PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25582105-4 2015 Kupffer cells and IL-1beta were required for the hepatic iNKT accumulation, as either blocking IL-1beta signaling with a recombinant IL-1 receptor antagonist (IL-1Ra), depleting Kupffer cells by clodronate liposomes, or specifically silencing IL-1beta in Kupffer cells by nanoparticle-encapsulated siRNA, resulted in inhibited hepatic iNKT cell accumulation and activation, as well as amelioration of alcoholic fatty liver. Clodronic Acid 195-205 interleukin 1 beta Mus musculus 18-26 28955817-8 2016 Clodronate liposome treatment also decreased the mRNA expression levels of inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6) in the skeletal muscle after exhaustive exercise. Clodronic Acid 0-10 interleukin 1 beta Mus musculus 110-118 25930080-5 2015 In vivo depletion of Kupffer cells (KCs) by liposomal clodronate reduced liver injury and the expression of Il1b, but not Cxcl1, Cxcl2, and Cxcl5, suggesting that KCs are partly associated with liver injury, but not neutrophil recruitment, in a chronic-binge ethanol-feeding model. Clodronic Acid 54-64 interleukin 1 beta Mus musculus 108-112 31534976-16 2019 The depletion of MDMs by clodronate liposomes alleviated diabetes-induced tactile allodynia (P < 0.05) and reduced the infiltration of MDMs (P < 0.001) as well as the expression of IL-1beta and TNF-alpha in the spinal cord (P < 0.05). Clodronic Acid 25-35 interleukin 1 beta Mus musculus 187-195 30764851-12 2019 Depletion of macrophages by injection of clodronate liposomes attenuated LPS-induced IL-1beta expression in the SFO. Clodronic Acid 41-51 interleukin 1 beta Mus musculus 85-93 27528423-10 2016 In contrast, the depletion of TAMs by means of clodronate liposomes reduced lung tumorigenesis, associated to lower in vivo release of IL-1alpha and IL-1beta.In conclusion, our data imply lung tumor lesions are populated by macrophages which pro-tumor activity is regulated by the activation of the NLRP3 inflammasome that leads to the release of IL-1alpha and IL-1beta in a caspase-11/caspase-1-dependent manner. Clodronic Acid 47-57 interleukin 1 beta Mus musculus 149-157 22041028-8 2012 Monocyte depletion with clodronate restored the endothelial response to IL-1beta in Psgl-1(-/-) mice. Clodronic Acid 24-34 interleukin 1 beta Mus musculus 72-80 23489421-10 2013 Clodronate administration significantly reduced Gr1(+) cell infiltration and local IL-1beta levels. Clodronic Acid 0-10 interleukin 1 beta Mus musculus 83-91 20804833-0 2010 Pro-IL-1beta accumulation in macrophages by alendronate and its prevention by clodronate. Clodronic Acid 78-88 interleukin 1 beta Mus musculus 4-12 20804833-7 2010 (d) In vitro, 100 muM alendronate directly stimulates RAW 264 cells (murine macrophage-like cells) to produce pro-IL-1beta, and 1 muM clodronate inhibits this effect. Clodronic Acid 134-144 interleukin 1 beta Mus musculus 114-122 16203021-6 2006 These results suggest that (1) there are mutual augmentations between alendronate and immuno-stimulants (IL-1, TNF, and LPS) in HDC induction, (2) tissue IL-1beta is important in alendronate-stimulated HDC induction, and (3) combination use of clodronate may have the potential to reduce the inflammatory effects of alendronate (we previously found that clodronate, conveniently, does not inhibit the anti-bone-resorptive activity of alendronate). Clodronic Acid 244-254 interleukin 1 beta Mus musculus 154-162 17924976-3 2007 When macrophages were depleted using clodronate liposomes, both neovascularization and tumor growth were reduced in the IL-1beta-expressing tumors. Clodronic Acid 37-47 interleukin 1 beta Mus musculus 120-128 16203021-6 2006 These results suggest that (1) there are mutual augmentations between alendronate and immuno-stimulants (IL-1, TNF, and LPS) in HDC induction, (2) tissue IL-1beta is important in alendronate-stimulated HDC induction, and (3) combination use of clodronate may have the potential to reduce the inflammatory effects of alendronate (we previously found that clodronate, conveniently, does not inhibit the anti-bone-resorptive activity of alendronate). Clodronic Acid 354-364 interleukin 1 beta Mus musculus 154-162 15380476-6 2004 Clodronate (0.01, 0.1, 1 microg/ml) significantly down-regulated the LPS-stimulated microglial secretion of tumor necrosis factor (TNF)-alpha, Interleukin (IL)-1beta and NO, but not of IL-6. Clodronic Acid 0-10 interleukin 1 beta Mus musculus 143-165 16239969-9 2005 After day 4, clodronate liposomes, which kill macrophages, reduced IL-1beta-induced angiogenesis and partially inhibited VEGF-induced angiogenesis. Clodronic Acid 13-23 interleukin 1 beta Mus musculus 67-75 12734370-5 2003 In independent experiments, ELISA analysis showed that protein levels for IL-1 beta, macrophage-inflammatory protein 2, and macrophage-inflammatory protein 1 alpha, all regulators of PMN chemotaxis, also were elevated in both groups of mice treated with clodronate-liposomes. Clodronic Acid 254-264 interleukin 1 beta Mus musculus 74-83 9500698-9 1998 Gadolinium chloride and liposome-encapsulated dichloromethylene diphosphonate lowered LPS-mediated HO-1 mRNA accumulation (by about 50%); in these groups hepatic levels of interleukin (IL)-1beta were decreased, by more than 75%. Clodronic Acid 46-77 interleukin 1 beta Mus musculus 172-194