PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30037819-6 2018 Moreover, inhibition of c-myc by BRD4 antagonists sensitizes for imipridone-induced apoptosis in stem-like GBM cells in vitro and in vivo Imipridones affect energy metabolism by suppressing both glycolysis and oxidative phosphorylation, which is accompanied by a compensatory activation of the serine-one carbon-glycine (SOG) pathway, involving the transcription factor ATF4. Serine 294-300 bromodomain containing 4 Homo sapiens 33-37 9048422-4 1996 The McAP precursor contains an amino Cys(St-Bu) and an internal Lys(Ser). Serine 68-71 bromodomain containing 4 Homo sapiens 4-8 34045230-3 2021 Together, BRD4 and CDK9 phosphorylate serine 2 (pSer2) of heptad repeats in the C-terminal domain of RPB1, the large subunit of pol II, promoting transcriptional elongation. Serine 38-44 bromodomain containing 4 Homo sapiens 10-14 29743242-3 2018 Phosphorylation of a second highly conserved T-loop site, Ser-175, alters the competitive binding of Tat and the host recruitment factor bromodomain containing 4 (BRD4) to P-TEFb. Serine 58-61 bromodomain containing 4 Homo sapiens 137-161 29743242-3 2018 Phosphorylation of a second highly conserved T-loop site, Ser-175, alters the competitive binding of Tat and the host recruitment factor bromodomain containing 4 (BRD4) to P-TEFb. Serine 58-61 bromodomain containing 4 Homo sapiens 163-167 28945351-11 2017 Serine 1 phosphorylation inhibited binding of the BRD4 N-terminal bromodomain to polyacetylated H4 tails by >5-fold, whereas methylation had no effect. Serine 0-6 bromodomain containing 4 Homo sapiens 50-54 24939842-5 2014 Here, we report a novel role of phosphorylated Ser(10) of histone H3 (H3S10ph) in governing the functional transition of BRD4. Serine 47-50 bromodomain containing 4 Homo sapiens 121-125 25340539-0 2014 Phosphorylation of HPV-16 E2 at serine 243 enables binding to Brd4 and mitotic chromosomes. Serine 32-38 bromodomain containing 4 Homo sapiens 62-66 25340539-9 2014 Thus, phosphorylation of serine 243 in the hinge region of HPV-16 E2 is essential for interaction with Brd4 and required for host chromosome binding. Serine 25-31 bromodomain containing 4 Homo sapiens 103-107 23086925-0 2012 Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. Serine 68-74 bromodomain containing 4 Homo sapiens 0-32 23086925-0 2012 Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. Serine 68-74 bromodomain containing 4 Homo sapiens 34-38 23086925-2 2012 We used genome-wide chromatin immunoprecipitation sequencing in primary human CD4+ T cells to reveal that BRD4 co-localizes with Ser-2-phosphorylated Pol II (Pol II Ser-2) at both enhancers and promoters of active genes. Serine 129-132 bromodomain containing 4 Homo sapiens 106-110 23086925-2 2012 We used genome-wide chromatin immunoprecipitation sequencing in primary human CD4+ T cells to reveal that BRD4 co-localizes with Ser-2-phosphorylated Pol II (Pol II Ser-2) at both enhancers and promoters of active genes. Serine 165-168 bromodomain containing 4 Homo sapiens 106-110 23086925-7 2012 Our findings suggest that BRD4-driven Pol II phosphorylation at serine 2 plays an important role in regulating lineage-specific gene transcription in human CD4+ T cells. Serine 64-70 bromodomain containing 4 Homo sapiens 26-30 17088358-6 2007 Site-directed mutagenesis of a serine residue at position 62 of McaP, predicted to be important for the lipolytic activity of the protein, resulted in loss of hydrolysis of p-nitrophenyl ester of caproate. Serine 31-37 bromodomain containing 4 Homo sapiens 64-68 22649058-2 2012 IKKalpha can also be recruited directly to the promoter of NF-kappaB-dependent genes by NF-kappaB where it phosphorylates histone H3 at serine 10, triggering recruitment of the bromodomain-containing protein 4 and the positive transcription elongation factor b. Herein, we report that IKKalpha travels with the elongating form of ribonucleic acid polymerase II together with heterochromatin protein 1 gamma (HP1gamma) at NF-kappaB-dependent genes in activated macrophages. Serine 136-142 bromodomain containing 4 Homo sapiens 177-209