PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33895117-7 2021 PDGF stimulated transient CREB phosphorylation on Ser-133 via ERK1/2-, PI3-kinase- and Src-dependent pathways. Serine 50-53 mitogen-activated protein kinase 3 Homo sapiens 62-68 32296771-4 2020 Alanine-substitution revealed that a serine cluster at the distal end of the H4R C-terminal tail is essential for the recruitment of beta-arrestin1/2, and consequently, receptor internalization and desensitization of G protein-driven extracellular-signal-regulated kinase (ERK)1/2 phosphorylation and label-free cellular impedance. Serine 37-43 mitogen-activated protein kinase 3 Homo sapiens 273-280 32762307-0 2021 Serine 897 phosphorylation of EPHA2 is involved in signaling of oncogenic ERK1/2 drivers in thyroid cancer cells. Serine 0-6 mitogen-activated protein kinase 3 Homo sapiens 74-80 33000894-1 2021 The serine-threonine kinase, BRAF, is an upstream regulator of the MEK-ERK1/2 pathway and is commonly mutated in cancer. Serine 4-10 mitogen-activated protein kinase 3 Homo sapiens 71-77 32804243-8 2021 Mechanistic studies defined mTORC1 and ERK1/2 as routes implicated in neuregulin-induced serine 67 phosphorylation and PDCD4 degradation. Serine 89-95 mitogen-activated protein kinase 3 Homo sapiens 39-45 33582914-0 2021 Knockdown of Microtubule Associated Serine/threonine Kinase Like Expression Inhibits Gastric Cancer Cell Growth and Induces Apoptosis by Activation of ERK1/2 and Inactivation of NF-kappaB Signaling. Serine 36-42 mitogen-activated protein kinase 3 Homo sapiens 151-157 32989218-4 2020 Further experiments showed that ERK1/2 phosphorylate DHPS at Ser-233 site. Serine 61-64 mitogen-activated protein kinase 3 Homo sapiens 32-38 32989218-5 2020 The Ser-233 phosphorylation of DHPS by ERK1/2 is important for its function in cell proliferation. Serine 4-7 mitogen-activated protein kinase 3 Homo sapiens 39-45 32170114-5 2020 Mechanistically, FGF4-ERK1/2-RSK signalling inhibits EPHA2 via Ser/Thr phosphorylation, whilst FGF4-ERK1/2 disrupts a core pluripotency transcriptional circuit required for Epha2 gene expression. Serine 63-66 mitogen-activated protein kinase 3 Homo sapiens 22-28 30912166-6 2019 Next, we revealed that the modulation of the enzymic activity of EZH2 resulting from posttranslational phosphorylation at the serine-21 site was responsible for the increased enrichment of H3K27me3 at the RECK promoter region by ERK1/2 signaling. Serine 126-132 mitogen-activated protein kinase 3 Homo sapiens 229-235 31308216-4 2019 ERK1/2 phosphorylate DLC1 on serine S129, which increases both the binding of SRC to DLC1 and SRC-dependent phosphorylation of DLC1. Serine 29-35 mitogen-activated protein kinase 3 Homo sapiens 0-6 32183046-9 2020 Activation of the angiogenic factor with G patch and FHA domains 1 (AGGF1) caused enhanced phosphorylation of serine/threonine kinase (Akt) and extracellular regulated protein kinases (Erk1/2). Serine 110-116 mitogen-activated protein kinase 3 Homo sapiens 185-191 31917333-7 2020 Interestingly, acute exposure to both 2AG and Delta9-THC inhibited phosphorylation of serine/threonine kinase extracellular signal-regulated protein kinases (ERK1/2), whereas Delta9-THC also reduced phosphorylation of Akt (aka PKB). Serine 86-92 mitogen-activated protein kinase 3 Homo sapiens 158-164 30380514-6 2018 Our results showed that cyclonerodiol blocked serine phosphorylation of Stat6 by affecting its association with p38 and Erk1/2. Serine 46-52 mitogen-activated protein kinase 3 Homo sapiens 120-126 30986276-5 2019 In masseter muscle, however, chronic beta1-AR stimulation did not induce muscle hypertrophy, but did induce fibrosis and apoptosis concomitantly with increased levels of p44/42 MAPK (ERK1/2) (Thr-202/Tyr-204), calmodulin kinase II (Thr-286) and mammalian target of rapamycin (mTOR) (Ser-2481) phosphorylation. Serine 283-286 mitogen-activated protein kinase 3 Homo sapiens 183-189 30819803-4 2019 Mechanistically, we observed that the RING domain stabilizes c-Myc by inhibiting its phosphorylation at Thr-58 and that this inhibition is due to activated ERK1/2-mediated phosphorylation of glycogen synthase kinase-3beta (GSK-3beta) at Ser-9. Serine 237-240 mitogen-activated protein kinase 3 Homo sapiens 156-162 31013829-2 2019 Upon activation, Erk1 and Erk2 directly phosphorylate FGF receptor 1 (FGFR1) at a specific serine residue in the C-terminal part of the receptor, substantially reducing the tyrosine phosphorylation in the receptor kinase domain and its signaling. Serine 91-97 mitogen-activated protein kinase 3 Homo sapiens 17-21 30962349-3 2019 We show here that HIF-2alpha is phosphorylated under hypoxia (1% O2) by extracellular signal-regulated protein kinases 1 and 2 (ERK1/2; also known as MAPK3 and MAPK1, respectively) at serine residue 672, as identified by in vitro phosphorylation assays. Serine 184-190 mitogen-activated protein kinase 3 Homo sapiens 128-134 30962349-3 2019 We show here that HIF-2alpha is phosphorylated under hypoxia (1% O2) by extracellular signal-regulated protein kinases 1 and 2 (ERK1/2; also known as MAPK3 and MAPK1, respectively) at serine residue 672, as identified by in vitro phosphorylation assays. Serine 184-190 mitogen-activated protein kinase 3 Homo sapiens 150-155 30794926-0 2019 Targeting ERK1/2 protein-serine/threonine kinases in human cancers. Serine 25-31 mitogen-activated protein kinase 3 Homo sapiens 10-16 30794926-9 2019 The dephosphorylation and inactivation of ERK1/2 is catalyzed by dual specificity phosphatases, protein-tyrosine specific phosphatases, and protein-serine/threonine phosphatases. Serine 148-154 mitogen-activated protein kinase 3 Homo sapiens 42-48 30527445-5 2018 In vitro studies showed that a model kinase ERK1 (extracellular signal-regulated protein kinase 1) would phosphorylate Ser within the consensus sequence if the collagen-like peptide is in the denatured state but not in the triple-helical state. Serine 119-122 mitogen-activated protein kinase 3 Homo sapiens 44-48 30527445-5 2018 In vitro studies showed that a model kinase ERK1 (extracellular signal-regulated protein kinase 1) would phosphorylate Ser within the consensus sequence if the collagen-like peptide is in the denatured state but not in the triple-helical state. Serine 119-122 mitogen-activated protein kinase 3 Homo sapiens 50-97 31146385-7 2019 The putative ERK1/2 phosphorylation site at serine 780 (S780) in FGFR2 corresponds to serine 777 in FGFR1 which is directly phosphorylated by ERK1/2. Serine 44-50 mitogen-activated protein kinase 3 Homo sapiens 13-19 31146385-7 2019 The putative ERK1/2 phosphorylation site at serine 780 (S780) in FGFR2 corresponds to serine 777 in FGFR1 which is directly phosphorylated by ERK1/2. Serine 44-50 mitogen-activated protein kinase 3 Homo sapiens 142-148 31146385-7 2019 The putative ERK1/2 phosphorylation site at serine 780 (S780) in FGFR2 corresponds to serine 777 in FGFR1 which is directly phosphorylated by ERK1/2. Serine 86-92 mitogen-activated protein kinase 3 Homo sapiens 13-19 31146385-7 2019 The putative ERK1/2 phosphorylation site at serine 780 (S780) in FGFR2 corresponds to serine 777 in FGFR1 which is directly phosphorylated by ERK1/2. Serine 86-92 mitogen-activated protein kinase 3 Homo sapiens 142-148 30711252-0 2019 Extracellular signal-regulated kinase-1 phosphorylates early growth response-1 at serine 26. Serine 82-88 mitogen-activated protein kinase 3 Homo sapiens 0-39 30430306-7 2018 A serine residue in the distal region of mGlu5 CT was found to be a primary phosphorylation site sensitive to ERK1. Serine 2-8 mitogen-activated protein kinase 3 Homo sapiens 110-114 29945223-3 2018 The common allele (A) of the DISC1 single-nucleotide polymorphism (SNP) rs821616 encodes a serine (ser) at the Ser704Cys polymorphism, and has been shown to increase the phosphorylation of extracellular signal-regulated protein Kinases 1 and 2 (ERK1/2) that stimulate the phosphorylation of tyrosine hydroxylase, the rate-limiting enzyme for dopamine biosynthesis. Serine 91-97 mitogen-activated protein kinase 3 Homo sapiens 245-251 31352445-3 2019 FGF acts primarily through binding to tyrosine kinase receptors through the autophosphorylation of their residues, promoting the phosphorylation of serine, threonine, and tyrosine residues of specific target proteins such as Raf-1, MAPK/Erk kinase, and extracellular signal-regulated kinase-1, which are part of the cascade of MAP kinases (mitogen-activated protein kinase). Serine 148-154 mitogen-activated protein kinase 3 Homo sapiens 232-236 31352445-3 2019 FGF acts primarily through binding to tyrosine kinase receptors through the autophosphorylation of their residues, promoting the phosphorylation of serine, threonine, and tyrosine residues of specific target proteins such as Raf-1, MAPK/Erk kinase, and extracellular signal-regulated kinase-1, which are part of the cascade of MAP kinases (mitogen-activated protein kinase). Serine 148-154 mitogen-activated protein kinase 3 Homo sapiens 237-292 29405768-5 2018 The MEK inhibitor PD98059 and ERK1/2 siRNA significantly inhibited apoptosis, ERK1/2 activation, as well as p53 and phospho-p53 (serine-15) levels in human lymphoblasts undergoing