PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33711835-0 2021 Simultaneous Quantitative Detection of IL-6 and PCT Using SERS magnetic immunoassay with sandwich structure. Serine 58-62 interleukin 6 Homo sapiens 39-43 33885657-0 2021 Rapid, highly sensitive and quantitative detection of interleukin 6 based on SERS magnetic immunoassay. Serine 77-81 interleukin 6 Homo sapiens 54-67 33885657-3 2021 We have developed a method based on SERS for the rapid and quantitative detection of IL-6. Serine 36-40 interleukin 6 Homo sapiens 85-89 33711835-4 2021 Therefore, we have developed a SERS-based magnetic immunoassay method that uses the principle of sandwich method to quantitatively detect Interleukin 6 (IL-6) and Procalcitonin (PCT). Serine 31-35 interleukin 6 Homo sapiens 138-151 33711835-4 2021 Therefore, we have developed a SERS-based magnetic immunoassay method that uses the principle of sandwich method to quantitatively detect Interleukin 6 (IL-6) and Procalcitonin (PCT). Serine 31-35 interleukin 6 Homo sapiens 153-157 31001483-7 2019 In addition, the current study demonstrated that phosphorylation at Serine (Ser) 387 site was required for recruitment of Ago2-containing miRISC to IL6 mRNA and BAG3 knockdown facilitated Ago2 loading to IL6 mRNA via increasing its phosphorylation at Ser 387. Serine 68-74 interleukin 6 Homo sapiens 148-151 32786691-6 2020 As a function of IL-6 levels, we identified significant dysregulation in serum levels of various coagulation factors, accompanied by increased levels of antifibrinolytic components, including several serine protease inhibitors (SERPINs). Serine 200-206 interleukin 6 Homo sapiens 17-21 31001483-7 2019 In addition, the current study demonstrated that phosphorylation at Serine (Ser) 387 site was required for recruitment of Ago2-containing miRISC to IL6 mRNA and BAG3 knockdown facilitated Ago2 loading to IL6 mRNA via increasing its phosphorylation at Ser 387. Serine 68-74 interleukin 6 Homo sapiens 204-207 31001483-7 2019 In addition, the current study demonstrated that phosphorylation at Serine (Ser) 387 site was required for recruitment of Ago2-containing miRISC to IL6 mRNA and BAG3 knockdown facilitated Ago2 loading to IL6 mRNA via increasing its phosphorylation at Ser 387. Serine 68-71 interleukin 6 Homo sapiens 148-151 31001483-7 2019 In addition, the current study demonstrated that phosphorylation at Serine (Ser) 387 site was required for recruitment of Ago2-containing miRISC to IL6 mRNA and BAG3 knockdown facilitated Ago2 loading to IL6 mRNA via increasing its phosphorylation at Ser 387. Serine 68-71 interleukin 6 Homo sapiens 204-207 31001483-7 2019 In addition, the current study demonstrated that phosphorylation at Serine (Ser) 387 site was required for recruitment of Ago2-containing miRISC to IL6 mRNA and BAG3 knockdown facilitated Ago2 loading to IL6 mRNA via increasing its phosphorylation at Ser 387. Serine 76-79 interleukin 6 Homo sapiens 148-151 31001483-7 2019 In addition, the current study demonstrated that phosphorylation at Serine (Ser) 387 site was required for recruitment of Ago2-containing miRISC to IL6 mRNA and BAG3 knockdown facilitated Ago2 loading to IL6 mRNA via increasing its phosphorylation at Ser 387. Serine 76-79 interleukin 6 Homo sapiens 204-207 24487064-2 2014 We have shown recently that heteroarylketones (HAKs) interfere with stimulated interleukin-6 expression in astrocytes by suppression of STAT3 phosphorylation at serine 727. Serine 161-167 interleukin 6 Homo sapiens 79-92 27716424-7 2016 In BEAS-2B cells, both SE-A and SE-R inhibited the increase in production of the inflammatory cytokines IL-6 and IL-8. Serine 32-36 interleukin 6 Homo sapiens 104-108 19885032-3 2009 In cultured Schwann cells, we noted that ERK activation is required for the serine phosphorylation of STAT3 by neuropoietic cytokine interleukin-6 (IL-6). Serine 76-82 interleukin 6 Homo sapiens 133-146 20974848-7 2011 IL-6-stimulated