PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31387295-4 2019 CDDO-Me increased dynamin-related proteins 1 (DRP1)-serine 616 phosphorylation via activating extracellular-signal-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase (JNK), but not protein kinase A (PKA) or protein phosphatases (PPs). Serine 52-58 dynamin 1 like Homo sapiens 18-44 31305892-6 2019 The effect of CSF treatment on the morphology of mitochondria was characterized by phosphorylation of serine 637 on the dynamin-related protein DRP1, a post-translational modification responsible for unopposed mitochondrial fusion in response to low glucose conditions. Serine 102-108 dynamin 1 like Homo sapiens 144-148 31533986-0 2019 The phosphorylation status of Ser-637 in dynamin-related protein 1 (Drp1) does not determine Drp1 recruitment to mitochondria. Serine 30-33 dynamin 1 like Homo sapiens 41-66 31533986-0 2019 The phosphorylation status of Ser-637 in dynamin-related protein 1 (Drp1) does not determine Drp1 recruitment to mitochondria. Serine 30-33 dynamin 1 like Homo sapiens 68-72 31533986-2 2019 Reversible Drp1 phosphorylation has been implicated in the regulation of this process, but whether Drp1 phosphorylation at Ser-637 determines its subcellular localization and fission activity remains to be fully elucidated. Serine 123-126 dynamin 1 like Homo sapiens 99-103 31533986-3 2019 Here, using HEK 293T cells and immunofluorescence, immunoblotting, RNAi, subcellular fractionation, co-immunoprecipitation assays, and CRISPR/Cas9 genome editing, we show that Drp1 phosphorylated at Ser-637 (Drp1pS637) resides both in the cytosol and on mitochondria. Serine 199-202 dynamin 1 like Homo sapiens 176-180 31533986-5 2019 We also noted that protein kinase A (PKA), which mediates phosphorylation of Drp1 on Ser-637, is partially present on mitochondria and interacts with both MIEFs and Mff. Serine 85-88 dynamin 1 like Homo sapiens 77-81 31533986-9 2019 In conclusion, the Ser-637 phosphorylation status in Drp1 is not a determinant that controls Drp1 recruitment to mitochondria. Serine 19-22 dynamin 1 like Homo sapiens 53-57 31387295-4 2019 CDDO-Me increased dynamin-related proteins 1 (DRP1)-serine 616 phosphorylation via activating extracellular-signal-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase (JNK), but not protein kinase A (PKA) or protein phosphatases (PPs). Serine 52-58 dynamin 1 like Homo sapiens 46-50 29953931-5 2018 Our studies show that expression of constitutively active RhoA in cardiomyocytes increases phosphorylation of Dynamin-related protein 1 (Drp1) at serine-616, and leads to localization of Drp1 at mitochondria. Serine 146-152 dynamin 1 like Homo sapiens 110-135 29890853-9 2019 Mechanistically, Numb depletion triggered dynamin-related protein 1 (Drp1) recruitment to mitochondria by increasing the phosphorylation of Drp1 at serine 656 residue (human Drp1 ser637). Serine 148-154 dynamin 1 like Homo sapiens 42-67 29890853-9 2019 Mechanistically, Numb depletion triggered dynamin-related protein 1 (Drp1) recruitment to mitochondria by increasing the phosphorylation of Drp1 at serine 656 residue (human Drp1 ser637). Serine 148-154 dynamin 1 like Homo sapiens 69-73 29890853-9 2019 Mechanistically, Numb depletion triggered dynamin-related protein 1 (Drp1) recruitment to mitochondria by increasing the phosphorylation of Drp1 at serine 656 residue (human Drp1 ser637). Serine 148-154 dynamin 1 like Homo sapiens 140-144 29890853-9 2019 Mechanistically, Numb depletion triggered dynamin-related protein 1 (Drp1) recruitment to mitochondria by increasing the