulted in suppressed ERK2 packaging inside virions and decreased the Ser(16) phosphorylation level inside virions. Serine 158-161 mitogen-activated protein kinase 1 Homo sapiens 32-36 24626525-7 2014 Furthermore, it was demonstrated that cholera toxin downregulated the activation of the c-Raf/Mek/Erk cascade, an important mediator of tumor cell proliferation, via the PKA-dependent c-Raf phosphorylation at Ser-43. Serine 209-212 mitogen-activated protein kinase 1 Homo sapiens 98-101 25353341-4 2014 In contrast, ERK and JNK phosphorylate SREBP-1c at two major sites, i.e. threonine 81 and serine 93, instead of one site in SREBP-1a. Serine 90-96 mitogen-activated protein kinase 1 Homo sapiens 13-16 24681962-8 2014 nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) was the major activator of C7ORF41 that in turn repressed NF-kappaB activity by inhibiting its phosphorylation at serine 536, while MAPK/ERK was the potent repressor of C7ORF41. Serine 189-195 mitogen-activated protein kinase 1 Homo sapiens 207-211 24681962-8 2014 nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) was the major activator of C7ORF41 that in turn repressed NF-kappaB activity by inhibiting its phosphorylation at serine 536, while MAPK/ERK was the potent repressor of C7ORF41. Serine 189-195 mitogen-activated protein kinase 1 Homo sapiens 212-215 24049075-4 2013 Here we report that MED14, a core subunit of the Mediator, is a bona fide ERK substrate and identify serine 986 (S986) within a serine-proline rich region of MED14 as the major ERK phosphorylation site. Serine 101-107 mitogen-activated protein kinase 1 Homo sapiens 177-180 24520095-7 2014 However, sorafenib blocked MPT0E028-induced Erk activation and its downstream signaling cascades, such as Stat3 phosphorylation (Ser(727)) and Mcl-1 upregulation. Serine 129-132 mitogen-activated protein kinase 1 Homo sapiens 44-47 24498195-0 2014 ERK MAP kinase activation in spinal cord regulates phosphorylation of Cdk5 at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity. Serine 78-84 mitogen-activated protein kinase 1 Homo sapiens 0-3 24525237-3 2014 Here, we show that downregulation of wild-type H-Ras or N-Ras in mutant K-Ras cancer cells leads to hyperactivation of the Erk/p90RSK and PI3K/Akt pathways and, consequently, the phosphorylation of Chk1 at an inhibitory site, Ser 280. Serine 226-229 mitogen-activated protein kinase 1 Homo sapiens 123-126 24049075-4 2013 Here we report that MED14, a core subunit of the Mediator, is a bona fide ERK substrate and identify serine 986 (S986) within a serine-proline rich region of MED14 as the major ERK phosphorylation site. Serine 128-134 mitogen-activated protein kinase 1 Homo sapiens 177-180 24312439-0 2013 The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation. Serine 37-43 mitogen-activated protein kinase 1 Homo sapiens 8-11 23874979-2 2013 In response to T cell receptor agonist engagement, ERK is activated to positively regulate T cell receptor signaling through phosphorylation of Ser(59) Lck. Serine 144-147 mitogen-activated protein kinase 1 Homo sapiens 51-54 24080014-11 2013 Collectively, these data suggest that Serine-204 phosphorylation in the Smad3LR is a critical event by which ERK enhances Smad3-mediated COL1A2 promoter activity in mesenchymal cells. Serine 38-44 mitogen-activated protein kinase 1 Homo sapiens 109-112 23892079-2 2013 ERK"s role in NO induction may be through phosphorylation of serine-171 of IRF3 and expression of NO-inducing cytokines, IL-6 and IFN-beta. Serine 61-67 mitogen-activated protein kinase 1 Homo sapiens 0-3 24023871-7 2013 Acetylated 14-3-3zeta released its mask effect on serine 259 of c-Raf and serine 216 of Cdc25C subsequent to de-phosphorylation by PP1alpha, which contributed to ERK activation. Serine 63-69 mitogen-activated protein kinase 1 Homo sapiens 175-178 24023871-7 2013 Acetylated 14-3-3zeta released its mask effect on serine 259 of c-Raf and serine 216 of Cdc25C subsequent to de-phosphorylation by PP1alpha, which contributed to ERK activation. Serine 87-93 mitogen-activated protein kinase 1 Homo sapiens 175-178 22183614-8 2013 For the first time, this study demonstrated that the poultry PM-induced IL-8 secretion by human lung epithelial cells was regulated by cPLA2 activation through ERK-mediated serine phosphorylation, suggesting a mechanism of airway inflammation among poultry farm workers. Serine 173-179 mitogen-activated protein kinase 1 Homo sapiens 160-163 23822636-1 2013 We have recently identified tumor necrosis factor (TNF)-alpha-induced phosphorylation of epidermal growth factor receptor (EGFR) at Thr-669 and Ser-1046/1047 via ERK and p38 pathways, respectively. Serine 144-147 mitogen-activated protein kinase 1 Homo sapiens 162-165 23348708-7 2013 Taken together, these results suggest that the ERK-mediated Ser phosphorylation of p47(phox) is not implicated in the assembly of NADPH oxidase or O2( -) generation, and that O2( -) generation is partly attributable to p38 MAPK signaling through mechanisms other than p47(phox) activation, Akt activation and S100A9 membrane recruitment in fMLP-stimulated neutrophils. Serine 60-63 mitogen-activated protein kinase 1 Homo sapiens 47-50 