DEB-induced apoptosis. Serine 129-135 mitogen-activated protein kinase 3 Homo sapiens 30-36 29242151-11 2018 In summary, these results demonstrate that inducible COX-2 associates with phosphorylated ERK1/2 to induce the phosphorylation of Ser-15 in p53 and then complexes with p53 and SUMO-1 which binds to p53-responsive pro-apoptotic genes to enhance their expression. Serine 130-133 mitogen-activated protein kinase 3 Homo sapiens 90-96 29454706-6 2018 Mutations of a conserved serine residue (S264) for Erk1/2 phosphorylation in GATA6 protein drastically impacted its ability to activate its own promoter. Serine 25-31 mitogen-activated protein kinase 3 Homo sapiens 51-57 28801242-8 2017 H2O2 contributed to T/B-mediated ERK1/2 activation that mediated p53 phosphorylation at serine 15 (Ser15) and increased p21 expression. Serine 88-94 mitogen-activated protein kinase 3 Homo sapiens 33-39 28847747-4 2017 Hypoxia induced phosphorylation of ERalpha at serine residue 118 (S118) in the absence of estrogen through the mitogen-activated protein kinase (MAPK)/ERK1/2 pathway. Serine 46-52 mitogen-activated protein kinase 3 Homo sapiens 145-149 28847747-4 2017 Hypoxia induced phosphorylation of ERalpha at serine residue 118 (S118) in the absence of estrogen through the mitogen-activated protein kinase (MAPK)/ERK1/2 pathway. Serine 46-52 mitogen-activated protein kinase 3 Homo sapiens 151-157 27559307-6 2016 Subsequent phosphorylation and binding of ERK1/2 to and ERK-dependent phosphorylation of serine 180 in Jacob encodes synaptic but not extrasynaptic NMDAR activation. Serine 89-95 mitogen-activated protein kinase 3 Homo sapiens 42-48 28393288-1 2017 p38 mitogen-activated protein kinase (MAPK) belongs to the MAPK superfamily, phosphorylating serine and/or threonine residues of the target proteins. Serine 93-99 mitogen-activated protein kinase 3 Homo sapiens 38-42 28393288-1 2017 p38 mitogen-activated protein kinase (MAPK) belongs to the MAPK superfamily, phosphorylating serine and/or threonine residues of the target proteins. Serine 93-99 mitogen-activated protein kinase 3 Homo sapiens 59-63 28365441-4 2017 In Jak2-V617F-expressing cells Gab1 is constitutively phosphorylated by Erk1/2 on serine residue 552, which regulates binding to PIP3. Serine 82-88 mitogen-activated protein kinase 3 Homo sapiens 72-78 28542650-11 2017 These results suggest cross-communication between ERK1/2 and JAK-STAT pathways during EGF-mediated increase in invasion of trophoblast cells; phosphorylation at ser 727 residue of both STAT3 and STAT1 appears to be critical. Serine 161-164 mitogen-activated protein kinase 3 Homo sapiens 50-56 28279977-2 2017 We found that, after AKT-mediated phosphorylation at serine 319, FOXO1 binds to IQGAP1, a hub for activation of the MAPK pathway, and impedes IQGAP1-dependent phosphorylation of ERK1/2 (pERK1/2). Serine 53-59 mitogen-activated protein kinase 3 Homo sapiens 178-184 28099845-6 2017 TRAP1 silencing or mutagenesis at the serine residues targeted by ERK1/2 abrogates tumorigenicity, a phenotype that is reverted by addition of a cell-permeable succinate analog. Serine 38-44 mitogen-activated protein kinase 3 Homo sapiens 66-72 27470585-7 2016 Also, phosphorylation of Raf kinase inhibitory protein (RKIP) at serine 153, consequently stimulating extracellular-signal regulated kinase (ERK)1 activity, was significantly increased during adipogenesis induced by either poly-l-lysine-assisted adenoviral GFP-LC3 transduction or culture in the presence of dexamethasone, 1-methyl-3-isobutylxanthine, and insulin. Serine 65-71 mitogen-activated protein kinase 3 Homo sapiens 141-146 27793200-1 2016 BACKGROUND: MEK1 (MAP2K1) and MEK2 (MAP2K2) are closely related dual-specificity protein kinases which function by phosphorylating both serine/threonine and tyrosine residues of their substrates ERK1 and ERK2, controlling fundamental cellular processes that include cell growth and proliferation. Serine 136-142 mitogen-activated protein kinase 3 Homo sapiens 195-199 27086924-6 2016 We show that the MAP kinases ERK1/2 phosphorylate TC21 and R-Ras on this C-terminal serine residue both in vitro and in vivo. Serine 84-90 mitogen-activated protein kinase 3 Homo sapiens 29-35 27094035-7 2016 The cytokines contained in the supernatants of insulin-treated U937 macrophages activated ERK1/2 and IKKbeta, resulting in an inhibitory serine phosphorylation of the insulin receptor substrate. Serine 137-143 mitogen-activated protein kinase 3 Homo sapiens 90-96 27452456-6 2016 During differentiation, ERK1/2 phosphorylates RAM serine-36, targeting it for ubiquitination and proteasomal degradation, ultimately resulting in changes in gene expression associated with loss of pluripotency. Serine 50-56 mitogen-activated protein kinase 3 Homo sapiens 24-30 27181361-8 2016 The tyrosine phosphorylation of PAX5 co-operatively functioned with PAX5 serine phosphorylation by ERK1/2, which was our previous findings, to cancel the PAX5-dependent repression of BLIMP1. Serine 73-79 mitogen-activated protein kinase 3 Homo sapiens 99-105 27366950-4 2016 We showed that TRF2 was phosphorylated in vitro and in vivo on serine 323 by extracellular signal-regulated kinase (ERK1/2) in both normal and cancer cells. Serine 63-69 mitogen-activated protein kinase 3 Homo sapiens 116-122 26346493-7 2016 S421 resides within a Ser-Pro phosphoacceptor motif that is typical for ERK1/2 and recombinant ERK2 phosphorylated DYRK1B at S421 in vitro. Serine 22-25 mitogen-activated protein kinase 3 Homo sapiens 72-78 26615958-5 2016 Under resting conditions PEA-15 is regulated through phosphorylation of two key serine residues to inhibit extrinsic apoptosis and ERK1/2 signaling. Serine 80-86 mitogen-activated protein kinase 3 Homo sapiens 131-137 26211551-9 2015 Moreover, we demonstrated that coupling of the PKCdelta/EGFR/beta-arrestin2 transactivation pathway to delta receptor-mediated ERK1/2 activation was ligand-specific and the Ser(363) of delta receptors was crucial for ligand-specific implementation of this ERK1/2 activation pathway. Serine 173-176 mitogen-activated protein kinase 3 Homo sapiens 127-133 26211551-9 2015 Moreover, we demonstrated that coupling of the PKCdelta/EGFR/beta-arrestin2 transactivation pathway to delta receptor-mediated ERK1/2 activation was ligand-specific and the Ser(363) of delta receptors was crucial for ligand-specific implementation of this ERK1/2 activation pathway. Serine 173-176 mitogen-activated protein kinase 3 Homo sapiens 256-262 25584415-6 2015 Specific inhibition of ERK-1/2 activity blocked EGF- and BK-induced STAT-3 activation and Ser-727 phosphorylation. Serine 90-93 mitogen-activated protein kinase 3 Homo sapiens 23-30 25667991-0 2015 Amyloid beta oligomer-induced ERK1/2-dependent serine 636/639 phosphorylation of insulin receptor substrate-1 impairs insulin signaling and glycogen storage in human astrocytes. Serine 47-53 mitogen-activated protein kinase 3 Homo sapiens 30-36 25667991-9 2015 In addition, the levels of phosphorylated ERK1/2 and insulin receptor substrate-1 at serine 636/639 were significantly increased in response to treatment with Abeta1-42 oligomers. Serine 85-91 mitogen-activated protein kinase 3 Homo sapiens 42-48 25667991-11 2015 CONCLUSIONS: Our results demonstrated that Abeta1-42 oligomers impaired insulin signaling and suppressed insulin-induced glycogen storage in human astrocytes, probably due to ERK1/2-dependent serine phosphorylation of insulin receptor substrate-1 at 636/639 induced by Abeta1-42 oligomers. Serine 192-198 mitogen-activated protein kinase 3 Homo sapiens 175-181 25584415-12 2015 Thus, EGF-promoted Ser-727 phosphorylation by ERK-1/2 is not only sufficient to fully activate hypothalamic STAT-3, but, in terms of targeted genes and required cofactors, entails distinct modes of STAT-3 actions compared with IFN-gamma-induced Tyr-705 phosphorylation. Serine 19-22 mitogen-activated protein kinase 3 Homo sapiens 46-53 25658204-5 2015 These phenotypes are mechanistically linked by ERK1/2 phosphorylation of DRP1 serine 616; DRP1(S616) phosphorylation is sufficient to phenocopy transformation-induced mitochondrial dysfunction, and DRP1(S616) phosphorylation status dichotomizes BRAF(WT) from BRAF(V600E)-positive lesions. Serine 78-84 mitogen-activated protein kinase 3 Homo sapiens 47-53 25569096-5 2015 ATCM activated the phosphorylation of ERK1/2, JNK and Akt at serine 308 in SH-SY5Y cells. Serine 61-67 mitogen-activated protein kinase 3 Homo sapiens 38-44 25447552-8 2015 Migration of the Ishikawa cells was impaired when STIM1 phosphorylation was targeted by Ser-to-Ala substitution mutation of ERK1/2 target sites. Serine 88-91 mitogen-activated protein kinase 3 Homo sapiens 124-130 24269383-6 2014 We demonstrated that ERK1/2 phosphorylate KIBRA at Ser(548) in cells as well as in vitro. Serine 51-54 mitogen-activated protein kinase 3 Homo sapiens 21-27 24570070-7 2014 ERK1/2-mediated GRK2 phosphorylation at Ser-670 confirmed that ERK1/2 participated in a negative feedback regulatory loop. Serine 40-43 mitogen-activated protein kinase 3 Homo sapiens 0-6 24570070-7 2014 ERK1/2-mediated GRK2 phosphorylation at Ser-670 confirmed that ERK1/2 participated in a negative feedback