PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16546963-6 2006 In MDA-MB468 cells, cerulenin- and LY294002-mediated apoptosis was associated with caspase-3 activation and the release of cytochrome c from mitochondria to cytosol. Cerulenin 20-29 cytochrome c, somatic Homo sapiens 123-135 12181752-6 2002 The significance of the mitochondrial pathway for the cerulenin-mediated apoptosis was confirmed by the rapid mitochondrial release of cytochrome c both in wild-type p53 and mutant cell lines. Cerulenin 54-63 cytochrome c, somatic Homo sapiens 135-147 23441619-4 2013 Cerulenin treatment resulted in significant upregulation of cytochrome c (CYCS) by 1.2-fold, whereas S-phase kinase-associated protein-2 (SKP2), a negative regulator of cell cycle, and the lipid metabolic genes (PPARA, RXRA, and ACACB) were significantly downregulated by -1.59-, -1.8-, -1.83-, and -1.5-fold, respectively, in comparison with untreated cancer cells. Cerulenin 0-9 cytochrome c, somatic Homo sapiens 60-72 23441619-4 2013 Cerulenin treatment resulted in significant upregulation of cytochrome c (CYCS) by 1.2-fold, whereas S-phase kinase-associated protein-2 (SKP2), a negative regulator of cell cycle, and the lipid metabolic genes (PPARA, RXRA, and ACACB) were significantly downregulated by -1.59-, -1.8-, -1.83-, and -1.5-fold, respectively, in comparison with untreated cancer cells. Cerulenin 0-9 cytochrome c, somatic Homo sapiens 74-78