PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27251362-4	2016	From 794 natural compounds, kurarinone, a flavanone from Sophora flavescens, strongly potentiated BKCa channels.	kurarinone	28-38	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	98-102	
27251362-6	2016	Whereas kurarinone strongly potentiated the homomeric BKCa channel composed of only the alpha subunit, its effects were much smaller on heteromeric channels coassembled with auxiliary beta subunits.	kurarinone	8-18	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	54-58	
27251362-7	2016	Although the activation kinetics was not altered significantly, the deactivation of BKCa channels was dramatically slowed by kurarinone treatment.	kurarinone	125-135	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	84-88	
27251362-8	2016	At the single-channel level, kurarinone increased the open probability of the BKCa channel without affecting its single-channel conductance.	kurarinone	29-39	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	78-82	
27251362-10	2016	These results indicate that kurarinone can directly potentiate BKCa channels and demonstrate the therapeutic potentials of kurarinone and its derivatives for developing antioveractive bladder medications and supplements.	kurarinone	28-38	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	63-67