PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28955817-8	2016	Clodronate liposome treatment also decreased the mRNA expression levels of inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6) in the skeletal muscle after exhaustive exercise.	Clodronic Acid	0-10	interleukin 1 beta	Mus musculus	110-118	
27528423-10	2016	In contrast, the depletion of TAMs by means of clodronate liposomes reduced lung tumorigenesis, associated to lower in vivo release of IL-1alpha and IL-1beta.In conclusion, our data imply lung tumor lesions are populated by macrophages which pro-tumor activity is regulated by the activation of the NLRP3 inflammasome that leads to the release of IL-1alpha and IL-1beta in a caspase-11/caspase-1-dependent manner.	Clodronic Acid	47-57	interleukin 1 beta	Mus musculus	149-157	
23489421-10	2013	Clodronate administration significantly reduced Gr1(+) cell infiltration and local IL-1beta levels.	Clodronic Acid	0-10	interleukin 1 beta	Mus musculus	83-91	
25930080-5	2015	In vivo depletion of Kupffer cells (KCs) by liposomal clodronate reduced liver injury and the expression of Il1b, but not Cxcl1, Cxcl2, and Cxcl5, suggesting that KCs are partly associated with liver injury, but not neutrophil recruitment, in a chronic-binge ethanol-feeding model.	Clodronic Acid	54-64	interleukin 1 beta	Mus musculus	108-112	
25582105-4	2015	Kupffer cells and IL-1beta were required for the hepatic iNKT accumulation, as either blocking IL-1beta signaling with a recombinant IL-1 receptor antagonist (IL-1Ra), depleting Kupffer cells by clodronate liposomes, or specifically silencing IL-1beta in Kupffer cells by nanoparticle-encapsulated siRNA, resulted in inhibited hepatic iNKT cell accumulation and activation, as well as amelioration of alcoholic fatty liver.	Clodronic Acid	195-205	interleukin 1 beta	Mus musculus	18-26	
17924976-3	2007	When macrophages were depleted using clodronate liposomes, both neovascularization and tumor growth were reduced in the IL-1beta-expressing tumors.	Clodronic Acid	37-47	interleukin 1 beta	Mus musculus	120-128	
20804833-7	2010	(d) In vitro, 100 muM alendronate directly stimulates RAW 264 cells (murine macrophage-like cells) to produce pro-IL-1beta, and 1 muM clodronate inhibits this effect.	Clodronic Acid	134-144	interleukin 1 beta	Mus musculus	114-122	
22041028-8	2012	Monocyte depletion with clodronate restored the endothelial response to IL-1beta in Psgl-1(-/-) mice.	Clodronic Acid	24-34	interleukin 1 beta	Mus musculus	72-80	
20804833-0	2010	Pro-IL-1beta accumulation in macrophages by alendronate and its prevention by clodronate.	Clodronic Acid	78-88	interleukin 1 beta	Mus musculus	4-12	
16239969-9	2005	After day 4, clodronate liposomes, which kill macrophages, reduced IL-1beta-induced angiogenesis and partially inhibited VEGF-induced angiogenesis.	Clodronic Acid	13-23	interleukin 1 beta	Mus musculus	67-75	
16203021-6	2006	These results suggest that (1) there are mutual augmentations between alendronate and immuno-stimulants (IL-1, TNF, and LPS) in HDC induction, (2) tissue IL-1beta is important in alendronate-stimulated HDC induction, and (3) combination use of clodronate may have the potential to reduce the inflammatory effects of alendronate (we previously found that clodronate, conveniently, does not inhibit the anti-bone-resorptive activity of alendronate).	Clodronic Acid	244-254	interleukin 1 beta	Mus musculus	154-162	
16203021-6	2006	These results suggest that (1) there are mutual augmentations between alendronate and immuno-stimulants (IL-1, TNF, and LPS) in HDC induction, (2) tissue IL-1beta is important in alendronate-stimulated HDC induction, and (3) combination use of clodronate may have the potential to reduce the inflammatory effects of alendronate (we previously found that clodronate, conveniently, does not inhibit the anti-bone-resorptive activity of alendronate).	Clodronic Acid	354-364	interleukin 1 beta	Mus musculus	154-162	
31534976-16	2019	The depletion of MDMs by clodronate liposomes alleviated diabetes-induced tactile allodynia (P < 0.05) and reduced the infiltration of MDMs (P < 0.001) as well as the expression of IL-1beta and TNF-alpha in the spinal cord (P < 0.05).	Clodronic Acid	25-35	interleukin 1 beta	Mus musculus	187-195	
15380476-6	2004	Clodronate (0.01, 0.1, 1 microg/ml) significantly down-regulated the LPS-stimulated microglial secretion of tumor necrosis factor (TNF)-alpha, Interleukin (IL)-1beta and NO, but not of IL-6.	Clodronic Acid	0-10	interleukin 1 beta	Mus musculus	143-165	
12734370-5	2003	In independent experiments, ELISA analysis showed that protein levels for IL-1 beta, macrophage-inflammatory protein 2, and macrophage-inflammatory protein 1 alpha, all regulators of PMN chemotaxis, also were elevated in both groups of mice treated with clodronate-liposomes.	Clodronic Acid	254-264	interleukin 1 beta	Mus musculus	74-83	
9500698-9	1998	Gadolinium chloride and liposome-encapsulated dichloromethylene diphosphonate lowered LPS-mediated HO-1 mRNA accumulation (by about 50%); in these groups hepatic levels of interleukin (IL)-1beta were decreased, by more than 75%.	Clodronic Acid	46-77	interleukin 1 beta	Mus musculus	172-194	
30764851-12	2019	Depletion of macrophages by injection of clodronate liposomes attenuated LPS-induced IL-1beta expression in the SFO.	Clodronic Acid	41-51	interleukin 1 beta	Mus musculus	85-93