PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34096887-0 2021 Calycosin inhibits breast cancer cell migration and invasion by suppressing EMT via BATF/TGF-beta1. 7,3'-dihydroxy-4'-methoxyisoflavone 0-9 transforming growth factor beta 1 Homo sapiens 89-98 34096887-5 2021 Calycosin treatment inhibited epithelial-mesenchymal transition (EMT) of breast cancer cells by significantly increasing E-cadherin levels and decreasing N-cadherin, Vimentin, CD147, MMP-2, and MMP-9 levels through downregulation of BATF and TGFbeta1. 7,3'-dihydroxy-4'-methoxyisoflavone 0-9 transforming growth factor beta 1 Homo sapiens 242-250 34096887-6 2021 TGFbeta1 knockdown reduced the migration and invasiveness of BATF-overexpressing breast cancer cells, whereas incubation with TGFbeta1 enhanced the migration and invasiveness of calycosin-treated breast cancer cells. 7,3'-dihydroxy-4'-methoxyisoflavone 178-187 transforming growth factor beta 1 Homo sapiens 126-134 34096887-7 2021 Our findings demonstrated that calycosin inhibited EMT and progression of breast cancer cells by suppressing BATF/TGFbeta1 signaling. 7,3'-dihydroxy-4'-methoxyisoflavone 31-40 transforming growth factor beta 1 Homo sapiens 114-122 31174572-0 2019 Calycosin suppresses TGF-beta-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3K/Akt signaling pathways in colorectal cancer cells. 7,3'-dihydroxy-4'-methoxyisoflavone 0-9 transforming growth factor beta 1 Homo sapiens 21-29 31174572-8 2019 RESULTS: Calycosin up-regulated the expression of BATF2 via the signal transducer and activator of transcription 3 (STAT3) pathway, which was antagonized by transforming growth factor beta (TGF-beta), calycosin promoted the cell apoptosis and growth inhibition via phosphoinositide 3-kinase (PI3K)/Akt pathway. 7,3'-dihydroxy-4'-methoxyisoflavone 9-18 transforming growth factor beta 1 Homo sapiens 157-188 31174572-8 2019 RESULTS: Calycosin up-regulated the expression of BATF2 via the signal transducer and activator of transcription 3 (STAT3) pathway, which was antagonized by transforming growth factor beta (TGF-beta), calycosin promoted the cell apoptosis and growth inhibition via phosphoinositide 3-kinase (PI3K)/Akt pathway. 7,3'-dihydroxy-4'-methoxyisoflavone 9-18 transforming growth factor beta 1 Homo sapiens 190-198 31174572-9 2019 TGF-beta promoted cell growth, which was inhibited by calycosin regulating the expression of proliferating cell nuclear antigen (PCNA) via the phosphoinositide 3-kinase pathway. 7,3'-dihydroxy-4'-methoxyisoflavone 54-63 transforming growth factor beta 1 Homo sapiens 0-8 31174572-10 2019 TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1. 7,3'-dihydroxy-4'-methoxyisoflavone 108-117 transforming growth factor beta 1 Homo sapiens 141-149 31174572-10 2019 TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1. 7,3'-dihydroxy-4'-methoxyisoflavone 108-117 transforming growth factor beta 1 Homo sapiens 141-149 31174572-10 2019 TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1. 7,3'-dihydroxy-4'-methoxyisoflavone 181-190 transforming growth factor beta 1 Homo sapiens 0-8 31174572-10 2019 TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1. 7,3'-dihydroxy-4'-methoxyisoflavone 181-190 transforming growth factor beta 1 Homo sapiens 141-149 31174572-10 2019 TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1. 7,3'-dihydroxy-4'-methoxyisoflavone 181-190 transforming growth factor beta 1 Homo sapiens 141-149 31174572-11 2019 TGF-beta-induced EMT was inhibited by calycosin in human CRC LoVo and HCT116 cell lines via the Wnt signaling pathway. 7,3'-dihydroxy-4'-methoxyisoflavone 38-47 transforming growth factor beta 1 Homo sapiens 0-8 33188878-8 2021 In addition, calycosin reduced the expression of TGF-beta1, SMAD2/3, SLUG, and vimentin. 7,3'-dihydroxy-4'-methoxyisoflavone 13-22 transforming growth factor beta 1 Homo sapiens 49-58 31277716-0 2019 Correction to: Calycosin suppresses TGF-beta-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3K/Akt signaling pathways in colorectal cancer cells. 7,3'-dihydroxy-4'-methoxyisoflavone 15-24 transforming growth factor beta 1 Homo sapiens 36-44 31163422-0 2019 Calycosin Inhibits Intestinal Fibrosis on CCD-18Co Cells via Modulating Transforming Growth Factor-beta/Smad Signaling Pathway. 7,3'-dihydroxy-4'-methoxyisoflavone 0-9 transforming growth factor beta 1 Homo sapiens 72-103 30312543-0 2018 Inhibition effect of phytoestrogen calycosin on TGF-beta1-induced hepatic stellate cell activation, proliferation, and migration via estrogen receptor beta. 7,3'-dihydroxy-4'-methoxyisoflavone 35-44 transforming growth factor beta 1 Homo sapiens 48-57 30312543-11 2018 In conclusion, calycosin inhibits proliferation, activation, and migration of TGF-beta1-induced HSCs. 7,3'-dihydroxy-4'-methoxyisoflavone 15-24 transforming growth factor beta 1 Homo sapiens 78-87 29849130-6 2018 In this study we evaluated 14 ingredients from DBT in human hepatic stellate cell line LX-2, and found that astragaloside I (A), levistilide A (L) and calycosin (C) produced synergistic proliferation inhibition on LX-2 cells and TGF-beta1-activated LX-2 cells. 7,3'-dihydroxy-4'-methoxyisoflavone 151-160 transforming growth factor beta 1 Homo sapiens 229-238 21669275-9 2011 Pre-treatment with calycosin strikingly down-regulated HUVEC TGF-beta1, ICAM-1 and RAGE expressions in both protein and mRNA levels. 7,3'-dihydroxy-4'-methoxyisoflavone 19-28 transforming growth factor beta 1 Homo sapiens 61-70