PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22326051-5	2012	Treatment with leonurine blocked TNF-alpha-induced mRNA and protein expression of adhesion molecules (intercellular adhesion molecule-1 and vascular cell adhesion molecule-1), cyclooxygenase-2, and monocyte chemoattractant protein-1 in endothelial cells.	leonurine	15-24	prostaglandin-endoperoxide synthase 2	Homo sapiens	176-192	
29763636-6	2018	In the in vitro cultured RAW264.7 and human monocyte-derived macrophages (MDMs), blockade of COX-2/mPGES-1 and 5-LOX by leonurine inhibited macrophage M1 polarization and NLRP3 inflammasome activation in response to MSU crystals, and thus down-regulated IL-1beta and TNF-alpha with STAT1 and NF-kappaB inactivation.	leonurine	120-129	prostaglandin-endoperoxide synthase 2	Homo sapiens	93-98	
29763636-8	2018	Furthermore, leonurine prevented a positive feedback loop between COX-2/mPGES-1/5-LOX and IL-1beta/TNF-alpha in MSU crystal-induced inflammation.	leonurine	13-22	prostaglandin-endoperoxide synthase 2	Homo sapiens	66-71	
29763636-9	2018	Together, simultaneous down-regulation of COX-2/mPGES-1 and 5-LOX by leonurine ameliorates MSU crystal-induced inflammation through decreasing IL-1beta and TNF-alpha production.	leonurine	69-78	prostaglandin-endoperoxide synthase 2	Homo sapiens	42-47	
29763636-0	2018	Inhibition of COX-2/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate crystal-induced inflammation.	leonurine	56-65	prostaglandin-endoperoxide synthase 2	Homo sapiens	14-19	
29763636-2	2018	Here, we investigated whether inhibition of COX-2/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate (MSU) crystal-induced inflammation.	leonurine	86-95	prostaglandin-endoperoxide synthase 2	Homo sapiens	44-49	
29763636-3	2018	Virtual screening assay and in vitro enzyme inhibition assay showed that leonurine was a potential inhibitor of COX-2, mPGES-1 and 5-LOX.	leonurine	73-82	prostaglandin-endoperoxide synthase 2	Homo sapiens	112-117	
29763636-4	2018	Compared with COX-2 inhibitor celecoxib, leonurine (30 mg/kg) significantly decreased ankle perimeter, gait score and neutrophil number in synovial fluid in MSU crystal-treated rats, accompanied with the decreased expression of COX-2, mPGES-1 and 5-LOX and production of prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) in the synovial fluid macrophages.	leonurine	41-50	prostaglandin-endoperoxide synthase 2	Homo sapiens	14-19	
29763636-4	2018	Compared with COX-2 inhibitor celecoxib, leonurine (30 mg/kg) significantly decreased ankle perimeter, gait score and neutrophil number in synovial fluid in MSU crystal-treated rats, accompanied with the decreased expression of COX-2, mPGES-1 and 5-LOX and production of prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) in the synovial fluid macrophages.	leonurine	41-50	prostaglandin-endoperoxide synthase 2	Homo sapiens	228-233	
22305882-4	2012	Meanwhile, LPS-mediated expression/release of ICAM-1, VCAM-1, and cyclooxygenase-2, and tumor necrosis factor-alpha was also reduced by leonurine.	leonurine	136-145	prostaglandin-endoperoxide synthase 2	Homo sapiens	66-115