PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16906041-13	2006	Treatment of allograft recipient rats with bosentan prevented upregulation of ED-B FN and TGF-beta1.	Bosentan	43-51	transforming growth factor, beta 1	Rattus norvegicus	90-99	
17097496-9	2006	The beneficial effects of bosentan and ramipril, alone or in combination, were associated with reduced mRNA levels of transforming growth factor (TGF)-beta1 and platelet-derived growth factor (PDGF)-A in the tracheal allografts.	Bosentan	26-34	transforming growth factor, beta 1	Rattus norvegicus	118-156	
12887768-8	2003	The mRNA expressions of ColI, TGF-beta1 and TIMP-1 in renal tissue subjected to ureter ligation were significantly lower in the bosentan group then in the animal model group (all P < 0.05).	Bosentan	128-136	transforming growth factor, beta 1	Rattus norvegicus	30-39	
14639097-9	2003	The statistical analysis of the results demonstrates that Bosentan has prevented the increase in urinary protein excretion and that of renal immunoreactive collagen I, fibronectin, and TGFbeta induced by diabetes without reducing blood pressure.	Bosentan	58-66	transforming growth factor, beta 1	Rattus norvegicus	185-192	
12887768-9	2003	The positive staining areas of ColI, TGF-beta1 and TIMP-1 in the tubulointerstitium were significantly smaller in bosentan group than in the animal model group (all P < 0.05).	Bosentan	114-122	transforming growth factor, beta 1	Rattus norvegicus	37-46	
24918345-7	2015	Bosentan treatment showed a significant up-regulatory effect on ET-1, TNF-alpha and TGF-beta mRNA expression.	Bosentan	0-8	transforming growth factor, beta 1	Rattus norvegicus	84-92	
12150723-10	2002	CONCLUSION: Bosentan combined with amlodipine can offer similar renoprotective effects on that of cilazapril and may be a potent therapy to attenuate renal injury by reducing renal protein levels of TGF-beta1 in diabetes with a hypertensive state.	Bosentan	12-20	transforming growth factor, beta 1	Rattus norvegicus	199-208