PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34498800-12 2021 Importantly, we discovered that circGNG7 could bind to serine residues 78 and 82 of the functional heat shock protein 27 (HSP27), occupying its phosphorylation sites and hindering its phosphorylation, which reduced HSP27-JNK/P38 mitogen-activated protein kinase (MAPK) oncogenic signaling. Serine 55-61 mitogen-activated protein kinase 8 Homo sapiens 221-224 31524273-5 2019 For example, Aurora-A induces cell transformation by phosphorylating hepatoma upregulated protein (HURP) at four serine residues, which in turn decreases the phosphorylated levels of cell-growth suppressive Jun N-terminal kinase (p-JNK). Serine 113-119 mitogen-activated protein kinase 8 Homo sapiens 207-228 32404348-7 2020 In contrast, JNK-independent phosphorylation of Tob2 at serine 254 (S254) greatly enhances Tob2 interaction with PABP and its ability to promote deadenylation. Serine 56-62 mitogen-activated protein kinase 8 Homo sapiens 13-16 35608791-0 2022 Correction to: JNK1-Dependent Phosphorylation of GAP-43 Serine 142 is a Novel Molecular Marker for Axonal Growth. Serine 56-62 mitogen-activated protein kinase 8 Homo sapiens 15-19 35347634-0 2022 JNK1-Dependent Phosphorylation of GAP-43 Serine 142 is a Novel Molecular Marker for Axonal Growth. Serine 41-47 mitogen-activated protein kinase 8 Homo sapiens 0-4 33224105-6 2020 As a bridge between AD and type 2 diabetes, activation of c-Jun N-terminal kinase (JNK) pathway with the ensued serine phosphorylation of the insulin response substrate (IRS)-1/2 may be at the crossroads of insulin resistance and its subsequent dysmetabolic consequences. Serine 112-118 mitogen-activated protein kinase 8 Homo sapiens 58-81 33224105-6 2020 As a bridge between AD and type 2 diabetes, activation of c-Jun N-terminal kinase (JNK) pathway with the ensued serine phosphorylation of the insulin response substrate (IRS)-1/2 may be at the crossroads of insulin resistance and its subsequent dysmetabolic consequences. Serine 112-118 mitogen-activated protein kinase 8 Homo sapiens 83-86 32404348-5 2020 In this study, we found that c-Jun amino-terminal kinase (JNK) increases phosphorylation of Tob2 at many Ser/Thr sites in the intrinsically disordered region (IDR) that contains two separate PABP-interacting PAM2 motifs. Serine 105-108 mitogen-activated protein kinase 8 Homo sapiens 29-56 32404348-5 2020 In this study, we found that c-Jun amino-terminal kinase (JNK) increases phosphorylation of Tob2 at many Ser/Thr sites in the intrinsically disordered region (IDR) that contains two separate PABP-interacting PAM2 motifs. Serine 105-108 mitogen-activated protein kinase 8 Homo sapiens 58-61 32067279-0 2020 Abeta monomer induces phosphorylation of Tau at Ser-214 through beta2AR-PKA-JNK signaling pathway. Serine 48-51 mitogen-activated protein kinase 8 Homo sapiens 76-79 29361525-7 2018 JNK1 (also known as MAPK8) phosphorylates Net1A on serine 52, and alanine substitution at this site prevents Net1A relocalization caused by EGF or JNK activation. Serine 51-57 mitogen-activated protein kinase 8 Homo sapiens 0-4 30333228-8 2018 These results indicate that JNK-mediated phosphorylation of SARM1 at Ser-548 is a regulator of SARM1 leading to inhibition of mitochondrial respiration. Serine 69-72 mitogen-activated protein kinase 8 Homo sapiens 28-31 31223033-5 2019 PTS reversed PA-mediated activation of c-Jun N-terminal kinase (JNK), which in turn altered insulin signalling pathway by phosphorylating IRS-1 at Ser 307, leading to inhibition of phosphorylation of Akt and GSK-3beta. Serine 147-150 mitogen-activated protein kinase 8 Homo sapiens 39-62 31223033-5 2019 PTS reversed PA-mediated activation of c-Jun N-terminal kinase (JNK), which in turn altered insulin signalling pathway by phosphorylating IRS-1 at Ser 307, leading to inhibition of phosphorylation of Akt and GSK-3beta. Serine 147-150 mitogen-activated protein kinase 8 Homo sapiens 64-67 29361525-7 2018 JNK1 (also known as MAPK8) phosphorylates Net1A on serine 52, and alanine substitution at this site prevents Net1A relocalization caused by EGF or JNK activation. Serine 51-57 mitogen-activated protein kinase 8 Homo sapiens 20-25 29361525-7 2018 JNK1 (also known as MAPK8) phosphorylates Net1A on serine 52, and alanine substitution at this site prevents Net1A relocalization caused by EGF or JNK activation. Serine 51-57 mitogen-activated protein kinase 8 Homo sapiens 0-3 29166604-5 2017 Phosphorylation of serine 135 of Syt4 by JNK steers DCV trafficking by destabilizing Syt4-Kif1A interaction, leading to a transition from microtubule-dependent DCV trafficking to capture at en passant presynaptic boutons by actin. Serine 19-25 mitogen-activated protein kinase 8 Homo sapiens 41-44 27686967-7 2016 Early activation of the N-terminal Janus activated kinase (JNK) was also observed, thereby increasing IRS1 Ser 307 phosphorylation. Serine 107-110 mitogen-activated protein kinase 8 Homo sapiens 35-57 28550372-8 2017 The phosphorylation of DLK on Ser-302 within the activation loop was required for DLK to stimulate JNK and to inhibit CREB-dependent gene transcription. Serine 30-33 mitogen-activated protein kinase 8 Homo sapiens 99-102 29088796-9 2017 TNC/JNK also markedly induced the phosphorylation of Paxillin on serine 178, which is critical for the association between FAK and Paxillin and promoted the formation of focal adhesions. Serine 65-71 mitogen-activated protein kinase 8 Homo sapiens 4-7 29088796-10 2017 TNC/JNK initiates cell migration and invasion of pancreatic cancer cells through the promotion of EMT, the transactivation of MMP9 and the phosphorylation of Paxillin on serine 178. Serine 170-176 mitogen-activated protein kinase 8 Homo sapiens 4-7 28011403-6 2017 We observed that these effects were exerted by changes on the phosphorylation of IRS-1 on specific serine and tyrosine residues modulated by PA through the modulation of JNK and IKK activity. Serine 99-105 mitogen-activated protein kinase 8 Homo sapiens 170-173 26705936-7 2017 MCF-7 cells cocultured with M2 TAM showed activated JAK1/STAT3 and Raf/MEK/JNK pathways contributing to tyrosine and serine phophorylation of STAT3, respectively. Serine 117-123 mitogen-activated protein kinase 8 Homo sapiens 75-78 27686967-7 2016 Early activation of the N-terminal Janus activated kinase (JNK) was also observed, thereby increasing IRS1 Ser 307 phosphorylation. Serine 107-110 mitogen-activated protein kinase 8 Homo sapiens 59-62 27568560-4 2016 We show that the stress-activated protein kinase, c-Jun N-terminal kinase (JNK), phosphorylates SIRT6 on serine 10 in response to oxidative stress. Serine 105-111 mitogen-activated protein kinase 8 Homo sapiens 50-73 27568560-4 2016 We show that the stress-activated protein kinase, c-Jun N-terminal kinase (JNK), phosphorylates SIRT6 on serine 10 in response to oxidative stress. Serine 105-111 mitogen-activated protein kinase 8 Homo sapiens 75-78 27481183-3 2016 At the protein expression level, compared to the lean, the phosphorylation of AMPK, and p-Akt at serine 473 were significantly reduced from the overweight (OW) and/or obese (OB); while the protein expression of p-JNK, cleaved caspase 3, CHOP and p-eIF2alpha were elevated from the OW and/or OB. Serine 97-103 mitogen-activated protein kinase 8 Homo sapiens 213-216 26470730-4 2016 In this study we demonstrate that exposure of hepatocytes to ethanol or exposure of macrophages to lipopolysaccharide (LPS) induces the c-Jun N-terminal kinase (JNK)-dependent phosphorylation of FOXO3 at serine-574. Serine 204-210 mitogen-activated protein kinase 8 Homo sapiens 136-159 26470730-4 2016 In this study we demonstrate that exposure of hepatocytes to ethanol or exposure of macrophages to lipopolysaccharide (LPS) induces the c-Jun N-terminal kinase (JNK)-dependent phosphorylation of FOXO3 at serine-574. Serine 204-210 mitogen-activated protein kinase 8 Homo sapiens 161-164 26518652-8 2015 In addition, paxillin, one of the known JNK effectors which is phosphorylated and affects cell migration, was phosphorylated at serine 178 in JNK activity-dependent manner. Serine 128-134 mitogen-activated protein kinase 8 Homo sapiens 40-43 27013170-1 2016 BACKGROUND: We have recently reported that protein phosphate 2A (PP2A) inactivation resulted in increased phosphorylation of the mitogen-activated protein kinase (MAPK) c-Jun N-terminal kinase 1 (JNK1) and glucocorticoid receptors (GR) at Ser(226), thereby reducing GR nuclear translocation and causing corticosteroid insensitivity in severe asthmatics. Serine 239-242 mitogen-activated protein kinase 8 Homo sapiens 169-194 27013170-1 2016 BACKGROUND: We have recently reported that protein phosphate 2A (PP2A) inactivation resulted in increased phosphorylation of the mitogen-activated protein kinase (MAPK) c-Jun N-terminal kinase 1 (JNK1) and glucocorticoid receptors (GR) at Ser(226), thereby reducing GR nuclear translocation and causing corticosteroid insensitivity in severe asthmatics. Serine 239-242 mitogen-activated protein kinase 8 Homo sapiens 196-200 26518652-8 2015 In addition, paxillin, one of the known JNK effectors which is phosphorylated and affects cell migration, was phosphorylated at serine 178 in JNK activity-dependent manner. Serine 128-134 mitogen-activated protein kinase 8 Homo sapiens 142-145 25627174-8 2015 In addition, our analyses using fluorescent recovery after photobleaching revealed that kinases such as c-Jun N-terminal kinase and IkappaB kinase beta, which phosphorylate serine/threonine residues of IRS and contribute to insulin resistance, altered the interaction kinetics of IRS with insulin receptor. Serine 173-179 mitogen-activated protein kinase 8 Homo sapiens 106-127 26370512-7 2015 Collectively, our data suggest that hypercapnia leads to JNK-induced LMO7b phosphorylation at Ser-1295, which facilitates the interaction of LMO7b with Na,K-ATPase at the plasma membrane promoting the endocytosis of Na,K-ATPase in alveolar epithelial cells. Serine 94-97 mitogen-activated protein kinase 8 Homo sapiens 57-60 26376801-7 2015 Immunoblot analysis showed that the phosphorylation on Ser-7 of