23814485-8 2013 Moreover, modification of the p53 serine 46 residue was critical for RKIP induction and ERK suppression as well as cellular senescence. Serine 34-40 mitogen-activated protein kinase 1 Homo sapiens 88-91 23667643-8 2013 Further, ERK overexpression increased IL-10 promoter activity stimulated by wild-type human GR but not by its mutant defective in serine 203, whereas ERK knockdown abolished NDV/DEX cooperation on IL-10 mRNA and phosphorylation of the mouse GR at serine 213. Serine 130-136 mitogen-activated protein kinase 1 Homo sapiens 9-12 23667643-8 2013 Further, ERK overexpression increased IL-10 promoter activity stimulated by wild-type human GR but not by its mutant defective in serine 203, whereas ERK knockdown abolished NDV/DEX cooperation on IL-10 mRNA and phosphorylation of the mouse GR at serine 213. Serine 247-253 mitogen-activated protein kinase 1 Homo sapiens 9-12 23653349-1 2013 PAK1 plays an important role in proliferation and tumorigenesis, at least partially by promoting ERK phosphorylation of C-RAF (Ser-338) or MEK1 (Ser-298). Serine 127-130 mitogen-activated protein kinase 1 Homo sapiens 97-100 23529931-7 2013 Our results suggest that endothelial ERK signaling is critical for both arteriogenesis and arterial-venous patterning and that RAF1 Ser(259) phosphorylation plays a critical role in preventing unopposed ERK activation. Serine 132-135 mitogen-activated protein kinase 1 Homo sapiens 203-206 23426330-5 2013 Moreover, the phosphorylation of XBP1u by mitogen-activated protein kinases 1 and 3 (MAPK1/3, also known as ERK2/1) on serine residues 61 and 176 was found to be essential for the enhancement of the interaction between XBP1u and FOXO1. Serine 119-125 mitogen-activated protein kinase 1 Homo sapiens 108-114 23017243-10 2012 PD98059 (ERK inhibitor) suppressed Comp A-induced phosphorylation of serine 431 and reorganization of K8. Serine 69-75 mitogen-activated protein kinase 1 Homo sapiens 9-12 23434660-6 2013 We find that ERK phosphorylates IC-2 on a novel, highly conserved Serine residue proximal to the binding site for the p150Glued subunit of the cargo adapter dynactin. Serine 66-72 mitogen-activated protein kinase 1 Homo sapiens 13-16 23405013-4 2013 We identified a regulatory mechanism of FGFR signaling involving phosphorylation of Ser(777) in the C-terminal region of FGFR1 by the MAPKs extracellular signal-regulated kinase 1 (ERK1) and ERK2. Serine 84-87 mitogen-activated protein kinase 1 Homo sapiens 140-179 23405013-4 2013 We identified a regulatory mechanism of FGFR signaling involving phosphorylation of Ser(777) in the C-terminal region of FGFR1 by the MAPKs extracellular signal-regulated kinase 1 (ERK1) and ERK2. Serine 84-87 mitogen-activated protein kinase 1 Homo sapiens 181-185 23405013-4 2013 We identified a regulatory mechanism of FGFR signaling involving phosphorylation of Ser(777) in the C-terminal region of FGFR1 by the MAPKs extracellular signal-regulated kinase 1 (ERK1) and ERK2. Serine 84-87 mitogen-activated protein kinase 1 Homo sapiens 191-195 23811561-9 2013 Under hypoxic condition without reperfusion, EPO-induced ERK activation was associated with post-translational modification of GATA-4, mediated by enhancement of phosphorylation of GATA-4 at Ser-105. Serine 191-194 mitogen-activated protein kinase 1 Homo sapiens 57-60 22298426-9 2012 The netrin-2-mediated NFATc3 activation was coincident with robust interactions between Cdo and Stim1 in myoblasts and the ERK-mediated Stim1 phosphorylation at serine 575. Serine 161-167 mitogen-activated protein kinase 1 Homo sapiens 123-126 22955283-6 2012 Mutation of either Ser-354 or Ser-359 abolished ERK-dependent NIPA phosphorylation. Serine 19-22 mitogen-activated protein kinase 1 Homo sapiens 48-51 22955283-6 2012 Mutation of either Ser-354 or Ser-359 abolished ERK-dependent NIPA phosphorylation. Serine 30-33 mitogen-activated protein kinase 1 Homo sapiens 48-51 23178880-2 2012 Here we demonstrate that EGFR-activated ERK2 binds directly to PKM2 Ile 429/Leu 431 through the ERK2 docking groove and phosphorylates PKM2 at Ser 37, but does not phosphorylate PKM1. Serine 143-146 mitogen-activated protein kinase 1 Homo sapiens 40-44 22767595-6 2012 This decrease was mediated by MEK/ERK signaling, which enhanced phosphorylation at serine 6 in the neprilysin intracellular domain (S6-NEP-ICD). Serine 83-89 mitogen-activated protein kinase 1 Homo sapiens 34-37 22370157-3 2012 Here, using mass spectrometry, we uncovered three serines (S75, S87, and S105) in the N-terminus of hERbeta as targets of ERK1/2 and p38 kinases. Serine 50-57 mitogen-activated protein kinase 1 Homo sapiens 133-136 22586091-7 2012 The luciferase reporter assays in combination with mutations of MEK and Etv1 indicated that the Erk-mediated, phosphorylated Etv1 interacted with the Ets motifs of the NR2C promoter sequence and that phosphorylation at both serine 94 and a cluster of threonines and a serine (Thr139, Thr143, and Ser146) of Etv1 was indispensable for the BDNF-mediated activation of the NR2C promoter activity. Serine 224-230 mitogen-activated protein kinase 1 Homo sapiens 96-99 22586091-7 2012 The luciferase reporter assays in combination