regulatory loop. Serine 40-43 mitogen-activated protein kinase 3 Homo sapiens 63-69 25197063-4 2014 We identify a proline-directed phosphorylation motif, at serines 861/864 upstream of these sites, which is a substrate for the peptidylprolyl cis/trans isomerase, Pin1, as well as the ERK1/2 kinases. Serine 57-64 mitogen-activated protein kinase 3 Homo sapiens 184-190 23831387-3 2013 We show that NGF stimulates serine phosphorylation (S727) of STAT3 in sympathetic neurons via ERK1/2, in contrast to cytokine phosphorylation of Y705. Serine 28-34 mitogen-activated protein kinase 3 Homo sapiens 94-100 24055291-4 2013 Interestingly, we observed a decrease in expression of proteins that control the tumor micro environment such as VEGF-A, STAT-3, ERK1/2, ERK-p, AKT-1 ser 473 phosphorylation in compounds treated breast cancer cells. Serine 20-23 mitogen-activated protein kinase 3 Homo sapiens 129-135 22183614-6 2013 The poultry PM-induced cPLA2 serine phosphorylation and IL-8 release were attenuated by AACOCF3, PD98059, and by transfection with dominant-negative ERK-1/2 DNA in cells. Serine 29-35 mitogen-activated protein kinase 3 Homo sapiens 149-156 23562553-10 2013 Inhibition of ERK1/2 by MG or MEK1/2 inhibitor significantly inhibited paxillin phosphorylation at Ser(83) and focal adhesion turn-over produced inefficient glioma cell migration. Serine 99-102 mitogen-activated protein kinase 3 Homo sapiens 14-20 23188829-7 2013 Two serine residues, i.e. serine 362 and serine 604, were identified as putative ERK1/2 phosphorylation sites in human EPLIN, whose point mutation rendered resistance to EGF-induced protein turnover. Serine 4-10 mitogen-activated protein kinase 3 Homo sapiens 81-87 23667255-6 2013 Moreover, we revealed that the nuclear import of HBXIP was required for phosphorylation of c-Fos at Thr(232), Thr(325), Thr(331), and Ser(374) by ERK1/2. Serine 134-137 mitogen-activated protein kinase 3 Homo sapiens 146-152 23712012-7 2013 Detailed characterization of one newly identified substrate, the transcriptional regulator JunB, revealed that ERK1/2 phosphorylate JunB on a serine adjacent to the DNA-binding domain, resulting in increased DNA-binding affinity and transcriptional activity. Serine 142-148 mitogen-activated protein kinase 3 Homo sapiens 111-117 23549785-7 2013 We demonstrate that HGF stimulation results in a time-dependent phosphorylation of paxillin on serine 126, a process that can be blocked by inhibition of the ERK1/2 upstream kinase mitogen-activated protein kinase/ERK kinase 1 (MEK1) or inhibition of glycogen synthase kinase 3 (GSK3). Serine 95-101 mitogen-activated protein kinase 3 Homo sapiens 158-164 23292247-4 2013 The expression of c-ros receptor tyrosine kinase (ROS1) was increased and activated by autophosphorylation, thereby activating mitogen- and stress-activated protein kinase 1 (MSK1) through the mitogen-activated protein kinase (MAPK) pathway; activated MSK1, in turn, phosphorylated histone 3 serine 10 (H3S10p) residues in the nucleus. Serine 340-346 mitogen-activated protein kinase 3 Homo sapiens 263-267 23452857-4 2013 Exclusively synaptic, but not extrasynaptic, NMDAR activation induces phosphorylation of Jacob at serine-180 by ERK1/2. Serine 98-104 mitogen-activated protein kinase 3 Homo sapiens 112-118 23188829-7 2013 Two serine residues, i.e. serine 362 and serine 604, were identified as putative ERK1/2 phosphorylation sites in human EPLIN, whose point mutation rendered resistance to EGF-induced protein turnover. Serine 26-32 mitogen-activated protein kinase 3 Homo sapiens 81-87 23188829-7 2013 Two serine residues, i.e. serine 362 and serine 604, were identified as putative ERK1/2 phosphorylation sites in human EPLIN, whose point mutation rendered resistance to EGF-induced protein turnover. Serine 26-32 mitogen-activated protein kinase 3 Homo sapiens 81-87 23178880-6 2012 In addition, levels of PKM2 Ser 37 phosphorylation correlate with EGFR and ERK1/2 activity in human glioblastoma specimens. Serine 28-31 mitogen-activated protein kinase 3 Homo sapiens 75-81 22988300-0 2012 IkappaB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400. Serine 129-135 mitogen-activated protein kinase 3 Homo sapiens 47-93 23002436-8 2012 Phosphorylation of Ser(345), Ser(328), and Ser(315) was decreased by inhibitors of p38 MAPK and the ERK1/2 pathway. Serine 19-22 mitogen-activated protein kinase 3 Homo sapiens 100-106 23002436-8 2012 Phosphorylation of Ser(345), Ser(328), and Ser(315) was decreased by inhibitors of p38 MAPK and the ERK1/2 pathway. Serine 29-32 mitogen-activated protein kinase 3 Homo sapiens 100-106 23002436-8 2012 Phosphorylation of Ser(345), Ser(328), and Ser(315) was decreased by inhibitors of p38 MAPK and the ERK1/2 pathway. Serine 29-32 mitogen-activated protein kinase 3 Homo sapiens 100-106 22988300-5 2012 LPS activation of ERK-1/2 additionally requires transphosphorylation of TPL-2 on serine 400 in its C terminus, which controls TPL-2 signaling to ERK-1/2 independently of p105. Serine 81-87 mitogen-activated protein kinase 3 Homo sapiens 18-25 22988300-5 2012 LPS activation of ERK-1/2 additionally requires transphosphorylation of TPL-2 on serine 400 in its C terminus, which controls TPL-2 signaling to ERK-1/2 independently of p105. Serine 81-87 mitogen-activated protein kinase 3 Homo sapiens 145-152 21045017-5 2011 All of these three serine residues are biologically important as mutation of any one of these residues resulted in a significant reduction in the tumorigenicity of NPM-ALK (assessed by cell viability and clonogenic assay), which correlated with a substantial reduction in the phosphorylation of extracellular signal-regulated kinase 1/2, c-jun N-terminal kinase and signal transducer and activator of transcription 6. Serine 19-25 mitogen-activated protein kinase 3 Homo sapiens 295-336 23387271-3 2012 Also it has been predicted 16 novel potential phosphorylation sites of serine residues (positions 13, 124, 144, 182, 183, 190, 215, 216 and 230), tyrosine residues (positions 100 and 189) and threonine residues (positions 23, 69, 94, 126 and 229), as well as five binding sites for kinases and other proteins (Serl3 with 14-3-3, Val21 and Ile172 with D-domain, Pro78 and Pro111 with SH3-domain, Pro111 with MAPK3). Serine 71-77 mitogen-activated protein kinase 3 Homo sapiens 407-412 22638989-0 2012 beta-arrestin 2-dependent activation of ERK1/2 is required for ADP-induced paxillin phosphorylation at Ser(83) and microglia chemotaxis. Serine 103-106 mitogen-activated protein kinase 3 Homo sapiens 40-46 22638989-5 2012 Inhibition of ERK1/2 significantly inhibited paxillin phosphorylation at Ser(83) and the retraction of membrane ruffles, causing inefficient chemotaxis. Serine 73-76 mitogen-activated protein kinase 3 Homo sapiens 14-20 22370157-3 2012 Here, using mass spectrometry, we uncovered three serines (S75, S87, and S105) in the N-terminus of hERbeta as targets of ERK1/2 and p38 kinases. Serine 50-57 mitogen-activated protein kinase 3 Homo sapiens 122-128 22298426-0 2012 Phosphorylation of Stim1 at serine 575 via netrin-2/Cdo-activated ERK1/2 is critical for the promyogenic function of Stim1. Serine 28-34 mitogen-activated protein kinase 3 Homo sapiens 66-72 22085529-3 2012 We show that the activated mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinases (ERK) 1/2 pathway phosphorylated the E twenty-six (ETS)-like transcription factor 1 (Elk-1) mainly at serine 383 residue. Serine 208-214 mitogen-activated protein kinase 3 Homo sapiens 61-65 22085529-3 2012 We show that the activated mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinases (ERK) 1/2 pathway phosphorylated the E twenty-six (ETS)-like transcription factor 1 (Elk-1) mainly at serine 383 residue. Serine 208-214 mitogen-activated protein kinase 3 Homo sapiens 67-115 21487005-6 2011 Conversion of serine to glycine at an ERK1/2 phosphorylation site (S281G) abolished the cAMP activation of TRPC6 as determined by whole-cell and cell-attached single-channel patch recordings. Serine 14-20 mitogen-activated protein kinase 3 Homo sapiens 38-44 21325637-3 2011 To date, the roles of PDGF-induced key proliferative signaling components including Akt, p70S6kinase, and ERK1/2 on the serine phosphorylation/expression of IRS-1 and IRS-2 isoforms remain unclear in VSMCs. Serine 120-126 mitogen-activated protein kinase 3 Homo sapiens 106-112 21502402-4 2011 This Ser 68 is phosphorylated by p38, c-Jun N-terminal kinases (JNK), and extracellular signal-regulated kinases1/2 in vitro, and its phosphorylation levels positively correlate with Twist1 protein levels in human embryonic kidney 293 and breast cancer cells. Serine 5-8 mitogen-activated protein kinase 3 Homo sapiens 74-115 22569528-6 2012 ERK1/2 are proline-directed kinases that preferentially catalyze the phosphorylation of substrates containing a Pro-Xxx-Ser/Thr-Pro sequence. Serine 120-123 mitogen-activated protein kinase 3 Homo sapiens 0-6 23115616-8 2012 Present data also support that the 15dPGJ(2)-induced serine phosphorylation of the LXRalpha molecule is mediated by ERK1/2. Serine 53-59 mitogen-activated protein kinase 3 Homo sapiens 116-122 21617040-5 2011 Nuclear localization and activity of TFEB were regulated