PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34186122-7 2021 It was also shown that after incubation of the IFN-gamma samples at 50 C for 60 min in the presence of calycosin (5 muM), the IFN-gamma-calycosin system showed a significant antiproliferative effects against hepatocellular carcinoma (HepG2) cells through caspase-9/3 activation and this anticancer effect was more pronounced than free IFN-gamma. 7,3'-dihydroxy-4'-methoxyisoflavone 104-113 caspase 9 Homo sapiens 256-267 32901836-8 2020 In addition, calycosin increased the expression of the proapoptotic antiapoptotic proteins cleaved caspase-3, cleaved caspase-9, cleaved poly(ADP-ribose) polymerase and Bcl-2-associated X protein (Bax), and decreased the expression of the antiapoptotic proapoptotic protein B-cell lymphoma-2 (Bcl-2), thus altering the Bax/Bcl-2 ratio. 7,3'-dihydroxy-4'-methoxyisoflavone 13-22 caspase 9 Homo sapiens 118-127