with mutations of MEK and Etv1 indicated that the Erk-mediated, phosphorylated Etv1 interacted with the Ets motifs of the NR2C promoter sequence and that phosphorylation at both serine 94 and a cluster of threonines and a serine (Thr139, Thr143, and Ser146) of Etv1 was indispensable for the BDNF-mediated activation of the NR2C promoter activity. Serine 268-274 mitogen-activated protein kinase 1 Homo sapiens 96-99 22298426-11 2012 Taken together, the results indicate that cell adhesion signaling triggered by netrin-2/Cdo induces Stim1 phosphorylation at serine 575 by ERK, which promotes myoblast differentiation. Serine 125-131 mitogen-activated protein kinase 1 Homo sapiens 139-142 22392765-4 2012 The function of eIF4E is modulated through phosphorylation of a conserved serine (Ser209) by Mnk1 and Mnk2 downstream of ERK. Serine 74-80 mitogen-activated protein kinase 1 Homo sapiens 121-124 22258404-0 2012 ERK2 phosphorylation of serine 77 regulates Bmf pro-apoptotic activity. Serine 24-30 mitogen-activated protein kinase 1 Homo sapiens 0-4 22258404-7 2012 Extracellular signal-regulated kinase (ERK2) directly phosphorylates Bmf on serine 74 and serine 77 residues with serine 77 being the predominant site. Serine 76-82 mitogen-activated protein kinase 1 Homo sapiens 39-43 22033920-10 2011 Using phospho-specific antibodies, we identified Ser-403 and Ser-505 as the ERK2 targets that promote Pin1-mediated PML degradation. Serine 49-52 mitogen-activated protein kinase 1 Homo sapiens 76-80 22033920-10 2011 Using phospho-specific antibodies, we identified Ser-403 and Ser-505 as the ERK2 targets that promote Pin1-mediated PML degradation. Serine 61-64 mitogen-activated protein kinase 1 Homo sapiens 76-80 22292133-4 2011 Activation of the MAPK pathway, which results from a mutation of NRAS, induces phosphorylation of BRAF on serine 151 by ERK which prevents its binding to NRAS. Serine 106-112 mitogen-activated protein kinase 1 Homo sapiens 18-22 21908610-5 2011 DUSP9/MKP-4 is phosphorylated on Ser-58 by PKA in vitro, and phosphorylation abrogates the binding of DUSP9/MKP-4 to both ERK2 and p38alpha MAP kinases. Serine 33-36 mitogen-activated protein kinase 1 Homo sapiens 122-126 21730285-4 2011 Here we show that the phosphorylation of both Ser residues is mediated mainly by casein kinase 2 (CK2) and that active ERK may assist in the phosphorylation of the N-terminal Ser. Serine 175-178 mitogen-activated protein kinase 1 Homo sapiens 119-122 22292133-4 2011 Activation of the MAPK pathway, which results from a mutation of NRAS, induces phosphorylation of BRAF on serine 151 by ERK which prevents its binding to NRAS. Serine 106-112 mitogen-activated protein kinase 1 Homo sapiens 120-123 21392397-2 2011 Phosphorylation of YB-1 at serine residue 102 (S102) in response to growth factors is required for its transcriptional activity and is thought to be regulated by cytoplasmic signaling phosphatidylinositol 3-kinase (PI3K)/Akt and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathways. Serine 27-33 mitogen-activated protein kinase 1 Homo sapiens 306-309 21285457-9 2011 The Ser(132) loop of CD154 is not involved in CD40 binding but its substitution significantly reduces p38- and ERK-dependent signaling by CD40, whereas JNK-dependent signaling is not affected. Serine 4-7 mitogen-activated protein kinase 1 Homo sapiens 111-114 21187384-4 2011 Serine 91 is the principal residue in GRH that is phosphorylated by ERK. Serine 0-6 mitogen-activated protein kinase 1 Homo sapiens 68-71 21148411-8 2011 AII-induced ERK activation was reduced by >65% by synthetic peptides containing an RGD (arginine-glycine-aspartic acid) sequence that inhibit alpha(5)beta(1)-integrin, and by ~60% by the KTS (lysine-threonine-serine)-containing peptides specific for integrin-alpha(1)beta(1). Serine 212-218 mitogen-activated protein kinase 1 Homo sapiens 12-15 20015194-2 2011 The B1 kinin receptor (B1R) post-translationally activates iNOS beyond its basal activity via extracellular signal regulated kinase (ERK)-mediated phosphorylation of Ser(745) . Serine 166-169 mitogen-activated protein kinase 1 Homo sapiens 94-131 20015194-2 2011 The B1 kinin receptor (B1R) post-translationally activates iNOS beyond its basal activity via extracellular signal regulated kinase (ERK)-mediated phosphorylation of Ser(745) . Serine 166-169 mitogen-activated protein kinase 1 Homo sapiens 133-136 20729206-3 2010 Growth factor receptors activate m-calpain secondary to phosphorylation on serine 50 by ERK. Serine 75-81 mitogen-activated protein kinase 1 Homo sapiens 88-91 21102438-7 2010 AKAP-Lbc functions as an enhancer of ERK signalling by securing RAF in the vicinity of MEK1 and synchronizing protein kinase A (PKA)-mediated phosphorylation of Ser 838 on KSR-1. Serine 161-164 mitogen-activated protein kinase 1 Homo sapiens 37-40 20675591-3 2010 In this study, we demonstrate that the IFN-gamma-mediated phosphorylation of STAT1 on Ser(727), crucial for its maximal activity, was attenuated in human macrophages by pharmacological inhibition of ERK. Serine 86-89 mitogen-activated protein kinase 1 Homo sapiens 199-202 20101459-6 2010 RESULTS: Our results revealed that the specific