by serine phosphorylation mediated by the extracellular signal-regulated kinase 2, whose activity was tuned by the levels of extracellular nutrients. Serine 60-66 mitogen-activated protein kinase 3 Homo sapiens 99-138 21321112-6 2011 The sustained activation of Erk1/2 resulted in the phosphorylation of insulin receptor substrate-1 at Serine 612. Serine 102-108 mitogen-activated protein kinase 3 Homo sapiens 28-34 20861348-8 2010 Our findings indicate that IL-13 induces Egr-1 nuclear accumulation and CREB serine phosphorylation and that both are markedly attenuated by inhibition of ERK1/2 activity. Serine 77-83 mitogen-activated protein kinase 3 Homo sapiens 155-161 21071439-6 2011 Using mass spectrometry and phosphospecific antibodies, we found three proline-directed residues within Raptor, Ser(8), Ser(696), and Ser(863), which are directly phosphorylated by ERK1/2. Serine 112-115 mitogen-activated protein kinase 3 Homo sapiens 181-187 21071439-6 2011 Using mass spectrometry and phosphospecific antibodies, we found three proline-directed residues within Raptor, Ser(8), Ser(696), and Ser(863), which are directly phosphorylated by ERK1/2. Serine 120-123 mitogen-activated protein kinase 3 Homo sapiens 181-187 21071439-6 2011 Using mass spectrometry and phosphospecific antibodies, we found three proline-directed residues within Raptor, Ser(8), Ser(696), and Ser(863), which are directly phosphorylated by ERK1/2. Serine 120-123 mitogen-activated protein kinase 3 Homo sapiens 181-187 21261644-3 2011 Resveratrol treatment in vitro causes activation and nuclear translocation of mitogen-activated protein kinase (ERK1/2), consequent phosphorylation of Ser-15 of p53, and apoptosis. Serine 151-154 mitogen-activated protein kinase 3 Homo sapiens 112-118 21098639-0 2010 Serine 363 of the {delta}-opioid receptor is crucial for adopting distinct pathways to activate ERK1/2 in response to stimulation with different ligands. Serine 0-6 mitogen-activated protein kinase 3 Homo sapiens 96-102 20383279-5 2010 Tyrosine nitration of ERK1/2 was required for their phosphorylation on Thr and Tyr and their subsequent activation, whereas it completely inhibited Akt phosphorylation on Ser(473) and Thr(308) as well as its activity. Serine 171-174 mitogen-activated protein kinase 3 Homo sapiens 22-28 20648624-6 2010 Furthermore, we show that the expression of a constitutively active Rac, affected PED-Ser(104) phosphorylation, which is important for PED-regulated ERK 1/2 nuclear localization. Serine 86-89 mitogen-activated protein kinase 3 Homo sapiens 149-156 20615878-9 2010 Thus, inactivation of PP2Acalpha promotes hyperphosphorylation of PTP-1B Ser-50, elevates PTP-1B activity, which dephosphorylates Src Tyr-529 to activate Src and its downstream ERK1/2 signaling pathways that regulate alpha(IIb)beta(3) adhesion. Serine 73-76 mitogen-activated protein kinase 3 Homo sapiens 177-183 20371703-7 2010 Kinase assays showed that VDR ligands specifically activated the c-Raf/MEK1/2/extracellular signal-regulated kinase (ERK) 1/2 pathway, which stimulates serine phosphorylation of VDR and hepatocyte nuclear factor-4alpha, and their interaction. Serine 152-158 mitogen-activated protein kinase 3 Homo sapiens 78-125 19554262-5 2010 ERK1/2 enhanced stability of mcl-1 protein expression by serine-163 phosphorylation. Serine 57-63 mitogen-activated protein kinase 3 Homo sapiens 0-6 20701798-4 2010 Unlike after c-Kit stimulation, inhibiting p90RSK-1 did not abolish the band shift of MiTF protein, nor did it abolish the UVC-mediated MiTF degradation, suggesting that phosphorylation on serine 73 by Erk1/2 is a key event after UVC. Serine 189-195 mitogen-activated protein kinase 3 Homo sapiens 202-208 20701798-9 2010 These data suggest that MiTF mediates a survival signal linking Erk1/2 activation and p21 WAF1/CIP1 regulation via phosphorylation on serine 73, which facilitates cell cycle arrest. Serine 134-140 mitogen-activated protein kinase 3 Homo sapiens 64-70 18632853-0 2008 ERK1/2-mediated phosphorylation of small hepatitis delta antigen at serine 177 enhances hepatitis delta virus antigenomic RNA replication. Serine 68-74 mitogen-activated protein kinase 3 Homo sapiens 0-6 19815548-3 2009 Its C-terminal cytosolic oriented extension has an ERK1 phosphorylation site at Ser(563) affecting calnexin association with the translocon. Serine 80-83 mitogen-activated protein kinase 3 Homo sapiens 51-55 19575453-12 2009 CONCLUSION: PGE(2) might contribute to hepatic insulin resistance via an EP3-receptor-dependent ERK1/2 activation resulting in a serine phosphorylation of insulin receptor substrate, thereby preventing an insulin-dependent activation of Akt and glycogen synthesis. Serine 129-135 mitogen-activated protein kinase 3 Homo sapiens 96-102 19401382-8 2009 TLR2 ligands elicited the time-dependent activation of p38 MAPK and ERK1/2 pathways, which led to phosphorylation of cPLA(2)alpha at Ser(505). Serine 133-136 mitogen-activated protein kinase 3 Homo sapiens 68-74 19386603-6 2009 Both ADAM17 activation and IL-8 release were suppressed by inhibitors of EGFR/ERK1/2 signaling, which can regulate ADAM17 activity by serine/threonine phosphorylation. Serine 134-140 mitogen-activated protein kinase 3 Homo sapiens 78-84 18852266-3 2008 We have previously identified extracellular signal-regulated kinases 1 and 2 (ERK1/2) as the kinases responsible for the phosphorylation of human SK1 at Ser(225), but the corresponding phosphatase targeting this phosphorylation has remained undefined. Serine 153-156 mitogen-activated protein kinase 3 Homo sapiens 78-84 19835659-5 2009 By phosphorylating at Ser and Thr residues, MEK activates ERK1/2, which then phosphorylates cytoplasmic and nuclear substrates. Serine 22-25 mitogen-activated protein kinase 3 Homo sapiens 58-64 19217170-2 2009 It is now recognized that human BVR (hBVR) is a dual-specificity kinase (Ser/Thr and Tyr) upstream activator of the insulin/insulin growth factor-1 (IGF-1) and mitogen-activated protein kinase (MAPK) signaling pathways. Serine 73-76 mitogen-activated protein kinase 3 Homo sapiens 194-198 19004007-3 2009 Activation of the Ras-MAPK pathway results in the stimulation of the histone H3 kinase, mitogen and stress activated kinase (MSK) 1, and increased phosphorylation of histone H3 at serine 10 (H3 S10ph). Serine 180-186 mitogen-activated protein kinase 3 Homo sapiens 22-26 18662673-4 2008 The phosphorylation of MEK1/2 and Raf at Ser 338 as the upstream molecules of ERK 1/2 was also prevented by thalidomide. Serine 41-44 mitogen-activated protein kinase 3 Homo sapiens 78-85 18632853-5 2008 In an in vitro kinase assay, serine 177 of SHDAg was phosphorylated directly by either Flag-ERK1 or Flag-ERK2. Serine 29-35 mitogen-activated protein kinase 3 Homo sapiens 92-96 18632853-6 2008 Activation of endogenous ERK1/2 by a constitutively active MEK1 (hemagglutinin-AcMEK1) increased phosphorylation of SHDAg at Ser-177; this phosphorylation was confirmed by immunoblotting using an antibody against phosphorylated S177 and mass spectrometric analysis. Serine 125-128 mitogen-activated protein kinase 3 Homo sapiens 25-31 18632853-9 2008 These results demonstrate the role of ERK1/2-mediated Ser-177 phosphorylation in modulating HDV antigenomic RNA replication, possibly through RNAPII regulation. Serine 54-57 mitogen-activated protein kinase 3 Homo sapiens 38-44 18694962-4 2008 The key site, serine 454, resembles a mitogen-activated protein kinase phosphorylation site, and its modification was blocked by the MEK1 inhibitor U0126, implying that extracellular signal-regulated kinase 1/2 (ERK1/2) is the serum-inducible kinase that phosphorylates MKL1. Serine 14-20 mitogen-activated protein kinase 3 Homo sapiens 212-218 18283037-8 2008 Conversely, lapatinib treatment caused a drastic decrease in the phosphorylation of p70S6K1 at ERK1/2-regulated sites (Thr(421)/Ser(424)) and, as a consequence, p70S6K1 activity measured by its phospho-Thr(389) levels was abolished. Serine 128-131 mitogen-activated protein kinase 3 Homo sapiens 95-101 18664492-5 2008 Deleting a Ser/Thr motif at the tip of the intracellular tail of CCR7 resulted in an impaired chemokine-mediated activation of Erk1/2 kinases. Serine 11-14 mitogen-activated protein kinase 3 Homo sapiens 127-133 18424438-7 2008 We further show that inhibition of MSK1, a kinase acting downstream of MEK1/2-ERK1/2, by H89 or knockdown of MSK1 expression also inhibited phosphorylation of p65/RelA(Ser(276)), suggesting that this phosphorylation is dependent on MSK1. Serine 168-171 mitogen-activated protein kinase 3 Homo sapiens 78-84 18424438-9 2008 Our results indicate that the induction of inflammatory genes by farnesol is mediated by the activation of the NF-kappaB pathway and involves MEK1/2-ERK1/2-MSK1-dependent phosphorylation of p65/RelA(Ser(276)). Serine 199-202 mitogen-activated protein kinase 3 Homo sapiens 149-155 18378670-5 2008 Active p42/p44 MAPK-ERK phosphorylates STAT1 on serine 727 and targets it for proteasomal degradation. Serine 48-54 mitogen-activated protein kinase 3 Homo sapiens 11-19 18398416-8 2008 Inhibition of either varepsilonPKC or ERK1/2 activation abolished PC-induced serine phosphorylation of STAT3. Serine 