PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25937027-10 2015 HB-EGF activated the ERK and p38 MAP kinases and stimulated phosphorylation of Smad1 at an inhibitory serine site which was associated with inhibition of OP-1 mediated proteoglycan synthesis and reduced aggrecan (ACAN) but not COL2A1 expression. Serine 102-108 SMAD family member 1 Homo sapiens 79-84 22021003-5 2012 Deletion analyses of Zranb2 indicated that the serine/arginine-rich (SR) domain and the glutamine-rich domain were required for the inhibition of BMP activity and the interaction with Smad1, respectively. Serine 47-53 SMAD family member 1 Homo sapiens 184-189 25469313-11 2014 The role of preconditioning with BMP2 in osteogenesis was validated by findings of increased gene expression of SMAD1 and an increase in dual phosphorylation of ser 463 and ser 465 in the SMAD 1/5/8 pathway. Serine 161-164 SMAD family member 1 Homo sapiens 188-196 24664641-10 2014 Oxidative stress also increased p38 phosphorylation, which resulted in phosphorylation of Smad1 at the Ser(206) inhibitory site and reduced nuclear accumulation of Smad1. Serine 103-106 SMAD family member 1 Homo sapiens 90-95 25469313-11 2014 The role of preconditioning with BMP2 in osteogenesis was validated by findings of increased gene expression of SMAD1 and an increase in dual phosphorylation of ser 463 and ser 465 in the SMAD 1/5/8 pathway. Serine 173-176 SMAD family member 1 Homo sapiens 188-196 19594322-1 2010 Phosphorylation of Smad1/5/8 at carboxyl-terminal serine residues by type I receptors activates downstream bone morphogenetic protein (BMP) signaling. Serine 50-56 SMAD family member 1 Homo sapiens 19-26 18436795-7 2008 The mechanism involves ERK1/2-dependent phosphorylation of the Smad1 linker region (serine 206), which limits C-terminal serine 463/465 phosphorylation and inhibits Smad nuclear accumulation. Serine 84-90 SMAD family member 1 Homo sapiens 63-68 18436795-7 2008 The mechanism involves ERK1/2-dependent phosphorylation of the Smad1 linker region (serine 206), which limits C-terminal serine 463/465 phosphorylation and inhibits Smad nuclear accumulation. Serine 84-90 SMAD family member 1 Homo sapiens 63-67 18436795-7 2008 The mechanism involves ERK1/2-dependent phosphorylation of the Smad1 linker region (serine 206), which limits C-terminal serine 463/465 phosphorylation and inhibits Smad nuclear accumulation. Serine 121-127 SMAD family member 1 Homo sapiens 63-68 18436795-7 2008 The mechanism involves ERK1/2-dependent phosphorylation of the Smad1 linker region (serine 206), which limits C-terminal serine 463/465 phosphorylation and inhibits Smad nuclear accumulation. Serine 121-127 SMAD family member 1 Homo sapiens 63-67 17363596-3 2007 Expression of dominant-negative Smad1, in which serines at the COOH-terminal SSVS motif are converted to alanines, suppressed MIS-induced Smad1 phosphorylation and impaired MIS-stimulated Gro-beta promoter-driven reporter expression and Gro-beta mRNA. Serine 48-55 SMAD family member 1 Homo sapiens 32-37 11509558-3 2001 BMP addition triggers Smad1 serine phosphorylation, binding of Smad4, and its accumulation in the nucleus. Serine 28-34 SMAD family member 1 Homo sapiens 22-27 9335504-4 1997 Phosphorylation occurs at specific serines within the region linking the inhibitory and effector domains of Smad1, and is catalysed by the Erk family of mitogen-activated protein kinases. Serine 35-42 SMAD family member 1 Homo sapiens 108-113 9335504-5 1997 In contrast to the BMP-stimulated phosphorylation of Smad1, which affects carboxy-terminal serines and induces nuclear accumulation of Smad1, Erk-mediated phosphorylation specifically inhibits the nuclear accumulation of Smad1. Serine 91-98 SMAD family member 1 Homo sapiens 53-58 9136927-5 1997 Phosphorylation of Smad1 in vivo involves serines in the carboxy-terminal motif SSXS. Serine 42-49 SMAD family member 1 Homo sapiens 19-24 9136927-7 1997 Mutation of these carboxy-terminal serines prevents several Smad1 activation events, namely, Smad1 association with the related protein DPC4, accumulation in the nucleus, and gain of transcriptional activity. Serine 35-42 SMAD family member 1 Homo sapiens 60-65 9136927-7 1997 Mutation of these carboxy-terminal serines prevents several Smad1 activation events, namely, Smad1 association with the related protein DPC4, accumulation in the nucleus, and gain of transcriptional activity. Serine 35-42 SMAD family member 1 Homo sapiens 93-98 8663601-0 1996 Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1. Serine 0-6 SMAD family member 1 Homo sapiens 115-120