phosphorylation of Drp1 at serine 656 residue (human Drp1 ser637). Serine 148-154 dynamin 1 like Homo sapiens 140-144 29953931-5 2018 Our studies show that expression of constitutively active RhoA in cardiomyocytes increases phosphorylation of Dynamin-related protein 1 (Drp1) at serine-616, and leads to localization of Drp1 at mitochondria. Serine 146-152 dynamin 1 like Homo sapiens 137-141 26306039-6 2015 Moreover, depletion of DAP3 dramatically decreases the phosphorylation of Drp1 at Ser-637 on mitochondria, enhancing the retention time of Drp1 puncta on mitochondria during the fission process. Serine 82-85 dynamin 1 like Homo sapiens 74-78 29620184-8 2018 ZEA also increased JNK phosphorylation and subsequently Drp1 phosphorylation at the serine 616 position, resulting in Drp1 activation. Serine 84-90 dynamin 1 like Homo sapiens 56-60 29217195-0 2018 Calmodulin-dependent protein kinase II (CaMKII) mediates radiation-induced mitochondrial fission by regulating the phosphorylation of dynamin-related protein 1 (Drp1) at serine 616. Serine 170-176 dynamin 1 like Homo sapiens 134-159 29217195-0 2018 Calmodulin-dependent protein kinase II (CaMKII) mediates radiation-induced mitochondrial fission by regulating the phosphorylation of dynamin-related protein 1 (Drp1) at serine 616. Serine 170-176 dynamin 1 like Homo sapiens 161-165 29217195-4 2018 First, we found that X-irradiation triggered Drp1 phosphorylation at serine 616 (S616) but not at serine 637 (S637). Serine 69-75 dynamin 1 like Homo sapiens 45-49 26432782-5 2016 In the present study, we reported that the phosphorylation status of Drp1-Ser(637) was essential for its interaction with Mff. Serine 74-77 dynamin 1 like Homo sapiens 69-73 26432782-6 2016 UV stimulation induced a decrease in cytoplasmic and mitochondrial Drp1 phosphorylation on Ser(637) and enhanced the interaction between Drp1 and Mff, resulting in mitochondrial fragmentation. Serine 91-94 dynamin 1 like Homo sapiens 67-71 30158524-2 2018 DRP1 activity is modulated by phosphorylation and S-nitrosylation on serine and cysteine residues, respectively. Serine 69-75 dynamin 1 like Homo sapiens 0-4 29444369-9 2018 Interestingly, RV-NSP4 was found to interact with and be involved in recruiting fission-active pool of Serine 616 phosphoDrp1 (Ser616 pDrp1) to mitochondria independent of accessory adaptors Mitochondrial fission factor and Fission protein 1 (Fis1). Serine 103-109 dynamin 1 like Homo sapiens 127-139 30566949-10 2018 CONCLUSION: Glomerular overproduction of Drp1, phospho-Drp1 (Ser 616) and Fis1 occurred mainly in children with membranous nephropathy. Serine 61-64 dynamin 1 like Homo sapiens 55-59 27739424-4 2016 Mechanistically, this effect is mediated by phosphorylation of mitochondrial fission protein, dynamin-related protein 1 (Drp1), by Ca2+/calmodulin-dependent kinase II (CaMKII) at a serine 616 (S616) site. Serine 181-187 dynamin 1 like Homo sapiens 94-119 27739424-4 2016 Mechanistically, this effect is mediated by phosphorylation of mitochondrial fission protein, dynamin-related protein 1 (Drp1), by Ca2+/calmodulin-dependent kinase II (CaMKII) at a serine 616 (S616) site. Serine 181-187 dynamin 1 like Homo sapiens 121-125 26122121-5 2015 All three patients harboured decreased levels of DRP1 phosphorylated at serine residue 616 (P-DRP1(S616)), a post-translational modification known to activate DRP1, and increased levels of DRP1 phosphorylated at serine 637 (P-DRP1(S637)), associated with the inactive state of the DRP1 GTPase. Serine 72-78 dynamin 1 like Homo sapiens 49-53 26122121-5 2015 All three patients harboured