MAPK-ERK cascade inhibitor, PD98059, significantly attenuated phosphorylation of c-Myc on Ser-62 and FasL upregulation in QBC-939 cells and these cells showed decreased cytotoxicity against Fas-sensitive Jurkat T cells. Serine 138-141 mitogen-activated protein kinase 1 Homo sapiens 53-56 20178980-8 2010 8-Br-cAMP greatly increased the phosphorylation of CREB1 (Ser(133)) and ATF2 (Thr(71)) in a PKA-, PI3K-, and ERK-dependent fashion. Serine 58-61 mitogen-activated protein kinase 1 Homo sapiens 109-112 20361728-1 2010 ERK2, a major effector of the BRAF oncogene, is a promiscuous protein kinase that has a strong preference for phosphorylating substrates on Ser-Pro or Thr-Pro motifs. Serine 140-143 mitogen-activated protein kinase 1 Homo sapiens 0-4 20459645-15 2010 However, OPN-induced phosphorylation of p70S6 kinase at Thr-421/Ser-424 is being controlled by MEK/ERK pathway. Serine 64-67 mitogen-activated protein kinase 1 Homo sapiens 99-102 20122898-3 2010 We previously showed that as a physiological consequence of their interaction, activated ERK phosphorylates MKP-7 at Ser-446, and stabilizing MKP-7. Serine 117-120 mitogen-activated protein kinase 1 Homo sapiens 89-92 20015475-11 2010 Pretreatment of U87-MG cells with the ERK inhibitor PD98059, accentuated ERK inhibition and increased CREB phosphorylation at Ser-133 and CREB-driven transcription stimulated by PGE(2), suggesting that inhibition of ERK contributes to PGE(2)-induced CREB activation. Serine 126-129 mitogen-activated protein kinase 1 Homo sapiens 38-41 20160123-7 2010 Furthermore, treatment with inhibitors of the MAPK kinase 1/ERK or mTOR/p70S6K1 signaling pathways prevented PGF2alpha-induced serine phosphorylation of IRS1 and abrogated the inhibitory actions of PGF2alpha on Akt activation. Serine 127-133 mitogen-activated protein kinase 1 Homo sapiens 46-50 20160123-7 2010 Furthermore, treatment with inhibitors of the MAPK kinase 1/ERK or mTOR/p70S6K1 signaling pathways prevented PGF2alpha-induced serine phosphorylation of IRS1 and abrogated the inhibitory actions of PGF2alpha on Akt activation. Serine 127-133 mitogen-activated protein kinase 1 Homo sapiens 60-63 19429262-11 2009 Data suggest that STAT3 is phosphorylated at serine 727 by a Cd stress-activated signaling pathway inducing NADPH oxidase activity which produced ROS, leading ERK activation. Serine 45-51 mitogen-activated protein kinase 1 Homo sapiens 159-162 19464346-7 2010 Independently, the PKC-alpha/Erk pathway, participates in LHR gene expression through induction of Sp1 phosphorylation at Ser site(s) other than Ser641. Serine 122-125 mitogen-activated protein kinase 1 Homo sapiens 29-32 19801668-8 2009 In addition to confirming ERK-dependent phosphorylation at Ser(319), mass spectroscopy identified two other ERK-phosphorylated sites at Ser(43) and Ser(510). Serine 59-62 mitogen-activated protein kinase 1 Homo sapiens 26-29 19801668-8 2009 In addition to confirming ERK-dependent phosphorylation at Ser(319), mass spectroscopy identified two other ERK-phosphorylated sites at Ser(43) and Ser(510). Serine 136-139 mitogen-activated protein kinase 1 Homo sapiens 108-111 19801668-8 2009 In addition to confirming ERK-dependent phosphorylation at Ser(319), mass spectroscopy identified two other ERK-phosphorylated sites at Ser(43) and Ser(510). Serine 136-139 mitogen-activated protein kinase 1 Homo sapiens 108-111 19447520-6 2009 Furthermore, SGK1 mediated the phosphorylation of ERK2 on Ser(29) in a serum-dependent manner. Serine 58-61 mitogen-activated protein kinase 1 Homo sapiens 50-54 19447520-7 2009 Replacement of Ser(29) to aspartic acid, which mimics the phosphorylation of Ser(29), enhanced the ERK2 activity as well as the MEK/ERK complexes formation. Serine 15-18 mitogen-activated protein kinase 1 Homo sapiens 99-103 19447520-7 2009 Replacement of Ser(29) to aspartic acid, which mimics the phosphorylation of Ser(29), enhanced the ERK2 activity as well as the MEK/ERK complexes formation. Serine 15-18 mitogen-activated protein kinase 1 Homo sapiens 99-102 19623651-7 2009 Further, mechanistic study revealed that PGE(2) increased the protein stability and nuclear accumulation of c-Myc via phosphorylation on serine 62 in an extracellular signal regulated kinase (ERK)-dependent manner. Serine 137-143 mitogen-activated protein kinase 1 Homo sapiens 153-190 19623651-7 2009 Further, mechanistic study revealed that PGE(2) increased the protein stability and nuclear accumulation of c-Myc via phosphorylation on serine 62 in an extracellular signal regulated kinase (ERK)-dependent manner. Serine 137-143 mitogen-activated protein kinase 1 Homo sapiens 192-195 20087429-5 2009 A complex of activated PR, Erk and Msk1 is recruited to promoter after 5 min of hormone treatment and phosphorylates histone H3 at serine 10. Serine 131-137 mitogen-activated protein kinase 1 Homo sapiens 27-30 19687304-4 2009 Experiments using chemical inhibitors and small interfering RNA demonstrated that TNF-alpha-mediated phosphorylation of Thr-669 and Ser-1046/7 were differently regulated via TAK1-extracellular signal-regulated kinase (ERK) and TAK1-p38 pathways, respectively. Serine 132-135 mitogen-activated protein kinase 1 