77-83 mitogen-activated protein kinase 3 Homo sapiens 38-44 17983645-5 2008 Acting at the integrin receptor and without cell entry, thyroid hormone can foster ERK1/2-dependent serine phosphorylation of nuclear thyroid hormone receptor-beta1 (TRbeta1) and de-repress the latter. Serine 100-106 mitogen-activated protein kinase 3 Homo sapiens 83-89 18436795-7 2008 The mechanism involves ERK1/2-dependent phosphorylation of the Smad1 linker region (serine 206), which limits C-terminal serine 463/465 phosphorylation and inhibits Smad nuclear accumulation. Serine 84-90 mitogen-activated protein kinase 3 Homo sapiens 23-29 18436795-7 2008 The mechanism involves ERK1/2-dependent phosphorylation of the Smad1 linker region (serine 206), which limits C-terminal serine 463/465 phosphorylation and inhibits Smad nuclear accumulation. Serine 121-127 mitogen-activated protein kinase 3 Homo sapiens 23-29 18245089-5 2008 In this study we show that the extracellular signal-regulated kinases 1 and 2 (ERK1/2) interact directly with CIITA, targeting serine residues in the amino terminus of the protein, including serine 288. Serine 127-133 mitogen-activated protein kinase 3 Homo sapiens 79-85 18372406-0 2008 Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-alpha activity. Serine 19-26 mitogen-activated protein kinase 3 Homo sapiens 42-48 18245089-5 2008 In this study we show that the extracellular signal-regulated kinases 1 and 2 (ERK1/2) interact directly with CIITA, targeting serine residues in the amino terminus of the protein, including serine 288. Serine 191-197 mitogen-activated protein kinase 3 Homo sapiens 79-85 18372406-3 2008 Previous studies have shown that serine 118 (S118) in AF-1 is phosphorylated by extracellular signal-regulated kinases 1 and 2 (Erk1/2) mitogen-activated protein kinase (MAPK) in a ligand-independent manner. Serine 33-39 mitogen-activated protein kinase 3 Homo sapiens 128-134 18171912-5 2008 Ser(112) is phosphorylated by p90 ribosomal S6 kinase (RSK), a Ser/Thr kinase, which is a downstream effector of ERK1/2. Serine 0-3 mitogen-activated protein kinase 3 Homo sapiens 113-119 18063582-9 2008 Consistent with this, ERK1/2-mediated Ser(69) phosphorylation of Bim, a key signal for turnover of Bim, is suppressed by the removal of PINCH-1. Serine 38-41 mitogen-activated protein kinase 3 Homo sapiens 22-28 17884340-4 2007 However, this is controversial since most Cbl substrates are tyrosine phosphoproteins and yet Bim(EL) is targeted for destruction by ERK1/2-catalysed serine phosphorylation. Serine 150-156 mitogen-activated protein kinase 3 Homo sapiens 133-139 18583177-5 2008 Janus-activated kinase 2 was required for signal transducer and activator of transcription 3 tyrosine phosphorylation, whereas the extracellular signal-regulated kinase 1/2 mediated signal transducer and activator of transcription 3 serine phosphorylation in response to platelet-derived growth factor-BB. Serine 233-239 mitogen-activated protein kinase 3 Homo sapiens 131-172 18596912-5 2008 The genomic activity of PPARgamma is modulated, in addition to ligand binding, by phosphorylation of a serine residue by MAPKs, such as extracellular signal-regulated protein kinases-1/2 (ERK-1/2), or by nucleocytoplasmic compartmentalization through the ERK activators MAPK kinases-1/2 (MEK-1/2). Serine 103-109 mitogen-activated protein kinase 3 Homo sapiens 188-195 18596912-5 2008 The genomic activity of PPARgamma is modulated, in addition to ligand binding, by phosphorylation of a serine residue by MAPKs, such as extracellular signal-regulated protein kinases-1/2 (ERK-1/2), or by nucleocytoplasmic compartmentalization through the ERK activators MAPK kinases-1/2 (MEK-1/2). Serine 103-109 mitogen-activated protein kinase 3 Homo sapiens 121-125 18055485-5 2007 In MDA-MB-231 cells, a breast cancer cell line showing constitutive phosphorylated ERK1/2, CT phosphorylated c-Raf at Ser(259) via the protein kinase A pathway, resulting in suppression of ERK1/2 phosphorylation. Serine 118-121 mitogen-activated protein kinase 3 Homo sapiens 83-89 18055485-5 2007 In MDA-MB-231 cells, a breast cancer cell line showing constitutive phosphorylated ERK1/2, CT phosphorylated c-Raf at Ser(259) via the protein kinase A pathway, resulting in suppression of ERK1/2 phosphorylation. Serine 118-121 mitogen-activated protein kinase 3 Homo sapiens 189-195 17551925-6 2007 Inhibitors of MAPK- ERK1/2 and -p38 caused partial closure of GJIC under CP and HP, which was maintained for 6 h. Inhibition of Big Mitogen-Activated Kinase 1/ERK5 (BMK1/ERK5) caused partial closure under CP and HP followed by full recovery after 6 h. Inhibition of MAPK did not affect the HP-induced increase in Cx43 serine 279/282 phosphorylation. Serine 318-324 mitogen-activated protein kinase 3 Homo sapiens 20-26 17667937-6 2007 The molecular mechanism of ERK1/2 activation in WNK2-depleted cells lies downstream of the Raf kinases and involves MEK1 phosphorylation at serine 298 in both HeLa and HT29 colon cancer cells. Serine 140-146 mitogen-activated protein kinase 3 Homo sapiens 27-33 17665439-10 2007 JNK, ERK-1/2, and Akt (at both Ser-473 and Thr-308) were each up-regulated in a time-dependent manner. Serine 31-34 mitogen-activated protein kinase 3 Homo sapiens 5-12 17371847-8 2007 Two serines therein, S252 and S265, are phosphorylated by kinases of the Erk1/2 pathway, which compromises protein destruction upon both normal physiological induction and tumorigenic constitutive activation of this cascade. Serine 4-11 mitogen-activated protein kinase 3 Homo sapiens 73-79 17525735-7 2007 The dissociation of Bim from Mcl-1 is specific for Bim(EL) and requires ERK1/2-dependent phosphorylation of Bim(EL) at Ser(65). Serine 119-122 mitogen-activated protein kinase 3 Homo sapiens 72-78 17311928-9 2007 Site-directed mutagenesis indicated that hSphK2 is phosphorylated on Ser-351 and Thr-578 by ERK1 and that phosphorylation of these residues is important for EGF-stimulated migration of MDA-MB-453 cells. Serine 69-72 mitogen-activated protein kinase 3 Homo sapiens 92-96 16920714-7 2006 Furthermore, intracellular Tat activated the CREB-1 transcription factor through Ser(133) phosphorylation that was regulated by ERK MAPK as determined by IL-10 promoter analysis and gel shift assays. Serine 81-84 mitogen-activated protein kinase 3 Homo sapiens 132-136 17279354-7 2007 The stimulatory effects of hrCRP on IRS-1 phosphorylation at Ser(307) and Ser(612) were partially reversed by treatment with specific JNK and ERK1/2 inhibitors, respectively. Serine 61-64 mitogen-activated protein kinase 3 Homo sapiens 142-148 17279354-7 2007 The stimulatory effects of hrCRP on IRS-1 phosphorylation at Ser(307) and Ser(612) were partially reversed by treatment with specific JNK and ERK1/2 inhibitors, respectively. Serine 74-77 mitogen-activated protein kinase 3 Homo sapiens 142-148 17209045-3 2007 Using inhibitors and dominant negative constructs, we have demonstrated that RET(Y791F) and RET(S891A) induce STAT3 Ser(727) phosphorylation via a canonical Ras/ERK1/2 pathway and that integration of the Ras/ERK1/2/ELK-1 and STAT3 pathways was required for up-regulation of the c-fos promoter by FMTC-RET. Serine 116-119 mitogen-activated protein kinase 3 Homo sapiens 161-167 17209045-3 2007 Using inhibitors and dominant negative constructs, we have demonstrated that RET(Y791F) and RET(S891A) induce STAT3 Ser(727) phosphorylation via a canonical Ras/ERK1/2 pathway and that integration of the Ras/ERK1/2/ELK-1 and STAT3 pathways was required for up-regulation of the c-fos promoter by FMTC-RET. Serine 116-119 mitogen-activated protein kinase 3 Homo sapiens 208-214 17209045-10 2007 These data show that FMTC-RET mutants activate a Ras/ERK1/2/STAT3 Ser(727) pathway, which plays an important role in cell mitogenicity and transformation. Serine 66-69 mitogen-activated protein kinase 3 Homo sapiens 53-59 16885155-6 2007 H(2)O(2) induced activation of caspase-3 and phosphorylation of histone H2B at serine 14, a posttranslational modification required for nuclear condensation, which also were blocked by ERK1/2 inhibition. Serine 79-85 mitogen-activated protein kinase 3 Homo sapiens 185-191 17095509-3 2006 Erk1/2 then phosphorylates the serine at position 357, which is located in a degron of CIITA isoform 1 that leads to its monoubiquitylation. Serine 31-37 mitogen-activated protein kinase 3 Homo sapiens 0-6 16920714-8 2006 Overall, our results suggest that intracellular HIV-Tat induces IL-10 transcription by ERK MAPK-dependent CREB-1 transcription factor activation through Ser(133) phosphorylation. Serine 153-156 mitogen-activated protein kinase 3 Homo sapiens 91-95 16624816-0 2006 Heat shock protein 25 or inducible heat shock protein 70 activates heat shock factor 1: dephosphorylation on serine 307 through inhibition of ERK1/2 phosphorylation. Serine 109-115 mitogen-activated protein kinase 3 Homo sapiens 142-148 16815847-5 2006 PPARgamma induces the p110alpha subunit of phosphoinositide 3-kinase (PI3K), and inhibition of PI3K blocks PPARgamma-dependent phosphorylation of MEK1 Ser(298), activation of ERK1/2, and EMT. Serine 151-154 mitogen-activated protein kinase 3 Homo sapiens 175-181 16767165-9 2006 