decreased levels of DRP1 phosphorylated at serine residue 616 (P-DRP1(S616)), a post-translational modification known to activate DRP1, and increased levels of DRP1 phosphorylated at serine 637 (P-DRP1(S637)), associated with the inactive state of the DRP1 GTPase. Serine 72-78 dynamin 1 like Homo sapiens 94-98 26122121-5 2015 All three patients harboured decreased levels of DRP1 phosphorylated at serine residue 616 (P-DRP1(S616)), a post-translational modification known to activate DRP1, and increased levels of DRP1 phosphorylated at serine 637 (P-DRP1(S637)), associated with the inactive state of the DRP1 GTPase. Serine 72-78 dynamin 1 like Homo sapiens 94-98 26122121-5 2015 All three patients harboured decreased levels of DRP1 phosphorylated at serine residue 616 (P-DRP1(S616)), a post-translational modification known to activate DRP1, and increased levels of DRP1 phosphorylated at serine 637 (P-DRP1(S637)), associated with the inactive state of the DRP1 GTPase. Serine 72-78 dynamin 1 like Homo sapiens 94-98 26122121-5 2015 All three patients harboured decreased levels of DRP1 phosphorylated at serine residue 616 (P-DRP1(S616)), a post-translational modification known to activate DRP1, and increased levels of DRP1 phosphorylated at serine 637 (P-DRP1(S637)), associated with the inactive state of the DRP1 GTPase. Serine 72-78 dynamin 1 like Homo sapiens 94-98 26122121-5 2015 All three patients harboured decreased levels of DRP1 phosphorylated at serine residue 616 (P-DRP1(S616)), a post-translational modification known to activate DRP1, and increased levels of DRP1 phosphorylated at serine 637 (P-DRP1(S637)), associated with the inactive state of the DRP1 GTPase. Serine 72-78 dynamin 1 like Homo sapiens 94-98 26122121-5 2015 All three patients harboured decreased levels of DRP1 phosphorylated at serine residue 616 (P-DRP1(S616)), a post-translational modification known to activate DRP1, and increased levels of DRP1 phosphorylated at serine 637 (P-DRP1(S637)), associated with the inactive state of the DRP1 GTPase. Serine 212-218 dynamin 1 like Homo sapiens 49-53 26122121-8 2015 Taken together, these findings implicate STAT2 as a novel regulator of DRP1 phosphorylation at serine 616, and thus of mitochondrial fission, and suggest that there are interactions between immunity and mitochondria. Serine 95-101 dynamin 1 like Homo sapiens 71-75 25658204-5 2015 These phenotypes are mechanistically linked by ERK1/2 phosphorylation of DRP1 serine 616; DRP1(S616) phosphorylation is sufficient to phenocopy transformation-induced mitochondrial dysfunction, and DRP1(S616) phosphorylation status dichotomizes BRAF(WT) from BRAF(V600E)-positive lesions. Serine 78-84 dynamin 1 like Homo sapiens 73-77 26002103-4 2015 CDK5-mediated phosphorylation of DRP1 at a conserved Serine residue, S585, is elevated at the mitochondria and is associated with increased mitochondrial fission. Serine 53-59 dynamin 1 like Homo sapiens 33-37 23334860-9 2013 O2 rapidly (<5 minutes) causes mitochondrial fission by a cyclin-dependent kinase- mediated phosphorylation of dynamin-related protein 1 (Drp1) at serine 616. Serine 150-156 dynamin 1 like Homo sapiens 114-139 24947026-8 2014 Phosphorylation of Drp1 at Ser(616) was decreased (pre vs. post: 0.81 +- 0.15 vs. 0.58 +- 0.14 arbitrary units; P < 0.05) following the intervention. Serine 27-30 dynamin 1 like Homo sapiens 19-23 23798729-7 2013 Phosphorylation of a conserved Ser residue adjacent to the microtubule-binding exon released Drp1-x01 from microtubules and promoted mitochondrial fragmentation in a splice form-specific