PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34958116-3	2022	In the present study, it was revealed that a specific inhibitor of histone deacetylase 6, ACY-1215, caused increased acetylation of p53 in breast cancer cells with mutated p53, which was accompanied by increased expression of p21.	ricolinostat	90-98	transformation related protein 53, pseudogene	Mus musculus	132-135	
34958116-3	2022	In the present study, it was revealed that a specific inhibitor of histone deacetylase 6, ACY-1215, caused increased acetylation of p53 in breast cancer cells with mutated p53, which was accompanied by increased expression of p21.	ricolinostat	90-98	transformation related protein 53, pseudogene	Mus musculus	172-175	
34958116-4	2022	These results suggested that ACY-1215 may lead to enhanced transcriptional activity of p53.	ricolinostat	29-37	transformation related protein 53, pseudogene	Mus musculus	87-90	
34958116-7	2022	More importantly, it was observed that combination of ACY-1215 and ATM inhibitors exhibited markedly more potent antitumor activity than the individual compound in xenograft mouse models of breast cancer with mutant p53.	ricolinostat	54-62	transformation related protein 53, pseudogene	Mus musculus	216-219	
34958116-8	2022	Collectively, our results demonstrated that ACY-1215 is a novel chemotherapeutic agent that could restore mutant p53 function in cancer cells with strong antitumor activity, either alone or in combination with inhibitors of the ATM protein kinase.	ricolinostat	44-52	transformation related protein 53, pseudogene	Mus musculus	113-116	
34180140-4	2021	Furthermore, ACY1215 pretreatment increased the level of ATM, gamma-H2AX, Chk2, p53, p21, F-actin and vinculin in ALF.	ricolinostat	13-20	transformation related protein 53, pseudogene	Mus musculus	80-83	
34180140-6	2021	The ATM inhibitor KU55933 could decrease the level of ATM, gamma-H2AX, Chk2, p53, p21, F-actin and vinculin in ALF with ACY1215 pretreatment.	ricolinostat	120-127	transformation related protein 53, pseudogene	Mus musculus	77-80