Homo sapiens 174-216 19687304-4 2009 Experiments using chemical inhibitors and small interfering RNA demonstrated that TNF-alpha-mediated phosphorylation of Thr-669 and Ser-1046/7 were differently regulated via TAK1-extracellular signal-regulated kinase (ERK) and TAK1-p38 pathways, respectively. Serine 132-135 mitogen-activated protein kinase 1 Homo sapiens 218-221 19401382-8 2009 TLR2 ligands elicited the time-dependent activation of p38 MAPK and ERK1/2 pathways, which led to phosphorylation of cPLA(2)alpha at Ser(505). Serine 133-136 mitogen-activated protein kinase 1 Homo sapiens 55-58 19274665-10 2009 Our results demonstrated for the first time how stromal CM acts in synergy with androgen by activation of ERK kinase and AR phosphorylation at Ser-81 but not Ser-213, for AR-regulated PSA promoter and anchorage-independent growth of human prostate cancer cells. Serine 143-146 mitogen-activated protein kinase 1 Homo sapiens 106-109 19274665-11 2009 CONCLUSIONS: A stromal factor-activated ERK pathway mediated by AR phosphorylation at Ser-81 could be responsible for stimulating the growth of human prostate cancer cells. Serine 86-89 mitogen-activated protein kinase 1 Homo sapiens 40-43 19361221-5 2009 Here we have modeled the interaction of ERK with a target peptide and analyzed the specificity toward Ser/Thr-Pro motifs. Serine 102-105 mitogen-activated protein kinase 1 Homo sapiens 40-43 19885032-7 2009 Finally, we determined that the inhibition of ERK prevented injury-induced serine phosphorylation of STAT3 in an ex-vivo explants culture of the sciatic nerves. Serine 75-81 mitogen-activated protein kinase 1 Homo sapiens 46-49 19885032-8 2009 Collectively, the results of this study show that ERK may be an upstream kinase for the serine phosphorylation of STAT3 induced by multiple stimuli in Schwann cells after peripheral nerve injury. Serine 88-94 mitogen-activated protein kinase 1 Homo sapiens 50-53 19885032-2 2009 In this study, we determined that nerve injury-induced ERK activation was temporally correlated with STAT3 phosphorylation at the serine 727 residue. Serine 130-136 mitogen-activated protein kinase 1 Homo sapiens 55-58 19885032-3 2009 In cultured Schwann cells, we noted that ERK activation is required for the serine phosphorylation of STAT3 by neuropoietic cytokine interleukin-6 (IL-6). Serine 76-82 mitogen-activated protein kinase 1 Homo sapiens 41-44 19885032-4 2009 Serine phosphorylated STAT3 by IL-6 was transported into Schwann cell nuclei, thereby indicating that ERK may regulate the transcriptional activity of STAT3 via the induction of serine phosphorylation of STAT3. Serine 0-6 mitogen-activated protein kinase 1 Homo sapiens 102-105 19885032-4 2009 Serine phosphorylated STAT3 by IL-6 was transported into Schwann cell nuclei, thereby indicating that ERK may regulate the transcriptional activity of STAT3 via the induction of serine phosphorylation of STAT3. Serine 178-184 mitogen-activated protein kinase 1 Homo sapiens 102-105 19885032-5 2009 Neuregulin-1 (NRG) also induced the serine phosphorylation of STAT3 in an ERK-dependent fashion. Serine 36-42 mitogen-activated protein kinase 1 Homo sapiens 74-77 18632853-5 2008 In an in vitro kinase assay, serine 177 of SHDAg was phosphorylated directly by either Flag-ERK1 or Flag-ERK2. Serine 29-35 mitogen-activated protein kinase 1 Homo sapiens 105-109 19153083-5 2009 ERK-dependent phosphorylation at Ser(412) was compromised in the D26A/D29A-betaarrestin1 mutant. Serine 33-36 mitogen-activated protein kinase 1 Homo sapiens 0-3 19109187-4 2009 Elucidation of the cell-signaling pathway by which GSK3 controlled ERK activity demonstrated that GSK3 inhibition resulted in an abrogation in the levels of the inhibitory residue serine 71 on Rac1 and increased the ability of Rac1 to interact with and activate p21-activated protein kinase. Serine 180-186 mitogen-activated protein kinase 1 Homo sapiens 67-70 18829462-9 2008 Combination of the Arg to Ser mutation with the sevenmaker mutation (producing Erk2(R65S+D319N) and Rolled(R80S+D334N)) resulted in even higher activity (45 and 70%, respectively, in reference to fully active dually phosphorylated Erk2 or Rolled). Serine 26-29 mitogen-activated protein kinase 1 Homo sapiens 79-83 18829462-9 2008 Combination of the Arg to Ser mutation with the sevenmaker mutation (producing Erk2(R65S+D319N) and Rolled(R80S+D334N)) resulted in even higher activity (45 and 70%, respectively, in reference to fully active dually phosphorylated Erk2 or Rolled). Serine 26-29 mitogen-activated protein kinase 1 Homo sapiens 231-235 19405034-9 2009 Interestingly, (41)Ser is a predicted p38/MAPK phosphorylation site, consistent with the loss of phosphorylation induced by SB203580. Serine 19-22 mitogen-activated protein kinase 1 Homo sapiens 38-41 18658095-10 2009 ADAM17 was found to be physically associated with active ERK and phosphorylated at serine residues in an ERK-dependent manner in wounded cells. Serine 83-89 mitogen-activated protein kinase 1 Homo sapiens 105-108 18852266-3 2008 We have previously identified extracellular signal-regulated kinases 1 and 2 (ERK1/2) as the kinases responsible for the phosphorylation of human SK1 at