cytoplasmic localization was mediated by alterations in the C-terminal M9 peptide of A1, and this correlated with the ability of IL-6 to induce serine phosphorylation of this domain. Serine 160-166 interleukin 6 Homo sapiens 0-4 21474440-8 2011 Ser-226 is shown to be required for the ligand-independent GR-mediated repression of IL-6 in response to TNFalpha. Serine 0-3 interleukin 6 Homo sapiens 85-89 20974848-7 2011 IL-6-stimulated cytoplasmic localization was mediated by alterations in the C-terminal M9 peptide of A1, and this correlated with the ability of IL-6 to induce serine phosphorylation of this domain. Serine 160-166 interleukin 6 Homo sapiens 145-149 20978825-3 2011 In response to IL-6, the signal transducer and activator of transcription 3 (STAT3) becomes phosphorylated on tyrosine and serine residues. Serine 123-129 interleukin 6 Homo sapiens 15-19 20379953-4 2010 These results suggest that blocking of IL-6-induced signal transduction is partially due to the sustained activation of ERK1/2 by kansuinine A and B, which in turn results in an increase of Stat3 serine phosphorylation and SOCS-3 expression. Serine 196-202 interleukin 6 Homo sapiens 39-43 19009233-6 2009 In addition, trichodimerol blocked IFN-gamma, IL-6 and IL-4 induced activation of Stat1, Stat3 and Stat6 transcription factors by inhibiting serine and tyrosine phosphorylation. Serine 141-147 interleukin 6 Homo sapiens 46-50 19670249-9 2009 Transcription up-regulation of IL-6 and IL-8 was associated with re-expression of the serine active-site mutant prostasin in the PC-3 cells. Serine 86-92 interleukin 6 Homo sapiens 31-35 19885032-3 2009 In cultured Schwann cells, we noted that ERK activation is required for the serine phosphorylation of STAT3 by neuropoietic cytokine interleukin-6 (IL-6). Serine 76-82 interleukin 6 Homo sapiens 148-152 19885032-4 2009 Serine phosphorylated STAT3 by IL-6 was transported into Schwann cell nuclei, thereby indicating that ERK may regulate the transcriptional activity of STAT3 via the induction of serine phosphorylation of STAT3. Serine 0-6 interleukin 6 Homo sapiens 31-35 19885032-4 2009 Serine phosphorylated STAT3 by IL-6 was transported into Schwann cell nuclei, thereby indicating that ERK may regulate the transcriptional activity of STAT3 via the induction of serine phosphorylation of STAT3. Serine 178-184 interleukin 6 Homo sapiens 31-35 19365107-10 2009 Upon tumor necrosis factor-alpha stimulation, IL-6 and IL-8 mRNA and protein levels in A549-PLA2G2D-Ser cells were elevated compared with those of A549-PLA2G2D-Gly cells. Serine 100-103 interleukin 6 Homo sapiens 46-50 19038492-2 2009 Recent reports show that phosphorylation of p65 at serine 276 regulates only a subset of genes, such as those encoding IL-6, IL-8, Gro-beta, and ICAM-1. Serine 51-57 interleukin 6 Homo sapiens 119-123 19182994-4 2009 Interleukin-6 (IL-6)-induced phosphorylation of tyrosine-705 and serine-727, as well as DNA-binding and transcriptional activity of Stat3 were further enhanced by Ha-ras overexpression. Serine 65-71 interleukin 6 Homo sapiens 0-13 19182994-4 2009 Interleukin-6 (IL-6)-induced phosphorylation of tyrosine-705 and serine-727, as well as DNA-binding and transcriptional activity of Stat3 were further enhanced by Ha-ras overexpression. Serine 65-71 interleukin 6 Homo sapiens 15-19 19365107-12 2009 CONCLUSIONS: PLA2G2D-Ser enhances the expression of IL-6 and IL-8 compared with PLA2G2D-Gly. Serine 21-24 interleukin 6 Homo sapiens 52-56 18204781-4 2008 Treatment of cells with interleukin-6 neutralizing antibody inhibited the phosphorylation of STAT3 Tyr 705 and Ser 727. Serine 111-114 interleukin 6 Homo sapiens 24-37 19026125-1 2008 OBJECTIVE: To assess the association of polymorphisms of the IL-6 receptor gene (+24013A/G:Ala31Ala; +48892 A/C:Asp358Ala), the IL-8 receptor gene (+2607G/C:Ser/Thr IL-8RA), and TNF-alpha 238 (G/A) single nucleotide polymorphism (SNP) with Behcet"s disease