PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30182951-9	2018	In MG-63 cells, calycosin treatment increased the expression of the PI3K/AKT/mTOR pathway proteins; inhibitor assays showed that expression of the PI3K protein was most strongly associated with the antitumor effects of calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	16-25	AKT serine/threonine kinase 1	Homo sapiens	73-76	
30182951-0	2018	Calycosin, a Phytoestrogen Isoflavone, Induces Apoptosis of Estrogen Receptor-Positive MG-63 Osteosarcoma Cells via the Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	AKT serine/threonine kinase 1	Homo sapiens	157-160	
30182951-11	2018	CONCLUSIONS The phytoestrogen, calycosin, induced apoptosis of cells of the ER-positive osteosarcoma cell line, MG-63, via the PI3K/AKT/mTOR pathway, with these effects being mainly due to PI3K.	7,3'-dihydroxy-4'-methoxyisoflavone	31-40	AKT serine/threonine kinase 1	Homo sapiens	132-135	
29096683-8	2017	Additionally, in all four GPR30-positive breast cancer lines, calycosin decreased the phosphorylation levels of SRC, EGFR, ERK1/2 and Akt, but the inhibition of WDR7-7 blocked these changes and increased proliferation.	7,3'-dihydroxy-4'-methoxyisoflavone	62-71	AKT serine/threonine kinase 1	Homo sapiens	134-137	
28368679-0	2017	Calycosin Enhances Some Chemotherapeutic Drugs Inhibition of Akt Signaling Pathway in Gastric Cells.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	AKT serine/threonine kinase 1	Homo sapiens	61-64	
28368679-8	2017	We found that calycosin can enhance the suppression of cisplatin to gastric cell line by inhibiting the phosphorylation of protein kinase B (Akt).	7,3'-dihydroxy-4'-methoxyisoflavone	14-23	AKT serine/threonine kinase 1	Homo sapiens	141-144	
34176787-4	2021	Molecular docking analysis indicated the binding efficacy of calycosin with three of the targets, namely TP53, AKT1, and VEGFA.	7,3'-dihydroxy-4'-methoxyisoflavone	61-70	AKT serine/threonine kinase 1	Homo sapiens	111-115	
25613518-0	2015	Calycosin and genistein induce apoptosis by inactivation of HOTAIR/p-Akt signaling pathway in human breast cancer MCF-7 cells.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	AKT serine/threonine kinase 1	Homo sapiens	69-72	
25613518-9	2015	Treatment of MCF-7 cells with calycosin or genistein resulted in decreased phosphorylation of Akt, and decreased expression of its downstream target, HOTAIR.	7,3'-dihydroxy-4'-methoxyisoflavone	30-39	AKT serine/threonine kinase 1	Homo sapiens	94-97	
25613518-10	2015	CONCLUSION: Calycosin is more effective in inhibiting breast cancer growth in comparison with genistein, through its regulation of Akt signaling pathways and HOTAIR expression.	7,3'-dihydroxy-4'-methoxyisoflavone	12-21	AKT serine/threonine kinase 1	Homo sapiens	131-134	
24618835-0	2014	Calycosin suppresses breast cancer cell growth via ERbeta-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	AKT serine/threonine kinase 1	Homo sapiens	108-111	
24618835-8	2014	Taken together, our results indicate that calycosin tends to inhibit growth and induce apoptosis in ER-positive breast cancer cells, which is mediated by ERbeta-induced inhibition of IGF-1R, along with the selective regulation of MAPK and phosphatidylinositol 3-kinase (PI3K)/Akt pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	42-51	AKT serine/threonine kinase 1	Homo sapiens	276-279	
34176787-6	2021	In addition, the anti-CIRI actions of calycosin were primarily through suppression of the toll-like receptor, PI3K-AKT, TNF, MAPK, and VEGF signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	38-47	AKT serine/threonine kinase 1	Homo sapiens	115-118	
32236598-0	2020	Calycosin induces apoptosis in osteosarcoma cell line via ERbeta-mediated PI3K/Akt signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	AKT serine/threonine kinase 1	Homo sapiens	79-82	
33188878-7	2021	Calycosin induced the activation of MAPK, STAT3, NF-kappaB, apoptosis-related proteins, and induced cell cycle arrest in the G0/G1 phase by regulating AKT.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	AKT serine/threonine kinase 1	Homo sapiens	151-154	
32236598-7	2020	Moreover, phosphorylation levels of PI3K and Akt were significantly downregulated after calycosin treatment, whereas PHTPP reversed their phosphorylation.	7,3'-dihydroxy-4'-methoxyisoflavone	88-97	AKT serine/threonine kinase 1	Homo sapiens	45-48	
32236598-1	2020	Previous studies have shown that calycosin, a natural phytoestrogen which is structurally similar to estrogen, inhibits proliferation and induces apoptosis in estrogen-dependent cancer types via the estrogen receptor (ER)beta-induced inhibition of PI3K/Akt.	7,3'-dihydroxy-4'-methoxyisoflavone	33-42	AKT serine/threonine kinase 1	Homo sapiens	253-256	
32236598-9	2020	Thus, the present results indicated that calycosin inhibited proliferation and induced apoptosis in OS MG-63 cells, and that these effects were mediated by ERbeta-dependent inhibition of the PI3K/Akt pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	AKT serine/threonine kinase 1	Homo sapiens	196-199	
31502574-5	2019	Meanwhile a western blot assay showed that c-Met together with matrix metalloproteinases-9 (MMP9) and phosphorylation of the serine/threonine kinase AKT (p-AKT) was significantly down-regulated by calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	197-206	AKT serine/threonine kinase 1	Homo sapiens	149-152	
31276230-0	2019	Calycosin induces apoptosis in adenocarcinoma HT29 cells by inducing cytotoxic autophagy mediated by SIRT1/AMPK-induced inhibition of Akt/mTOR.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	AKT serine/threonine kinase 1	Homo sapiens	134-137	
31276230-13	2019	In conclusion, Calycosin stimulates CRC cell apoptosis and inhibits their invasion by acting as SIRT1 activator which induces activation of AMPK-induced inhibition of Akt/mTOR axis.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	AKT serine/threonine kinase 1	Homo sapiens	167-170	
31502574-5	2019	Meanwhile a western blot assay showed that c-Met together with matrix metalloproteinases-9 (MMP9) and phosphorylation of the serine/threonine kinase AKT (p-AKT) was significantly down-regulated by calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	197-206	AKT serine/threonine kinase 1	Homo sapiens	154-159	
31502574-7	2019	Additionally, the expression levels of c-Met, MMP9 and p-AKT were inhibited by calycosin in c-Met overexpressed cells.	7,3'-dihydroxy-4'-methoxyisoflavone	79-88	AKT serine/threonine kinase 1	Homo sapiens	57-60	
31502574-9	2019	These data collectively indicated that calycosin possibility targeting on c-Met and exert an anti-tumor role via MMP9 and AKT.	7,3'-dihydroxy-4'-methoxyisoflavone	39-48	AKT serine/threonine kinase 1	Homo sapiens	122-125	
31277716-0	2019	Correction to: Calycosin suppresses TGF-beta-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3K/Akt signaling pathways in colorectal cancer cells.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	AKT serine/threonine kinase 1	Homo sapiens	163-166