manner. Serine 31-34 dynamin 1 like Homo sapiens 93-97 25595902-6 2015 Only dephosphorylated cofilin (Ser 3) and Drp1 (Ser 637) are translocated to the mitochondria. Serine 48-51 dynamin 1 like Homo sapiens 42-46 24902900-3 2014 The exact mechanisms of mitochondrial fragmentation and DRP1 overactivation in AD remain unknown; however, DRP1 serine 616 (S616) phosphorylation is likely involved. Serine 112-118 dynamin 1 like Homo sapiens 107-111 23486469-3 2013 Phosphorylation of Ser-656 by cAMP-dependent protein kinase (PKA) inhibits Drp1, whereas dephosphorylation by a mitochondrial protein phosphatase 2A isoform and the calcium-calmodulin-dependent phosphatase calcineurin (CaN) activates Drp1. Serine 19-22 dynamin 1 like Homo sapiens 75-79 23486469-3 2013 Phosphorylation of Ser-656 by cAMP-dependent protein kinase (PKA) inhibits Drp1, whereas dephosphorylation by a mitochondrial protein phosphatase 2A isoform and the calcium-calmodulin-dependent phosphatase calcineurin (CaN) activates Drp1. Serine 19-22 dynamin 1 like Homo sapiens 234-238 23334860-9 2013 O2 rapidly (<5 minutes) causes mitochondrial fission by a cyclin-dependent kinase- mediated phosphorylation of dynamin-related protein 1 (Drp1) at serine 616. Serine 150-156 dynamin 1 like Homo sapiens 141-145 22745122-7 2012 Increased O-GlcNAcylation decreases the phosphorylation of DRP1 at serine 637, which is known to regulate DRP1 function. Serine 67-73 dynamin 1 like Homo sapiens 59-63 22745122-7 2012 Increased O-GlcNAcylation decreases the phosphorylation of DRP1 at serine 637, which is known to regulate DRP1 function. Serine 67-73 dynamin 1 like Homo sapiens 106-110 35304783-7 2022 The expression of PGAM5 in JEG3 cells was up-regulated under hypoxia, which promoted dephosphorylation of Drp1 at Serine 637 residue, mitochondrial dysfunction (elevated ROS level and reduced mitochondrial membrane potential and ATP content) and cellular necroptosis (increased PI+ /Annexin V+ cells and decreased cell viability), accompanied by increased expression of necroptosis-relevant proteins; knockdown of PGAM5 attenuated these phenomena. Serine 114-120 dynamin 1 like Homo sapiens 106-110 22511751-3 2012 Dynamin-related protein-1 (DRP1) is a GTPase that, when activated by kinases that phosphorylate serine 616, causes mitochondrial fission. Serine 96-102 dynamin 1 like Homo sapiens 0-25 22511751-3 2012 Dynamin-related protein-1 (DRP1) is a GTPase that, when activated by kinases that phosphorylate serine 616, causes mitochondrial fission. Serine 96-102 dynamin 1 like Homo sapiens 27-31 22511751-8 2012 HIF-1alpha activation in human PAH leads to mitochondrial fission by cyclin B1/CDK1-dependent phosphorylation of DRP1 at serine 616. Serine 121-127 dynamin 1 like Homo sapiens 113-117 18838687-5 2008 Calcineurin-dependent dephosphorylation of Drp1, and in particular of its conserved serine 637, regulates its translocation to mitochondria as substantiated by site directed mutagenesis. Serine 84-90 dynamin 1 like Homo sapiens 43-47 18695047-5 2008 VDCC-associated Ca2+ signaling stimulates phosphorylation of dynamin-related protein 1 (Drp1) at serine 600 via activation of Ca2+/calmodulin-dependent protein kinase Ialpha (CaMKIalpha). Serine 97-103 dynamin 1 like Homo sapiens 61-86 18695047-5 2008 VDCC-associated Ca2+ signaling stimulates phosphorylation of dynamin-related protein 1 (Drp1) at serine 600 via activation of Ca2+/calmodulin-dependent protein kinase Ialpha (CaMKIalpha). Serine 97-103 dynamin 1 like Homo sapiens 88-92 18695047-6 2008 In neurons and HeLa cells, phosphorylation of Drp1 at serine 600 is