Ser(225), but the corresponding phosphatase targeting this phosphorylation has remained undefined. Serine 153-156 mitogen-activated protein kinase 1 Homo sapiens 30-76 18855718-4 2008 At early intracellular level angiotensin II acts on JAK-2/IRS1-IRS2/PI3-kinase, JNK and ERK to phosphorylate serine residues of key elements of insulin signaling pathway therefore inhibiting signaling by the insulin receptor. Serine 109-115 mitogen-activated protein kinase 1 Homo sapiens 88-91 18694962-4 2008 The key site, serine 454, resembles a mitogen-activated protein kinase phosphorylation site, and its modification was blocked by the MEK1 inhibitor U0126, implying that extracellular signal-regulated kinase 1/2 (ERK1/2) is the serum-inducible kinase that phosphorylates MKL1. Serine 14-20 mitogen-activated protein kinase 1 Homo sapiens 169-210 18454176-6 2008 Moreover, GATA-6 was phosphorylated at serine residues by MEK-activated ERK, which increased GATA-6 DNA binding, correlating with suppression of the Nox1 promoter activity by an MEK inhibitor PD98059. Serine 39-45 mitogen-activated protein kinase 1 Homo sapiens 72-75 18762583-2 2008 We show that stimulation of interphase cells with the mitogens epidermal growth factor or lysophosphatidic acid activates the extracellular signal-regulated kinase (ERK), which phosphorylates the Golgi structural protein GRASP65 at serine 277. Serine 232-238 mitogen-activated protein kinase 1 Homo sapiens 126-163 18762583-2 2008 We show that stimulation of interphase cells with the mitogens epidermal growth factor or lysophosphatidic acid activates the extracellular signal-regulated kinase (ERK), which phosphorylates the Golgi structural protein GRASP65 at serine 277. Serine 232-238 mitogen-activated protein kinase 1 Homo sapiens 165-168 18476811-4 2008 Phosphorylation of Ago2 at serine-387 was significantly induced by treatment with sodium arsenite or anisomycin, and arsenite-induced phosphorylation was inhibited by a p38 MAPK (mitogen-activated protein kinase) inhibitor, but not by inhibitors of JNK (c-Jun N-terminal kinase) or MEK [MAPK/ERK (extracellular-signal-regulated kinase) kinase]. Serine 27-33 mitogen-activated protein kinase 1 Homo sapiens 169-172 18476811-4 2008 Phosphorylation of Ago2 at serine-387 was significantly induced by treatment with sodium arsenite or anisomycin, and arsenite-induced phosphorylation was inhibited by a p38 MAPK (mitogen-activated protein kinase) inhibitor, but not by inhibitors of JNK (c-Jun N-terminal kinase) or MEK [MAPK/ERK (extracellular-signal-regulated kinase) kinase]. Serine 27-33 mitogen-activated protein kinase 1 Homo sapiens 173-177 18476811-7 2008 These results suggest a potential regulatory mechanism for RNA silencing acting through Ago2 serine-387 phosphorylation mediated by the p38 MAPK pathway. Serine 93-99 mitogen-activated protein kinase 1 Homo sapiens 136-139 18476811-7 2008 These results suggest a potential regulatory mechanism for RNA silencing acting through Ago2 serine-387 phosphorylation mediated by the p38 MAPK pathway. Serine 93-99 mitogen-activated protein kinase 1 Homo sapiens 140-144 18487214-6 2008 Further analysis indicated that the p38 MAPK inhibitor SB 203580 inhibited EGF-stimulated phosphorylation of Akt on serine 473, which may be responsible for the effect SB 203580 has on CTB motility. Serine 116-122 mitogen-activated protein kinase 1 Homo sapiens 36-39 18378670-5 2008 Active p42/p44 MAPK-ERK phosphorylates STAT1 on serine 727 and targets it for proteasomal degradation. Serine 48-54 mitogen-activated protein kinase 1 Homo sapiens 20-23 18372343-6 2008 PMA caused a significant enhancement of Sp1 phosphorylation at serine residue (s), which was blocked by PKCalpha or ERK inhibition. Serine 63-69 mitogen-activated protein kinase 1 Homo sapiens 116-119 18245089-5 2008 In this study we show that the extracellular signal-regulated kinases 1 and 2 (ERK1/2) interact directly with CIITA, targeting serine residues in the amino terminus of the protein, including serine 288. Serine 191-197 mitogen-activated protein kinase 1 Homo sapiens 31-77 18245089-5 2008 In this study we show that the extracellular signal-regulated kinases 1 and 2 (ERK1/2) interact directly with CIITA, targeting serine residues in the amino terminus of the protein, including serine 288. Serine 127-133 mitogen-activated protein kinase 1 Homo sapiens 31-77 18258304-7 2008 In addition, we also observed that inhibition of the ERK pathway led to a reduction in TNF-induced NF-kappaB transcriptional activity; this was accompanied by an ablation of TNF-induced p65 phosphorylation at serine 276. Serine 209-215 mitogen-activated protein kinase 1 Homo sapiens 53-56 18084034-4 2008 We identified serine 537 of PAP as a unique phosphorylation site by ERK. Serine 14-20 mitogen-activated protein kinase 1 Homo sapiens 68-71 18372406-3 2008 Previous studies have shown that serine 118 (S118) in AF-1 is phosphorylated by extracellular signal-regulated kinases 1 and 2 (Erk1/2) mitogen-activated protein kinase (MAPK) in a ligand-independent manner. Serine 33-39 mitogen-activated protein kinase 1 Homo sapiens 80-126 18417338-6 2008 A complex of activated PR, Erk and Msk1 is recruited