Whereas, epidermal growth factor activates a MAPK/ERK/RSK1 module leading to inactivation of BAD via Ser(75) phosphorylation, the presence of serum, on the other hand, induces a nonconducive intracellular environment for mitochondrial translocation of dephosphorylated BAD. Serine 101-104 mitogen-activated protein kinase 3 Homo sapiens 45-49 16760675-7 2006 Furthermore, SLD dose- and time-dependently inhibited the phosphorylation of Raf-1 on Ser 259, which is an established event by which Akt inhibits ERK1/2 activation. Serine 86-89 mitogen-activated protein kinase 3 Homo sapiens 147-153 16567810-8 2006 The present study also implicates that extracellular signal-regulated kinase (ERK1/2), which are serine/threonine kinases, are the mediators of STAT3 serine phosphorylation upon AVP stimulation. Serine 97-103 mitogen-activated protein kinase 3 Homo sapiens 78-84 15940250-6 2005 Furthermore, the FGF-induced activation of ERK 1/2 contributed to the serine phosphorylation of STAT 3, suggesting that the signaling crosstalk between the cytokine receptor, IL-6 receptor alpha/gp 130 and the growth factor receptor tyrosine kinase, FGFR 3. Serine 70-76 mitogen-activated protein kinase 3 Homo sapiens 43-50 16261397-9 2006 These findings suggest that ERalpha function in Tam-R cells is maintained as a consequence of EGFR/MAPK-mediated phosphorylation at serine residue 118 resulting in the generation of a self-propogating autocrine growth-regulatory loop through the ERalpha-mediated production of AR. Serine 132-138 mitogen-activated protein kinase 3 Homo sapiens 99-103 17168719-6 2006 Moreover, it has been recently reported that nicotine in lung adenocarcinoma A549 cells, potently induces Bad phosphorylation at serine (S)112, S136 and S155 in a mechanism involving activation of MAPKs, ERK1/2, PI3K/AKT and PKA through the linking to alpha7-receptors [9]. Serine 129-135 mitogen-activated protein kinase 3 Homo sapiens 204-210 16239230-7 2005 In parallel with the activation of MEK1/2 and ERK1/2, the inhibitory phosphorylation site of Raf1 (Ser-259) was dephosphorylated in cells overexpressing Balpha or Bdelta. Serine 99-102 mitogen-activated protein kinase 3 Homo sapiens 46-52 16641227-7 2006 Interestingly, bFGF induced a long-lasting phosphorylation of BAD at serine 112, suggesting BAD inactivation through the ERK1/2 signaling pathway. Serine 69-75 mitogen-activated protein kinase 3 Homo sapiens 121-127 15893541-7 2005 Treatment of the NHBE cells with PD98059, an ERK1/2 (extracellular signal-regulated protein kinase)-specific inhibitor, specifically suppressed the NNK-induced IkappaBalpha phosphorylation at position 32 of the serine residue, suggesting that the ERK1/2 kinase was involved in the IkappaBalpha phosphorylation induced by NFkappaB activation. Serine 211-217 mitogen-activated protein kinase 3 Homo sapiens 45-51 15833272-9 2005 Inhibition of ERK1/2 by PD98059 prevented serine phosphorylation of STAT-3, whereas inhibition of Src by PP1 prevented STAT-3 tyrosine phosphorylation. Serine 42-48 mitogen-activated protein kinase 3 Homo sapiens 14-20 15833272-12 2005 Serine phosphorylation of STAT-3 is mediated by ERK1/2, while tyrosine phosphorylation is mediated by Src. Serine 0-6 mitogen-activated protein kinase 3 Homo sapiens 48-54 15788397-0 2005 Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death. Serine 19-25 mitogen-activated protein kinase 3 Homo sapiens 53-59 15788397-4 2005 Wild type tis21 phosphorylated by p-Erk1/2 clearly increased its binding to Pin-1, but not the P148A mutant, indicating that Pin-1 was bound to the Ser(P)147-Pro148 region of tis21. Serine 148-151 mitogen-activated protein kinase 3 Homo sapiens 36-42 14996842-8 2004 The p44/42 mitogen-activated protein kinase (MAPK; ERK1/2) also was activated by MPTP, but was not associated with activation of STAT3, because serine (Ser-727) was not phosphorylated. Serine 144-150 mitogen-activated protein kinase 3 Homo sapiens 45-49 15728578-3 2005 ERK1/2-dependent phosphorylation correlates with the presence of a domain unique to the Bim(EL) splice variant that includes the major ERK1/2 phosphorylation site Ser(65). Serine 163-166 mitogen-activated protein kinase 3 Homo sapiens 0-6 15728578-3 2005 ERK1/2-dependent phosphorylation correlates with the presence of a domain unique to the Bim(EL) splice variant that includes the major ERK1/2 phosphorylation site Ser(65). Serine 163-166 mitogen-activated protein kinase 3 Homo sapiens 135-141 15568999-2 2005 In the present study, we show that, in addition to being phosphorylated on Thr-581 and Ser-360 by ERK1/2 or p38, MSK1 can autophosphorylate on at least six sites: Ser-212, Ser-376, Ser-381, Ser-750, Ser-752 and Ser-758. Serine 87-90 mitogen-activated protein kinase 3 Homo sapiens 98-104 15379552-7 2004 Our results demonstrate that ERK1/2 phosphorylate Gab1 at six serine/threonine residues (T312, S381, S454, T476, S581, S597) in consensus motifs for MAP kinase phosphorylation. Serine 62-68 mitogen-activated protein kinase 3 Homo sapiens 29-35 15379552-11 2004 These data demonstrate that ERK1/2 modulate insulin action via Gab1 by targeting serine and threonine residues beside YXXM motifs. Serine 81-87 mitogen-activated protein kinase 3 Homo sapiens 28-34 15059947-1 2004 Activated by thyroid hormone, the MAPK (ERK1/2) signaling pathway causes serine phosphorylation by MAPK of several nucleoproteins, including the nuclear thyroid hormone receptor beta1. Serine 73-79 mitogen-activated protein kinase 3 Homo sapiens 34-38 15059947-1 2004 Activated by thyroid hormone, the MAPK (ERK1/2) signaling pathway causes serine phosphorylation by MAPK of several nucleoproteins, including the nuclear thyroid hormone receptor beta1. Serine 73-79 mitogen-activated protein kinase 3 Homo sapiens 40-46 15059947-1 2004 Activated by thyroid hormone, the MAPK (ERK1/2) signaling pathway causes serine phosphorylation by MAPK of several nucleoproteins, including the nuclear thyroid hormone receptor beta1. Serine 73-79 mitogen-activated protein kinase 3 Homo sapiens 99-103 15059947-2 2004 Because estrogen can activate MAPK and cause MAPK-dependent serine phosphorylation of nuclear estrogen receptor (ER)alpha, we studied whether thyroid hormone also promoted MAPK-mediated ERalpha phosphorylation. Serine 60-66 mitogen-activated protein kinase 3 Homo sapiens 45-49 15059947-2 2004 Because estrogen can activate MAPK and cause MAPK-dependent serine phosphorylation of nuclear estrogen receptor (ER)alpha, we studied whether thyroid hormone also promoted MAPK-mediated ERalpha phosphorylation. Serine 60-66 mitogen-activated protein kinase 3 Homo sapiens 45-49 15059947-10 2004 Thus, T(4), like E(2), causes phosphorylation by MAPK of nuclear ERalpha at serine-118 in MCF-7 cells and promotes cell proliferation through the ER by a MAPK-dependent pathway. Serine 76-82 mitogen-activated protein kinase 3 Homo sapiens 49-53 15632084-5 2005 Tetracycline-inducible cell clones expressing either single or double serine mutants of MKP-3 or MKP-3-GFP confirmed that these two sites are targeted by the MEK1/2-ERK1/2 module in vivo. Serine 70-76 mitogen-activated protein kinase 3 Homo sapiens 165-171 15632084-6 2005 Double serine mutants of MKP-3 or MKP-3-GFP were more efficiently protected from degradation than single mutants or wild-type MKP-3, indicating that phosphorylation of either serine by ERK1/2 enhances proteasomal degradation of MKP-3. Serine 175-181 mitogen-activated protein kinase 3 Homo sapiens 185-191 15188005-2 2004 The mechanism of this effect was dependent on mitogen-activated protein kinase (MAPK, ERK1/2) activation and was associated with serine phosphorylation and acetylation of p53. Serine 129-135 mitogen-activated protein kinase 3 Homo sapiens 80-84 15188005-2 2004 The mechanism of this effect was dependent on mitogen-activated protein kinase (MAPK, ERK1/2) activation and was associated with serine phosphorylation and acetylation of p53. Serine 129-135 mitogen-activated protein kinase 3 Homo sapiens 86-92 15001544-10 2004 These results suggest that activation of the HBP accounts, in part, for glucose-induced phosphorylation at Ser(307) and Ser(612) of IRS-1 mediated by JNK and ERK1/2, respectively. Serine 107-110 mitogen-activated protein kinase 3 Homo sapiens 158-164 15149291-2 2004 The activation of ERK-1/2 and CREB can be monitored by immunoblotting with antibodies that specifically recognize p-ERK-1/2 (phosphorylated on Thr-202 and Tyr-204) and p-CREB (phosphorylated on Ser-133). Serine 194-197 mitogen-activated protein kinase 3 Homo sapiens 18-25 14996842-8 2004 The p44/42 mitogen-activated protein kinase (MAPK; ERK1/2) also was activated by MPTP, but was not associated with activation of STAT3, because serine (Ser-727) was not phosphorylated. Serine 144-150 mitogen-activated protein kinase 3 Homo sapiens 51-57 14996842-8 2004 The p44/42 mitogen-activated protein kinase (MAPK; ERK1/2) also was activated by MPTP, but was not associated with activation of STAT3, because serine (Ser-727) was not phosphorylated. Serine 152-155 mitogen-activated protein kinase 3 Homo sapiens 45-49 14996842-8 2004 The p44/42 mitogen-activated protein kinase (MAPK; ERK1/2) also was activated by MPTP, but was not associated with