FOXO3a is associated with p38/JNK activation, whereas the acetylation on Lys-242/5 is correlated with the downregulation of SIRT1/2/6 and the induction of the acetyltransferase CBP/p300. Serine 55-58 mitogen-activated protein kinase 8 Homo sapiens 94-97 26052031-5 2015 We propose that modulation of glucocorticoid phosphorylation at serine 226, by targeting JNK signaling pathway, could be a potential strategy for antidepressant treatment. Serine 64-70 mitogen-activated protein kinase 8 Homo sapiens 89-92 26057631-5 2015 Further studies demonstrated that MUC1-mediated JNK activation not only enhances the phosphorylation of Smad2 C-terminal at Ser-465/467 site (Smad2C) through TGF-beta/TbetaRI, but also directly enhances the phosphorylation of Smad2 linker region at Ser-245/250/255 site (Smad2L), and then both of them collaborate to upregulate matrix metalloproteinase (MMP)-9-mediated cell migration and invasion of HCC. Serine 124-127 mitogen-activated protein kinase 8 Homo sapiens 48-51 26057631-5 2015 Further studies demonstrated that MUC1-mediated JNK activation not only enhances the phosphorylation of Smad2 C-terminal at Ser-465/467 site (Smad2C) through TGF-beta/TbetaRI, but also directly enhances the phosphorylation of Smad2 linker region at Ser-245/250/255 site (Smad2L), and then both of them collaborate to upregulate matrix metalloproteinase (MMP)-9-mediated cell migration and invasion of HCC. Serine 249-252 mitogen-activated protein kinase 8 Homo sapiens 48-51 25791820-8 2015 Kinase inhibition revealed sustained activation of the JNK pathway caused increased Bcl-2 protein Ser(70) hypo-and hyper-phosphorylation. Serine 98-101 mitogen-activated protein kinase 8 Homo sapiens 55-58 25446109-7 2015 In addition, reduction of JNK activation attenuated HSP27 phosphorylation envoked by TNF-alpha, especially the phosphorylation of HSP27 at serine 78 residue. Serine 139-145 mitogen-activated protein kinase 8 Homo sapiens 26-29 25168245-4 2015 An nSMase1 was identified as a JNK substrate, and the phosphorylation site responsible for its effects on stress and cytokine induction was Ser-270. Serine 140-143 mitogen-activated protein kinase 8 Homo sapiens 31-34 25623542-17 2015 The results showed that amygdalin and cinnamic acid inhibit serine phosphorylation of IRS-1 through targeting JNK serine kinase and enhance insulin sensitivity. Serine 60-66 mitogen-activated protein kinase 8 Homo sapiens 110-113 25310587-0 2014 JNK1-mediated phosphorylation of Smac/DIABLO at the serine 6 residue is functionally linked to its mitochondrial release during TNF-alpha--induced apoptosis of HeLa cells. Serine 52-58 mitogen-activated protein kinase 8 Homo sapiens 0-4 25353341-4 2014 In contrast, ERK and JNK phosphorylate SREBP-1c at two major sites, i.e. threonine 81 and serine 93, instead of one site in SREBP-1a. Serine 90-96 mitogen-activated protein kinase 8 Homo sapiens 21-24 25156145-5 2014 JNK signaling led to Bcl-xL phosphorylation at serine 62, dissociation of Bak from Bcl-xL, oligomerization of Bak, alteration of mitochondrial membrane potential, and subsequent cytochrome c release. Serine 47-53 mitogen-activated protein kinase 8 Homo sapiens 0-3 25341038-12 2014 Concurrently, stress-activated JNK phosphorylates TAp73 at multiple serine and threonine residues, which is crucial to ablate TAp73/MDM2 complex and to promote TAp73 transcriptional function and induction of robust apoptosis. Serine 68-74 mitogen-activated protein kinase 8 Homo sapiens 31-34 24699331-8 2014 These findings suggest that a balance between O-GlcNac modification and JNK-induced phosphorylation may exist, with decreased Ser/Thr O-GlcNac modification following trauma and hemorrhage, allowing JNK to phosphorylate the IR on neighboring Ser/Thr residues, which subsequently inhibits IR activity. Serine 126-129 mitogen-activated protein kinase 8 Homo sapiens 198-201 25285524-6 2014 Oxidative stress from menadione-generated superoxide induced JNK-dependent stathmin phosphorylation at Ser-16, Ser-25 and Ser-38 in hepatocytes. Serine 103-106 mitogen-activated protein kinase 8 Homo sapiens 61-64 25285524-6 2014 Oxidative stress from menadione-generated superoxide induced JNK-dependent stathmin phosphorylation at Ser-16, Ser-25 and Ser-38 in hepatocytes. Serine 111-114 mitogen-activated protein kinase 8 Homo sapiens 61-64 25285524-6 2014 Oxidative stress from menadione-generated superoxide induced JNK-dependent stathmin phosphorylation at Ser-16, Ser-25 and Ser-38 in hepatocytes. Serine 111-114 mitogen-activated protein kinase 8 Homo sapiens 61-64 24889144-4 2014 Based on a bioinformatics approach, we estimated the potential phosphorylation site of angulin-1/LSR by JNK1 to be serine 288 and experimentally confirmed that JNK1 directly phosphorylates angulin-1/LSR at this site. Serine 115-121 mitogen-activated protein kinase 8 Homo sapiens 104-108 24889144-4 2014 Based on a bioinformatics approach, we estimated the potential phosphorylation site of angulin-1/LSR by JNK1 to be serine 288 and experimentally confirmed that JNK1 directly phosphorylates angulin-1/LSR at this site. Serine 115-121 mitogen-activated protein kinase 8 Homo sapiens 160-164 24699331-8 2014 These findings suggest that a balance between O-GlcNac modification and JNK-induced phosphorylation may exist, with decreased Ser/Thr O-GlcNac modification following trauma and hemorrhage, allowing JNK to phosphorylate the IR on neighboring Ser/Thr residues, which subsequently inhibits IR activity. Serine 241-244 mitogen-activated protein kinase 8 Homo sapiens 198-201 24582688-1 2014 Our previous studies suggested that arsenic is able to induce serine 21 phosphorylation of the EZH2 protein through activation of JNK, STAT3, and Akt signaling pathways in the bronchial epithelial cell line, BEAS-2B. Serine 62-68 mitogen-activated protein kinase 8 Homo sapiens 130-133 24486574-6 2014 JNK signaling led to Bcl-xL phosphorylation at serine 62, oligomerization of Bax, alteration of mitochondrial membrane potential, and subsequent cytochrome c release. Serine 47-53 mitogen-activated protein kinase 8 Homo sapiens 0-3 24589734-3 2014 Previously, we characterized mechanisms underlying JNK phosphorylation of STMN at proline-flanked serine residues (Ser25 and Ser38) that are conserved across STMN-like proteins. Serine 98-104 mitogen-activated protein kinase 8 Homo sapiens 51-54 24589734-4 2014 In this study, we demonstrated using in vitro kinase assays and alanine replacement of serine residues that JNK phosphorylated the STMN-like domain (SLD) of SCG10 on Ser73, consistent with our previous finding that STMN Ser38 was the primary JNK target site. Serine 87-93 mitogen-activated protein kinase 8 Homo sapiens 108-111 24037783-7 2014 The TNF-alpha-induced JNK1 phosphorylation was significantly blocked by treatment with GSK-3beta inhibitors (either LiCl or TWS119), and stimulation of beta-adrenergic receptors induced the inhibition of GSK-3beta through the phosphorylation of Ser(9) . Serine 245-248 mitogen-activated protein kinase 8 Homo sapiens 22-26 24349153-8 2013 In conclusion, p66(Shc) acts as a novel intermediate in the TNFalpha pathway mediating endothelial dysfunction, and its action requires JNK-dependent phosphorylation of p66(Shc) on Ser(36). Serine 181-184 mitogen-activated protein kinase 8 Homo sapiens 136-139 24302736-11 2014 Taken together our study indicates that JNK- and PKA-mediated STMN Ser-38 and Ser-63 phosphorylation are required to preserve interphase microtubules in response to hyperosmotic stress. Serine 67-70 mitogen-activated protein kinase 8 Homo sapiens 40-44 24302736-11 2014 Taken together our study indicates that JNK- and PKA-mediated STMN Ser-38 and Ser-63 phosphorylation are required to preserve interphase microtubules in response to hyperosmotic stress. Serine 78-81 mitogen-activated protein kinase 8 Homo sapiens 40-44 22771387-6 2012 Akt phosphorylation at serine 473 correlated with JNK activity, and co-immunoprecipitation studies revealed a direct interaction between JNK and Akt. Serine 23-29 mitogen-activated protein kinase 8 Homo sapiens 50-53 24013390-4 2013 Death signaling was activated by c-Jun N-terminal kinase (JNK) signaling which led to Bcl-xL phosphorylation at serine 62, decreasing the anti-apoptotic activity of Bcl-xL, which contributed to the intrinsic pathway. Serine 112-118 mitogen-activated protein kinase 8 Homo sapiens 33-56 24013390-4 2013 Death signaling was activated by c-Jun N-terminal kinase (JNK) signaling which led to Bcl-xL phosphorylation at serine 62, decreasing the anti-apoptotic activity of Bcl-xL, which contributed to the intrinsic pathway. Serine 112-118 mitogen-activated protein kinase 8 Homo sapiens 58-61 23608534-6 2013 Ribosome-associated JNK phosphorylates the eukaryotic translation elongation factor 1A isoform 2 (eEF1A2) on serines 205 and 358 to promote degradation of NSPs by the proteasome. Serine 109-116 mitogen-activated protein kinase 8 Homo sapiens 20-23 21993018-3 2012 Bortezomib treatment led to phosphorylation/activation of jun N-terminal kinase (JNK) enzymes and JNK-dependent phosphorylation of Bcl-2 on serine 70. Serine 140-146 mitogen-activated protein kinase 8 Homo sapiens 98-101 22750292-6 2012 Phosphorylation of paxillin at the Ser-178 position, the JNK phosphorylation site, is observed following stimulation with neuronal CM. Serine 35-38 mitogen-activated protein kinase 8 Homo sapiens 57-60 22924711-7 2012 LPS increased p38 MAPK and JNK phosphorylation at 4 and 2-4 h, respectively, whereas treatment reduced p38 MAPK and JNK phosphorylation only at 2 h. In addition, treatment reversed the LPS-induced elevation of NF-kappaB p65 protein and phosphorylation at serine 468 and induced acetylation at lysine 310. Serine 255-261 mitogen-activated protein kinase 8 Homo sapiens 116-119 22609131-6 2012 FFA cause insulin resistance by inhibiting insulin signaling through the activation of serin-kinases, i.e. protein kinase C-Theta, and the kinases JNK and IKK, which promote a mechanism of serine phosphorylation of Insulin Receptor Substrates (IRS), leading to interruption of the downstream insulin receptor (IR) signaling. Serine 