in patients of German or Turkish origin. Serine 157-160 interleukin 6 Homo sapiens 61-65 19074889-7 2008 Treatment of myeloma cells with IL-6 induced serine phosphorylation of A1 and increased its binding to the myc IRES in vivo in myeloma cells. Serine 45-51 interleukin 6 Homo sapiens 32-36 17703129-5 2007 We propose that the protective character of IL-6-type cytokine signaling in cardiac myocytes is determined principally by three mechanisms: redox status of the nonreceptor tyrosine kinase Janus kinase 1 (JAK) 1 that activates STAT3, phosphorylation of STAT3 within the transcriptional activation domain on serine 727, and STAT3-mediated induction of suppressor of cytokine signaling (SOCS) 3 that terminates IL-6-type cytokine signaling. Serine 306-312 interleukin 6 Homo sapiens 44-48 17993646-6 2008 Interestingly, we find that the phosphorylation of STAT3 on Ser(727) and STAT3 transcriptional activity are regulated by mTOR upon IL-6 stimulation and that STAT3 is required for IL-6 inhibition of insulin signaling. Serine 60-63 interleukin 6 Homo sapiens 131-135 17993646-6 2008 Interestingly, we find that the phosphorylation of STAT3 on Ser(727) and STAT3 transcriptional activity are regulated by mTOR upon IL-6 stimulation and that STAT3 is required for IL-6 inhibition of insulin signaling. Serine 60-63 interleukin 6 Homo sapiens 179-183 16467451-9 2006 The two coding variants, Pro32Ser (present only in black patients, 10% Ser allele) and Asp162Val (present only in white patients, 1% Val), were associated with lower levels of IL-6 and higher levels of albumin. Serine 30-33 interleukin 6 Homo sapiens 176-180 17242212-4 2007 We observed that IL-6 increased IRS-1 phosphorylation at Ser(312) and Ser(616); these effects were paralleled by increased Jun N-terminal protein kinase (JNK) and extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and reversed by JNK and ERK1/2 inhibition. Serine 57-60 interleukin 6 Homo sapiens 17-21 17242212-4 2007 We observed that IL-6 increased IRS-1 phosphorylation at Ser(312) and Ser(616); these effects were paralleled by increased Jun N-terminal protein kinase (JNK) and extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and reversed by JNK and ERK1/2 inhibition. Serine 70-73 interleukin 6 Homo sapiens 17-21 17242212-6 2007 Furthermore, IL-6 treatment reduced insulin-stimulated phosphorylation of eNOS at the stimulatory Ser(1177) site and impaired insulin-stimulated eNOS dephosphorylation at the inhibitory Thr(495) site. Serine 98-101 interleukin 6 Homo sapiens 13-17 16714289-7 2006 PGE(2)-stimulated [phospho-Ser(15)]p53 transactivated a p53 response element (GADD45)-luciferase reporter in transiently transfected HSF (SN7); the effect was compromised by overexpression of a dominant-negative mutant (dnm) of p53 or excess p53S15A expression plasmid but mimicked by a constitutively active p53S15E expression construct. Serine 27-30 interleukin 6 Homo sapiens 133-136 17258468-8 2006 Inhibition of tyrosine/serine phosphorylation mediated by MAPKs of STAT1 and STAT3 decrease the IL-6 secretion following porin stimulation. Serine 23-29 interleukin 6 Homo sapiens 96-100 15940250-6 2005 Furthermore, the FGF-induced activation of ERK 1/2 contributed to the serine phosphorylation of STAT 3, suggesting that the signaling crosstalk between the cytokine receptor, IL-6 receptor alpha/gp 130 and the growth factor receptor tyrosine kinase, FGFR 3. Serine 70-76 interleukin 6 Homo sapiens 175-179 16362041-6 2006 We found that the serine phosphorylation was crucial for TLR-induced interleukin 6 production and this process is regulated by TRAF6, a key adaptor molecule for the TLR pathway. Serine 18-24 interleukin 6 Homo sapiens 69-82 11335711-0 2001 Sequential activation of Rac-1, SEK-1/MKK-4, and protein kinase Cdelta is required for interleukin-6-induced STAT3 Ser-727 phosphorylation and transactivation. Serine 115-118 interleukin 6 Homo sapiens 87-100 15764709-4 2005 