activation of STAT3, because serine (Ser-727) was not phosphorylated. Serine 152-155 mitogen-activated protein kinase 3 Homo sapiens 51-57 14657255-5 2004 We found that the adenylyl cyclase/PKA pathway has the capacity to markedly decrease UCN-induced ERK1/2 activation, and that these effects were due in part to the ability of PKA to phosphorylate the CRH-R1alpha at position Ser(301) in the third intracellular loop. Serine 223-226 mitogen-activated protein kinase 3 Homo sapiens 97-103 14656714-6 2004 TNF-alpha increased activation of ERK1/2 and JNK, previously implicated in phosphorylation of Ser(82) of PPARgamma1 and resultant negative regulation of PPARgamma transactivity. Serine 94-97 mitogen-activated protein kinase 3 Homo sapiens 34-40 14656714-9 2004 These results suggest that TNF-alpha inhibits PPARgamma transactivity in cultured HSC, at least in part, by diminished PPARgamma-PPRE (DNA) binding and ERK1/2-mediated phosphorylation of Ser(82) of PPARgamma1, but not via the NF-kappaB pathway. Serine 187-190 mitogen-activated protein kinase 3 Homo sapiens 152-158 15115615-10 2004 Based upon these results, it is concluded that ERK1/2 negatively modulates STAT3 phosphorylation and this function is dependent on residual serine-727 (S727) of STAT3. Serine 140-146 mitogen-activated protein kinase 3 Homo sapiens 47-53 14701740-4 2004 This inhibition is mediated by extracellular signal-regulated kinases 1 and/or 2 (ERK1/2), which interact with C/EBPalpha through an FXFP docking site and phosphorylate serine 21. Serine 169-175 mitogen-activated protein kinase 3 Homo sapiens 82-88 14670955-4 2004 A mutant P2Y(2) receptor lacking the PXXP motifs was found to stimulate calcium mobilization and serine/threonine phosphorylation of the Erk1/2 mitogen-activated protein kinases, like the wild-type receptor, but was defective in its ability to stimulate tyrosine phosphorylation of Src and Src-dependent tyrosine phosphorylation of the proline-rich tyrosine kinase 2, epidermal growth factor receptor (EGFR), and platelet-derived growth factor receptor. Serine 97-103 mitogen-activated protein kinase 3 Homo sapiens 137-143 14977836-8 2004 In addition P-Ser(118)-ERalpha was significantly associated with detection of active MAPK (Erk1/2; Spearman r = 0.649, P < 0.0001; Fisher"s exact test, P = 0.0004). Serine 14-17 mitogen-activated protein kinase 3 Homo sapiens 91-97 15488168-5 2004 We showed that GAIP is phosphorylated on its serine 151 and that this phosphorylation is dependent on the presence of amino acids that modulate Raf-1 activity, the kinase upstream of Erk1/2. Serine 45-51 mitogen-activated protein kinase 3 Homo sapiens 183-189 14662762-7 2004 The H(2)O(2)-induced ubiquitination is likely dependent on unusual Ser-5 phosphorylation by ERK1/2. Serine 67-70 mitogen-activated protein kinase 3 Homo sapiens 92-98 14555991-0 2003 Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. Serine 39-45 mitogen-activated protein kinase 3 Homo sapiens 29-35 14555991-4 2003 Using different cellular models we evidence that serine 69 is both necessary and sufficient for Erk1/2-mediated phosphorylation and degradation of Bim-EL. Serine 49-55 mitogen-activated protein kinase 3 Homo sapiens 96-102 14555991-7 2003 Altogether, our findings demonstrate that phosphorylation of Bim-EL by Erk1/2 on serine 69 selectively leads to its proteasomal degradation and therefore represents a new and important mechanism of Bim regulation. Serine 81-87 mitogen-activated protein kinase 3 Homo sapiens 71-77 12832467-6 2003 Using recombinant RSK1 proteins, we find that serine 749 is phosphorylated by the N-terminal kinase domain of RSK1 in vitro, suggesting that ERK1/2 dissociation is mediated through RSK1 autophosphorylation of this residue. Serine 46-52 mitogen-activated protein kinase 3 Homo sapiens 141-147 12917326-5 2003 We previously showed that ERK1 phosphorylates HSF1 on serine 307 and leads to secondary phosphorylation by glycogen synthase kinase 3 (GSK3) on serine 303 within the regulatory domain and that these phosphorylation events repress HSF1. Serine 54-60 mitogen-activated protein kinase 3 Homo sapiens 26-30 12917326-5 2003 We previously showed that ERK1 phosphorylates HSF1 on serine 307 and leads to secondary phosphorylation by glycogen synthase kinase 3 (GSK3) on serine 303 within the regulatory domain and that these phosphorylation events repress HSF1. Serine 144-150 mitogen-activated protein kinase 3 Homo sapiens 26-30 12974390-8 2003 These results indicate a ligand-stimulated negative regulatory feedback loop in which activated ERK1/2 phosphorylates FRS2 on serine/threonine residues thereby down-regulating its tyrosine phosphorylation. Serine 126-132 mitogen-activated protein kinase 3 Homo sapiens 96-102 12045255-4 2002 The binding of renin induced a fourfold increase of the catalytic efficiency of angiotensinogen conversion to angiotensin I and induced an intracellular signal with phosphorylation of serine and tyrosine residues associated to an activation of MAP kinases ERK1 and ERK2. Serine 184-190 mitogen-activated protein kinase 3 Homo sapiens 256-260 12556484-5 2003 Nudel was specifically phosphorylated in M phase in its serine/threonine phosphorylation motifs, probably by Cdc2 and also Erk1 and -2. Serine 56-62 mitogen-activated protein kinase 3 Homo sapiens 123-134 11940578-9 2002 Therefore, during PKC activation, the c-Raf/MEK/extracellular signal-regulated kinase-1/2 (ERK1/2) pathway mediates both the Thr-421/Ser-424 and the Thr-389 phosphorylation in an mTOR-independent and -dependent manner, respectively. Serine 133-136 mitogen-activated protein kinase 3 Homo sapiens 91-97 12393899-10 2002 Furthermore, ERK1/2 inhibits GSK3beta activity via a novel mechanism that is independent of Ser-9 phosphorylation and likely does not involve Tyr-216 phosphorylation. Serine 92-95 mitogen-activated protein kinase 3 Homo sapiens 13-19 12186555-2 2002 Previously, we have shown that phosphorylation of beta-arrestin1 by ERKs at Ser-412 regulates its association with clathrin and its function in promoting clathrin-mediated internalization of the receptor. Serine 76-79 mitogen-activated protein kinase 3 Homo sapiens 68-72 12050114-0 2002 Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation. Serine 36-43 mitogen-activated protein kinase 3 Homo sapiens 54-58 12050114-2 2002 Tob is rapidly phosphorylated at Ser 152, Ser 154, and Ser 164 by Erk1 and Erk2 upon growth-factor stimulation. Serine 33-36 mitogen-activated protein kinase 3 Homo sapiens 66-70 11827968-9 2002 A peptide from the first loop of the globular domain (alpha1:Ser(2179)-Ser(2198)) triggered the phosphorylation of MAPK(erk1/2) and stimulated the expression of macrophage urokinase type plasminogen activator and MMP-9. Serine 61-64 mitogen-activated protein kinase 3 Homo sapiens 115-119 11827968-9 2002 A peptide from the first loop of the globular domain (alpha1:Ser(2179)-Ser(2198)) triggered the phosphorylation of MAPK(erk1/2) and stimulated the expression of macrophage urokinase type plasminogen activator and MMP-9. Serine 61-64 mitogen-activated protein kinase 3 Homo sapiens 120-126 11827968-2 2002 We have reported that alpha1:Ser(2091)-Arg(2108), a peptide derived from the alpha1-chain of laminin-1, triggers protein kinase C-dependent activation of MAPK(erk1/2), leading to the up-regulation of macrophage urokinase type plasminogen activator and matrix metalloproteinase (MMP)-9 expression. Serine 29-32 mitogen-activated protein kinase 3 Homo sapiens 154-158 11827968-9 2002 A peptide from the first loop of the globular domain (alpha1:Ser(2179)-Ser(2198)) triggered the phosphorylation of MAPK(erk1/2) and stimulated the expression of macrophage urokinase type plasminogen activator and MMP-9. Serine 71-74 mitogen-activated protein kinase 3 Homo sapiens 115-119 11827968-2 2002 We have reported that alpha1:Ser(2091)-Arg(2108), a peptide derived from the alpha1-chain of laminin-1, triggers protein kinase C-dependent activation of MAPK(erk1/2), leading to the up-regulation of macrophage urokinase type plasminogen activator and matrix metalloproteinase (MMP)-9 expression. Serine 29-32 mitogen-activated protein kinase 3 Homo sapiens 159-165 11827968-9 2002 A peptide from the first loop of the globular domain (alpha1:Ser(2179)-Ser(2198)) triggered the phosphorylation of MAPK(erk1/2) and stimulated the expression of macrophage urokinase type plasminogen activator and MMP-9. Serine 71-74 mitogen-activated protein kinase 3 Homo sapiens 120-126 11466319-6 2001 The MAPKs extracellular signal-regulated kinases 1 and 2 physically interact with ICER and mediated the phosphorylation of ICER on a critical serine residue (Ser-41). Serine 142-148 mitogen-activated protein kinase 3 Homo sapiens 10-56 11733495-7 2002 Moreover, the inhibition of ERKs 1 and 2 with a MEK inhibitor, U1026, lead to an inhibition in the decay of PPARgamma proteins, indicating that serine phosphorylation influences the degradation of PPARgamma in fat cells. Serine 144-150 mitogen-activated protein kinase 3 Homo sapiens 28-40 11818515-7 2002 The phospho-Ser/Thr-Pro content (characteristic of ERK1/2 substrates) of Triton-insoluble proteins (75 and 80 kDa) increased during capacitation and