189-195 mitogen-activated protein kinase 8 Homo sapiens 147-150 22865050-2 2012 Recent studies reveal that serine phosphorylation of paxillin by JNK and p38 MAPK is essential for cell migration or neurite extension, but their cellular targets remain unclear. Serine 27-33 mitogen-activated protein kinase 8 Homo sapiens 65-68 22441692-2 2012 Here we show that c-Jun N-terminal kinase (JNK), identified by inhibitor screening of BMAL1 phosphorylation at Ser 520/Thr 527/Ser 592, confers dynamic regulation on the clock. Serine 111-114 mitogen-activated protein kinase 8 Homo sapiens 18-41 22441692-2 2012 Here we show that c-Jun N-terminal kinase (JNK), identified by inhibitor screening of BMAL1 phosphorylation at Ser 520/Thr 527/Ser 592, confers dynamic regulation on the clock. Serine 111-114 mitogen-activated protein kinase 8 Homo sapiens 43-46 22476196-5 2012 We found that amyloid-beta peptide (Abeta) oligomers, synaptotoxins that accumulate in the brains of AD patients, activated the JNK/TNF-alpha pathway, induced IRS-1 phosphorylation at multiple serine residues, and inhibited physiological IRS-1pTyr in mature cultured hippocampal neurons. Serine 193-199 mitogen-activated protein kinase 8 Homo sapiens 128-131 21540183-4 2011 Mouse SIRT1 is phosphorylated by JNK1 at Ser-46 (Ser-47 in human SIRT1), which is one of the four potential residues targeted by JNK1. Serine 41-44 mitogen-activated protein kinase 8 Homo sapiens 129-133 23056407-4 2012 Hypercapnia-induced activation of JNK required AMP-activated protein kinase (AMPK) and protein kinase C-zeta leading to subsequent phosphorylation of JNK at Ser-129. Serine 157-160 mitogen-activated protein kinase 8 Homo sapiens 34-37 23056407-4 2012 Hypercapnia-induced activation of JNK required AMP-activated protein kinase (AMPK) and protein kinase C-zeta leading to subsequent phosphorylation of JNK at Ser-129. Serine 157-160 mitogen-activated protein kinase 8 Homo sapiens 150-153 22006247-10 2012 Indeed, tunicamycin induced a robust activation of the inositol-requiring enzyme 1 (IRE-1)/c-JUN NH2-terminal kinase (JNK) pathway, leading to serine phosphorylation of insulin receptor substrate 1 (IRS-1) and a decrease in IRS-1 tyrosine phosphorylation. Serine 143-149 mitogen-activated protein kinase 8 Homo sapiens 118-121 21900690-3 2011 While the pathway responsible for IRS-1 degradation in this system is unknown, c-Jun NH(2)-terminal kinase (JNK) has been linked with serine phosphorylation of IRS-1 and insulin resistance. Serine 134-140 mitogen-activated protein kinase 8 Homo sapiens 79-106 21900690-3 2011 While the pathway responsible for IRS-1 degradation in this system is unknown, c-Jun NH(2)-terminal kinase (JNK) has been linked with serine phosphorylation of IRS-1 and insulin resistance. Serine 134-140 mitogen-activated protein kinase 8 Homo sapiens 108-111 21840417-5 2011 An inhibitor of c-Jun N-terminal kinase (JNK), SP600125, suppressed the SPC-induced phosphorylation of serine 431 in K8 and keratin reorganization. Serine 103-109 mitogen-activated protein kinase 8 Homo sapiens 16-39 21840417-5 2011 An inhibitor of c-Jun N-terminal kinase (JNK), SP600125, suppressed the SPC-induced phosphorylation of serine 431 in K8 and keratin reorganization. Serine 103-109 mitogen-activated protein kinase 8 Homo sapiens 41-44 21840417-6 2011 Next, we examined the effect of Tgase-2 on JNK activation of serine 431 phosphorylation in K8. Serine 61-67 mitogen-activated protein kinase 8 Homo sapiens 43-46 21807946-4 2011 Point mutation of these Ser residues to alanine (Ala) abolished the JNK-induced ubiquitylation by SCF(betaTrCP), and point mutation of DAG to AAG or DAA eradicated both betaTrCP binding and ubiquitylation. Serine 24-27 mitogen-activated protein kinase 8 Homo sapiens 68-71 21465527-8 2011 We also identified the phosphorylation of MEF serine 641 by in vitro and in vivo JNK1 kinase assays combined with a proteomics approach. Serine 46-52 mitogen-activated protein kinase 8 Homo sapiens 81-85 21540183-4 2011 Mouse SIRT1 is phosphorylated by JNK1 at Ser-46 (Ser-47 in human SIRT1), which is one of the four potential residues targeted by JNK1. Serine 49-52 mitogen-activated protein kinase 8 Homo sapiens 129-133 20541543-5 2010 IRS-1 serine(307) phosphorylation was significantly reduced by JNK or IKKbeta inhibitor, especially by combination of these two inhibitors. Serine 6-12 mitogen-activated protein kinase 8 Homo sapiens 63-66 21478152-7 2011 Inhibition of JNK (with JNK inhibitor SP600125 or using dominant-negative JNK) reduced serine 307 phosphorylation of IRS1. Serine 87-93 mitogen-activated protein kinase 8 Homo sapiens 24-27 21478152-7 2011 Inhibition of JNK (with JNK inhibitor SP600125 or using dominant-negative JNK) reduced serine 307 phosphorylation of IRS1. Serine 87-93 mitogen-activated protein kinase 8 Homo sapiens 24-27 21123173-0 2011 Deactivation of STAT6 through serine 707 phosphorylation by JNK. Serine 30-36 mitogen-activated protein kinase 8 Homo sapiens 60-63 21123173-4 2011 Our analyses suggest that Ser-707 is phosphorylated by c-Jun N-terminal kinase (JNK). Serine 26-29 mitogen-activated protein kinase 8 Homo sapiens 55-78 21123173-4 2011 Our analyses suggest that Ser-707 is phosphorylated by c-Jun N-terminal kinase (JNK). Serine 26-29 mitogen-activated protein kinase 8 Homo sapiens 80-83 21123173-6 2011 Inactivation of STAT6 by JNK-dependent Ser-707 phosphorylation may be one mechanism of controlling the balance between IL-1beta and IL-4 signals. Serine 39-42 mitogen-activated protein kinase 8 Homo sapiens 25-28 21030692-1 2011 We recently reported that c-Jun N-terminal kinase (JNK) is associated with adherens junctions and phosphorylates beta-catenin at serine 33/37 and threonine 41. Serine 129-135 mitogen-activated protein kinase 8 Homo sapiens 26-49 21030692-1 2011 We recently reported that c-Jun N-terminal kinase (JNK) is associated with adherens junctions and phosphorylates beta-catenin at serine 33/37 and threonine 41. Serine 129-135 mitogen-activated protein kinase 8 Homo sapiens 51-54 21502402-4 2011 This Ser 68 is phosphorylated by p38, c-Jun N-terminal kinases (JNK), and extracellular signal-regulated kinases1/2 in vitro, and its phosphorylation levels positively correlate with Twist1 protein levels in human embryonic kidney 293 and breast cancer cells. Serine 5-8 mitogen-activated protein kinase 8 Homo sapiens 64-67 21502402-8 2011 Importantly, the levels of Ser 68 phosphorylation in the invasive human breast ductal carcinomas positively correlate with the levels of Twist1 protein and JNK activity and are significantly higher in progesterone receptor-negative and HER2-positive breast cancers. Serine 27-30 mitogen-activated protein kinase 8 Homo sapiens 156-159 21478152-6 2011 Furthermore, resistin increased serine phosphorylation of insulin receptor substrate (IRS1) through the activation of the apoptosis signal-regulating kinase 1/c-Jun N-terminal Kinase (JNK) pathway, a module known to stimulate insulin resistance. Serine 32-38 mitogen-activated protein kinase 8 Homo sapiens 184-187 21478152-7 2011 Inhibition of JNK (with JNK inhibitor SP600125 or using dominant-negative JNK) reduced serine 307 phosphorylation of IRS1. Serine 87-93 mitogen-activated protein kinase 8 Homo sapiens 14-17 20452983-5 2010 The PEA-15-induced JNK activation depends on the phosphorylation of PEA-15 at both phosphorylation sites (serine 104 and serine 116). Serine 106-112 mitogen-activated protein kinase 8 Homo sapiens 19-22 20630875-3 2010 Here we show that in response to hyperosmotic stress, JNK phosphorylates a key cytoplasmic microtubule regulatory protein, stathmin (STMN), on conserved Ser-25 and Ser-38 residues. Serine 153-156 mitogen-activated protein kinase 8 Homo sapiens 54-57 20630875-3 2010 Here we show that in response to hyperosmotic stress, JNK phosphorylates a key cytoplasmic microtubule regulatory protein, stathmin (STMN), on conserved Ser-25 and Ser-38 residues. Serine 164-167 mitogen-activated protein kinase 8 Homo sapiens 54-57 20630875-4 2010 In in vitro biochemical studies, we identified STMN Ser-38 as the critical residue required for efficient phosphorylation by JNK and identified a novel kinase interaction domain in STMN required for recognition by JNK. Serine 52-55 mitogen-activated protein kinase 8 Homo sapiens 125-128 20630875-4 2010 In in vitro biochemical studies, we identified STMN Ser-38 as the critical residue required for efficient phosphorylation by JNK and identified a novel kinase interaction domain in STMN required for recognition by JNK. Serine 52-55 mitogen-activated protein kinase 8 Homo sapiens 214-217 20452983-5 2010 The PEA-15-induced JNK activation depends on the phosphorylation of PEA-15 at both phosphorylation sites (serine 104 and serine 116). Serine 121-127 mitogen-activated protein kinase 8 Homo sapiens 19-22 20219981-6 2010 However, in the presence of a JNK inhibitor, TNFalpha-induced apoptosis was diminished and serine phosphorylation of IRS proteins was prevented. Serine 91-97 mitogen-activated protein kinase 8 Homo sapiens 30-33 20510162-7 2010 We further demonstrated that serine-140 residue of AIMP1 was phosphorylated by JNK and alanine mutation of serine-140 suppressed LPS-induced cell surface expression of gp96. Serine 29-35 mitogen-activated protein kinase 8 Homo sapiens 79-82 20220133-4 2010 Here we show that JNK directly phosphorylates Cdc25C at serine 168 during G(2) phase of the cell cycle. Serine 56-62 mitogen-activated protein kinase 8 Homo sapiens 18-21 20814545-4 2010 TLR4, expressed in insulin target tissues, activates proinflammatory kinases JNK, IKK, and p38 that impair insulin signal transduction directly through inhibitory phosphorylation of insulin receptor substrate (IRS) on serine residues. Serine 218-224 mitogen-activated protein kinase 8 Homo sapiens 77-80 20028971-0 2010 c-Jun N-terminal kinase enhances MST1-mediated pro-apoptotic signaling through phosphorylation at serine 82. Serine 98-104 mitogen-activated protein kinase 8 Homo sapiens 0-23 20028971-5 2010 In this study, we report that JNK (c-Jun N-terminal kinase) phosphorylates MST1 at serine 82, which leads