associated with an increase in Drp1 translocation to mitochondria, whereas in vitro, phosphorylation of Drp1 results in an increase in its affinity for Fis1. Serine 54-60 dynamin 1 like Homo sapiens 46-50 18695047-6 2008 In neurons and HeLa cells, phosphorylation of Drp1 at serine 600 is associated with an increase in Drp1 translocation to mitochondria, whereas in vitro, phosphorylation of Drp1 results in an increase in its affinity for Fis1. Serine 54-60 dynamin 1 like Homo sapiens 99-103 18695047-6 2008 In neurons and HeLa cells, phosphorylation of Drp1 at serine 600 is associated with an increase in Drp1 translocation to mitochondria, whereas in vitro, phosphorylation of Drp1 results in an increase in its affinity for Fis1. Serine 54-60 dynamin 1 like Homo sapiens 99-103 17721437-8 2007 Thus, Drp1 phosphorylation at Ser 656 provides a mechanism for the integration of cAMP and calcium signals in the control of mitochondrial shape, apoptosis and other aspects of mitochondrial function. Serine 30-33 dynamin 1 like Homo sapiens 6-10 17301055-6 2007 Drp1 was specifically phosphorylated in mitosis by Cdk1/cyclin B on Ser-585. Serine 68-71 dynamin 1 like Homo sapiens 0-4 17301055-8 2007 These results suggest that phosphorylation of Drp1 on Ser-585 promotes mitochondrial fission in mitotic cells. Serine 54-57 dynamin 1 like Homo sapiens 46-50 33802063-5 2021 NAM treatment induced mitochondrial fission, at least in part by activating dynamin-1-like protein (Drp1), and this was through attenuation of the inhibitory phosphorylation at serine 637 (S637) of Drp1. Serine 177-183 dynamin 1 like Homo sapiens 198-202 34963686-8 2021 Mechanistically, CPT1A overexpression increased the phosphorylation of dynamin-related protein 1 at Ser-637 to promote mitochondrial fusion. Serine 100-103 dynamin 1 like Homo sapiens 71-96 34403210-4 2021 Hypoxia significantly activated extracellular signal-regulated kinase (ERK), increased phosphorylation of dynamin-related protein 1 (Drp1) at serine 616 and decreased phosphorylation of Drp1 at serine 637. Serine 142-148 dynamin 1 like Homo sapiens 106-131 34403210-4 2021 Hypoxia significantly activated extracellular signal-regulated kinase (ERK), increased phosphorylation of dynamin-related protein 1 (Drp1) at serine 616 and decreased phosphorylation of Drp1 at serine 637. Serine 142-148 dynamin 1 like Homo sapiens 133-137 34403210-4 2021 Hypoxia significantly activated extracellular signal-regulated kinase (ERK), increased phosphorylation of dynamin-related protein 1 (Drp1) at serine 616 and decreased phosphorylation of Drp1 at serine 637. Serine 194-200 dynamin 1 like Homo sapiens 186-190 34403210-7 2021 PD325901 and Mdivi-1 inhibited phosphorylation of Drp1 at serine 616, resulting in reduced mitochondrial fission under hypoxia. Serine 58-64 dynamin 1 like Homo sapiens 50-54 34090870-5 2021 RESULTS: Overnight lipid infusion increased dynamin related protein 1 (DRP1) phosphorylation at serine 616 and PTEN-induced kinase 1 (PINK1) expression (P = 0.003 and P = 0.008, respectively) in skeletal muscle while reducing mitochondrial membrane potential (P = 0.042). Serine 96-102 dynamin 1 like Homo sapiens 44-69 34090870-5 2021 RESULTS: Overnight lipid infusion increased dynamin related protein 1 (DRP1) phosphorylation at serine 616 and PTEN-induced kinase 1 (PINK1) expression (P = 0.003 and P = 0.008, respectively) in skeletal muscle while reducing mitochondrial membrane potential (P = 0.042). Serine 96-102 dynamin 1 like Homo sapiens 71-75 20463395-12 2010 Finally, we show that NO triggers DRP1 phosphorylation at serine 616, which