Here, we show that TGF-beta-activated kinase 1 (TAK1) interacts with STAT3, that the TAK1-Nemo-like kinase (NLK) pathway is efficiently activated by IL-6 through the YXXQ motif, and that this is the YXXQ-mediated H7-sensitive pathway that leads to STAT3 Ser-727 phosphorylation. Serine 254-257 interleukin 6 Homo sapiens 149-153 12710894-4 2003 The ability of IL-6 to promote transcription of CRP is mediated, in large part, by activation of the transcription factor STAT3; this activation requires both a tyrosine phosphorylation (mediated by the IL-6 receptor complex) and a serine phosphorylation (Ser-727), the origin of which has been more obscure. Serine 232-238 interleukin 6 Homo sapiens 15-19 12710894-4 2003 The ability of IL-6 to promote transcription of CRP is mediated, in large part, by activation of the transcription factor STAT3; this activation requires both a tyrosine phosphorylation (mediated by the IL-6 receptor complex) and a serine phosphorylation (Ser-727), the origin of which has been more obscure. Serine 256-259 interleukin 6 Homo sapiens 15-19 12710894-5 2003 There is new evidence that, when hepatocytes are exposed to IL-6, the consequent serine phosphorylation of STATS is mediated by a signal transduction pathway in which the G-protein Rac-1 plays an obligate role. Serine 81-87 interleukin 6 Homo sapiens 60-64 12496440-6 2003 Arg-Gly-Asp-Ser peptide and neo-glycoproteins galactose-BSA and mannose-BSA inhibited the Der f-induced IL-6 and TNF-alpha productions and enhanced accessory function of AMs. Serine 12-15 interleukin 6 Homo sapiens 104-108 15764709-0 2005 STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation. Serine 120-123 interleukin 6 Homo sapiens 67-71 15764709-3 2005 In IL-6 signaling, the two major pathways that derive from the YXXQ and the YSTV motifs of gp130 cause Ser-727 phosphorylation. Serine 103-106 interleukin 6 Homo sapiens 3-7 11335711-8 2001 Furthermore, the IL-6-induced PKCdelta Thr-505 and STAT3 Ser-727 phosphorylation were only observed in nuclear fractions of HepG2 cells. Serine 57-60 interleukin 6 Homo sapiens 17-21 11335711-1 2001 Activation of signal transducer and activator of transcription 3 (STAT3) by interleukin-6 (IL-6) involves phosphorylation of Tyr-705 and Ser-727, both of which are critical for STAT3 transactivation. Serine 137-140 interleukin 6 Homo sapiens 76-89 11335711-1 2001 Activation of signal transducer and activator of transcription 3 (STAT3) by interleukin-6 (IL-6) involves phosphorylation of Tyr-705 and Ser-727, both of which are critical for STAT3 transactivation. Serine 137-140 interleukin 6 Homo sapiens 91-95 11270639-8 2001 CONCLUSIONS: IL-6 up-regulates uterine OTR mRNA expression and binding capacity in cultured human myocytes most likely through tyrosine and serine phosphorylation pathways involving the nuclear factor STAT-3. Serine 140-146 interleukin 6 Homo sapiens 13-17 11429693-8 2001 Thus, the YXXQ motif regulates STAT3 activities in two ways in response to even a low concentration of IL-6: it recruits STAT3 to the receptor for tyrosine phosphorylation, and activates an unidentified H7-sensitive pathway leading to the serine phosphorylation of STAT3. Serine 239-245 interleukin 6 Homo sapiens 103-107 11027495-6 2000 Studies on the mode of action revealed that CPDHC (1) affects the IL-6-dependent pathway by inhibiting the tyrosine phosphorylation of the STAT3 and STAT1 as well as the serine phosphorylation of the Stat3 transcription factor. Serine 170-176 interleukin 6 Homo sapiens 66-70 11056211-2 2000 Galiellalactone inhibits the IL-6-induced SEAP expression with IC(50) values of 250-500 nM by blocking the binding of the activated Stat3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation of the Stat3 transcription factor. Serine 208-214 interleukin 6 Homo sapiens 29-33 9808569-9 1998 Thymocyte adhesion or cross-linking of MoAbs bound to integrins clustered at the TEC/thymocyte contact sites