to the enhancement of MST1 activation. Serine 83-89 mitogen-activated protein kinase 8 Homo sapiens 30-33 20028971-5 2010 In this study, we report that JNK (c-Jun N-terminal kinase) phosphorylates MST1 at serine 82, which leads to the enhancement of MST1 activation. Serine 83-89 mitogen-activated protein kinase 8 Homo sapiens 35-58 19778898-6 2009 Expression of specific activators of different mitogen-activated protein kinases showed that phosphorylation of cPLA(2)alpha at Ser-505 is due to JNK. Serine 128-131 mitogen-activated protein kinase 8 Homo sapiens 146-149 19220809-2 2009 In particular, constitutive tyrosine kinase (TK) activity of p210 BCR-ABL blocks c-Jun N-terminal kinase (JNK) phosphorylation leading to 14-3-3 sigma phosphorylation at a critical residue (Ser(186)) for c-ABL binding in response to DNA damage. Serine 190-193 mitogen-activated protein kinase 8 Homo sapiens 106-109 19667122-4 2009 Specifically, we provide evidence that JNK binds to E-cadherin/beta-catenin complex and phosphorylates beta-catenin at serine 37 and threonine 41, the sites also phosphorylated by GSK-3beta. Serine 119-125 mitogen-activated protein kinase 8 Homo sapiens 39-42 19789335-3 2009 ASK1 directly phosphorylates Daxx at Ser(176) and Ser(184) and Daxx is required for the sustained activation of JNK. Serine 50-53 mitogen-activated protein kinase 8 Homo sapiens 112-115 19625654-8 2009 Collectively, these data support a key role for JNK-mediated cPLA(2)alpha phosphorylation at Ser(505) in the sequence of events leading to translocation and activation of the enzyme to phagosomal membranes in human macrophages. Serine 93-96 mitogen-activated protein kinase 8 Homo sapiens 48-51 19567513-9 2009 Accordingly, silencing JNK1/2 with either small interfering RNA or chemical inhibitors impaired serine phosphorylation of IRS1, restored downstream insulin signaling, and normalized insulin-induced glucose uptake in the presence of TNF-alpha. Serine 96-102 mitogen-activated protein kinase 8 Homo sapiens 23-27 19567513-13 2009 Activation of JNK1/2 appears to be involved in serine phosphorylation of IRS1 and subsequently insulin resistance on glucose uptake, a state that can be reversed by liver X receptor agonists. Serine 47-53 mitogen-activated protein kinase 8 Homo sapiens 14-20 19054758-8 2009 We further raised another phosphospecific antibody to confirm that delta-catenin Ser-447 is modified in neurons by the MAPK JNK in a synaptic activity-dependent manner. Serine 81-84 mitogen-activated protein kinase 8 Homo sapiens 124-127 19153595-3 2009 In this study, we show that another kinase, c-Jun-NH(2)-terminal kinase (JNK), phosphorylates IRF3 on its N-terminal serine 173 residue, and TAK1 can stimulate IRF3 phosphorylation via JNK. Serine 117-123 mitogen-activated protein kinase 8 Homo sapiens 44-71 19153595-3 2009 In this study, we show that another kinase, c-Jun-NH(2)-terminal kinase (JNK), phosphorylates IRF3 on its N-terminal serine 173 residue, and TAK1 can stimulate IRF3 phosphorylation via JNK. Serine 117-123 mitogen-activated protein kinase 8 Homo sapiens 73-76 19054758-9 2009 Ser-447 phosphorylation by JNK appears to be correlated with delta-catenin degradation, and a delta-catenin mutant defective in Ser-447 phosphorylation showed enhanced ability to promote dendrite branching in cultured neurons. Serine 0-3 mitogen-activated protein kinase 8 Homo sapiens 27-30 18822310-5 2008 In addition, JNK phosphorylates c-Jun (Ser(63/73)) to recruit TGIF/HDAC1 to suppress p21 gene expression. Serine 39-42 mitogen-activated protein kinase 8 Homo sapiens 13-16 18713649-9 2008 Taken together, these results suggest that phosphorylation of paxillin on Ser 178 by JNK is required for the association of paxillin with FAK, and subsequent tyrosine phosphorylation of paxillin. Serine 74-77 mitogen-activated protein kinase 8 Homo sapiens 85-88 18375956-0 2008 Nickel compounds induce phosphorylation of histone H3 at serine 10 by activating JNK-MAPK pathway. Serine 57-63 mitogen-activated protein kinase 8 Homo sapiens 81-84 18813807-7 2008 Furthermore, inhibition of Rac1 reduced phosphorylation of paxillin, a focal adhesion component and a downstream effector of JNK, at serine 178 (Ser178). Serine 133-139 mitogen-activated protein kinase 8 Homo sapiens 125-128 18553930-5 2008 Phosphorylation of these Ser and Thr residues of PP2Czeta ectopically expressed in 293 cells was enhanced by osmotic stress and was attenuated by a JNK inhibitor but not by p38 or MEK inhibitors. Serine 25-28 mitogen-activated protein kinase 8 Homo sapiens 148-151 18553930-7 2008 Taken together, these results suggest that specific phosphorylation of PP2Czeta at Ser (92) by stress-activated JNK attenuates its phosphatase activity in cells. Serine 83-86 mitogen-activated protein kinase 8 Homo sapiens 112-115 18713649-2 2008 Although the c-Jun amino-terminal kinase (JNK) phosphorylation of paxillin on Ser 178 has been found to be critical for cell migration, the precise mechanism by which JNK regulates cell migration is still not very clear. Serine 78-81 mitogen-activated protein kinase 8 Homo sapiens 42-45 18667537-3 2008 Here, we demonstrate that TNF-alpha triggers JNK-dependent serine/threonine phosphorylation of PS1 and NCT to stimulate gamma-secretase activity. Serine 59-65 mitogen-activated protein kinase 8 Homo sapiens 45-48 18375956-6 2008 These results are the first to show the specific JNK-mediated phosphorylation of histone H3 at its serine 10 residue. Serine 99-105 mitogen-activated protein kinase 8 Homo sapiens 49-52 18375956-2 2008 Here, we provide evidence that Ni can induce phosphorylation of histone H3 at its serine 10 residue in a c-jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK)-dependent manner. Serine 82-88 mitogen-activated protein kinase 8 Homo sapiens 105-128 18375956-2 2008 Here, we provide evidence that Ni can induce phosphorylation of histone H3 at its serine 10 residue in a c-jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK)-dependent manner. Serine 82-88 mitogen-activated protein kinase 8 Homo sapiens 130-133 18375956-4 2008 An inhibitor of JNK eliminated the Ni-initiated JNK-mediated induction of histone H3 phosphorylation at serine 10, whereas inhibitors specific for ERK or p38 kinases had no effect on the phosphorylation levels of histone H3 at serine 10 (P-H3S10) in Ni-treated cells. Serine 104-110 mitogen-activated protein kinase 8 Homo sapiens 16-19 18375956-4 2008 An inhibitor of JNK eliminated the Ni-initiated JNK-mediated induction of histone H3 phosphorylation at serine 10, whereas inhibitors specific for ERK or p38 kinases had no effect on the phosphorylation levels of histone H3 at serine 10 (P-H3S10) in Ni-treated cells. Serine 104-110 mitogen-activated protein kinase 8 Homo sapiens 48-51 18375956-4 2008 An inhibitor of JNK eliminated the Ni-initiated JNK-mediated induction of histone H3 phosphorylation at serine 10, whereas inhibitors specific for ERK or p38 kinases had no effect on the phosphorylation levels of histone H3 at serine 10 (P-H3S10) in Ni-treated cells. Serine 227-233 mitogen-activated protein kinase 8 Homo sapiens 48-51 18172084-0 2008 Role of JNK-dependent serine phosphorylation of paxillin in migration of corneal epithelial cells during wound closure. Serine 22-28 mitogen-activated protein kinase 8 Homo sapiens 8-11 17647275-10 2008 From the results, it was concluded that PMA-induced insulin resistance, through induction of serine phosphorylation of IRS1 mediated by activated JNK and PKCs, increases ApoB secretion in Chang liver cells. Serine 93-99 mitogen-activated protein kinase 8 Homo sapiens 146-149 18431843-8 2008 Inactivation of JNK prior to mitosis prevents expression of Aurora B and phosphorylation of Histone-H3 at Ser 10. Serine 106-109 mitogen-activated protein kinase 8 Homo sapiens 16-19 17933493-6 2008 The inhibition of JNK activity by its specific inhibitor or its dominant negative mutant suppressed both IFIT4 expression and serine phosphorylation of STAT1 but not the activation of PKCdelta, while inhibition of PKCdelta suppressed activation of IFIT4, STAT1, and JNK. Serine 126-132 mitogen-activated protein kinase 8 Homo sapiens 18-21 18337589-4 2008 GR is targeted for phosphorylation at serine 246 (S246) by the JNK protein family in a rapid and transient manner. Serine 38-44 mitogen-activated protein kinase 8 Homo sapiens 63-66 17602798-1 2008 In order to better understand the structural and chemical features of c-Jun N-terminal kinase-1 (JNK-1), which is a member of the mitogen activated protein kinase (MAP kinase) family of enzymes responsible for the serine/threonine phosphorylation of intracellular targets, 3D-QSAR studies of some aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors were performed by comparative molecular field analysis (CoMFA) to rationalize the structural requirements responsible for the inhibitory activity of these compounds. Serine 214-220 mitogen-activated protein kinase 8 Homo sapiens 70-95 17602798-1 2008 In order to better understand the structural and chemical features of c-Jun N-terminal kinase-1 (JNK-1), which is a member of the mitogen activated protein kinase (MAP kinase) family of enzymes responsible for the serine/threonine phosphorylation of intracellular targets, 3D-QSAR studies of some aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors were performed by comparative molecular field analysis (CoMFA) to rationalize the structural requirements responsible for the inhibitory activity of these compounds. Serine 214-220 mitogen-activated protein kinase 8 Homo sapiens 97-102 18172084-7 2008 Immunoblot analysis showed that wounding increased the phosphorylation of JNK and of paxillin on serine (Ser) 178 in a manner sensitive to SP600125. Serine 105-108 mitogen-activated protein kinase 8 Homo sapiens 74-77 16632641-0 2006 Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase-mediated phosphorylation at serine 15 in vitro and in vivo. Serine 187-193 mitogen-activated protein kinase 8 Homo sapiens 133-158 17988632-3 2007 We present evidence that a Rac1-JNK1 signaling pathway mediates ser-295 phosphorylation and regulates