PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29763636-5	2018	In addition, leonurine decreased representative M1 marker (iNOS and CD86) expression, NLRP3 inflammasome activation and M1 cytokine (TNF-alpha and IL-1beta) production.	leonurine	13-22	NLR family pyrin domain containing 3	Homo sapiens	86-91	
29763636-6	2018	In the in vitro cultured RAW264.7 and human monocyte-derived macrophages (MDMs), blockade of COX-2/mPGES-1 and 5-LOX by leonurine inhibited macrophage M1 polarization and NLRP3 inflammasome activation in response to MSU crystals, and thus down-regulated IL-1beta and TNF-alpha with STAT1 and NF-kappaB inactivation.	leonurine	120-129	NLR family pyrin domain containing 3	Homo sapiens	171-176