PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33103445-6 2020 ACY-1215 treatment also suppressed phosphorylation of epidermal growth factor receptor (EGFR) and several signaling molecules associated with renal fibrogenesis, including AKT, signal transducer and activator of transcription 3 and nuclear factor kappa light chain enhancer of activated B cells in the injured kidney. ricolinostat 0-8 thymoma viral proto-oncogene 1 Mus musculus 172-175 30050135-0 2018 Ricolinostat (ACY-1215) suppresses proliferation and promotes apoptosis in esophageal squamous cell carcinoma via miR-30d/PI3K/AKT/mTOR and ERK pathways. ricolinostat 0-12 thymoma viral proto-oncogene 1 Mus musculus 127-130 30050135-0 2018 Ricolinostat (ACY-1215) suppresses proliferation and promotes apoptosis in esophageal squamous cell carcinoma via miR-30d/PI3K/AKT/mTOR and ERK pathways. ricolinostat 14-22 thymoma viral proto-oncogene 1 Mus musculus 127-130 30050135-5 2018 We further demonstrated that ACY-1215 treatment reduced the expression of PI3K, P-AKT, P-mTOR, and P-ERK1/2 and increased that of Ac-H3K9 and Ac-H4K8. ricolinostat 29-37 thymoma viral proto-oncogene 1 Mus musculus 82-85 30050135-10 2018 In conclusion, our study showed that ACY-1215 suppressed proliferation and promoted apoptosis in ESCC via miR-30d/PI3K/AKT/mTOR and ERK pathways and that ACY-1215 may be a promising antitumor agent in ESCC. ricolinostat 37-45 thymoma viral proto-oncogene 1 Mus musculus 119-122 34958116-6 2022 Furthermore, ACY-1215 displayed a synergistic effect with specific inhibitors of ATM, an activator of Akt, in inducing cancer cell apoptosis and inhibiting their motility. ricolinostat 13-21 thymoma viral proto-oncogene 1 Mus musculus 102-105