PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25189466-8	2015	Therefore, the results demonstrated that leonurine could downregulate the expression of TNF-alpha, IL-6, iNOS, and COX-2 and upregulate the expression of IL-10 mainly by inhibiting the expression of TLR4 and the activation of NF-kappaB and the phosphorylation of p38, ERK, and JNK.	leonurine	41-50	prostaglandin-endoperoxide synthase 2	Mus musculus	115-120	
25189466-6	2015	The results showed that leonurine significantly alleviated LPS-induced histopathological changes, downregulated the levels of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), upregulated the level of anti-inflammatory cytokine interleukin-10 (IL-10), and inhibited the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).	leonurine	24-33	prostaglandin-endoperoxide synthase 2	Mus musculus	367-383	
25189466-6	2015	The results showed that leonurine significantly alleviated LPS-induced histopathological changes, downregulated the levels of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), upregulated the level of anti-inflammatory cytokine interleukin-10 (IL-10), and inhibited the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).	leonurine	24-33	prostaglandin-endoperoxide synthase 2	Mus musculus	385-390