synaptic content of PSD-95. Serine 64-67 mitogen-activated protein kinase 8 Homo sapiens 32-36 17568190-3 2007 This perspective presents a sophisticated signaling pathway that triggers neuronal apoptosis upon JNK-mediated phosphorylation of the BH3-only protein BIM(EL) at serine 65. Serine 162-168 mitogen-activated protein kinase 8 Homo sapiens 98-101 17440071-9 2007 Inhibition of the JNK activity by chemical inhibitor significantly reduced the migration rates of HCC cells via attenuation of paxillin phosphorylation at Ser(178). Serine 155-158 mitogen-activated protein kinase 8 Homo sapiens 18-21 17023523-5 2007 We also identified the exact phosphorylation site of JNK to be serine 95 at the N terminus of TR3, around which a classical JNK phosphorylation motif exists. Serine 63-69 mitogen-activated protein kinase 8 Homo sapiens 53-56 17023523-5 2007 We also identified the exact phosphorylation site of JNK to be serine 95 at the N terminus of TR3, around which a classical JNK phosphorylation motif exists. Serine 63-69 mitogen-activated protein kinase 8 Homo sapiens 124-127 18069897-6 2007 We show that PR55gamma binds c-SRC and modulates the phosphorylation of serine 12 of c-SRC, a residue we demonstrate to be required for JNK activation by c-SRC. Serine 72-78 mitogen-activated protein kinase 8 Homo sapiens 136-139 17665439-10 2007 JNK, ERK-1/2, and Akt (at both Ser-473 and Thr-308) were each up-regulated in a time-dependent manner. Serine 31-34 mitogen-activated protein kinase 8 Homo sapiens 0-3 17568772-5 2007 Furthermore, activated SGK1 mediated the phosphorylation of SEK1 on serine 78, resulting in inhibition of the binding of SEK1 to JNK1, as well as to MEKK1. Serine 68-74 mitogen-activated protein kinase 8 Homo sapiens 129-133 17637928-10 2007 Mutation of tyrosine to serine at the 21st amino acid of the Bcl-2 protein BH4 domain resulted in a loss both of suppression of JNK1/2 phosphorylation and its anti-apoptotic function. Serine 24-30 mitogen-activated protein kinase 8 Homo sapiens 128-132 17389591-10 2007 We further show that RIP1 (the Ser/Thr protein kinase receptor-interacting protein) associates with the GAP domain of AIP1 and mediates TNF-induced AIP1 phosphorylation at Ser-604 and JNK/p38 activation as demonstrated by both overexpression and small interfering RNA knockdown of RIP1 in EC. Serine 31-34 mitogen-activated protein kinase 8 Homo sapiens 184-187 17389591-12 2007 Our results demonstrate that RIP1-mediated AIP1 phosphorylation at the 14-3-3-binding site Ser-604 is essential for TNF-induced TRAF2-RIP1-AIP1-ASK1 complex formation and for the activation of ASK1-JNK/p38 apoptotic signaling. Serine 91-94 mitogen-activated protein kinase 8 Homo sapiens 198-201 17279354-7 2007 The stimulatory effects of hrCRP on IRS-1 phosphorylation at Ser(307) and Ser(612) were partially reversed by treatment with specific JNK and ERK1/2 inhibitors, respectively. Serine 61-64 mitogen-activated protein kinase 8 Homo sapiens 134-137 17279354-7 2007 The stimulatory effects of hrCRP on IRS-1 phosphorylation at Ser(307) and Ser(612) were partially reversed by treatment with specific JNK and ERK1/2 inhibitors, respectively. Serine 74-77 mitogen-activated protein kinase 8 Homo sapiens 134-137 17279354-11 2007 CONCLUSIONS/INTERPRETATION: Our data suggest that hrCRP may cause insulin resistance by increasing IRS-1 phosphorylation at Ser(307) and Ser(612) via JNK and ERK1/2, respectively, leading to impaired insulin-stimulated glucose uptake, GLUT4 translocation, and glycogen synthesis mediated by the IRS-1/PI-3K/Akt/GSK-3 pathway. Serine 124-127 mitogen-activated protein kinase 8 Homo sapiens 150-153 17279354-11 2007 CONCLUSIONS/INTERPRETATION: Our data suggest that hrCRP may cause insulin resistance by increasing IRS-1 phosphorylation at Ser(307) and Ser(612) via JNK and ERK1/2, respectively, leading to impaired insulin-stimulated glucose uptake, GLUT4 translocation, and glycogen synthesis mediated by the IRS-1/PI-3K/Akt/GSK-3 pathway. Serine 137-140 mitogen-activated protein kinase 8 Homo sapiens 150-153 17505626-6 2007 At an early intracellular level, AII, acting through JAK-2/IRS-1/PI3-kinase, JNK and ERK, may induce the serine phosphorylation and inhibition of key elements of the Ins-signaling pathway. Serine 105-111 mitogen-activated protein kinase 8 Homo sapiens 77-80 16632641-8 2006 Activation of JNK by plumbagin phosphorylated p53 at serine 15, resulting in increased stability of p53 by decreasing p53 and MDM2 interaction. Serine 53-59 mitogen-activated protein kinase 8 Homo sapiens 14-17 16632641-9 2006 SP600125 (anthra [1,9-cd]pyrazol-6(2H)-one-1,9-pyrazoloanthrone), a specific inhibitor of JNK, significantly decreased apoptosis by inhibiting the phosphorylation of p53 (serine 15) and subsequently increased the interaction of p53 and MDM2. Serine 171-177 mitogen-activated protein kinase 8 Homo sapiens 90-93 16772869-1 2006 The mitogen-activated protein (MAP) kinase SAPK/JNK phosphorylates tau protein at many of its proline-directed serine/threonine residues in vitro and is a likely candidate kinase to phosphorylate the pathologically relevant S422 site on tau. Serine 111-117 mitogen-activated protein kinase 8 Homo sapiens 48-51 16551633-7 2006 Mutational studies identify one residue, serine 260, a JNK phosphoacceptor site whose phosphorylation status had an unknown role in RXRalpha function, as critical for IL-1beta-mediated nuclear export of transfected human RXRalpha-green fluorescent fusion constructs. Serine 41-47 mitogen-activated protein kinase 8 Homo sapiens 55-58 16407301-4 2006 MEKK3-dependent activation of an NF-kappaB reporter gene as well as ERK, JNK, and p38 MAP kinases correlated with a requirement for serine at position 526. Serine 132-138 mitogen-activated protein kinase 8 Homo sapiens 73-76 16618812-5 2006 Furthermore, SCG10 is also phosphorylated by JNK in vivo on sites that regulate its microtubule depolymerizing activity, serines 62 and 73. Serine 121-128 mitogen-activated protein kinase 8 Homo sapiens 45-48 16389635-6 2006 At an early intracellular level, angiotensin II, acting through JAK-2/IRS-1/PI3-kinase, JNK and ERK, may induce the serine phosphorylation and inhibition of key elements of the insulin-signaling pathway. Serine 116-122 mitogen-activated protein kinase 8 Homo sapiens 88-91 16450001-2 2006 We demonstrated here that long-term tamoxifen treatment causes G2/M cell cycle arrest through c-jun N-terminal kinase (JNK) activation, which is dependent on phosphorylation of Fas-associated death domain-containing protein (FADD) at 194 serine in an oestrogen (ER) receptor-positive breast cancer cell line, MCF-7. Serine 238-244 mitogen-activated protein kinase 8 Homo sapiens 94-117 16282370-3 2006 In LNCaP prostate cancer cells, activation of either MAPK kinase (MKK) 4:c-Jun N-terminal kinase (JNK) or MKK6:p38 signaling pathways increased Ser 650 phosphorylation, whereas pharmacologic inhibition of JNK or p38 signaling led to a reduction of AR Ser 650 phosphorylation. Serine 144-147 mitogen-activated protein kinase 8 Homo sapiens 98-101 16282370-4 2006 Both p38alpha and JNK1 phosphorylated Ser 650 in vitro. Serine 38-41 mitogen-activated protein kinase 8 Homo sapiens 18-22 16450001-2 2006 We demonstrated here that long-term tamoxifen treatment causes G2/M cell cycle arrest through c-jun N-terminal kinase (JNK) activation, which is dependent on phosphorylation of Fas-associated death domain-containing protein (FADD) at 194 serine in an oestrogen (ER) receptor-positive breast cancer cell line, MCF-7. Serine 238-244 mitogen-activated protein kinase 8 Homo sapiens 119-122 17119350-2 2006 We have previously demonstrated that phosphorylation of Fas-associated death domain-containing protein (FADD) at 194 serine through c-jun NH2-terminal kinase (JNK) activation sensitizes breast cancer cells to chemotherapy through accelerating cell cycle arrest at G2/M, and that Bcl-2 phosphorylation downstream of JNK/FADD plays an important role in cell growth suppression by paclitaxel. Serine 117-123 mitogen-activated protein kinase 8 Homo sapiens 132-157 16309849-2 2006 This in turn triggers a kinase cascade which activates both IkappaB kinase-beta (IKK-beta) and c-Jun N-terminal kinase (JNK), each of which can phosphorylate a key serine residue in IRS-1, rendering it a poor substrate for the activated insulin receptor. Serine 164-170 mitogen-activated protein kinase 8 Homo sapiens 95-118 16309849-2 2006 This in turn triggers a kinase cascade which activates both IkappaB kinase-beta (IKK-beta) and c-Jun N-terminal kinase (JNK), each of which can phosphorylate a key serine residue in IRS-1, rendering it a poor substrate for the activated insulin receptor. Serine 164-170 mitogen-activated protein kinase 8 Homo sapiens 120-123 17119350-2 2006 We have previously demonstrated that phosphorylation of Fas-associated death domain-containing protein (FADD) at 194 serine through c-jun NH2-terminal kinase (JNK) activation sensitizes breast cancer cells to chemotherapy through accelerating cell cycle arrest at G2/M, and that Bcl-2 phosphorylation downstream of JNK/FADD plays an important role in cell growth suppression by paclitaxel. Serine 117-123 mitogen-activated protein kinase 8 Homo sapiens 159-162 17119350-2 2006 We have previously demonstrated that phosphorylation of Fas-associated death domain-containing protein (FADD) at 194 serine through c-jun NH2-terminal kinase (JNK) activation sensitizes breast cancer cells to chemotherapy through accelerating cell cycle arrest at G2/M, and that Bcl-2 phosphorylation downstream of JNK/FADD plays an important role in cell growth suppression by paclitaxel. Serine 117-123 mitogen-activated protein kinase 8 Homo sapiens 315-318 16260419-5 2005 Furthermore, PKCdelta-mediated activation of STAT1 required the activation of JNK, as the inhibition of JNK activity by its specific inhibitor or transfection of its dominant negative mutant suppressed both serine phosphorylation of STAT1 and PLSCR1 expression but not the activation of PKCdelta. Serine 207-213 mitogen-activated protein kinase 8 Homo sapiens 78-81 16260419-5 2005 Furthermore, PKCdelta-mediated