to promoter already 5 min after hormone treatment and phosphorylates histone H3 at serine 10, leading to displacement of HP1gamma, as a requisite for recruitment of Src1, chromatin remodeling complexes (hSnf2h and Brg1) and RNA polymerase II. Serine 136-142 mitogen-activated protein kinase 1 Homo sapiens 27-30 18204781-7 2008 Inhibition of ERK activity by an inhibitor (PD98059) of MAPK/extracellular signal-regulated kinase kinase (MEK1) decreased the LMP1-induced activation of STAT3 Ser 727. Serine 160-163 mitogen-activated protein kinase 1 Homo sapiens 14-17 18204781-7 2008 Inhibition of ERK activity by an inhibitor (PD98059) of MAPK/extracellular signal-regulated kinase kinase (MEK1) decreased the LMP1-induced activation of STAT3 Ser 727. Serine 160-163 mitogen-activated protein kinase 1 Homo sapiens 61-98 18084034-5 2008 PAP phosphorylation of serine 537 by ERK increased its nonspecific polyadenylation activity in vitro. Serine 23-29 mitogen-activated protein kinase 1 Homo sapiens 37-40 18596912-5 2008 The genomic activity of PPARgamma is modulated, in addition to ligand binding, by phosphorylation of a serine residue by MAPKs, such as extracellular signal-regulated protein kinases-1/2 (ERK-1/2), or by nucleocytoplasmic compartmentalization through the ERK activators MAPK kinases-1/2 (MEK-1/2). Serine 103-109 mitogen-activated protein kinase 1 Homo sapiens 188-191 17685427-2 2007 Here, we show that Sp3, which, as Sp1, belongs to the GC-rich binding transcription factor family, is also phosphorylated by Erk in vitro on serine 73. Serine 141-147 mitogen-activated protein kinase 1 Homo sapiens 125-128 17804409-5 2007 In HEK293 cells transfected with human iNOS and B1R, ERK phosphorylated iNOS on Ser745 as determined by Western analysis using phospho-Ser antibody, in vitro kinase assays with activated ERK, and MALDI-TOF mass spectrometry. Serine 80-83 mitogen-activated protein kinase 1 Homo sapiens 53-56 17804409-5 2007 In HEK293 cells transfected with human iNOS and B1R, ERK phosphorylated iNOS on Ser745 as determined by Western analysis using phospho-Ser antibody, in vitro kinase assays with activated ERK, and MALDI-TOF mass spectrometry. Serine 80-83 mitogen-activated protein kinase 1 Homo sapiens 187-190 17709378-0 2007 Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages. Serine 28-34 mitogen-activated protein kinase 1 Homo sapiens 89-126 17615152-9 2007 These data suggest that there may be distinct groups of genes down-regulated by ERalpha and suggest a novel role for ERK phosphorylation at serine 118 in AF1 in regulating expression of the set of genes down-regulated by OHT. Serine 140-146 mitogen-activated protein kinase 1 Homo sapiens 117-120 17693641-11 2007 The combination of our in vitro and in vivo data suggests that ERK2 can regulate TPPP activity via the phosphorylation of Thr(14) and/or Ser(18) in its unfolded N-terminal tail. Serine 137-140 mitogen-activated protein kinase 1 Homo sapiens 63-67 17640984-9 2007 Finally, in vitro phosphorylation of a Ser(629)-containing IRS-1 fragment with Akt reduces the subsequent ability of ERK to phosphorylate Ser(636/639). Serine 39-42 mitogen-activated protein kinase 1 Homo sapiens 117-120 17640984-9 2007 Finally, in vitro phosphorylation of a Ser(629)-containing IRS-1 fragment with Akt reduces the subsequent ability of ERK to phosphorylate Ser(636/639). Serine 138-141 mitogen-activated protein kinase 1 Homo sapiens 117-120 17623675-10 2007 Taken together, these results strongly suggested that the ERK2-mediated C-terminal serine phosphorylation of p300 was a key event in the regulation of EGF-induced keratin 16 expression. Serine 83-89 mitogen-activated protein kinase 1 Homo sapiens 58-62 17314031-4 2007 We find that PAK phosphorylation of MEK1 serine 298 stimulates MEK1 autophosphorylation on the activation loop, and activation of MEK1 activity towards ERK in in vitro reconstitution experiments. Serine 41-47 mitogen-activated protein kinase 1 Homo sapiens 152-155 17404396-0 2007 Involvement of ERKs, RSK2 and PKR in UVA-induced signal transduction toward phosphorylation of eIF2alpha (Ser(51)). Serine 106-109 mitogen-activated protein kinase 1 Homo sapiens 15-19 17404396-9 2007 In vitro and in vivo kinase assays indicated that phosphorylation of eIF2alpha at Ser(51) occurred indirectly through ERK2, RSK2 or p38 kinase in the cellular response to UVA. Serine 82-85 mitogen-activated protein kinase 1 Homo sapiens 118-122 17404396-9 2007 In vitro and in vivo kinase assays indicated that phosphorylation of eIF2alpha at Ser(51) occurred indirectly through ERK2, RSK2 or p38 kinase in the cellular response to UVA. Serine 82-85 mitogen-activated protein kinase 1 Homo sapiens 132-135 17623675-0 2007 ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression. Serine 25-31 mitogen-activated protein kinase 1 Homo sapiens 0-4 17623675-5 2007 The six potential ERK2 phosphorylation sites, including three threonine and three serine residues as revealed by sequential analysis, were first identified in vitro. Serine 82-88 mitogen-activated protein kinase 1 Homo sapiens 18-22 17314031-5 2007 Serines 218 and/or 222 in the MEK1 activation loop are required for PAK-stimulated