PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19531490-5	2009	Phospho-GST-MYPT1 fragments docked directly at the active site of MLCP, and this was blocked by a PP1/PP2A inhibitor microcystin (MC)-LR or by mutation of the active sites in PP1.	microcystin	117-128	protein phosphatase 2 phosphatase activator	Homo sapiens	102-106	
27723199-4	2016	Our approach led to the first MC analogue with submicromolar inhibitory potency that is strongly selective for PP2A over PP1 and does not require the complex lipophilic Adda group.	microcystin	30-32	protein phosphatase 2 phosphatase activator	Homo sapiens	111-115	
26891928-2	2016	The inhibition of PP2A is widely assumed as the principal mechanism of toxicity of MCs, however recently it has been found that MC modulates PP2A activity not only by direct inhibition of its activity, but also by regulating its expression.	microcystin	83-85	protein phosphatase 2 phosphatase activator	Homo sapiens	18-22	
25922137-5	2015	Protein phosphatase 2A (PP2A) is emerging as a critical regulator of the microcystin-induced molecular network.	microcystin	73-84	protein phosphatase 2 phosphatase activator	Homo sapiens	24-28	
19501114-2	2009	The representative MC, MC-LR, strongly inhibits protein phosphatase 2A (PP2A), while the inhibitory potencies of at least 60MC analogs characterized from bloom samples and cultured strains have not been fully elucidated.	microcystin	19-21	protein phosphatase 2 phosphatase activator	Homo sapiens	56-70	
19501114-2	2009	The representative MC, MC-LR, strongly inhibits protein phosphatase 2A (PP2A), while the inhibitory potencies of at least 60MC analogs characterized from bloom samples and cultured strains have not been fully elucidated.	microcystin	19-21	protein phosphatase 2 phosphatase activator	Homo sapiens	72-76	
19501114-6	2009	To obtain further insight into the MC-PP2A interaction, we substituted cysteine at position 269 in PP2Ac with glycine.	microcystin	35-37	protein phosphatase 2 phosphatase activator	Homo sapiens	38-42	
10206668-6	1999	It was found that the affinity of PL-a to microcystin-bound PP-2A was four times smaller compared to unbound PP-2A, due to 50% decreases in the association rates and two-fold increases in dissociation rates of PL-a binding to PP-2A.	microcystin	42-53	protein phosphatase 2 phosphatase activator	Homo sapiens	60-65	
17308056-9	2007	Cytotoxicity of microcystin analogues seems to correlate to the inhibition of PP2A in these cells and induces rapid cell death as seen by chromatin condensation and cell fragmentation.	microcystin	16-27	protein phosphatase 2 phosphatase activator	Homo sapiens	78-82	
14611855-0	2003	Microcystin analogues comprised only of Adda and a single additional amino acid retain moderate activity as PP1/PP2A inhibitors.	microcystin	0-11	protein phosphatase 2 phosphatase activator	Homo sapiens	112-116	
8384557-3	1993	Its substrate specificity and sensitivity to the inhibitors, okadaic acid and microcystin, were similar (but not identical) to the catalytic subunit of PP2A.	microcystin	78-89	protein phosphatase 2 phosphatase activator	Homo sapiens	152-156