PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34890854-1 2022 The separation of daclatasvir and its R,R,R,R-enantiomer was studied by capillary electrophoresis using various randomly methylated beta-CDs and the single isomer heptakis(2,6-di-O-methyl)-beta-CD (2,6-DM-beta-CD) as chiral selectors in an acidic background electrolyte. daclatasvir 18-29 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 189-196 34890854-1 2022 The separation of daclatasvir and its R,R,R,R-enantiomer was studied by capillary electrophoresis using various randomly methylated beta-CDs and the single isomer heptakis(2,6-di-O-methyl)-beta-CD (2,6-DM-beta-CD) as chiral selectors in an acidic background electrolyte. daclatasvir 18-29 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 205-212 34890854-3 2022 HPLC and NMR analyses confirmed that the presence of a high 2,6-DM-beta-CD content in the CDs enables to achieve the migration order R,R,R,R-enantiomer > daclatasvir. daclatasvir 154-165 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 67-74 34560933-1 2021 In capillary electrophoresis an enantioseparation of daclatasvir (DCV) was observed in case of heptakis(2,6-di-O-methyl)-beta-CD, heptakis(2-O-methyl)-beta-CD and beta-CD, while two peaks with a plateau were noted for heptakis(2,3,6-tri-O-methyl)-beta-CD and heptakis(2,3-di-O-methyl)-beta-CD indicating a slow equilibrium. daclatasvir 53-64 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 121-128 34560933-1 2021 In capillary electrophoresis an enantioseparation of daclatasvir (DCV) was observed in case of heptakis(2,6-di-O-methyl)-beta-CD, heptakis(2-O-methyl)-beta-CD and beta-CD, while two peaks with a plateau were noted for heptakis(2,3,6-tri-O-methyl)-beta-CD and heptakis(2,3-di-O-methyl)-beta-CD indicating a slow equilibrium. daclatasvir 53-64 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 151-158 34560933-1 2021 In capillary electrophoresis an enantioseparation of daclatasvir (DCV) was observed in case of heptakis(2,6-di-O-methyl)-beta-CD, heptakis(2-O-methyl)-beta-CD and beta-CD, while two peaks with a plateau were noted for heptakis(2,3,6-tri-O-methyl)-beta-CD and heptakis(2,3-di-O-methyl)-beta-CD indicating a slow equilibrium. daclatasvir 53-64 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 163-170 34560933-1 2021 In capillary electrophoresis an enantioseparation of daclatasvir (DCV) was observed in case of heptakis(2,6-di-O-methyl)-beta-CD, heptakis(2-O-methyl)-beta-CD and beta-CD, while two peaks with a plateau were noted for heptakis(2,3,6-tri-O-methyl)-beta-CD and heptakis(2,3-di-O-methyl)-beta-CD indicating a slow equilibrium. daclatasvir 53-64 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 247-254 34560933-1 2021 In capillary electrophoresis an enantioseparation of daclatasvir (DCV) was observed in case of heptakis(2,6-di-O-methyl)-beta-CD, heptakis(2-O-methyl)-beta-CD and beta-CD, while two peaks with a plateau were noted for heptakis(2,3,6-tri-O-methyl)-beta-CD and heptakis(2,3-di-O-methyl)-beta-CD indicating a slow equilibrium. daclatasvir 53-64 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 285-292 34560933-6 2021 Higher order complexes between DCV and heptakis(2,6-di-O-methyl)-beta-CD were corroborated by mass spectrometry. daclatasvir 31-34 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 65-72