results in its activation and recruitment to mitochondria. Serine 58-64 dynamin 1 like Homo sapiens 34-38 17553808-6 2007 Here, we have identified cAMP-dependent protein kinase-dependent phosphorylation of Drp1 within the GED domain at Ser(637) that inhibits Drp1 GTPase activity. Serine 114-117 dynamin 1 like Homo sapiens 84-88 17553808-6 2007 Here, we have identified cAMP-dependent protein kinase-dependent phosphorylation of Drp1 within the GED domain at Ser(637) that inhibits Drp1 GTPase activity. Serine 114-117 dynamin 1 like Homo sapiens 137-141 17553808-9 2007 Thus, protein phosphorylation at Ser(637) results in clear alterations in Drp1 function and mitochondrial morphology that are likely involved in dynamic regulation of mitochondrial division in cells. Serine 33-36 dynamin 1 like Homo sapiens 74-78 34965411-5 2021 In parallel, downregulation of SIRT2 hyperacetylates the serine/threonine protein kinase AKT1 at Lys20 in a non-canonical way, activating DRP1 and metabolic reprogramming. Serine 57-63 dynamin 1 like Homo sapiens 138-142 34725875-10 2021 More specifically, AR up-regulated the phosphorylation of Drp1 at Serine 637 by activating AMP-activated protein kinase (AMPK), thereby inhibiting the mitochondrial translocation of Drp1. Serine 66-72 dynamin 1 like Homo sapiens 58-62 32433544-11 2020 Our findings provide novel insight into the role of EBV-LMP1-driven mitochondrial fission in regulating Drp1 phosphorylation at serine 616 and serine 637. Serine 128-134 dynamin 1 like Homo sapiens 104-108 33219495-1 2021 PURPOSE: Dynamin-related protein 1 (DRP1), a mitochondrial fission protein, and its active form phosphorylated at Serine 616 (S616-p-DRP1) have been increasingly associated with tumorigenesis and invasion in various tumor models, including oncocytic thyroid cancer (TC). Serine 114-120 dynamin 1 like Homo sapiens 9-34 33219495-1 2021 PURPOSE: Dynamin-related protein 1 (DRP1), a mitochondrial fission protein, and its active form phosphorylated at Serine 616 (S616-p-DRP1) have been increasingly associated with tumorigenesis and invasion in various tumor models, including oncocytic thyroid cancer (TC). Serine 114-120 dynamin 1 like Homo sapiens 36-40 33219495-1 2021 PURPOSE: Dynamin-related protein 1 (DRP1), a mitochondrial fission protein, and its active form phosphorylated at Serine 616 (S616-p-DRP1) have been increasingly associated with tumorigenesis and invasion in various tumor models, including oncocytic thyroid cancer (TC). Serine 114-120 dynamin 1 like Homo sapiens 133-137 35523103-1 2022 BACKGROUND: Dynamin-related protein 1 (DRP1) is a key regulator of mitochondrial fission and is activated by phosphorylation at serine 616. Serine 128-134 dynamin 1 like Homo sapiens 12-37 35523103-1 2022 BACKGROUND: Dynamin-related protein 1 (DRP1) is a key regulator of mitochondrial fission and is activated by phosphorylation at serine 616. Serine 128-134 dynamin 1 like Homo sapiens 39-43 35523103-6 2022 The activation status of DRP1 in cancer cells was quantified based on the immunohistochemical stain of phosphorylated DRP1 at serine 616 (P(S616)-DRP1). Serine 126-132 dynamin 1 like Homo sapiens 25-29 35523103-6 2022 The activation status of DRP1 in cancer cells was quantified based on the immunohistochemical stain of phosphorylated DRP1 at serine 616 (P(S616)-DRP1). Serine 126-132 dynamin 1 like Homo sapiens 118-122 33152171-6 2021 Our data further revealed that DRP1 activation through serine 616 phosphorylation is regulated by ERK/AKT and CDK2 in lung adenocarcinoma cell lines. Serine 55-61 dynamin 1 like Homo sapiens 31-35