PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32209837-6	2020	Linear regressions, Mann-Whitney U-test or Kruskal-Wallis tests were conducted to examine the association of lumefantrine plasma level with CYP2B6 c.516G>T, NR1I3 152c-1089T>C, CYP2B6 c.983T>C, CYP3A5*3 and CYP3A4*22.	Lumefantrine	109-121	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	140-146	
32209837-11	2020	Composite genotypes for both CYP2B6 Single-nucleotide polymorphisms strongly associated with lumefantrine plasma concentration.	Lumefantrine	93-105	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	29-35	
32209837-8	2020	In nonpregnant group, CYP2B6 c.516G>T was significantly associated with lower log Cday 7 of lumefantrine using multivariate linear regressions (beta = -0.239; P = 0.013).	Lumefantrine	92-104	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	22-28	
32209837-9	2020	In 59% of women with CYP2B6 c.516T, Cday 7 of lumefantrine was below the target of 280 ng/mL compared to 47% in the noncarriers.	Lumefantrine	46-58	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	21-27	
29635009-0	2018	The impact of CYP2B6 polymorphisms on the interactions of efavirenz with lumefantrine: Implications for paediatric antimalarial therapy.	Lumefantrine	73-85	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	14-20	
29635009-2	2018	The concomitant use of lumefantrine with the antiretroviral efavirenz, which is metabolised by CYP2B6 and is an inducer of CYP3A4, increases the risk of lumefantrine failure and can result in an increased recrudescence rate in HIV-infected children.	Lumefantrine	23-35	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	95-101	
25963334-0	2016	CYP2B6*6 genotype and high efavirenz plasma concentration but not nevirapine are associated with low lumefantrine plasma exposure and poor treatment response in HIV-malaria-coinfected patients.	Lumefantrine	101-113	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-6	
25963334-5	2016	High EFV plasma concentrations and CYP2B6*6/*6 genotype significantly correlated with low lumefantrine plasma concentrations and high rate of recurrent parasitemia.	Lumefantrine	90-102	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	35-41	
25906774-2	2015	EFV, NVP, artemether and lumefantrine are substrates, inhibitors or inducers of CYP3A4 and CYP2B6, creating a potential for drug-drug interactions.	Lumefantrine	25-37	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	91-97