led to activation of interleukin-6 (IL-6) gene transcription factors, namely NF-IL6 serine phosphorylation and NF-kappaB nuclear targeting, as well as to increased IL-6 secretion. Serine 193-199 interleukin 6 Homo sapiens 130-143 10727406-1 2000 In the present study, signal transducer and activator of transcription 3 (STAT3) Ser(727) phosphorylation and transactivation was investigated in relation to activation of mitogen-activated protein (MAP) kinase family members including extracellular-signal-regulated protein kinase (ERK)-1, c-Jun N-terminal kinase (JNK)-1 and p38 ("reactivating kinase") in response to interleukin (IL)-6 stimulation. Serine 81-84 interleukin 6 Homo sapiens 370-388 10727406-4 2000 However, SEK-1/MKK-4 [where SEK-1 stands for stress-activated protein kinase (SAPK)/ERK kinase 1, and MKK-4 stands for MAP kinase kinase 4] was activated in response to IL-6 and overexpression of dominant-negative SEK-1/MKK-4(A-L) reduced both IL-6-induced STAT3 Ser(727) phosphorylation as well as STAT3 transactivation. Serine 263-266 interleukin 6 Homo sapiens 169-173 10727406-7 2000 In conclusion, these data indicate that IL-6-induced STAT3 transactivation and Ser(727) phosphorylation is independent of ERK-1 or JNK-1 activity, but involves a gp130 receptor-signalling cascade that includes Vav, Rac-1, MEKK and SEK-1/MKK-4 as signal transduction components. Serine 79-82 interleukin 6 Homo sapiens 40-44 10446219-3 1999 Serine phosphorylation of Stat3 is also induced by interleukin-6 (IL-6) stimulation, which is shown to be independent of mitogen-activated protein kinase and sensitive to the Ser/Thr kinase inhibitor H7. Serine 0-6 interleukin 6 Homo sapiens 51-64 10446219-3 1999 Serine phosphorylation of Stat3 is also induced by interleukin-6 (IL-6) stimulation, which is shown to be independent of mitogen-activated protein kinase and sensitive to the Ser/Thr kinase inhibitor H7. Serine 0-6 interleukin 6 Homo sapiens 66-70 10446219-4 1999 In this study, we investigated whether protein kinase C (PKC) is the kinase that is induced and responsible for Stat3 serine phosphorylation by IL-6 stimulation and which isoform of PKCs is likely to be involved. Serine 118-124 interleukin 6 Homo sapiens 144-148 10636920-1 2000 The role of signal transducer and activator of transcription (STAT) signaling pathways in the interleukin-6 (IL-6)-induced morphological differentiation of PC12-E2 cells was assessed using wild type and dominant negative mutants of Stat1 and Stat3, containing Tyr --> Phe (YF), Ser --> Ala (SA), and the double mutations (DM), respectively. Serine 281-284 interleukin 6 Homo sapiens 94-107 10636920-1 2000 The role of signal transducer and activator of transcription (STAT) signaling pathways in the interleukin-6 (IL-6)-induced morphological differentiation of PC12-E2 cells was assessed using wild type and dominant negative mutants of Stat1 and Stat3, containing Tyr --> Phe (YF), Ser --> Ala (SA), and the double mutations (DM), respectively. Serine 281-284 interleukin 6 Homo sapiens 109-113 9808569-9 1998 Thymocyte adhesion or cross-linking of MoAbs bound to integrins clustered at the TEC/thymocyte contact sites led to activation of interleukin-6 (IL-6) gene transcription factors, namely NF-IL6 serine phosphorylation and NF-kappaB nuclear targeting, as well as to increased IL-6 secretion. Serine 193-199 interleukin 6 Homo sapiens 145-149 9558728-13 1998 We propose that the STAT3 serine phosphorylation is required for transactivation of IL-6 target genes which is also inhibited by H7. Serine 26-32 interleukin 6 Homo sapiens 84-88 9736697-8 1998 MEKs and ERKs inhibited IL-6 activation of Stat3 harboring a mutation at serine-727, the major site for serine phosphorylation, similar to inhibition of wild-type Stat3, and inhibited Janus kinases Jak1 and Jak2 upstream of Stat3 in the Jak-STAT-signaling pathway. Serine 73-79 interleukin 6 Homo sapiens 24-28 9736697-8 1998 MEKs and ERKs