PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23127783-0 2013 Leonurine (SCM-198) attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4. leonurine 0-9 NADPH oxidase 4 Rattus norvegicus 78-93 23127783-5 2013 In vivo studies using a post-MI model in rats indicated that administration of leonurine inhibited myocardial fibrosis while reducing cardiac Nox4 expression, ROS production, NF-kappaB activation, and plasma MMP-2 activity. leonurine 79-88 NADPH oxidase 4 Rattus norvegicus 142-146 23127783-6 2013 In conclusion, our results provide the first evidence that leonurine could prevent cardiac fibrosis and the activation of cardiac fibroblasts partly through modulation of a Nox4-ROS pathway. leonurine 59-68 NADPH oxidase 4 Rattus norvegicus 173-177