activation of STAT1 required the activation of JNK, as the inhibition of JNK activity by its specific inhibitor or transfection of its dominant negative mutant suppressed both serine phosphorylation of STAT1 and PLSCR1 expression but not the activation of PKCdelta. Serine 207-213 mitogen-activated protein kinase 8 Homo sapiens 104-107 16464740-11 2005 As expected, c-Jun, which is known to be a substrate of JNK, was also phosphorylated at serine residue 73 by treatment with CD40L, but not by TNF-alpha. Serine 88-94 mitogen-activated protein kinase 8 Homo sapiens 56-59 16099428-0 2005 Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1. Serine 25-31 mitogen-activated protein kinase 8 Homo sapiens 18-21 16099428-4 2005 These results indicate that mTOR and JNK play roles in phosphorylating IRS-1 serine residues, and that insulin and anisomycin are different in terms of the relationship of activation between mTOR and JNK, and the effects on IRS-1 localization and stability. Serine 77-83 mitogen-activated protein kinase 8 Homo sapiens 37-40 16099431-0 2005 Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes. Serine 96-102 mitogen-activated protein kinase 8 Homo sapiens 31-34 16055440-9 2005 This suggests an involvement of the phosphatidylinositol 3-kinase/mammalian target of rapamycin cascade and of JNK in this signaling pathway resulting in IRS-1 Ser-307 phosphorylation. Serine 160-163 mitogen-activated protein kinase 8 Homo sapiens 111-114 16082226-0 2005 Blockage of NF-kappaB induces serine 15 phosphorylation of mutant p53 by JNK kinase in prostate cancer cells. Serine 30-36 mitogen-activated protein kinase 8 Homo sapiens 73-76 16082226-5 2005 Serine 15-phosphorylation is due to GADD45alpha-dependent induction of JNK kinase, which can be blocked by SP600125, a JNK kinase inhibitor. Serine 0-6 mitogen-activated protein kinase 8 Homo sapiens 71-74 16082226-5 2005 Serine 15-phosphorylation is due to GADD45alpha-dependent induction of JNK kinase, which can be blocked by SP600125, a JNK kinase inhibitor. Serine 0-6 mitogen-activated protein kinase 8 Homo sapiens 119-122 15743762-6 2005 Likewise, the mutation of the phosphorylation sites identified revealed that Thr(116) and Ser(170) are critical for the transactivation of NFATc2 by JNK. Serine 90-93 mitogen-activated protein kinase 8 Homo sapiens 149-152 15582605-6 2005 Another action of JNK, phosphorylation at Ser(307) of insulin receptor substrate-1, was also predicted to contribute to the repression of adipogenesis. Serine 42-45 mitogen-activated protein kinase 8 Homo sapiens 18-21 15471539-7 2005 One post-translational modification, phosphorylation of a serine residue in the C-terminal portion of GSTP1 where JNK binds, was identified in GSTP1 purified from Kato III cells, but not in GSTP1 purified from human erythrocytes. Serine 58-64 mitogen-activated protein kinase 8 Homo sapiens 114-117 15228592-4 2004 Here we show that c-Jun N-terminal kinases JNK1, JNK2 and JNK3 phosphorylate tau at many serine/threonine-prolines, as assessed by the generation of the epitopes of phosphorylation-dependent anti-tau antibodies. Serine 89-95 mitogen-activated protein kinase 8 Homo sapiens 43-47 16238095-6 2005 In contrast, co-transfection of JNK-1 with the dual specific phosphatase serine/threonine M3/6 showed only a marginal effect in JNK-1 activity. Serine 73-79 mitogen-activated protein kinase 8 Homo sapiens 32-37 16238095-6 2005 In contrast, co-transfection of JNK-1 with the dual specific phosphatase serine/threonine M3/6 showed only a marginal effect in JNK-1 activity. Serine 73-79 mitogen-activated protein kinase 8 Homo sapiens 128-133 15304498-9 2004 These results indicate that ASBT undergoes ubiquitin-proteasome degradation under basal conditions and that ASBT proteasome disposal is increased by IL-1beta due to JNK-regulated serine/threonine phosphorylation of ASBT protein at both Ser-335 and Thr-339. Serine 179-185 mitogen-activated protein kinase 8 Homo sapiens 165-168 15304498-9 2004 These results indicate that ASBT undergoes ubiquitin-proteasome degradation under basal conditions and that ASBT proteasome disposal is increased by IL-1beta due to JNK-regulated serine/threonine phosphorylation of ASBT protein at both Ser-335 and Thr-339. Serine 236-239 mitogen-activated protein kinase 8 Homo sapiens 165-168 15292225-3 2004 The mitogen-activated protein (MAP) kinases, p38 and c-Jun N-terminal kinase (JNK), are important mediators of target gene activation by TNF, and JNK activation was earlier shown to inhibit GR-mediated transcriptional activation by direct phosphorylation of GR at Ser-246. Serine 264-267 mitogen-activated protein kinase 8 Homo sapiens 146-149 15470142-3 2004 Here, we report that JNK catalyzed the phosphorylation of the BH3-only protein Bcl-2 interacting mediator of cell death (BimEL) at serine 65, both in vitro and in vivo. Serine 131-137 mitogen-activated protein kinase 8 Homo sapiens 21-24 15470142-4 2004 The JNK-induced phosphorylation of BimEL at serine 65 promoted the apoptotic effect of BimEL in primary cerebellar granule neurons. Serine 44-50 mitogen-activated protein kinase 8 Homo sapiens 4-7 15470142-6 2004 We found that activation of p75NTR induced the JNK-dependent phosphorylation of endogenous BimEL at serine 65 in cells. Serine 100-106 mitogen-activated protein kinase 8 Homo sapiens 47-50 15470142-8 2004 Together, these results suggest that JNK-induced phosphorylation of BimEL at serine 65 mediates p75NTR-induced apoptosis. Serine 77-83 mitogen-activated protein kinase 8 Homo sapiens 37-40 15610029-5 2004 Mutation to alanine of any of the four serine or threonine residues in the activation loop reduces both the activity of the recombinant kinase domain and JNK pathway activation driven by full-length MLK1 expressed in mammalian cells. Serine 39-45 mitogen-activated protein kinase 8 Homo sapiens 154-157 14617628-0 2004 JNK-dependent phosphorylation of c-Jun on serine 63 mediates nitric oxide-induced apoptosis of neuroblastoma cells. Serine 42-48 mitogen-activated protein kinase 8 Homo sapiens 0-3 15001544-10 2004 These results suggest that activation of the HBP accounts, in part, for glucose-induced phosphorylation at Ser(307) and Ser(612) of IRS-1 mediated by JNK and ERK1/2, respectively. Serine 107-110 mitogen-activated protein kinase 8 Homo sapiens 150-153 14656714-6 2004 TNF-alpha increased activation of ERK1/2 and JNK, previously implicated in phosphorylation of Ser(82) of PPARgamma1 and resultant negative regulation of PPARgamma transactivity. Serine 94-97 mitogen-activated protein kinase 8 Homo sapiens 45-48 14617628-7 2004 NO-induced apoptosis, Ser-63 phosphorylation of c-Jun, and caspase-3 activity were all inhibited in SH-Sy5y cells transformed with dominant-negative jnk. Serine 22-25 mitogen-activated protein kinase 8 Homo sapiens 149-152 14617628-9 2004 In a different neuroblastoma cell line, NO-induced Ser-63 phosphorylation of c-Jun and apoptosis were blocked by a specific JNK inhibitor. Serine 51-54 mitogen-activated protein kinase 8 Homo sapiens 124-127 14617628-10 2004 We conclude that NO-inducible apoptosis is mediated by JNK-dependent Ser-63 phosphorylation of c-Jun upstream of caspase-3 activation in neuroblastoma cells. Serine 69-72 mitogen-activated protein kinase 8 Homo sapiens 55-58 12409308-8 2003 On the other hand, both PMA and TNFalpha activated the c-Jun N-terminal kinase (JNK), which has been reported to directly phosphorylate IRS1 Ser-307. Serine 141-144 mitogen-activated protein kinase 8 Homo sapiens 55-78 14657652-2 2004 We also showed that JNK phosphorylates serine 178 on paxillin, a focal adhesion adaptor, both in vitro and in vivo. Serine 39-45 mitogen-activated protein kinase 8 Homo sapiens 20-23 12853483-2 2003 The integrity of JNK phosphorylation sites at serines 63/73 and at threonines 91/93 in c-Jun is essential for signal-dependent target gene activation. Serine 46-53 mitogen-activated protein kinase 8 Homo sapiens 17-20 12714600-7 2003 Taken together, these data suggest that serine phosphorylation of IRS-1 in response to TNF-alpha is mediated, in part, by JNK and IKK. Serine 40-46 mitogen-activated protein kinase 8 Homo sapiens 122-125 12562765-8 2003 Taken together, our results demonstrate that the STAT3 phosphorylation at Ser(727) is triggered by active RSK2 or JNK1 in the presence of a downstream kinase or a cofactor, and thereby the intracellular phosphorylation process is stimulated through a signaling pathway involving ATM, MAPKs, RSK2, and an as yet unidentified kinase or cofactor. Serine 74-77 mitogen-activated protein kinase 8 Homo sapiens 114-118 12555073-10 2003 The inhibitory effect of JNK appears to be mediated by serine phosphorylation of IRS-1 (insulin receptor substrate) since both Taxol and IGF-I treatment enhanced Ser(312) IRS-1 phosphorylation, while LY294002 blocked IGF-I-mediated phosphorylation. Serine 55-61 mitogen-activated protein kinase 8 Homo sapiens 25-28 12555073-10 2003 The inhibitory effect of JNK appears to be mediated by serine phosphorylation of IRS-1 (insulin receptor substrate) since both Taxol and IGF-I treatment enhanced Ser(312) IRS-1 phosphorylation, while LY294002 blocked IGF-I-mediated phosphorylation. Serine 162-165 mitogen-activated protein kinase 8 Homo sapiens 25-28 12409308-8 2003 On the other hand, both PMA and TNFalpha activated the c-Jun N-terminal kinase (JNK), which has been reported to directly phosphorylate IRS1 Ser-307. Serine 141-144 mitogen-activated protein kinase 8 Homo sapiens 80-83 12409308-9 2003 SP600125, a JNK inhibitor, prevented PMA and TNFalpha-induced IRS1 Ser-307 phosphorylation. Serine 67-70 mitogen-activated protein kinase 8 Homo sapiens 12-15 12228228-3 2002 We show that serine 67 lies in a D domain, which binds to the c-Jun-NH(2)-terminal kinase/stress-activated protein kinases (JNK/SAPK). Serine 13-19 mitogen-activated protein kinase 8 Homo sapiens 124-132 12228228-6 2002 Thus, we propose a mechanism by which the MEKK1-dependent JNK/SAPK pathway is negatively regulated by PAK through phosphorylation of serine 67. Serine 133-139 mitogen-activated protein kinase 8 Homo sapiens 58-61 12058028-10 