PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29879659-6 2018 qRT-PCR and ELISA experiments suggested that leonurine inhibited the expression levels of TNF-alpha and IL-1beta in uterus tissues and bEECs. leonurine 45-54 interleukin 1 beta Mus musculus 104-112 30273917-0 2018 Leonurine inhibits IL-1beta induced inflammation in murine chondrocytes and ameliorates murine osteoarthritis. leonurine 0-9 interleukin 1 beta Mus musculus 19-27 30273917-8 2018 In this study, leonurine visibly inhibited the IL-1beta-induced production of NO, PGE2, IL-6 and TNF-alpha; and decreased the expression of iNOS, COX-2, MMP-3, MMP-13 and ADAMTS-5 in chondrocytes. leonurine 15-24 interleukin 1 beta Mus musculus 47-55 30273917-9 2018 Furthermore, leonurine significantly suppressed IL-1beta-stimulated NF-kappaB activation. leonurine 13-22 interleukin 1 beta Mus musculus 48-56 29016795-10 2017 Furthermore, leonurine (60 mg/kg) significantly inhibited the production of proinflammatory cytokine interleukin-1beta, interleukin-6 and TNF-alpha, and suppressed the nuclear factor kappa B signaling pathway. leonurine 13-22 interleukin 1 beta Mus musculus 101-118 28431044-8 2017 Results: Leonurine treatment significantly decreased the production of pro-inflammatory cytokines (IL-1beta, IL-6, IL-8 and TNFalpha) and MMPs (MMP-1 and MMP-3) and suppressed the migration and invasion of RA fibroblast-like synoviocytes. leonurine 9-18 interleukin 1 beta Mus musculus 99-107