PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29045950-0 2017 Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Ppargamma/Lxralpha Signaling Pathway-Dependent Manner. leonurine 0-9 nuclear receptor subfamily 1 group H member 3 Homo sapiens 98-106 29045950-10 2017 Besides, both the mRNA and protein levels of ABCA1/G1, PPARgamma and LXRalpha were enhanced by leonurine, which were attenuated by LXRalpha siRNA or PPARgamma siRNA transfection. leonurine 95-104 nuclear receptor subfamily 1 group H member 3 Homo sapiens 69-77 29045950-10 2017 Besides, both the mRNA and protein levels of ABCA1/G1, PPARgamma and LXRalpha were enhanced by leonurine, which were attenuated by LXRalpha siRNA or PPARgamma siRNA transfection. leonurine 95-104 nuclear receptor subfamily 1 group H member 3 Homo sapiens 131-139 29045950-12 2017 CONCLUSIONS: Leonurine can promote cholesterol efflux and alleviate cellular lipid accumulation by magnifying the expression of ABCA1/G1 in a PPARgamma/LXRalpha signaling pathway-dependent manner in human THP-1 macrophage-derived foam cells and abate atherogenesis in apoE-/- mice, which may offer a promising therapeutic intervention of leonurine in protecting against AS. leonurine 13-22 nuclear receptor subfamily 1 group H member 3 Homo sapiens 152-160