MEK1 activity towards ERK. Serine 0-7 mitogen-activated protein kinase 1 Homo sapiens 105-108 17579083-4 2007 SAA evoked concurrent activation of the ERK and PI3K/Akt signaling pathways, leading to phosphorylation of BAD at Ser(112) and Ser(136), respectively, and to prevention of collapse of mitochondrial transmembrane potential, cytochrome c release, and caspase-3 activation. Serine 114-117 mitogen-activated protein kinase 1 Homo sapiens 40-43 17579083-4 2007 SAA evoked concurrent activation of the ERK and PI3K/Akt signaling pathways, leading to phosphorylation of BAD at Ser(112) and Ser(136), respectively, and to prevention of collapse of mitochondrial transmembrane potential, cytochrome c release, and caspase-3 activation. Serine 127-130 mitogen-activated protein kinase 1 Homo sapiens 40-43 17334779-7 2007 Ser(15) phosphorylation of p53 was increased by anoxia in an NHE- and p38 MAPK-independent manner, while Akt activity was unaffected. Serine 0-3 mitogen-activated protein kinase 1 Homo sapiens 70-73 16710359-4 2006 This antiapoptotic effect is not mediated by an increase in H(+)-ATPase activity but through activation of the Ras-mitogen-activated protein kinase (MAPK)-signaling pathway that results in the serine phosphorylation of Bad at residues 112 and 155. Serine 193-199 mitogen-activated protein kinase 1 Homo sapiens 149-153 17209041-13 2007 Our results suggest that amino acids Ser(770) and Ser(771) mediate ERK-dependent activation of the Na(+)/H(+) exchanger in vivo. Serine 37-40 mitogen-activated protein kinase 1 Homo sapiens 67-70 17209041-13 2007 Our results suggest that amino acids Ser(770) and Ser(771) mediate ERK-dependent activation of the Na(+)/H(+) exchanger in vivo. Serine 50-53 mitogen-activated protein kinase 1 Homo sapiens 67-70 17505626-6 2007 At an early intracellular level, AII, acting through JAK-2/IRS-1/PI3-kinase, JNK and ERK, may induce the serine phosphorylation and inhibition of key elements of the Ins-signaling pathway. Serine 105-111 mitogen-activated protein kinase 1 Homo sapiens 85-88 17107963-0 2007 MEK-ERK-mediated phosphorylation of Mdm2 at Ser-166 in hepatocytes. Serine 44-47 mitogen-activated protein kinase 1 Homo sapiens 4-7 17107963-5 2007 Also, bile acids and oxidative stress induced phosphorylation of Mdm2 at Ser-166 by an apparently MEK-ERK-dependent mechanism. Serine 73-76 mitogen-activated protein kinase 1 Homo sapiens 102-105 16733250-7 2006 Because mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) has been suggested to phosphorylate Amph I at Ser-293, our efforts addressed whether Ser-293 is phosphorylated in vivo by MAPK/ERK or by Mnb/Dyrk1A. Serine 136-139 mitogen-activated protein kinase 1 Homo sapiens 80-84 17105191-10 2006 These data suggest that ERK2 uses two weak docking interactions to specifically assemble the complex, perhaps in doing so denying Ser-26 access to the active site. Serine 130-133 mitogen-activated protein kinase 1 Homo sapiens 24-28 16733250-7 2006 Because mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) has been suggested to phosphorylate Amph I at Ser-293, our efforts addressed whether Ser-293 is phosphorylated in vivo by MAPK/ERK or by Mnb/Dyrk1A. Serine 136-139 mitogen-activated protein kinase 1 Homo sapiens 85-88 16733250-9 2006 Epigallocatechin-3-gallate, a potent Mnb/Dyrk1A inhibitor in vitro, apparently reduced the phosphorylation at Ser-293, whereas PD98059, a potent MAPK/ERK inhibitor, did not. Serine 110-113 mitogen-activated protein kinase 1 Homo sapiens 150-153 16767165-9 2006 Whereas, epidermal growth factor activates a MAPK/ERK/RSK1 module leading to inactivation of BAD via Ser(75) phosphorylation, the presence of serum, on the other hand, induces a nonconducive intracellular environment for mitochondrial translocation of dephosphorylated BAD. Serine 101-104 mitogen-activated protein kinase 1 Homo sapiens 50-53 16644734-7 2006 Phosphorylation of the human TH isoform 1 at serine 31 by extracellular signal-regulated protein kinase (ERK) also produced a 9-fold increase in the rate of phosphorylation of serine 40, whereas little effect was seen in the TH isoforms 3 and 4. Serine 45-51 mitogen-activated protein kinase 1 Homo sapiens 58-103 16644734-7 2006 Phosphorylation of the human TH isoform 1 at serine 31 by extracellular signal-regulated protein kinase (ERK) also produced a 9-fold increase in the rate of phosphorylation of serine 40, whereas little effect was seen in the TH isoforms 3 and 4. Serine 45-51 mitogen-activated protein kinase 1 Homo sapiens 105-108 16644734-7 2006 Phosphorylation of the human TH isoform 1 at serine 31 by extracellular signal-regulated protein kinase (ERK) also produced a 9-fold increase in the rate of phosphorylation of serine 40, whereas little effect was seen in the TH isoforms 3 and 4. Serine 176-182 mitogen-activated protein kinase 1 Homo sapiens 58-103 16644734-7 2006 Phosphorylation of the human TH isoform 1 at serine 31 by extracellular signal-regulated protein kinase (ERK) also produced a 9-fold increase in the rate of phosphorylation of serine 40, whereas little effect was seen in the TH isoforms 3 and 4. Serine 176-182 mitogen-activated protein kinase 1 Homo sapiens 105-108