2002 p38 alpha and JNK1 phosphorylated p21 in vivo, and both p38 alpha and JNK1 phosphorylated p21 at Ser(130) in vitro. Serine 97-100 mitogen-activated protein kinase 8 Homo sapiens 70-74 12297496-9 2002 Mutant JUN proteins that lacked the N-terminal transactivation domain and serine substrates for JUN N-terminal kinase inhibited cell death in a dominant-negative manner. Serine 74-80 mitogen-activated protein kinase 8 Homo sapiens 96-117 12169099-2 2002 c-Jun may feed back to up-regulate its own transcription and, since the c-Jun N-terminal kinase (JNK) family of mitogen-activated protein kinases (MAPKs) phosphorylate c-Jun(Ser-63/73) to increase its transactivating activity, JNKs are thought to be the principal factors involved in c- jun up-regulation. Serine 174-177 mitogen-activated protein kinase 8 Homo sapiens 72-95 12169099-2 2002 c-Jun may feed back to up-regulate its own transcription and, since the c-Jun N-terminal kinase (JNK) family of mitogen-activated protein kinases (MAPKs) phosphorylate c-Jun(Ser-63/73) to increase its transactivating activity, JNKs are thought to be the principal factors involved in c- jun up-regulation. Serine 174-177 mitogen-activated protein kinase 8 Homo sapiens 97-100 12223490-4 2002 We found that JNK phosphorylated Ser-121 and Thr-163 of Mcl-1 in response to stimulation with H(2)O(2) and that transfection of unphosphorylatable Mcl-1 resulted in an enhanced anti-apoptotic activity in response to stimulation with H(2)O(2). Serine 33-36 mitogen-activated protein kinase 8 Homo sapiens 14-17 11983683-0 2002 Activation of JNK1, RSK2, and MSK1 is involved in serine 112 phosphorylation of Bad by ultraviolet B radiation. Serine 50-56 mitogen-activated protein kinase 8 Homo sapiens 14-18 11983683-4 2002 Here, we demonstrate that UVB induces Bad phosphorylation at serine 112 in JNK1, RSK2, and MSK1-dependent pathways. Serine 61-67 mitogen-activated protein kinase 8 Homo sapiens 75-79 11983683-6 2002 Incubation of active MAP kinase members with Bad protein showed serine 112 phosphorylation of Bad by JNK1 only. Serine 64-70 mitogen-activated protein kinase 8 Homo sapiens 101-105 11983683-10 2002 These data illustrated that UVB-induced phosphorylation of Bad at serine 112 was mediated through MAP kinase signaling pathways in which JNK1, RSK2, and MSK1 served as direct mediators. Serine 66-72 mitogen-activated protein kinase 8 Homo sapiens 137-141 11896587-4 2002 In a mouse JB6 epidermal cell line, dominant negative JNK1 abrogated UVB-induced phosphorylation of p53 at serine 20, whereas dominant negative p38 kinase or its inhibitor, SB202190, partially attenuated the phosphorylation. Serine 107-113 mitogen-activated protein kinase 8 Homo sapiens 54-58 11948398-3 2002 Here we show that PKD activation loop phosphorylation at serines 744/748 via PKC, or mutation of these serines to glutamic acid (PKD-S744/748E) also results in complex formation with JNK, indicating that suppression of JNK signaling by PKD involves a direct interaction with JNK. Serine 57-64 mitogen-activated protein kinase 8 Homo sapiens 183-186 11948398-3 2002 Here we show that PKD activation loop phosphorylation at serines 744/748 via PKC, or mutation of these serines to glutamic acid (PKD-S744/748E) also results in complex formation with JNK, indicating that suppression of JNK signaling by PKD involves a direct interaction with JNK. Serine 57-64 mitogen-activated protein kinase 8 Homo sapiens 219-222 11948398-3 2002 Here we show that PKD activation loop phosphorylation at serines 744/748 via PKC, or mutation of these serines to glutamic acid (PKD-S744/748E) also results in complex formation with JNK, indicating that suppression of JNK signaling by PKD involves a direct interaction with JNK. Serine 57-64 mitogen-activated protein kinase 8 Homo sapiens 219-222 11948398-3 2002 Here we show that PKD activation loop phosphorylation at serines 744/748 via PKC, or mutation of these serines to glutamic acid (PKD-S744/748E) also results in complex formation with JNK, indicating that suppression of JNK signaling by PKD involves a direct interaction with JNK. Serine 103-110 mitogen-activated protein kinase 8 Homo sapiens 183-186 11948398-3 2002 Here we show that PKD activation loop phosphorylation at serines 744/748 via PKC, or mutation of these serines to glutamic acid (PKD-S744/748E) also results in complex formation with JNK, indicating that suppression of JNK signaling by PKD involves a direct interaction with JNK. Serine 103-110 mitogen-activated protein kinase 8 Homo sapiens 219-222 11948398-3 2002 Here we show that PKD activation loop phosphorylation at serines 744/748 via PKC, or mutation of these serines to glutamic acid (PKD-S744/748E) also results in complex formation with JNK, indicating that suppression of JNK signaling by PKD involves a direct interaction with JNK. Serine 103-110 mitogen-activated protein kinase 8 Homo sapiens 219-222 11896587-7 2002 Furthermore, phosphorylation of p53 at serine 20 by UVB-activated JNKs and UVB-induced p53-dependent transcriptional activity were suppressed in Jnk1 or Jnk2 knockout (Jnk1(-/-) or Jnk2(-/-)) cells. Serine 39-45 mitogen-activated protein kinase 8 Homo sapiens 145-149 11896587-7 2002 Furthermore, phosphorylation of p53 at serine 20 by UVB-activated JNKs and UVB-induced p53-dependent transcriptional activity were suppressed in Jnk1 or Jnk2 knockout (Jnk1(-/-) or Jnk2(-/-)) cells. Serine 39-45 mitogen-activated protein kinase 8 Homo sapiens 168-172 11781324-7 2002 Furthermore, K8 was also phosphorylated on Ser-73 by JNK in vitro, yielding similar phosphopeptide maps as the in vivo phosphorylated material. Serine 43-46 mitogen-activated protein kinase 8 Homo sapiens 53-56 11896587-6 2002 Importantly, UVB-activated or active recombinant JNK1/2, or the p38 kinase downstream target, MAPKAPK-2, but not ERKs or p38 kinase, phosphorylated p53 at serine 20 in vitro. Serine 155-161 mitogen-activated protein kinase 8 Homo sapiens 49-55 11602589-8 2001 In conclusion, JNKs are the kinases that phosphorylate serine 36 of p66(ShcA) in response to UV irradiation in SH-SY5Y cells, and blocking p66(ShcA) phosphorylation by intervening in the JNK pathway may prevent cellular damage due to light-induced oxidative stress. Serine 55-61 mitogen-activated protein kinase 8 Homo sapiens 15-18 11606564-3 2002 One serine residue located near the phosphotyrosine-binding (PTB) domain in IRS-1 (Ser(307) in rat IRS-1 or Ser(312) in human IRS-1) is phosphorylated via several mechanisms, including insulin-stimulated kinases or stress-activated kinases like JNK1. Serine 4-10 mitogen-activated protein kinase 8 Homo sapiens 245-249 11606564-3 2002 One serine residue located near the phosphotyrosine-binding (PTB) domain in IRS-1 (Ser(307) in rat IRS-1 or Ser(312) in human IRS-1) is phosphorylated via several mechanisms, including insulin-stimulated kinases or stress-activated kinases like JNK1. Serine 83-86 mitogen-activated protein kinase 8 Homo sapiens 245-249 11606564-3 2002 One serine residue located near the phosphotyrosine-binding (PTB) domain in IRS-1 (Ser(307) in rat IRS-1 or Ser(312) in human IRS-1) is phosphorylated via several mechanisms, including insulin-stimulated kinases or stress-activated kinases like JNK1. Serine 108-111 mitogen-activated protein kinase 8 Homo sapiens 245-249 11606564-4 2002 During a yeast tri-hybrid assay, phosphorylation of Ser(307) by JNK1 disrupted the interaction between the catalytic domain of the insulin receptor and the PTB domain of IRS-1. Serine 52-55 mitogen-activated protein kinase 8 Homo sapiens 64-68 11598209-3 2001 Tyrosine phosphorylation is exerted via a member of the Src family of kinases (SrcFK) and JAK2, whereas the JNK pathway mediates serine phosphorylation. Serine 129-135 mitogen-activated protein kinase 8 Homo sapiens 108-111 11553624-5 2001 Phosphorylation of STAT3 (Ser(727)) is also markedly prevented by a dominant negative mutant of ERK2, c-Jun N-terminal kinase 1 (JNK1), or p38 kinase and in knockout Jnk1(-/-) or Jnk2(-/-) cells. Serine 26-29 mitogen-activated protein kinase 8 Homo sapiens 102-127 11553624-5 2001 Phosphorylation of STAT3 (Ser(727)) is also markedly prevented by a dominant negative mutant of ERK2, c-Jun N-terminal kinase 1 (JNK1), or p38 kinase and in knockout Jnk1(-/-) or Jnk2(-/-) cells. Serine 26-29 mitogen-activated protein kinase 8 Homo sapiens 129-133 11553624-5 2001 Phosphorylation of STAT3 (Ser(727)) is also markedly prevented by a dominant negative mutant of ERK2, c-Jun N-terminal kinase 1 (JNK1), or p38 kinase and in knockout Jnk1(-/-) or Jnk2(-/-) cells. Serine 26-29 mitogen-activated protein kinase 8 Homo sapiens 166-170 11749722-7 2001 Various JNK isoforms not only contained a DNA-PK phosphorylation consensus site (serine followed by glutamine) but also were phosphorylated by DNA-PK in vitro. Serine 81-87 mitogen-activated protein kinase 8 Homo sapiens 8-11 11401472-1 2001 Phosphorylation of c-Jun at Ser 63/73 by the c-Jun N-terminal kinase (JNK) potentiates the transactivation function of c-Jun. Serine 28-31 mitogen-activated protein kinase 8 Homo sapiens 45-68 11323415-4 2001 Results indicate that anisomycin, a potent activator of the stress kinase JNK/SAPK, can induce Bcl2 phosphorylation at Ser(70) and that JNK1 can be latently activated following IL-3 withdrawal to mediate Bcl2 phosphorylation. Serine 119-122 mitogen-activated protein kinase 8 Homo sapiens 74-82 11279232-6 2001 However, Ser(411), but not Thr(421)/Ser(424) phosphorylation, was suppressed in DNM-JNK1 and abrogated in Jnk1-/- or Jnk2-/- cells. Serine 9-12 mitogen-activated protein kinase 8 Homo sapiens 80-88 11279232-6 2001 However, Ser(411), but not Thr(421)/Ser(424) phosphorylation, was suppressed in DNM-JNK1 and abrogated in Jnk1-/- or Jnk2-/- cells. Serine 9-12 mitogen-activated protein kinase 8 Homo sapiens 106-110 11401472-1 2001 Phosphorylation of c-Jun at Ser 63/73 by the c-Jun N-terminal kinase (JNK) potentiates the transactivation function of c-Jun. Serine 28-31 mitogen-activated protein kinase 8 Homo sapiens 70-73 11145737-0 2001 Potentiation of estrogen receptor activation function 1 (AF-1) by Src/JNK