PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15746064-4	2005	Here we have investigated the effect of combined treatment with ionizing radiation and patupilone or paclitaxel in the P-glycoprotein-overexpressing, p53-mutated human colon adenocarcinoma cell line SW480 and in murine, genetically defined E1A/ras-transformed paclitaxel-sensitive embryo fibroblasts.	epothilone B	87-97	tumor protein p53	Homo sapiens	150-153	
18806741-5	2008	RESULTS: A clinically achievable concentration of epothilone B induced a cytotoxic response in p53 mutant glioblastoma cells, as a consequence of survivin down-regulation and tubulin redistribution, while a cytostatic response was observed in p53 null glioblastoma cells with a modest increase in survivin expression post-epothilone B treatment.	epothilone B	50-62	tumor protein p53	Homo sapiens	95-98	
18806741-5	2008	RESULTS: A clinically achievable concentration of epothilone B induced a cytotoxic response in p53 mutant glioblastoma cells, as a consequence of survivin down-regulation and tubulin redistribution, while a cytostatic response was observed in p53 null glioblastoma cells with a modest increase in survivin expression post-epothilone B treatment.	epothilone B	50-62	tumor protein p53	Homo sapiens	243-246	
18806741-7	2008	CONCLUSION: Epothilone B, induced positive differential responses in glioblastoma cells with abnormal p53 status, but not in p53 wild-type cells.	epothilone B	12-24	tumor protein p53	Homo sapiens	102-105	
18806741-8	2008	This suggests that epothilone B is a potential alternative to classic microtubule inhibiting agents (ie vincristine, paclitaxel) used to treat clinical glioblastomas with p53 mutations.	epothilone B	19-31	tumor protein p53	Homo sapiens	171-174	
17938270-7	2007	Moreover, epothilone B and D increased the expressions of NF-kappaB-dependent apoptotic cell death regulatory genes, i.e., Bax, p53, and the active form of caspase-3, but reduced Bcl-2 expression, and these actions were partially reversed by salicylic acid.	epothilone B	10-22	tumor protein p53	Homo sapiens	128-131	
15262986-4	2004	MDA, including epothilone B analogue (BMS-247550) and vinblastine, induced apoptosis of Bax-positive HCT116 cells in a p53-dependent manner; p53 was required for MDA-induced Bax conformational change.	epothilone B	15-27	tumor protein p53	Homo sapiens	119-122	
15262986-4	2004	MDA, including epothilone B analogue (BMS-247550) and vinblastine, induced apoptosis of Bax-positive HCT116 cells in a p53-dependent manner; p53 was required for MDA-induced Bax conformational change.	epothilone B	15-27	tumor protein p53	Homo sapiens	141-144