PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18806741-5 2008 RESULTS: A clinically achievable concentration of epothilone B induced a cytotoxic response in p53 mutant glioblastoma cells, as a consequence of survivin down-regulation and tubulin redistribution, while a cytostatic response was observed in p53 null glioblastoma cells with a modest increase in survivin expression post-epothilone B treatment. epothilone B 50-62 tumor protein p53 Homo sapiens 95-98 18806741-5 2008 RESULTS: A clinically achievable concentration of epothilone B induced a cytotoxic response in p53 mutant glioblastoma cells, as a consequence of survivin down-regulation and tubulin redistribution, while a cytostatic response was observed in p53 null glioblastoma cells with a modest increase in survivin expression post-epothilone B treatment. epothilone B 50-62 tumor protein p53 Homo sapiens 243-246 18806741-7 2008 CONCLUSION: Epothilone B, induced positive differential responses in glioblastoma cells with abnormal p53 status, but not in p53 wild-type cells. epothilone B 12-24 tumor protein p53 Homo sapiens 102-105 18806741-8 2008 This suggests that epothilone B is a potential alternative to classic microtubule inhibiting agents (ie vincristine, paclitaxel) used to treat clinical glioblastomas with p53 mutations. epothilone B 19-31 tumor protein p53 Homo sapiens 171-174 15262986-4 2004 MDA, including epothilone B analogue (BMS-247550) and vinblastine, induced apoptosis of Bax-positive HCT116 cells in a p53-dependent manner; p53 was required for MDA-induced Bax conformational change. epothilone B 15-27 tumor protein p53 Homo sapiens 119-122 15746064-4 2005 Here we have investigated the effect of combined treatment with ionizing radiation and patupilone or paclitaxel in the P-glycoprotein-overexpressing, p53-mutated human colon adenocarcinoma cell line SW480 and in murine, genetically defined E1A/ras-transformed paclitaxel-sensitive embryo fibroblasts. epothilone B 87-97 tumor protein p53 Homo sapiens 150-153 17938270-7 2007 Moreover, epothilone B and D increased the expressions of NF-kappaB-dependent apoptotic cell death regulatory genes, i.e., Bax, p53, and the active form of caspase-3, but reduced Bcl-2 expression, and these actions were partially reversed by salicylic acid. epothilone B 10-22 tumor protein p53 Homo sapiens 128-131 15262986-4 2004 MDA, including epothilone B analogue (BMS-247550) and vinblastine, induced apoptosis of Bax-positive HCT116 cells in a p53-dependent manner; p53 was required for MDA-induced Bax conformational change. epothilone B 15-27 tumor protein p53 Homo sapiens 141-144