through a serine 118-independent pathway. Serine 84-90 mitogen-activated protein kinase 8 Homo sapiens 70-73 11243879-3 2001 The ASK1-JNK pathway enhanced the protein stability of c-Myc through phosphorylation at Ser-62 and Ser-71, which was required for c-Myc-dependent apoptosis by ASK1-signaling. Serine 88-91 mitogen-activated protein kinase 8 Homo sapiens 9-12 11243879-3 2001 The ASK1-JNK pathway enhanced the protein stability of c-Myc through phosphorylation at Ser-62 and Ser-71, which was required for c-Myc-dependent apoptosis by ASK1-signaling. Serine 99-102 mitogen-activated protein kinase 8 Homo sapiens 9-12 11243879-5 2001 Together, these findings indicate that the ASK1-JNK pathway promotes the proapoptotic activity of c-Myc by modulating c-Myc protein stability through phosphorylation at Ser-62 and Ser-71. Serine 169-172 mitogen-activated protein kinase 8 Homo sapiens 48-51 11243879-5 2001 Together, these findings indicate that the ASK1-JNK pathway promotes the proapoptotic activity of c-Myc by modulating c-Myc protein stability through phosphorylation at Ser-62 and Ser-71. Serine 180-183 mitogen-activated protein kinase 8 Homo sapiens 48-51 11139390-8 2001 In addition, we performed experiments with a mutant of the glucocorticoid receptor in which the JNK phosphorylation target Ser-246 had been mutated to Ala. Our results demonstrate that the phosphorylation of the glucocorticoid receptor on Ser-246 is not responsible for the JNK repression of glucocorticoid-stimulated PF2K/Fru-2,6-BPase gene expression. Serine 123-126 mitogen-activated protein kinase 8 Homo sapiens 96-99 11139390-8 2001 In addition, we performed experiments with a mutant of the glucocorticoid receptor in which the JNK phosphorylation target Ser-246 had been mutated to Ala. Our results demonstrate that the phosphorylation of the glucocorticoid receptor on Ser-246 is not responsible for the JNK repression of glucocorticoid-stimulated PF2K/Fru-2,6-BPase gene expression. Serine 123-126 mitogen-activated protein kinase 8 Homo sapiens 274-277 10581177-5 1999 JNK phosphorylates c-Jun on Ser-63 and Ser-73, the result being induction of its transcriptional activity. Serine 28-31 mitogen-activated protein kinase 8 Homo sapiens 0-3 10652349-4 2000 We show that JNK, ERK, and p38 physically associate with the NFATc N-terminal regulatory domain and can directly phosphorylate functionally important residues involved in regulating NFATc subcellular localization, namely Ser(172) and the conserved NFATc Ser-Pro repeats. Serine 221-224 mitogen-activated protein kinase 8 Homo sapiens 13-16 10667594-7 2000 Furthermore, JNK activation correlates with the induction of c-Jun expression, c-Jun phosphorylation on serines 63 and 73, and increased AP-1 activity. Serine 104-111 mitogen-activated protein kinase 8 Homo sapiens 13-16 10727406-1 2000 In the present study, signal transducer and activator of transcription 3 (STAT3) Ser(727) phosphorylation and transactivation was investigated in relation to activation of mitogen-activated protein (MAP) kinase family members including extracellular-signal-regulated protein kinase (ERK)-1, c-Jun N-terminal kinase (JNK)-1 and p38 ("reactivating kinase") in response to interleukin (IL)-6 stimulation. Serine 81-84 mitogen-activated protein kinase 8 Homo sapiens 291-322 10644709-7 2000 Replacement of cysteine 116 in JNK1 by serine abolished the inhibitory effect of selenite on JNK1 activity both in vitro and in vivo. Serine 39-45 mitogen-activated protein kinase 8 Homo sapiens 93-97 10581177-5 1999 JNK phosphorylates c-Jun on Ser-63 and Ser-73, the result being induction of its transcriptional activity. Serine 39-42 mitogen-activated protein kinase 8 Homo sapiens 0-3 10521505-0 1999 Serine phosphorylation and negative regulation of Stat3 by JNK. Serine 0-6 mitogen-activated protein kinase 8 Homo sapiens 59-62 10523640-8 1999 Furthermore, inhibition of p38 and JNK activities suppresses constitutive Stat3 serine phosphorylation and Stat3-mediated gene regulation. Serine 80-86 mitogen-activated protein kinase 8 Homo sapiens 35-38 10523640-9 1999 In vitro kinase assays with purified full-length Stat3 as the substrate show that both JNK and p38 can phosphorylate Stat3 on serine. Serine 126-132 mitogen-activated protein kinase 8 Homo sapiens 87-90 10521505-3 1999 Here, we report that Ser-727 phosphorylation of Stat3 can also be induced by JNK and activated either by stress or by its upstream kinase and that various stress treatments induce serine phosphorylation of Stat3 in the absence of tyrosine phosphorylation. Serine 21-24 mitogen-activated protein kinase 8 Homo sapiens 77-80 10521505-3 1999 Here, we report that Ser-727 phosphorylation of Stat3 can also be induced by JNK and activated either by stress or by its upstream kinase and that various stress treatments induce serine phosphorylation of Stat3 in the absence of tyrosine phosphorylation. Serine 180-186 mitogen-activated protein kinase 8 Homo sapiens 77-80 10521505-8 1999 Our results suggest that Stat3 is a target of JNK that may regulate Stat3 activity via both Ser-727 phosphorylation-dependent and -independent mechanisms. Serine 92-95 mitogen-activated protein kinase 8 Homo sapiens 46-49 9407138-2 1997 Activation of JNK/SAPK leads to the phosphorylation of c-JUN protooncogene on serines 63 and 73. Serine 78-85 mitogen-activated protein kinase 8 Homo sapiens 14-22 10037172-6 1999 JNK was first extracted from the tumor lysates by incubation over a Sepharose-bound c-Jun(1-89) fusion protein, and its activity was then measured by chemiluminescent Western blot by detection of the phosphorylated product using a phospho-Jun(Ser-63)-specific primary antibody. Serine 243-246 mitogen-activated protein kinase 8 Homo sapiens 0-3 9482836-2 1998 We demonstrate that JNK and ERK but not p38 phosphorylate GR in vitro primarily at Ser-246. Serine 83-86 mitogen-activated protein kinase 8 Homo sapiens 20-23 9482836-3 1998 Selective activation of either ERK or JNK in vivo inhibits GR-mediated transcriptional activation, which depends on receptor phosphorylation at Ser-246 by JNK but not ERK. Serine 144-147 mitogen-activated protein kinase 8 Homo sapiens 38-41 9482836-3 1998 Selective activation of either ERK or JNK in vivo inhibits GR-mediated transcriptional activation, which depends on receptor phosphorylation at Ser-246 by JNK but not ERK. Serine 144-147 mitogen-activated protein kinase 8 Homo sapiens 155-158 9878062-2 1999 The regulation of c-Jun is complex and involves both increases in the levels of c-Jun protein as well as phosphorylation of specific serines (63 and 73) by Jun N-terminal kinase (JNK). Serine 133-140 mitogen-activated protein kinase 8 Homo sapiens 156-177 9878062-2 1999 The regulation of c-Jun is complex and involves both increases in the levels of c-Jun protein as well as phosphorylation of specific serines (63 and 73) by Jun N-terminal kinase (JNK). Serine 133-140 mitogen-activated protein kinase 8 Homo sapiens 179-182 9878062-6 1999 c-Jun mediated G1 progression is independent of phosphorylation of serines 63/73; however, protection from apoptosis in response to UV, a potent inducer of JNK/SAP kinase activity, requires serines 63/73. Serine 190-197 mitogen-activated protein kinase 8 Homo sapiens 156-159 9407028-5 1997 Here we present evidence that hormone-activated nuclear receptors prevent c-Jun phosphorylation on Ser-63/73 and, consequently, AP-1 activation, by blocking the induction of the JNK signaling cascade. Serine 99-102 mitogen-activated protein kinase 8 Homo sapiens 178-181 9084448-3 1997 We have now shown that purified recombinant stress-activated protein kinase/c-Jun N-terminal kinase, a proline-directed kinase of the MAP kinase extended family, phosphorylates recombinant tau in vitro on threonine and serine residues. Serine 219-225 mitogen-activated protein kinase 8 Homo sapiens 78-99 8607977-17 1995 A candidate for this extended family of MAP kinases is the c-Jun NH2-terminal kinase (Jnk), which binds to and phosphorylates the transcription factor c-Jun at the activating sites Ser-63 and Ser-73. Serine 192-195 mitogen-activated protein kinase 8 Homo sapiens 86-89 8607977-17 1995 A candidate for this extended family of MAP kinases is the c-Jun NH2-terminal kinase (Jnk), which binds to and phosphorylates the transcription factor c-Jun at the activating sites Ser-63 and Ser-73. Serine 181-184 mitogen-activated protein kinase 8 Homo sapiens 59-84 8607977-17 1995 A candidate for this extended family of MAP kinases is the c-Jun NH2-terminal kinase (Jnk), which binds to and phosphorylates the transcription factor c-Jun at the activating sites Ser-63 and Ser-73. Serine 181-184 mitogen-activated protein kinase 8 Homo sapiens 86-89 8607977-17 1995 A candidate for this extended family of MAP kinases is the c-Jun NH2-terminal kinase (Jnk), which binds to and phosphorylates the transcription factor c-Jun at the activating sites Ser-63 and Ser-73. Serine 192-195 mitogen-activated protein kinase 8 Homo sapiens 59-84 8875991-2 1996 The delta domain of c-jun is essential for its ubiquitination and also for the activating phosphorylation of neighboring serines by the stress activated jun-N-terminal kinases (JNK). Serine 121-128 mitogen-activated protein kinase 8 Homo sapiens 153-175 8875991-2 1996 The delta domain of c-jun is essential for its ubiquitination and also for the activating phosphorylation of neighboring serines by the stress activated jun-N-terminal kinases (JNK). Serine 121-128 mitogen-activated protein kinase 8 Homo sapiens 177-180 8137421-5 1994 JNK1 binds to the c-Jun transactivation domain and phosphorylates it on Ser-63 and Ser-73. Serine 72-75 mitogen-activated protein kinase 8 Homo sapiens 0-4 8137421-5 1994 JNK1 binds to the c-Jun transactivation domain and phosphorylates it on Ser-63 and Ser-73. Serine 83-86 mitogen-activated protein kinase 8 Homo sapiens 0-4 8224842-4 1993 This novel c-Jun amino-terminal kinase (JNK), whose major form is 46 kD, binds to a specific region within the c-Jun trans-activation domain and phosphorylates serines 63 and 73. Serine 160-167 mitogen-activated protein kinase 8 Homo sapiens 40-43