inhibited IL-6 activation of Stat3 harboring a mutation at serine-727, the major site for serine phosphorylation, similar to inhibition of wild-type Stat3, and inhibited Janus kinases Jak1 and Jak2 upstream of Stat3 in the Jak-STAT-signaling pathway. Serine 104-110 interleukin 6 Homo sapiens 24-28 9466577-9 1998 Sphingomyelinase activation was determined by quantitation of sphingomyelin and ceramide radioactivity in [14C]serine-prelabeled HSF cells. Serine 111-117 interleukin 6 Homo sapiens 129-132 9558728-11 1998 In addition to the tyrosine phosphorylation we have observed that IL-6 also induces a serine phosphorylation of STAT3. Serine 86-92 interleukin 6 Homo sapiens 66-70 9343414-9 1997 Interestingly, the cytokine interleukin-6 also stimulates STAT3 serine phosphorylation, but in contrast to growth factors, this occurs by an ERK-independent process. Serine 64-70 interleukin 6 Homo sapiens 28-41 8706672-0 1996 Participation of two Ser-Ser-Phe-Tyr repeats in interleukin-6 (IL-6)-binding sites of the human IL-6 receptor. Serine 21-24 interleukin 6 Homo sapiens 48-61 8706672-0 1996 Participation of two Ser-Ser-Phe-Tyr repeats in interleukin-6 (IL-6)-binding sites of the human IL-6 receptor. Serine 21-24 interleukin 6 Homo sapiens 63-67 8706672-0 1996 Participation of two Ser-Ser-Phe-Tyr repeats in interleukin-6 (IL-6)-binding sites of the human IL-6 receptor. Serine 21-24 interleukin 6 Homo sapiens 96-100 8706672-0 1996 Participation of two Ser-Ser-Phe-Tyr repeats in interleukin-6 (IL-6)-binding sites of the human IL-6 receptor. Serine 25-28 interleukin 6 Homo sapiens 48-61 8706672-0 1996 Participation of two Ser-Ser-Phe-Tyr repeats in interleukin-6 (IL-6)-binding sites of the human IL-6 receptor. Serine 25-28 interleukin 6 Homo sapiens 63-67 8706672-0 1996 Participation of two Ser-Ser-Phe-Tyr repeats in interleukin-6 (IL-6)-binding sites of the human IL-6 receptor. Serine 25-28 interleukin 6 Homo sapiens 96-100 7581271-1 1995 Porphyromonas gingivalis 381 fimbriae and a synthetic peptide composed of residues 69-73 (ALTTE) of the fimbrial subunit protein, FP381(69-73), function in the induction of interleukin 6 (IL-6) production, IL-6 mRNA expression, and tyrosine and serine/threonine phosphorylation of several proteins in human peripheral blood mononuclear cells (PBMC). Serine 245-251 interleukin 6 Homo sapiens 173-186 8621406-0 1996 A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor. Serine 35-41 interleukin 6 Homo sapiens 49-62 8621406-0 1996 A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor. Serine 35-41 interleukin 6 Homo sapiens 64-68 8621406-0 1996 A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor. Serine 35-41 interleukin 6 Homo sapiens 156-160 7533107-0 1995 Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction. Serine 22-28 interleukin 6 Homo sapiens 0-13 7533107-0 1995 Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction. Serine 22-28 interleukin 6 Homo sapiens 98-111 7533107-4 1995 We now show that IL-6 triggers a delayed phosphorylation of APRF at serine resudues which can be reversed in vitro by protein phosphatase 2A and is also inhibited by H7. Serine 68-74 interleukin 6 Homo sapiens 17-21 7533107-5 1995 Therefore, APRF serine phosphorylation is likely to represent a crucial event in IL-6 signal transduction leading to target gene induction. Serine 16-22 interleukin 6 Homo sapiens 81-85 7851440-1 1995 A mutant species of the 185-residue chain of human interleukin-6 lacking 22-residues at its N-terminus and with a Cys-->Ser substitution at positions 45 and 51 was produced in Escherichia coli. Serine 123-126 interleukin 6 Homo sapiens 51-64 8258686-6 1993 IL-2, IL-4, and IL-6 stimulated the rapid serine/threonine phosphorylation of 47-, 49-, and 91-kDa proteins. Serine 42-48 interleukin 6 Homo sapiens 16-20 8258686-8 1993 The observation that serine/threonine phosphorylation of the same proteins was stimulated by IL-2, IL-4, and IL-6 suggested