also appeared to be regulated by O(2)(-)* and the ERK pathway. Serine 12-15 mitogen-activated protein kinase 3 Homo sapiens 51-57 11585926-9 2001 These results suggest a molecular pathway whereby MEK1-ERK1/2 signaling regulates cardiomyocyte hypertrophic growth through the transcription factor GATA4 by direct phosphorylation of serine 105, which enhances DNA binding and transcriptional activation. Serine 184-190 mitogen-activated protein kinase 3 Homo sapiens 55-61 11581189-8 2001 Furthermore, tyrosine phosphorylation of FAK and phosphotyrosine kinase (Pyk) 2; serine phosphorylation of c-Raf, MEK1, and Elk 1; and tyrosine-threonine phosphorylation of Erk-1 and -2 were time-dependently activated in the presence of GDNF. Serine 81-87 mitogen-activated protein kinase 3 Homo sapiens 173-185 11466319-6 2001 The MAPKs extracellular signal-regulated kinases 1 and 2 physically interact with ICER and mediated the phosphorylation of ICER on a critical serine residue (Ser-41). Serine 158-161 mitogen-activated protein kinase 3 Homo sapiens 10-56 11443134-8 2001 Moreover, Akt phosphorylated Raf at Ser(259), resulting in a reduced Raf kinase activity and a termination of MEK and ERK1/2 phosphorylation. Serine 36-39 mitogen-activated protein kinase 3 Homo sapiens 118-124 10677502-7 2000 p44MAPK/extracellular signal-regulated kinase 1 (ERK1) and p42 MAPK/ERK2 are activated by IL-3, colocalize with mitochondrial Bcl2, and can directly phosphorylate Bcl2 on Ser-70 in a stauro-resistant manner both in vitro and in vivo. Serine 171-174 mitogen-activated protein kinase 3 Homo sapiens 0-7 10915800-0 2000 MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro. Serine 89-95 mitogen-activated protein kinase 3 Homo sapiens 12-18 10915800-2 2000 Here we report the identification of serine 117 in SREBP-1a as the major phosphorylation site of the MAP kinases Erk1/2. Serine 37-43 mitogen-activated protein kinase 3 Homo sapiens 113-119 11279232-7 2001 In vitro assays indicated that Ser(411) on immunoprecipitated p70(S6K) proteins is phosphorylated by active JNKs and ERKs, but not p38 kinase, and Thr(421)/Ser(424) is phosphorylated by ERK1, but not ERK2, JNKs, or p38 kinase. Serine 31-34 mitogen-activated protein kinase 3 Homo sapiens 117-121 11279232-7 2001 In vitro assays indicated that Ser(411) on immunoprecipitated p70(S6K) proteins is phosphorylated by active JNKs and ERKs, but not p38 kinase, and Thr(421)/Ser(424) is phosphorylated by ERK1, but not ERK2, JNKs, or p38 kinase. Serine 31-34 mitogen-activated protein kinase 3 Homo sapiens 186-190 11279232-7 2001 In vitro assays indicated that Ser(411) on immunoprecipitated p70(S6K) proteins is phosphorylated by active JNKs and ERKs, but not p38 kinase, and Thr(421)/Ser(424) is phosphorylated by ERK1, but not ERK2, JNKs, or p38 kinase. Serine 156-159 mitogen-activated protein kinase 3 Homo sapiens 117-121 10727406-1 2000 In the present study, signal transducer and activator of transcription 3 (STAT3) Ser(727) phosphorylation and transactivation was investigated in relation to activation of mitogen-activated protein (MAP) kinase family members including extracellular-signal-regulated protein kinase (ERK)-1, c-Jun N-terminal kinase (JNK)-1 and p38 ("reactivating kinase") in response to interleukin (IL)-6 stimulation. Serine 81-84 mitogen-activated protein kinase 3 Homo sapiens 236-289 10677502-7 2000 p44MAPK/extracellular signal-regulated kinase 1 (ERK1) and p42 MAPK/ERK2 are activated by IL-3, colocalize with mitochondrial Bcl2, and can directly phosphorylate Bcl2 on Ser-70 in a stauro-resistant manner both in vitro and in vivo. Serine 171-174 mitogen-activated protein kinase 3 Homo sapiens 8-47 10677502-7 2000 p44MAPK/extracellular signal-regulated kinase 1 (ERK1) and p42 MAPK/ERK2 are activated by IL-3, colocalize with mitochondrial Bcl2, and can directly phosphorylate Bcl2 on Ser-70 in a stauro-resistant manner both in vitro and in vivo. Serine 171-174 mitogen-activated protein kinase 3 Homo sapiens 49-53 10645003-6 2000 IFN-gamma also rapidly and transiently activates extracellular signal-regulated kinase 1,2 (ERK1,2) and blocking ERK1,2 pathway (Raf/MEK1,2/ERK1,2) by specific MEK1,2 inhibitor PD98059 partially (by 50%) prevents Ser-727 phosphorylation of STAT1 and suppression of MMP-13 expression by IFN-gamma. Serine 213-216 mitogen-activated protein kinase 3 Homo sapiens 113-119 10660623-0 2000 Selective activation of MAPK(erk1/2) by laminin-1 peptide alpha1:Ser(2091)-Arg(2108) regulates macrophage degradative phenotype. Serine 65-68 mitogen-activated protein kinase 3 Homo sapiens 24-28 10660623-0 2000 Selective activation of MAPK(erk1/2) by laminin-1 peptide alpha1:Ser(2091)-Arg(2108) regulates macrophage degradative phenotype. Serine 65-68 mitogen-activated protein kinase 3 Homo sapiens 29-35 10645003-6 2000 IFN-gamma also rapidly and transiently activates extracellular signal-regulated kinase 1,2 (ERK1,2) and blocking ERK1,2 pathway (Raf/MEK1,2/ERK1,2) by specific MEK1,2 inhibitor PD98059 partially (by 50%) prevents Ser-727 phosphorylation of STAT1 and suppression of MMP-13 expression by IFN-gamma. Serine 213-216 mitogen-activated protein kinase 3 Homo sapiens 113-119 10645003-7 2000 Furthermore, Ser-727 phosphorylation of STAT1 by ERK1,2, or independently of ERK1,2 activation is associated with marked reduction in MMP-13 expression. Serine 13-16 mitogen-activated protein kinase 3 Homo sapiens 49-55 10828601-2 2000 In this pathway, the MAP kinases ERK1/ERK2 are phosphorylated and activated by the dual-specificity kinases MEK1 and MEK2, which in turn are activated by serine phosphorylation by a number of MAP kinase kinase kinases. Serine 154-160 mitogen-activated protein kinase 3 Homo sapiens 33-37 10574913-7 1999 Ser(670) is located in a peptide sequence that conforms to an ERK consensus phosphorylation sequence, and in vitro, in the presence of heparin, ERK1 phosphorylates GRK2. Serine 0-3 mitogen-activated protein kinase 3 Homo sapiens 144-148 34265398-3 2021 Mechanistically, ERK1 phosphorylated serine 183 of ISX, facilitating its nuclear translocation and downstream target gene expression. Serine 37-43 mitogen-activated protein kinase 3 Homo sapiens 17-21 10473609-6 1999 ERKs 1 and 2 phosphorylate SH2-Bbeta primarily on Ser-96 in vitro. Serine 50-53 mitogen-activated protein kinase 3 Homo sapiens 0-12 10347142-5 1999 ERK1 and ERK2 phosphorylate beta-arrestin1 at Ser-412 in vitro. Serine 46-49 mitogen-activated protein kinase 3 Homo sapiens 0-4 7925583-5 1994 Using two-dimensional analysis we have shown that IL-8 induced a rapid serine/threonine phosphorylation of a number of neutrophil substrates the most prominent being phosphoprotein 39 (pp39), extracellular signal-related kinase-1, pp55 and pp66. Serine 71-77 mitogen-activated protein kinase 3 Homo sapiens 192-229 1322500-7 1992 c-Raf-1 reactivation of MAPK-K coincides with the selective phosphorylation at serine/threonine residues of a polypeptide with M(r) 50,000 which coelutes precisely on cation-exchange chromatography with the MAPK-K activatable by c-Raf-1. Serine 79-85 mitogen-activated protein kinase 3 Homo sapiens 24-28 1804309-2 1991 Using intact human peripheral blood B cells of young subjects labeled with orthophosphate, increased phosphorylation levels of serine/threonine and tyrosine substrates were demonstrated on indicator phosphoproteins corresponding to the CD20 isoforms and microtubule-associated protein 2 kinase after cross-linking sIg and costimulation with phorbol diesters. Serine 127-133 mitogen-activated protein kinase 3 Homo sapiens 254-293 9328838-6 1997 This region contains three serine residues that are potential ERK1 phosphorylation sites. Serine 27-33 mitogen-activated protein kinase 3 Homo sapiens 62-66 9067571-12 1997 p27 is phosphorylated exclusively on serine by Erk1 and almost exclusively on threonine by Cdk1 in in vitro experiments. Serine 37-43 mitogen-activated protein kinase 3 Homo sapiens 47-51 7970731-2 1994 TAL1 encodes a basic helix-loop-helix transcription factor that is phosphorylated on serine residue 122 by the mitogen-activated protein (MAP) kinase ERK1. Serine 85-91 mitogen-activated protein kinase 3 Homo sapiens 150-154 8152805-5 1994 Serine residue 100 is the major site of TAL2 phosphorylation in vivo, and it serves as an effective in vitro substrate for mitogen-activated protein (MAP) kinases such as ERK1. Serine 0-6 mitogen-activated protein kinase 3 Homo sapiens 171-175 8281932-10 1993 This suggests that serine/threonine dephosphorylation of ERK1 inhibitor leads to an increase in its activity. Serine 19-25 mitogen-activated protein kinase 3 Homo sapiens 57-61 34564169-8 2021 RSK is a vertebrate family of cytosolic serine-threonine kinases that act downstream of the ras-ERK1/2 (extracellular-signal-regulated kinase 1/2) pathway, which phosphorylates substrates shown to regulate several cellular processes, including growth, survival, and proliferation. Serine 40-46 mitogen-activated protein kinase 3 Homo sapiens 96-102 35460012-7 2022 It attenuates the ERK1/2-induced serine phosphorylation of IRS-1 and thus enhances IRS-1 tyrosine phosphorylation and Akt activation. Serine 33-39 mitogen-activated protein kinase 3 Homo sapiens 18-24