PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29016795-10	2017	Furthermore, leonurine (60 mg/kg) significantly inhibited the production of proinflammatory cytokine interleukin-1beta, interleukin-6 and TNF-alpha, and suppressed the nuclear factor kappa B signaling pathway.	leonurine	13-22	interleukin 1 beta	Mus musculus	101-118	
28431044-8	2017	Results: Leonurine treatment significantly decreased the production of pro-inflammatory cytokines (IL-1beta, IL-6, IL-8 and TNFalpha) and MMPs (MMP-1 and MMP-3) and suppressed the migration and invasion of RA fibroblast-like synoviocytes.	leonurine	9-18	interleukin 1 beta	Mus musculus	99-107	
30273917-0	2018	Leonurine inhibits IL-1beta induced inflammation in murine chondrocytes and ameliorates murine osteoarthritis.	leonurine	0-9	interleukin 1 beta	Mus musculus	19-27	
30273917-8	2018	In this study, leonurine visibly inhibited the IL-1beta-induced production of NO, PGE2, IL-6 and TNF-alpha; and decreased the expression of iNOS, COX-2, MMP-3, MMP-13 and ADAMTS-5 in chondrocytes.	leonurine	15-24	interleukin 1 beta	Mus musculus	47-55	
30273917-9	2018	Furthermore, leonurine significantly suppressed IL-1beta-stimulated NF-kappaB activation.	leonurine	13-22	interleukin 1 beta	Mus musculus	48-56	
29879659-6	2018	qRT-PCR and ELISA experiments suggested that leonurine inhibited the expression levels of TNF-alpha and IL-1beta in uterus tissues and bEECs.	leonurine	45-54	interleukin 1 beta	Mus musculus	104-112