that the cytokines activated either different protein kinases with the same substrate specificity or the same protein kinase. Serine 21-27 interleukin 6 Homo sapiens 109-113 2033081-2 1991 The 25-kDa O-glycosylated IL-6 (which contains only Ser- or Thr-GalNAc-Gal-NeuNAc and thus should not bind wheat germ or lentil lectins) bound to and was eluted from a wheat germ lectin affinity column by GlcNAc and from a lentil lectin affinity column by methyl-alpha-D-Man suggesting that the 25-kDa IL-6 species formed heteromeric complexes with the N-glycosylated 30-kDa IL-6. Serine 52-55 interleukin 6 Homo sapiens 26-30 34826187-9 2022 Taken together, these observations suggest that SIRT1 stabilized through phosphorylation on serine 27 exerts oncogenic effects at least partly through deacetylation-dependent activation of Snail and subsequent transcription of IL-6 and IL-8 in human colon cancer cells. Serine 92-98 interleukin 6 Homo sapiens 227-231 34682865-10 2021 Increased phosphorylation of Rictor at the Thr-1135 residue, AKT at the Ser-473 residue and PKCalpha at the Ser-657 residue were observed after treatment with IGF-1 and IL-6. Serine 72-75 interleukin 6 Homo sapiens 169-173 34682865-10 2021 Increased phosphorylation of Rictor at the Thr-1135 residue, AKT at the Ser-473 residue and PKCalpha at the Ser-657 residue were observed after treatment with IGF-1 and IL-6. Serine 108-111 interleukin 6 Homo sapiens 169-173 34544857-0 2021 Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells. Serine 44-50 interleukin 6 Homo sapiens 0-13 34544857-4 2021 U-13C glucose tracing revealed that IL-6 knockout reduced 3-phosphoserine and serine production in TSC2-deficient cells, implicating IL-6 in de novo serine metabolism. Serine 78-84 interleukin 6 Homo sapiens 36-40 34544857-4 2021 U-13C glucose tracing revealed that IL-6 knockout reduced 3-phosphoserine and serine production in TSC2-deficient cells, implicating IL-6 in de novo serine metabolism. Serine 78-84 interleukin 6 Homo sapiens 133-137 34544857-4 2021 U-13C glucose tracing revealed that IL-6 knockout reduced 3-phosphoserine and serine production in TSC2-deficient cells, implicating IL-6 in de novo serine metabolism. Serine 149-155 interleukin 6 Homo sapiens 36-40 34544857-4 2021 U-13C glucose tracing revealed that IL-6 knockout reduced 3-phosphoserine and serine production in TSC2-deficient cells, implicating IL-6 in de novo serine metabolism. Serine 149-155 interleukin 6 Homo sapiens 133-137 34544857-5 2021 IL-6 knockout reduced expression of phosphoserine aminotransferase 1 (PSAT1), an essential enzyme in serine biosynthesis. Serine 101-107 interleukin 6 Homo sapiens 0-4 1328443-3 1992 Substitution of serine for cysteine was associated with a reduction in the effectiveness of interleukin-6 in both fibrinogen secretion assays. Serine 16-22 interleukin 6 Homo sapiens 92-105 1618596-7 1992 NF-IL6 is also involved in the transcriptional regulation of various acute phase protein genes IL-6-triggered association of IL-6R and gp130 on hepatocytes, through intermediate steps including serine-phosphorylation of pre-existing NF-IL6 protein, leads to binding of NF-IL6 to IL-6-responsive elements and activation of acute-phase protein genes. Serine 194-200 interleukin 6 Homo sapiens 95-99 1618596-7 1992 NF-IL6 is also involved in the transcriptional regulation of various acute phase protein genes IL-6-triggered association of IL-6R and gp130 on hepatocytes, through intermediate steps including serine-phosphorylation of pre-existing NF-IL6 protein, leads to binding of NF-IL6 to IL-6-responsive elements and activation of acute-phase protein genes. Serine 194-200 interleukin 6 Homo sapiens 125-129 33972660-8 2021 Importantly, FMRP could promote the IL-6-mediated translation of STAT3, and serine 114 of FMRP is identified as a potential phosphorylation site required for IL-6-mediated STAT3 translation. Serine 76-82 interleukin 6 Homo sapiens 158-162